LOCUS       NM_001364157            5637 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens EBF transcription factor 1 (EBF1), transcript variant
            14, mRNA.
ACCESSION   NM_001364157
VERSION     NM_001364157.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5637)
  AUTHORS   Mladenic,T., Wagner,J., Kadivnik,M., Pereza,N., Ostojic,S.,
            Peterlin,B. and Devic Pavlic,S.
  TITLE     Protective Effect of EBF Transcription Factor 1 (EBF1) Polymorphism
            in Sporadic and Familial Spontaneous Preterm Birth: Insights from a
            Case-Control Study
  JOURNAL   Int J Mol Sci 25 (20), 11192 (2024)
   PUBMED   39456973
  REMARK    GeneRIF: Protective Effect of EBF Transcription Factor 1 (EBF1)
            Polymorphism in Sporadic and Familial Spontaneous Preterm Birth:
            Insights from a Case-Control Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5637)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5637)
  AUTHORS   Li,L., Zhang,D. and Cao,X.
  TITLE     EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms
  JOURNAL   Front Immunol 15, 1320689 (2024)
   PUBMED   38318177
  REMARK    GeneRIF: EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5637)
  AUTHORS   Liu,Y., Fan,M., Xian,S., Hu,P., Zhang,M., Zhang,X., Zhang,H.,
            Zhang,J., Dai,L., Lin,M., Mei,W., Huang,D., Huang,R., Zhang,J. and
            Huang,Z.
  TITLE     RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis
            Pathway in Bone Metastases of Bladder Urothelial Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 189 (2023)
   PUBMED   37664915
  REMARK    GeneRIF: RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte
            Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma.
REFERENCE   5  (bases 1 to 5637)
  AUTHORS   Al Madhoun,A., Haddad,D., Nizam,R., Miranda,L., Kochumon,S.,
            Thomas,R., Thanaraj,T.A., Ahmad,R., Bitar,M.S. and Al-Mulla,F.
  TITLE     Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New
            Binding Site for the Early B-Cell Factor 1 That Instigates Adipose
            Tissue CAV1 Protein Overexpression
  JOURNAL   Cells 11 (23), 3937 (2022)
   PUBMED   36497195
  REMARK    GeneRIF: Caveolin-1 rs1997623 Single Nucleotide Polymorphism
            Creates a New Binding Site for the Early B-Cell Factor 1 That
            Instigates Adipose Tissue CAV1 Protein Overexpression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5637)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
REFERENCE   7  (bases 1 to 5637)
  AUTHORS   Hagman,J., Gutch,M.J., Lin,H. and Grosschedl,R.
  TITLE     EBF contains a novel zinc coordination motif and multiple
            dimerization and transcriptional activation domains
  JOURNAL   EMBO J 14 (12), 2907-2916 (1995)
   PUBMED   7796816
REFERENCE   8  (bases 1 to 5637)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   9  (bases 1 to 5637)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5637)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134043.1, AC008640.6, AC140770.1 and AC008442.6.
            
            On Aug 14, 2020 this sequence version replaced NM_001364157.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.116490.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-732               AC134043.1         134483-135214
            733-889             AC134043.1         135309-135465
            890-953             AC134043.1         136033-136096
            954-1009            AC134043.1         136764-136819
            1010-1083           AC008640.6         126466-126539       c
            1084-1152           AC008640.6         115196-115264       c
            1153-1234           AC140770.1         56591-56672         c
            1235-1376           AC140770.1         39738-39879         c
            1377-1510           AC008442.6         2289-2422
            1511-1637           AC008442.6         21228-21354
            1638-1726           AC008442.6         67610-67698
            1727-1792           AC008442.6         84585-84650
            1793-1970           AC008442.6         85620-85797
            1971-2150           AC008442.6         86434-86613
            2151-2345           AC008442.6         90594-90788
            2346-2414           AC008442.6         91131-91199
            2415-5637           AC008442.6         99625-102847
FEATURES             Location/Qualifiers
     source          1..5637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..5637
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="EBF transcription factor 1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
     exon            1..732
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             713..2413
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="isoform 14 is encoded by transcript variant 14;
                     olfactory neuronal transcription factor 1; early B cell
                     factor 1; Collier, Olf and EBF transcription factor 1;
                     transcription factor COE1"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 14"
                     /protein_id="NP_001351086.1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
                     /translation="MFWGKRSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPV
                     EIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIV
                     YEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNC
                     LKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSY
                     LEHAATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQ
                     TPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPE
                     RLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSV
                     HAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTS
                     MNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSP
                     ANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQDQSFVDSSKFSSAGSLPGLAFS
                     "
     exon            733..889
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..953
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1009
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1083
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1152
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1234
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1376
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1510
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1637
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1726
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1792
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1970
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2150
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2345
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2414
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..5637
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5614..5619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="hexamer: ATTAAA"
     polyA_site      5637
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="major polyA site"
ORIGIN      
        1 gtgttcttct atgtgtgtgt gtgtgcctgt gcgcgcttgt gttgggcagg tccggctgtc
       61 agtggccgcc tggcgcccca ggcgctccag cctcccatcg ccggccggcg cactgagcca
      121 gcagccctgg cctttaggat ttctggaatg agtgtgagga tttctgcgga acagcgaaac
      181 tttgttagga caggtcttta agaaaacacc cctcttccct ttttcacagc gaccacccgc
      241 gacagttctg agccccgccc tcggaccctt ctccacatgc tttttggtgg tggggggatg
      301 tggcttccca aggccgggca ctcgcagttg gccagagctt gaggggttcc tggagggtgg
      361 ctgctgcggc gagacgccga gcatgttttc catccattcc cacctgccct gctagctgag
      421 acgtgagatt cgaggggtgc cggaatataa ctgtgggttc tactccgcga aggtgggttc
      481 acttcatcca ccgccacttt tcttcctccc cacgcagtgc gtgtcaggta ggagtaaatg
      541 cttatagagt ttcatctcgc gcgcaaaacc caaacaaaac tttcacacct cttcagcgag
      601 ttctgaggac gcacccgtcc ttggcggaga ggacgaggac atgaggggac atgtgtgtcc
      661 cgttgtcagc tgggtctatg tcgcctgaag gggcgtgaag agcgcccact ggatgttttg
      721 ggggaagagg agcggggtgg gtctggcccg ggctcacttt gagaagcagc cgccttccaa
      781 tctgcggaaa tccaacttct tccacttcgt cctggccctc tacgacagac agggccagcc
      841 cgtggagatc gagaggacag cgtttgtggg gttcgtggag aaggaaaaag aagccaacag
      901 cgaaaagacc aataacggaa ttcactaccg gcttcagctt ctctacagca atgggataag
      961 gacggagcag gatttctacg tgcgcctcat tgactccatg acaaaacaag ccatagtgta
     1021 tgaaggccaa gacaagaacc cagaaatgtg ccgagtcttg ctcacacatg agatcatgtg
     1081 cagccgctgt tgtgacaaga aaagctgtgg caaccgaaat gagactccct cagatccagt
     1141 gataattgac aggttcttct tgaaattttt cctcaaatgt aaccaaaatt gcctaaagaa
     1201 tgcgggaaac ccacgtgaca tgcggagatt ccaggtcgtg gtgtctacga cagtcaatgt
     1261 ggatggccat gtcctggcag tctctgataa catgtttgtc cataataatt ccaagcatgg
     1321 gcggagggct cggaggcttg acccctcgga aggtacgccc tcttatctgg aacatgcagc
     1381 tactccctgt atcaaagcca tcagcccgag tgaaggatgg acgacgggag gtgcgactgt
     1441 gatcatcata ggggacaatt tctttgatgg gttacaggtc atattcggta ccatgctggt
     1501 ctggagtgag ttgatcactc ctcatgccat ccgtgtgcag acccctcctc ggcacatccc
     1561 tggtgttgtg gaagtcacac tgtcctacaa atctaagcag ttctgcaaag gaacaccagg
     1621 cagattcatt tatacagcgc tcaacgaacc caccatcgat tatggtttcc agaggttaca
     1681 gaaggtcatt cctcggcacc ctggtgaccc tgagcgtttg ccaaaggaag taatactcaa
     1741 aagggctgcg gatctggtag aagcactgta tgggatgcca cacaacaacc aggaaatcat
     1801 tctgaagaga gcggccgaca ttgccgaggc cctgtacagt gttccccgca accacaacca
     1861 actcccggcc cttgctaaca cctcggtcca cgcagggatg atgggcgtga attcgttcag
     1921 tggacaactg gccgtgaatg tctccgaggc atcacaagcc accaatcagg gtttcacccg
     1981 caactcaagc agcgtatcac cacacgggta cgtgccgagc accactcccc agcagaccaa
     2041 ctataactcc gtcaccacga gcatgaacgg atacggctct gccgcaatgt ccaatttggg
     2101 cggctccccc accttcctca acggctcagc tgccaactcc ccctatgcca tagtgccatc
     2161 cagccccacc atggcctcct ccacaagcct cccctccaac tgcagcagct cctcgggcat
     2221 cttctccttc tcaccagcca acatggtctc agccgtgaaa cagaagagtg ctttcgcacc
     2281 agtcgtcaga ccccagacct ccccacctcc cacctgcacc agcaccaacg ggaacagcct
     2341 gcaagatcag tcttttgtgg actctagcaa gttctccagt gcagggtctc tcccgggact
     2401 ggccttctcc tgaacgatat ctggcatgat tgttcctcct atgtgaaaga attgccttga
     2461 agaattgtat taatgaagag gttggattct gctacagaga gtaatctgat acaagtccca
     2521 gagtggaact tttaactcag gcctttttaa gaggaatcac aataactgca gatttttaaa
     2581 caaacaaaat caccgacctt gcaaatactg aaattggaag agggatctgc aagtgcaggg
     2641 tgttggttaa agttgtacct cccaagtatt tgggggatat atttattctg tattgacaaa
     2701 agcaaatcca ctttttcttt ttcttttttt tttttaagct taattctgca atcatttgtc
     2761 ttttataaac cgtaaagctc tatacaaggg acactataaa taagactcca tgttttaatt
     2821 tatgatgttt ttaaagctgt gtaaaggaag aatgaagtgg tgatatttac aaaaaagtaa
     2881 aaaaaaaaaa aaagaaaaaa aggaaaaaaa aaaaagcttg tatgggacag aataggaatg
     2941 ccagttagat tttttagaaa aactaagggt cggcttttgc gccttaaagc atatcaaatg
     3001 gtagttagct cagacagtgc attttcaata tctaacttaa catgccaccc cttagcagtg
     3061 caagcttatt tatctctttt gtattgttgt cttaagcaac tgtgtaaata aatgcagcct
     3121 ggaaagttaa aacgcgatgt aagtgatcac atttttccct ctactcgaaa atccagtgcc
     3181 tctagacaga ttgttaaaac tgcatattta aatctgatct cattctctcc ttttacttaa
     3241 gtcagtttct tctgaagccg atggcctctc gagagcttgg tggcacacat actgtgtgag
     3301 aatctccttt gagacttcat ggaacagggt ccaggcacag aattccacac tctgccctcc
     3361 agttaacaag ccaaaacctc acgtacgctc ccccatttgc aagtttaaag tttactcgtc
     3421 ctaaatgcag acttcatacc tatcttccaa aagttgataa aagcaacgtg gcaggtattt
     3481 tcgattttcc cattccagat actgcctcta tcagtcgacc cttaccattt gtaacataat
     3541 agattgaaac aacaggttaa gtgctttgga attaagagtt aaagggaacc gggggtggag
     3601 aaaggaaaag aaggttgaga cctccaaaac atagttttct gttctatggg aatttttgct
     3661 ctcattatct gggaagtgtt cttaaaaata agaattaata gcaaagatgc agcaaagctc
     3721 tgaggatgca tttgcctgat atttttttct ttgctcttgt gtttttgtat gtagttataa
     3781 atactgtaga tttttttttt gtgatttttt gccaaagttg ttgttctatt tatacatttt
     3841 aatgtcttaa gacatttttt caatatcaca aaaagatttt actgcgtatt ttgcaaagaa
     3901 aaaaagctca ctacctttag cttgcacata cttgcaaagt taattaaaag gctttttgtt
     3961 ttaaagggga ttttgtaaaa tatccatata aataatgtat ttatctttcg aatttgtaca
     4021 ttgcttttcc cttcttcctc ttccttccac ccccaattta ttttattgtg tatgtttgct
     4081 acgtgaaaag tgcgtatttg tttggtcacc tacacttgta ttagctgttt caatgtgatt
     4141 tttaaacatt tcatttatag ttatttttag tattgttata aaccatgctt cagttttttt
     4201 aatttccacc caaaagtcat tgtctatttt tgtattattt gtaagttaag aagttttttc
     4261 caatatatgg caaaaaaaaa aaaatagtag catattattc ttgtagtatt tagttcagta
     4321 gatttaaaaa aaaatgtatc ctttgctttg gaagcttaca aaacaaccct aatgctgttt
     4381 tactctatta atatgcatgg aatctctccc tttggagtga cgcattttgt gcattaaatt
     4441 ctagggagaa acttcataga aatcaatgaa catactttct ttcttaagtc tgcttgtata
     4501 tttcctctgt ctttcacata aatataaacc agcagattgg atgccttaac aatgcaaatc
     4561 atattcattt cacttgtaca ttgtaactgt gcaccagaac tgtcagtcat cactaacatt
     4621 ctaagaaaaa agaaaaagaa aaaaagaaaa aaaaaaaaac aaagaaatcg aaaagcacaa
     4681 aagaactgtt ttgttacctt aagacaatgt aactttttct agtagagcaa gaaatcattt
     4741 acaacaatgc tgcaactgtg catgccccca tatggatttt gcaatggttt tcactaggct
     4801 gtcaagagtg cgatttttat gggttggggt gggtggggga ggggagttgt gggagggtag
     4861 gggagggagg aaagctgttt ttcatggtga gaaataataa tgatgactaa taataataaa
     4921 aaaaactgga aaatgtaagc aaggtggacg cattgcttct cggtactcag aaaggttatc
     4981 tgaatttgcg tggtaagcgc tggcctgaag atgtacacaa gttaaagcca tattttatct
     5041 ggtgagcccc ttaactgttt ctgaaggaat gaacggtcag ccgggaaggt gtccggctta
     5101 gaccttgaca acagacacta cccatctgtc agccatgtgc agtggttaga actcttcttg
     5161 aaagtccaaa gagcctttaa aatgtgtata atttgtgttt tgttgcttct atttctattg
     5221 attagatgaa aagacattct ggccctctga tcctctttct tctccacaaa agttttacaa
     5281 ataaaagatg ttcccctaaa tacagaatat ggctttaaga agaaaatgaa atgaagaatt
     5341 aaattaagat ttcagtgttg ggggaaaaaa tacagcttct ggatgactgg attgcataac
     5401 attgccctgg cctcacattg tactaggatg cagcttaaat gaagtcatct ctaaatctac
     5461 taacctttca ccttcttatc aaaacttttt gaatagacac acactgtaca gttcaattgt
     5521 tagagaacct aactactgta gagattgtta aatttttttt ttttttttgc aaaaattcaa
     5581 gctgtaaaaa cttttcaact ttcacaatat ttaattaaag ttacttcctg tctgtga
//
