LOCUS       NM_001364159            5360 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens EBF transcription factor 1 (EBF1), transcript variant
            16, mRNA.
ACCESSION   NM_001364159 XM_024454394
VERSION     NM_001364159.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5360)
  AUTHORS   Mladenic,T., Wagner,J., Kadivnik,M., Pereza,N., Ostojic,S.,
            Peterlin,B. and Devic Pavlic,S.
  TITLE     Protective Effect of EBF Transcription Factor 1 (EBF1) Polymorphism
            in Sporadic and Familial Spontaneous Preterm Birth: Insights from a
            Case-Control Study
  JOURNAL   Int J Mol Sci 25 (20), 11192 (2024)
   PUBMED   39456973
  REMARK    GeneRIF: Protective Effect of EBF Transcription Factor 1 (EBF1)
            Polymorphism in Sporadic and Familial Spontaneous Preterm Birth:
            Insights from a Case-Control Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5360)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5360)
  AUTHORS   Li,L., Zhang,D. and Cao,X.
  TITLE     EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms
  JOURNAL   Front Immunol 15, 1320689 (2024)
   PUBMED   38318177
  REMARK    GeneRIF: EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5360)
  AUTHORS   Liu,Y., Fan,M., Xian,S., Hu,P., Zhang,M., Zhang,X., Zhang,H.,
            Zhang,J., Dai,L., Lin,M., Mei,W., Huang,D., Huang,R., Zhang,J. and
            Huang,Z.
  TITLE     RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis
            Pathway in Bone Metastases of Bladder Urothelial Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 189 (2023)
   PUBMED   37664915
  REMARK    GeneRIF: RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte
            Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma.
REFERENCE   5  (bases 1 to 5360)
  AUTHORS   Al Madhoun,A., Haddad,D., Nizam,R., Miranda,L., Kochumon,S.,
            Thomas,R., Thanaraj,T.A., Ahmad,R., Bitar,M.S. and Al-Mulla,F.
  TITLE     Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New
            Binding Site for the Early B-Cell Factor 1 That Instigates Adipose
            Tissue CAV1 Protein Overexpression
  JOURNAL   Cells 11 (23), 3937 (2022)
   PUBMED   36497195
  REMARK    GeneRIF: Caveolin-1 rs1997623 Single Nucleotide Polymorphism
            Creates a New Binding Site for the Early B-Cell Factor 1 That
            Instigates Adipose Tissue CAV1 Protein Overexpression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5360)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
REFERENCE   7  (bases 1 to 5360)
  AUTHORS   Hagman,J., Gutch,M.J., Lin,H. and Grosschedl,R.
  TITLE     EBF contains a novel zinc coordination motif and multiple
            dimerization and transcriptional activation domains
  JOURNAL   EMBO J 14 (12), 2907-2916 (1995)
   PUBMED   7796816
REFERENCE   8  (bases 1 to 5360)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   9  (bases 1 to 5360)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5360)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134043.1, AC008640.6, AC140770.1 and AC008442.6.
            
            On Aug 14, 2020 this sequence version replaced NM_001364159.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.274614.1,
                                           SRR1803613.169197.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               AC134043.1         134483-135009
            528-684             AC134043.1         135309-135465
            685-748             AC134043.1         136033-136096
            749-804             AC134043.1         136764-136819
            805-878             AC008640.6         126466-126539       c
            879-947             AC008640.6         115196-115264       c
            948-1029            AC140770.1         56591-56672         c
            1030-1171           AC140770.1         39738-39879         c
            1172-1302           AC008442.6         2292-2422
            1303-1429           AC008442.6         21228-21354
            1430-1518           AC008442.6         67610-67698
            1519-1584           AC008442.6         84585-84650
            1585-1762           AC008442.6         85620-85797
            1763-1942           AC008442.6         86434-86613
            1943-2137           AC008442.6         90594-90788
            2138-5360           AC008442.6         99625-102847
FEATURES             Location/Qualifiers
     source          1..5360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..5360
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="EBF transcription factor 1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
     exon            1..527
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..684
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..748
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..804
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             793..2169
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="isoform 16 is encoded by transcript variant 16;
                     olfactory neuronal transcription factor 1; early B cell
                     factor 1; Collier, Olf and EBF transcription factor 1;
                     transcription factor COE1"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 16"
                     /protein_id="NP_001351088.1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
                     /translation="MTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETP
                     SDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVH
                     NNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQV
                     IFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPT
                     IDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAE
                     ALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSP
                     HGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMA
                     SSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAI
                     SGMIVPPM"
     exon            805..878
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..947
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1029
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1171
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1302
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1429
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1518
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1584
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1762
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1942
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2137
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..5360
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5337..5342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="hexamer: ATTAAA"
     polyA_site      5360
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="major polyA site"
ORIGIN      
        1 gtgttcttct atgtgtgtgt gtgtgcctgt gcgcgcttgt gttgggcagg tccggctgtc
       61 agtggccgcc tggcgcccca ggcgctccag cctcccatcg ccggccggcg cactgagcca
      121 gcagccctgg cctttaggat ttctggaatg agtgtgagga tttctgcgga acagcgaaac
      181 tttgttagga caggtcttta agaaaacacc cctcttccct ttttcacagc gaccacccgc
      241 gacagttctg agccccgccc tcggaccctt ctccacatgc tttttggtgg tggggggatg
      301 tggcttccca aggccgggca ctcgcagttg gccagagctt gaggggttcc tggagggtgg
      361 ctgctgcggc gagacgccga gcatgttttc catccattcc cacctgccct gctagctgag
      421 acgtgagatt cgaggggtgc cggaatataa ctgtgggttc tactccgcga aggtgggttc
      481 acttcatcca ccgccacttt tcttcctccc cacgcagtgc gtgtcagcgg ggtgggtctg
      541 gcccgggctc actttgagaa gcagccgcct tccaatctgc ggaaatccaa cttcttccac
      601 ttcgtcctgg ccctctacga cagacagggc cagcccgtgg agatcgagag gacagcgttt
      661 gtggggttcg tggagaagga aaaagaagcc aacagcgaaa agaccaataa cggaattcac
      721 taccggcttc agcttctcta cagcaatggg ataaggacgg agcaggattt ctacgtgcgc
      781 ctcattgact ccatgacaaa acaagccata gtgtatgaag gccaagacaa gaacccagaa
      841 atgtgccgag tcttgctcac acatgagatc atgtgcagcc gctgttgtga caagaaaagc
      901 tgtggcaacc gaaatgagac tccctcagat ccagtgataa ttgacaggtt cttcttgaaa
      961 tttttcctca aatgtaacca aaattgccta aagaatgcgg gaaacccacg tgacatgcgg
     1021 agattccagg tcgtggtgtc tacgacagtc aatgtggatg gccatgtcct ggcagtctct
     1081 gataacatgt ttgtccataa taattccaag catgggcgga gggctcggag gcttgacccc
     1141 tcggaaggta cgccctctta tctggaacat gctactccct gtatcaaagc catcagcccg
     1201 agtgaaggat ggacgacggg aggtgcgact gtgatcatca taggggacaa tttctttgat
     1261 gggttacagg tcatattcgg taccatgctg gtctggagtg agttgatcac tcctcatgcc
     1321 atccgtgtgc agacccctcc tcggcacatc cctggtgttg tggaagtcac actgtcctac
     1381 aaatctaagc agttctgcaa aggaacacca ggcagattca tttatacagc gctcaacgaa
     1441 cccaccatcg attatggttt ccagaggtta cagaaggtca ttcctcggca ccctggtgac
     1501 cctgagcgtt tgccaaagga agtaatactc aaaagggctg cggatctggt agaagcactg
     1561 tatgggatgc cacacaacaa ccaggaaatc attctgaaga gagcggccga cattgccgag
     1621 gccctgtaca gtgttccccg caaccacaac caactcccgg cccttgctaa cacctcggtc
     1681 cacgcaggga tgatgggcgt gaattcgttc agtggacaac tggccgtgaa tgtctccgag
     1741 gcatcacaag ccaccaatca gggtttcacc cgcaactcaa gcagcgtatc accacacggg
     1801 tacgtgccga gcaccactcc ccagcagacc aactataact ccgtcaccac gagcatgaac
     1861 ggatacggct ctgccgcaat gtccaatttg ggcggctccc ccaccttcct caacggctca
     1921 gctgccaact ccccctatgc catagtgcca tccagcccca ccatggcctc ctccacaagc
     1981 ctcccctcca actgcagcag ctcctcgggc atcttctcct tctcaccagc caacatggtc
     2041 tcagccgtga aacagaagag tgctttcgca ccagtcgtca gaccccagac ctccccacct
     2101 cccacctgca ccagcaccaa cgggaacagc ctgcaagcga tatctggcat gattgttcct
     2161 cctatgtgaa agaattgcct tgaagaattg tattaatgaa gaggttggat tctgctacag
     2221 agagtaatct gatacaagtc ccagagtgga acttttaact caggcctttt taagaggaat
     2281 cacaataact gcagattttt aaacaaacaa aatcaccgac cttgcaaata ctgaaattgg
     2341 aagagggatc tgcaagtgca gggtgttggt taaagttgta cctcccaagt atttggggga
     2401 tatatttatt ctgtattgac aaaagcaaat ccactttttc tttttctttt ttttttttaa
     2461 gcttaattct gcaatcattt gtcttttata aaccgtaaag ctctatacaa gggacactat
     2521 aaataagact ccatgtttta atttatgatg tttttaaagc tgtgtaaagg aagaatgaag
     2581 tggtgatatt tacaaaaaag taaaaaaaaa aaaaaagaaa aaaaggaaaa aaaaaaaagc
     2641 ttgtatggga cagaatagga atgccagtta gattttttag aaaaactaag ggtcggcttt
     2701 tgcgccttaa agcatatcaa atggtagtta gctcagacag tgcattttca atatctaact
     2761 taacatgcca ccccttagca gtgcaagctt atttatctct tttgtattgt tgtcttaagc
     2821 aactgtgtaa ataaatgcag cctggaaagt taaaacgcga tgtaagtgat cacatttttc
     2881 cctctactcg aaaatccagt gcctctagac agattgttaa aactgcatat ttaaatctga
     2941 tctcattctc tccttttact taagtcagtt tcttctgaag ccgatggcct ctcgagagct
     3001 tggtggcaca catactgtgt gagaatctcc tttgagactt catggaacag ggtccaggca
     3061 cagaattcca cactctgccc tccagttaac aagccaaaac ctcacgtacg ctcccccatt
     3121 tgcaagttta aagtttactc gtcctaaatg cagacttcat acctatcttc caaaagttga
     3181 taaaagcaac gtggcaggta ttttcgattt tcccattcca gatactgcct ctatcagtcg
     3241 acccttacca tttgtaacat aatagattga aacaacaggt taagtgcttt ggaattaaga
     3301 gttaaaggga accgggggtg gagaaaggaa aagaaggttg agacctccaa aacatagttt
     3361 tctgttctat gggaattttt gctctcatta tctgggaagt gttcttaaaa ataagaatta
     3421 atagcaaaga tgcagcaaag ctctgaggat gcatttgcct gatatttttt tctttgctct
     3481 tgtgtttttg tatgtagtta taaatactgt agattttttt tttgtgattt tttgccaaag
     3541 ttgttgttct atttatacat tttaatgtct taagacattt tttcaatatc acaaaaagat
     3601 tttactgcgt attttgcaaa gaaaaaaagc tcactacctt tagcttgcac atacttgcaa
     3661 agttaattaa aaggcttttt gttttaaagg ggattttgta aaatatccat ataaataatg
     3721 tatttatctt tcgaatttgt acattgcttt tcccttcttc ctcttccttc cacccccaat
     3781 ttattttatt gtgtatgttt gctacgtgaa aagtgcgtat ttgtttggtc acctacactt
     3841 gtattagctg tttcaatgtg atttttaaac atttcattta tagttatttt tagtattgtt
     3901 ataaaccatg cttcagtttt tttaatttcc acccaaaagt cattgtctat ttttgtatta
     3961 tttgtaagtt aagaagtttt ttccaatata tggcaaaaaa aaaaaaatag tagcatatta
     4021 ttcttgtagt atttagttca gtagatttaa aaaaaaatgt atcctttgct ttggaagctt
     4081 acaaaacaac cctaatgctg ttttactcta ttaatatgca tggaatctct ccctttggag
     4141 tgacgcattt tgtgcattaa attctaggga gaaacttcat agaaatcaat gaacatactt
     4201 tctttcttaa gtctgcttgt atatttcctc tgtctttcac ataaatataa accagcagat
     4261 tggatgcctt aacaatgcaa atcatattca tttcacttgt acattgtaac tgtgcaccag
     4321 aactgtcagt catcactaac attctaagaa aaaagaaaaa gaaaaaaaga aaaaaaaaaa
     4381 aacaaagaaa tcgaaaagca caaaagaact gttttgttac cttaagacaa tgtaactttt
     4441 tctagtagag caagaaatca tttacaacaa tgctgcaact gtgcatgccc ccatatggat
     4501 tttgcaatgg ttttcactag gctgtcaaga gtgcgatttt tatgggttgg ggtgggtggg
     4561 ggaggggagt tgtgggaggg taggggaggg aggaaagctg tttttcatgg tgagaaataa
     4621 taatgatgac taataataat aaaaaaaact ggaaaatgta agcaaggtgg acgcattgct
     4681 tctcggtact cagaaaggtt atctgaattt gcgtggtaag cgctggcctg aagatgtaca
     4741 caagttaaag ccatatttta tctggtgagc cccttaactg tttctgaagg aatgaacggt
     4801 cagccgggaa ggtgtccggc ttagaccttg acaacagaca ctacccatct gtcagccatg
     4861 tgcagtggtt agaactcttc ttgaaagtcc aaagagcctt taaaatgtgt ataatttgtg
     4921 ttttgttgct tctatttcta ttgattagat gaaaagacat tctggccctc tgatcctctt
     4981 tcttctccac aaaagtttta caaataaaag atgttcccct aaatacagaa tatggcttta
     5041 agaagaaaat gaaatgaaga attaaattaa gatttcagtg ttgggggaaa aaatacagct
     5101 tctggatgac tggattgcat aacattgccc tggcctcaca ttgtactagg atgcagctta
     5161 aatgaagtca tctctaaatc tactaacctt tcaccttctt atcaaaactt tttgaataga
     5221 cacacactgt acagttcaat tgttagagaa cctaactact gtagagattg ttaaattttt
     5281 tttttttttt tgcaaaaatt caagctgtaa aaacttttca actttcacaa tatttaatta
     5341 aagttacttc ctgtctgtga
//
