LOCUS       NM_001324108            5381 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens EBF transcription factor 1 (EBF1), transcript variant
            8, mRNA.
ACCESSION   NM_001324108 XM_005265834
VERSION     NM_001324108.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5381)
  AUTHORS   Mladenic,T., Wagner,J., Kadivnik,M., Pereza,N., Ostojic,S.,
            Peterlin,B. and Devic Pavlic,S.
  TITLE     Protective Effect of EBF Transcription Factor 1 (EBF1) Polymorphism
            in Sporadic and Familial Spontaneous Preterm Birth: Insights from a
            Case-Control Study
  JOURNAL   Int J Mol Sci 25 (20), 11192 (2024)
   PUBMED   39456973
  REMARK    GeneRIF: Protective Effect of EBF Transcription Factor 1 (EBF1)
            Polymorphism in Sporadic and Familial Spontaneous Preterm Birth:
            Insights from a Case-Control Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5381)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5381)
  AUTHORS   Li,L., Zhang,D. and Cao,X.
  TITLE     EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms
  JOURNAL   Front Immunol 15, 1320689 (2024)
   PUBMED   38318177
  REMARK    GeneRIF: EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5381)
  AUTHORS   Liu,Y., Fan,M., Xian,S., Hu,P., Zhang,M., Zhang,X., Zhang,H.,
            Zhang,J., Dai,L., Lin,M., Mei,W., Huang,D., Huang,R., Zhang,J. and
            Huang,Z.
  TITLE     RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis
            Pathway in Bone Metastases of Bladder Urothelial Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 189 (2023)
   PUBMED   37664915
  REMARK    GeneRIF: RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte
            Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma.
REFERENCE   5  (bases 1 to 5381)
  AUTHORS   Al Madhoun,A., Haddad,D., Nizam,R., Miranda,L., Kochumon,S.,
            Thomas,R., Thanaraj,T.A., Ahmad,R., Bitar,M.S. and Al-Mulla,F.
  TITLE     Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New
            Binding Site for the Early B-Cell Factor 1 That Instigates Adipose
            Tissue CAV1 Protein Overexpression
  JOURNAL   Cells 11 (23), 3937 (2022)
   PUBMED   36497195
  REMARK    GeneRIF: Caveolin-1 rs1997623 Single Nucleotide Polymorphism
            Creates a New Binding Site for the Early B-Cell Factor 1 That
            Instigates Adipose Tissue CAV1 Protein Overexpression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5381)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
REFERENCE   7  (bases 1 to 5381)
  AUTHORS   Hagman,J., Gutch,M.J., Lin,H. and Grosschedl,R.
  TITLE     EBF contains a novel zinc coordination motif and multiple
            dimerization and transcriptional activation domains
  JOURNAL   EMBO J 14 (12), 2907-2916 (1995)
   PUBMED   7796816
REFERENCE   8  (bases 1 to 5381)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   9  (bases 1 to 5381)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5381)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134043.1, AC008640.6, AC140770.1 and AC008442.6.
            
            On May 31, 2019 this sequence version replaced NM_001324108.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.125155.1,
                                           SRR14038193.2298288.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               AC134043.1         132523-133094
            573-729             AC134043.1         135309-135465
            730-793             AC134043.1         136033-136096
            794-849             AC134043.1         136764-136819
            850-923             AC008640.6         126466-126539       c
            924-992             AC008640.6         115196-115264       c
            993-1074            AC140770.1         56591-56672         c
            1075-1192           AC140770.1         39762-39879         c
            1193-1323           AC008442.6         2292-2422
            1324-1450           AC008442.6         21228-21354
            1451-1539           AC008442.6         67610-67698
            1540-1605           AC008442.6         84585-84650
            1606-1783           AC008442.6         85620-85797
            1784-1963           AC008442.6         86434-86613
            1964-2158           AC008442.6         90594-90788
            2159-5381           AC008442.6         99625-102847
FEATURES             Location/Qualifiers
     source          1..5381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..5381
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="EBF transcription factor 1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
     exon            1..572
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..2190
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="isoform 8 is encoded by transcript variant 8;
                     olfactory neuronal transcription factor 1; early B cell
                     factor 1; Collier, Olf and EBF transcription factor 1;
                     transcription factor COE1"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 8"
                     /protein_id="NP_001311037.1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
                     /translation="MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSE
                     KTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGATVIIIG
                     DNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRF
                     IYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEII
                     LKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGF
                     TRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYA
                     IVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTS
                     TNGNSLQAISGMIVPPM"
     exon            573..729
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..793
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..849
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..923
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..992
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1074
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1192
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1323
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1450
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1539
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1605
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1783
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1963
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2158
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..5381
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5358..5363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="hexamer: ATTAAA"
     polyA_site      5381
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="major polyA site"
ORIGIN      
        1 cctgcttctt caagtgaagg gtacctctac aaaaggaaac tccagcccct cctgtcctcc
       61 accggcctgt gatcattaca aaaaaaaaaa aaaaaaagca aaaaaaaaaa aaaagcaccc
      121 aaaccaaaaa tcaaccaacc aaacaacccc caacagccaa gcatacatct ctaattttat
      181 tattttggtc ttttcgttgg attttccctt tcttcttttt ttcgggttat cgctcagttt
      241 tgagcagagg tttacatttt ttaaaaattt gctttccagc ccgccttgat cttctaagtg
      301 cgagttcatc gtctgagaaa aaaaaaaatc tctggttggc gtttttgttt cttttctttt
      361 ctttcttttc tttccttttt tttttttttt aatttttttc aagggggagg agattttcca
      421 caagaaaagg ttgttttcat gtttgggatt caggaaagca tccaacggag tggaagcagc
      481 atgaaggaag agccgctggg cagcggcatg aacgcggtgc ggacgtggat gcagggcgcc
      541 ggggtgctgg acgccaacac ggcggcgcag agcggggtgg gtctggcccg ggctcacttt
      601 gagaagcagc cgccttccaa tctgcggaaa tccaacttct tccacttcgt cctggccctc
      661 tacgacagac agggccagcc cgtggagatc gagaggacag cgtttgtggg gttcgtggag
      721 aaggaaaaag aagccaacag cgaaaagacc aataacggaa ttcactaccg gcttcagctt
      781 ctctacagca atgggataag gacggagcag gatttctacg tgcgcctcat tgactccatg
      841 acaaaacaag ccatagtgta tgaaggccaa gacaagaacc cagaaatgtg ccgagtcttg
      901 ctcacacatg agatcatgtg cagccgctgt tgtgacaaga aaagctgtgg caaccgaaat
      961 gagactccct cagatccagt gataattgac aggttcttct tgaaattttt cctcaaatgt
     1021 aaccaaaatt gcctaaagaa tgcgggaaac ccacgtgaca tgcggagatt ccaggtcgtg
     1081 gtgtctacga cagtcaatgt ggatggccat gtcctggcag tctctgataa catgtttgtc
     1141 cataataatt ccaagcatgg gcggagggct cggaggcttg acccctcgga agctactccc
     1201 tgtatcaaag ccatcagccc gagtgaagga tggacgacgg gaggtgcgac tgtgatcatc
     1261 ataggggaca atttctttga tgggttacag gtcatattcg gtaccatgct ggtctggagt
     1321 gagttgatca ctcctcatgc catccgtgtg cagacccctc ctcggcacat ccctggtgtt
     1381 gtggaagtca cactgtccta caaatctaag cagttctgca aaggaacacc aggcagattc
     1441 atttatacag cgctcaacga acccaccatc gattatggtt tccagaggtt acagaaggtc
     1501 attcctcggc accctggtga ccctgagcgt ttgccaaagg aagtaatact caaaagggct
     1561 gcggatctgg tagaagcact gtatgggatg ccacacaaca accaggaaat cattctgaag
     1621 agagcggccg acattgccga ggccctgtac agtgttcccc gcaaccacaa ccaactcccg
     1681 gcccttgcta acacctcggt ccacgcaggg atgatgggcg tgaattcgtt cagtggacaa
     1741 ctggccgtga atgtctccga ggcatcacaa gccaccaatc agggtttcac ccgcaactca
     1801 agcagcgtat caccacacgg gtacgtgccg agcaccactc cccagcagac caactataac
     1861 tccgtcacca cgagcatgaa cggatacggc tctgccgcaa tgtccaattt gggcggctcc
     1921 cccaccttcc tcaacggctc agctgccaac tccccctatg ccatagtgcc atccagcccc
     1981 accatggcct cctccacaag cctcccctcc aactgcagca gctcctcggg catcttctcc
     2041 ttctcaccag ccaacatggt ctcagccgtg aaacagaaga gtgctttcgc accagtcgtc
     2101 agaccccaga cctccccacc tcccacctgc accagcacca acgggaacag cctgcaagcg
     2161 atatctggca tgattgttcc tcctatgtga aagaattgcc ttgaagaatt gtattaatga
     2221 agaggttgga ttctgctaca gagagtaatc tgatacaagt cccagagtgg aacttttaac
     2281 tcaggccttt ttaagaggaa tcacaataac tgcagatttt taaacaaaca aaatcaccga
     2341 ccttgcaaat actgaaattg gaagagggat ctgcaagtgc agggtgttgg ttaaagttgt
     2401 acctcccaag tatttggggg atatatttat tctgtattga caaaagcaaa tccacttttt
     2461 ctttttcttt ttttttttta agcttaattc tgcaatcatt tgtcttttat aaaccgtaaa
     2521 gctctataca agggacacta taaataagac tccatgtttt aatttatgat gtttttaaag
     2581 ctgtgtaaag gaagaatgaa gtggtgatat ttacaaaaaa gtaaaaaaaa aaaaaaagaa
     2641 aaaaaggaaa aaaaaaaaag cttgtatggg acagaatagg aatgccagtt agatttttta
     2701 gaaaaactaa gggtcggctt ttgcgcctta aagcatatca aatggtagtt agctcagaca
     2761 gtgcattttc aatatctaac ttaacatgcc accccttagc agtgcaagct tatttatctc
     2821 ttttgtattg ttgtcttaag caactgtgta aataaatgca gcctggaaag ttaaaacgcg
     2881 atgtaagtga tcacattttt ccctctactc gaaaatccag tgcctctaga cagattgtta
     2941 aaactgcata tttaaatctg atctcattct ctccttttac ttaagtcagt ttcttctgaa
     3001 gccgatggcc tctcgagagc ttggtggcac acatactgtg tgagaatctc ctttgagact
     3061 tcatggaaca gggtccaggc acagaattcc acactctgcc ctccagttaa caagccaaaa
     3121 cctcacgtac gctcccccat ttgcaagttt aaagtttact cgtcctaaat gcagacttca
     3181 tacctatctt ccaaaagttg ataaaagcaa cgtggcaggt attttcgatt ttcccattcc
     3241 agatactgcc tctatcagtc gacccttacc atttgtaaca taatagattg aaacaacagg
     3301 ttaagtgctt tggaattaag agttaaaggg aaccgggggt ggagaaagga aaagaaggtt
     3361 gagacctcca aaacatagtt ttctgttcta tgggaatttt tgctctcatt atctgggaag
     3421 tgttcttaaa aataagaatt aatagcaaag atgcagcaaa gctctgagga tgcatttgcc
     3481 tgatattttt ttctttgctc ttgtgttttt gtatgtagtt ataaatactg tagatttttt
     3541 ttttgtgatt ttttgccaaa gttgttgttc tatttataca ttttaatgtc ttaagacatt
     3601 ttttcaatat cacaaaaaga ttttactgcg tattttgcaa agaaaaaaag ctcactacct
     3661 ttagcttgca catacttgca aagttaatta aaaggctttt tgttttaaag gggattttgt
     3721 aaaatatcca tataaataat gtatttatct ttcgaatttg tacattgctt ttcccttctt
     3781 cctcttcctt ccacccccaa tttattttat tgtgtatgtt tgctacgtga aaagtgcgta
     3841 tttgtttggt cacctacact tgtattagct gtttcaatgt gatttttaaa catttcattt
     3901 atagttattt ttagtattgt tataaaccat gcttcagttt ttttaatttc cacccaaaag
     3961 tcattgtcta tttttgtatt atttgtaagt taagaagttt tttccaatat atggcaaaaa
     4021 aaaaaaaata gtagcatatt attcttgtag tatttagttc agtagattta aaaaaaaatg
     4081 tatcctttgc tttggaagct tacaaaacaa ccctaatgct gttttactct attaatatgc
     4141 atggaatctc tccctttgga gtgacgcatt ttgtgcatta aattctaggg agaaacttca
     4201 tagaaatcaa tgaacatact ttctttctta agtctgcttg tatatttcct ctgtctttca
     4261 cataaatata aaccagcaga ttggatgcct taacaatgca aatcatattc atttcacttg
     4321 tacattgtaa ctgtgcacca gaactgtcag tcatcactaa cattctaaga aaaaagaaaa
     4381 agaaaaaaag aaaaaaaaaa aaacaaagaa atcgaaaagc acaaaagaac tgttttgtta
     4441 ccttaagaca atgtaacttt ttctagtaga gcaagaaatc atttacaaca atgctgcaac
     4501 tgtgcatgcc cccatatgga ttttgcaatg gttttcacta ggctgtcaag agtgcgattt
     4561 ttatgggttg gggtgggtgg gggaggggag ttgtgggagg gtaggggagg gaggaaagct
     4621 gtttttcatg gtgagaaata ataatgatga ctaataataa taaaaaaaac tggaaaatgt
     4681 aagcaaggtg gacgcattgc ttctcggtac tcagaaaggt tatctgaatt tgcgtggtaa
     4741 gcgctggcct gaagatgtac acaagttaaa gccatatttt atctggtgag ccccttaact
     4801 gtttctgaag gaatgaacgg tcagccggga aggtgtccgg cttagacctt gacaacagac
     4861 actacccatc tgtcagccat gtgcagtggt tagaactctt cttgaaagtc caaagagcct
     4921 ttaaaatgtg tataatttgt gttttgttgc ttctatttct attgattaga tgaaaagaca
     4981 ttctggccct ctgatcctct ttcttctcca caaaagtttt acaaataaaa gatgttcccc
     5041 taaatacaga atatggcttt aagaagaaaa tgaaatgaag aattaaatta agatttcagt
     5101 gttgggggaa aaaatacagc ttctggatga ctggattgca taacattgcc ctggcctcac
     5161 attgtactag gatgcagctt aaatgaagtc atctctaaat ctactaacct ttcaccttct
     5221 tatcaaaact ttttgaatag acacacactg tacagttcaa ttgttagaga acctaactac
     5281 tgtagagatt gttaaatttt tttttttttt ttgcaaaaat tcaagctgta aaaacttttc
     5341 aactttcaca atatttaatt aaagttactt cctgtctgtg a
//
