LOCUS       NM_018456                998 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ELL associated factor 2 (EAF2), transcript variant 1,
            mRNA.
ACCESSION   NM_018456
VERSION     NM_018456.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 998)
  AUTHORS   Feng,M.L., Sun,M.J., Xu,B.Y., Liu,M.Y., Zhang,H.J. and Wu,C.
  TITLE     Mechanism of ELL-associated factor 2 and vasohibin 1 regulating
            invasion, migration, and angiogenesis in colorectal cancer
  JOURNAL   World J Gastroenterol 29 (24), 3770-3792 (2023)
   PUBMED   37426316
  REMARK    GeneRIF: Mechanism of ELL-associated factor 2 and vasohibin 1
            regulating invasion, migration, and angiogenesis in colorectal
            cancer.
REFERENCE   2  (bases 1 to 998)
  AUTHORS   Zhao,C.X., Yan,Z.X., Wen,J.J., Fu,D., Xu,P.P., Wang,L., Cheng,S.,
            Hu,J.D. and Zhao,W.L.
  TITLE     CircEAF2 counteracts Epstein-Barr virus-positive diffuse large
            B-cell lymphoma progression via miR-BART19-3p/APC/beta-catenin axis
  JOURNAL   Mol Cancer 20 (1), 153 (2021)
   PUBMED   34852843
  REMARK    GeneRIF: CircEAF2 counteracts Epstein-Barr virus-positive diffuse
            large B-cell lymphoma progression via
            miR-BART19-3p/APC/beta-catenin axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 998)
  AUTHORS   Han,W. and Shen,G.L.
  TITLE     Systematic expression analysis of EAF family reveals the importance
            of EAF2 in melanoma
  JOURNAL   Int Immunopharmacol 88, 106958 (2020)
   PUBMED   33182068
  REMARK    GeneRIF: Systematic expression analysis of EAF family reveals the
            importance of EAF2 in melanoma.
REFERENCE   4  (bases 1 to 998)
  AUTHORS   Liu,R., Chen,C., Li,Y., Huang,Q. and Xue,Y.
  TITLE     ELL-associated factors EAF1/2 negatively regulate HIV-1
            transcription through inhibition of Super Elongation Complex
            formation
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1863 (5), 194508 (2020)
   PUBMED   32087315
REFERENCE   5  (bases 1 to 998)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 998)
  AUTHORS   Xiao,W., Jiang,F. and Wang,Z.
  TITLE     ELL binding regulates U19/Eaf2 intracellular localization,
            stability, and transactivation
  JOURNAL   Prostate 66 (1), 1-12 (2006)
   PUBMED   16114057
  REMARK    GeneRIF: ELL may be an important factor required for U19/Eaf2
            function because U19/Eaf2 nuclear localization and transactivation
            activity are essential for its function as a transcription factor.
REFERENCE   7  (bases 1 to 998)
  AUTHORS   Kong,S.E., Banks,C.A., Shilatifard,A., Conaway,J.W. and
            Conaway,R.C.
  TITLE     ELL-associated factors 1 and 2 are positive regulators of RNA
            polymerase II elongation factor ELL
  JOURNAL   Proc Natl Acad Sci U S A 102 (29), 10094-10098 (2005)
   PUBMED   16006523
  REMARK    GeneRIF: ELL-associated factors 1 and 2 are positive regulators of
            RNA polymerase II elongation factor ELL.
REFERENCE   8  (bases 1 to 998)
  AUTHORS   Xiao,W., Zhang,Q., Jiang,F., Pins,M., Kozlowski,J.M. and Wang,Z.
  TITLE     Suppression of prostate tumor growth by U19, a novel
            testosterone-regulated apoptosis inducer
  JOURNAL   Cancer Res 63 (15), 4698-4704 (2003)
   PUBMED   12907652
  REMARK    GeneRIF: U19 is growth inhibitory and tumor suppressive and that
            the disruption of androgen-dependent growth inhibition via U19
            down-regulation is commonly associated with prostate cancer
            progression.
REFERENCE   9  (bases 1 to 998)
  AUTHORS   Saso,K., Ito,T., Natori,S. and Sekimizu,K.
  TITLE     Identification of a novel tissue-specific transcriptional activator
            FESTA as a protein that interacts with the transcription elongation
            factor S-II
  JOURNAL   J Biochem 133 (4), 493-500 (2003)
   PUBMED   12761297
REFERENCE   10 (bases 1 to 998)
  AUTHORS   Simone,F., Luo,R.T., Polak,P.E., Kaberlein,J.J. and Thirman,M.J.
  TITLE     ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with
            alternative ELL binding properties
  JOURNAL   Blood 101 (6), 2355-2362 (2003)
   PUBMED   12446457
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY005912.1 and AY049020.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018456.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.47926.1,
                                           SRR5189667.268300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273668.7/ ENSP00000273668.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 HY005912.1         31-36
            7-998               AY049020.1         1-992
FEATURES             Location/Qualifiers
     source          1..998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..998
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /note="ELL associated factor 2"
                     /db_xref="GeneID:55840"
                     /db_xref="HGNC:HGNC:23115"
                     /db_xref="MIM:607659"
     exon            1..183
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..860
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testosterone-regulated apoptosis inducer and tumor
                     suppressor protein"
                     /codon_start=1
                     /product="ELL-associated factor 2 isoform 1"
                     /protein_id="NP_060926.2"
                     /db_xref="CCDS:CCDS3006.1"
                     /db_xref="GeneID:55840"
                     /db_xref="HGNC:HGNC:23115"
                     /db_xref="MIM:607659"
                     /translation="MNSAAGFSHLDRRERVLKLGESFEKQPRCAFHTVRYDFKPASID
                     TSSEGYLEVGEGEQVTITLPNIEGSTPPVTVFKGSKKPYLKECILIINHDTGECRLEK
                     LSSNITVKKTRVEGSSKIQYRKEQQQQQMWNSARTPNLVKHSPSEDKMSPASPIDDIE
                     RELKAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSEDEDCKSSTSDTGNCVSGHPT
                     MTQYRIPDIDASHNRFRDNSGLLMNTLRNDLQLSESGSDSDD"
     exon            184..278
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            279..415
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            416..561
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            562..813
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /inference="alignment:Splign:2.1.0"
     exon            814..998
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      920..925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /note="hexamer: AATAAA"
     polyA_site      946
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /note="major polyA site"
     regulatory      975..980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /note="hexamer: ATTAAA"
     polyA_site      998
                     /gene="EAF2"
                     /gene_synonym="BM040; TRAITS; U19"
                     /note="major polyA site"
ORIGIN      
        1 aagtgcagct gcttcaggct gaggtggcag atagtgagcg ctggtggcgg agttaaagtc
       61 aaagcaggag agtaattatg aatagcgcag cgggattctc acacctagac cgtcgcgagc
      121 gggttctcaa gttaggggag agtttcgaga agcagccgcg ctgcgccttc cacactgtgc
      181 gctatgactt caaacctgct tctattgaca cttcttctga aggatacctt gaggttggtg
      241 aaggtgaaca ggtgaccata actctgccaa atatagaagg ttcaactcca ccagtaactg
      301 ttttcaaagg ttcaaaaaaa ccttacttaa aagaatgcat tttgattatt aaccatgata
      361 ctggagaatg tcggctagaa aaactcagca gcaacatcac tgtaaaaaaa acaagagttg
      421 aaggaagcag taaaattcag tatcgtaaag aacaacagca acaacaaatg tggaattcag
      481 ccaggactcc caatcttgta aaacattctc catctgaaga taagatgtcc ccagcatctc
      541 caatagatga tatcgaaaga gaactgaagg cagaagctag tctaatggac cagatgagta
      601 gttgtgatag ttcatcagat tccaaaagtt catcatcttc aagtagtgag gatagttcta
      661 gtgactcaga agatgaagat tgcaaatcct ctacttctga tacagggaat tgtgtctcag
      721 gacatcctac catgacacag tacaggattc ctgatataga tgccagtcat aatagatttc
      781 gagacaacag tggccttctg atgaatactt taagaaatga tttgcagctg agtgaatcag
      841 gaagtgacag tgatgactga agaaatattt agctataaat aaaaatttat acagcatgta
      901 taatttattt tgtattaaca ataaaaattc ctaagactga gggaaatatg tcttaacttt
      961 tgatgataaa agaaattaaa tttgattcag aaatttca
//
