LOCUS       NM_004424               2548 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens E4F transcription factor 1 (E4F1), transcript variant
            1, mRNA.
ACCESSION   NM_004424
VERSION     NM_004424.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2548)
  AUTHORS   Sun,S., Zhong,B., Zeng,X., Li,J. and Chen,Q.
  TITLE     Transcription factor E4F1 as a regulator of cell life and disease
            progression
  JOURNAL   Sci Adv 9 (39), eadh1991 (2023)
   PUBMED   37774036
  REMARK    GeneRIF: Transcription factor E4F1 as a regulator of cell life and
            disease progression.
            Review article
REFERENCE   2  (bases 1 to 2548)
  AUTHORS   Batnini,K., Houles,T., Kirsh,O., Du Manoir,S., Zaroual,M.,
            Delpech,H., Fallet,C., Lacroix,M., Le Cam,L., Theillet,C.,
            Sardet,C. and Rodier,G.
  TITLE     Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription
            Factor E4F1 in Triple-Negative Breast Cancer
  JOURNAL   Int J Mol Sci 23 (16), 9217 (2022)
   PUBMED   36012478
  REMARK    GeneRIF: Multi-Level Control of the ATM/ATR-CHK1 Axis by the
            Transcription Factor E4F1 in Triple-Negative Breast Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2548)
  AUTHORS   Lacroix,M., Linares,L.K., Rueda-Rincon,N., Bloch,K., Di Michele,M.,
            De Blasio,C., Fau,C., Gayte,L., Blanchet,E., Mairal,A., Derua,R.,
            Cardona,F., Beuzelin,D., Annicotte,J.S., Pirot,N., Torro,A.,
            Tinahones,F.J., Bernex,F., Bertrand-Michel,J., Langin,D., Fajas,L.,
            Swinnen,J.V. and Le Cam,L.
  TITLE     The multifunctional protein E4F1 links P53 to lipid metabolism in
            adipocytes
  JOURNAL   Nat Commun 12 (1), 7037 (2021)
   PUBMED   34857760
  REMARK    GeneRIF: The multifunctional protein E4F1 links P53 to lipid
            metabolism in adipocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2548)
  AUTHORS   Moison,C., Chagraoui,J., Caron,M.C., Gagne,J.P., Coulombe,Y.,
            Poirier,G.G., Masson,J.Y. and Sauvageau,G.
  TITLE     Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote
            DNA double-strand break repair
  JOURNAL   Proc Natl Acad Sci U S A 118 (11) (2021)
   PUBMED   33692124
  REMARK    GeneRIF: Zinc finger protein E4F1 cooperates with PARP-1 and BRG1
            to promote DNA double-strand break repair.
REFERENCE   5  (bases 1 to 2548)
  AUTHORS   Tan,Q., Li,J., Peng,J., Liu,Z., Liu,J., Zhang,H., Yuan,Q., Pan,Z.
            and Liu,L.
  TITLE     E4F1 silencing inhibits the cell growth through cell-cycle arrest
            in malignant transformed cells induced by hydroquinone
  JOURNAL   J Biochem Mol Toxicol 33 (4), e22269 (2019)
   PUBMED   30506647
  REMARK    GeneRIF: E4F1 silencing inhibits the cell growth through cell-cycle
            arrest in malignant transformed cells induced by hydroquinone
REFERENCE   6  (bases 1 to 2548)
  AUTHORS   Rooney,R.J., Daniels,R.R., Jenkins,N.A., Gilbert,D.J.,
            Rothammer,K., Morris,S.W., Higgs,D.R. and Copeland,N.G.
  TITLE     Chromosomal location and tissue expression of the gene encoding the
            adenovirus E1A-regulated transcription factor E4F in humans and
            mice
  JOURNAL   Mamm Genome 9 (4), 320-323 (1998)
   PUBMED   9530632
REFERENCE   7  (bases 1 to 2548)
  AUTHORS   Saccone,S., Sandy,P., Meroni,G., Gostissa,M., Della Valle,G. and
            Del Sal,G.
  TITLE     Assignment of the E1A-regulated transcription factor E4F gene
            (E4F1) to human chromosome band 16p13.3 by in situ hybridization
            and somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 99-100 (1998)
   PUBMED   9763670
REFERENCE   8  (bases 1 to 2548)
  AUTHORS   Fernandes,E.R. and Rooney,R.J.
  TITLE     The adenovirus E1A-regulated transcription factor E4F is generated
            from the human homolog of nuclear factor phiAP3
  JOURNAL   Mol Cell Biol 17 (4), 1890-1903 (1997)
   PUBMED   9121437
REFERENCE   9  (bases 1 to 2548)
  AUTHORS   Burn,T.C., Connors,T.D., Van Raay,T.J., Dackowski,W.R.,
            Millholland,J.M., Klinger,K.W. and Landes,G.M.
  TITLE     Generation of a transcriptional map for a 700-kb region surrounding
            the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis
            type 2 (TSC2) disease genes on human chromosome 16p3.3
  JOURNAL   Genome Res 6 (6), 525-537 (1996)
   PUBMED   8828041
REFERENCE   10 (bases 1 to 2548)
  AUTHORS   Rooney,R.J., Raychaudhuri,P. and Nevins,J.R.
  TITLE     E4F and ATF, two transcription factors that recognize the same
            site, can be distinguished both physically and functionally: a role
            for E4F in E1A trans activation
  JOURNAL   Mol Cell Biol 10 (10), 5138-5149 (1990)
   PUBMED   2169022
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009065.8.
            
            On Nov 23, 2018 this sequence version replaced NM_004424.4.
            
            Summary: The zinc finger protein encoded by this gene is one of
            several cellular transcription factors whose DNA-binding activities
            are regulated through the action of adenovirus E1A. A 50-kDa
            amino-terminal product is generated from the full-length protein
            through proteolytic cleavage. The protein is differentially
            regulated by E1A-induced phosphorylation. The full-length gene
            product represses transcription from the E4 promoter in the absence
            of E1A, while the 50-kDa form acts as a transcriptional activator
            in its presence. Alternative splicing results in multiple
            transcripts encoding different proteins. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080524.1, SRR3476690.890332.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301727.9/ ENSP00000301727.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC009065.8         53642-53821         c
            181-332             AC009065.8         48889-49040         c
            333-438             AC009065.8         47737-47842         c
            439-632             AC009065.8         45048-45241         c
            633-753             AC009065.8         44836-44956         c
            754-906             AC009065.8         44504-44656         c
            907-1079            AC009065.8         44229-44401         c
            1080-1289           AC009065.8         43765-43974         c
            1290-1398           AC009065.8         43422-43530         c
            1399-1616           AC009065.8         43024-43241         c
            1617-1815           AC009065.8         42631-42829         c
            1816-1958           AC009065.8         42411-42553         c
            1959-2021           AC009065.8         42269-42331         c
            2022-2548           AC009065.8         41670-42196         c
FEATURES             Location/Qualifiers
     source          1..2548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2548
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /note="E4F transcription factor 1"
                     /db_xref="GeneID:1877"
                     /db_xref="HGNC:HGNC:3121"
                     /db_xref="MIM:603022"
     exon            1..180
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..2378
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor E4F1; p50E4F; p120E4F; putative E3
                     ubiquitin-protein ligase E4F1; RING-type E3 ubiquitin
                     transferase E4F1"
                     /codon_start=1
                     /product="transcription factor E4F1 isoform 1"
                     /protein_id="NP_004415.4"
                     /db_xref="CCDS:CCDS32370.1"
                     /db_xref="GeneID:1877"
                     /db_xref="HGNC:HGNC:3121"
                     /db_xref="MIM:603022"
                     /translation="MEGAMAVRVTAAHTAEAQAEAGREAGEGAVAAVAAALAPSGFLG
                     LPAPFSEEDEDDVHRCGRCQAEFTALEDFVQHKIQKACQRAPPEALPATPATTALLGQ
                     EVVPAAPGPEEPITVAHIVVEAASLAADISHASDLVGGGHIKEVIVAAEAELGDGEMA
                     EAPGSPRQQGLGLAGEGEQAQVKLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRK
                     DHECKLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRESGALTRHLKSLTPCTEK
                     IRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVTDAKGTVIHE
                     VHVQMQELSLGMKALAPEPPVSQELPCSSEGSRENLLHQAMQNSGIVLERAAGEEGAL
                     EPAPAAGSSPQPLAVAAPQLPVLEVQPLETQVASEASAVPRTHPCPQCSETFPTAATL
                     EAHKRGHTGPRPFACAQCGKAFPKAYLLKKHQEVHVRERRFRCGDCGKLYKTIAHVRG
                     HRRVHSDERPYPCPKCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHV
                     RHHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEDSPAAATTVLTED
                     PHTVLVEFSSVVADTQEYIIEATADDAETSEATEIIEGTQTEVDSHIMKVVQQIVHQA
                     SAGHQIIVQNVTMDEETALGPEAAAADTITIATPESLTEQVAMTLASAISEGTVLAAR
                     AGTSGTEQATVTMVSSEDIEILEHAGELVIASPEGQLEVQTVIV"
     exon            181..332
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            333..438
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            439..632
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            633..753
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            754..906
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1079
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1289
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1398
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1616
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1815
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1958
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2021
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2548
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /note="hexamer: AATAAA"
     polyA_site      2548
                     /gene="E4F1"
                     /gene_synonym="E4F"
                     /note="major polyA site"
ORIGIN      
        1 atcttcctgc ggcgcgttgc gacatggagg gcgcgatggc agtgcgggtg acggccgctc
       61 atacggcaga agcccaggcc gaagccgggc gggaagcggg cgagggtgca gttgcggcgg
      121 tggcggcggc cttggccccc agcggcttcc tcggcctccc ggcgcccttc agcgaggaag
      181 atgaggacga tgtgcacaga tgcggccgct gccaggcaga gttcaccgcc ttggaggatt
      241 ttgttcagca caagattcag aaggcctgcc agcgggcccc tccggaggcc ctgcctgcca
      301 cccctgccac cacagcgttg ctgggccagg aggtggtgcc ggcagcacca ggcccagagg
      361 agcccatcac tgtggcccac atcgtggtgg aggcggcctc tctggcagca gacatcagcc
      421 acgcatctga ccttgttggt ggtgggcaca tcaaagaggt catcgtggct gctgaggcgg
      481 agctgggaga cggtgagatg gccgaggccc cgggcagccc ccgccagcag gggctggggc
      541 tcgcagggga gggtgagcag gcccaggtga agctactggt gaacaaggat ggccgctatg
      601 tgtgtgcgct gtgccacaag accttcaaga cgggcagcat cctcaaggcc cacatggtca
      661 ctcacagcag ccgcaaggac cacgagtgca agctctgtgg ggcctccttc cgcaccaagg
      721 gctcactcat ccggcaccac cggcggcaca cggatgagcg cccctacaag tgctccaagt
      781 gtggaaagag cttccgggag tcgggtgcac tgacccggca cctcaagtct ctcaccccct
      841 gcacagagaa aatccgcttc agtgtgagca aggacgtggt tgtcagcaaa gaggacgcac
      901 gtgcaggttc tggagctgga gctgccggct tggggacagc cacatcatcg gtgacaggcg
      961 agcctataga gacttcaccc gtgattcacc tggtgacaga tgccaagggc accgtcatcc
     1021 acgaagtcca cgtccagatg caggagctgt ccctgggcat gaaagccctg gccccagagc
     1081 cccccgtctc ccaggagctc ccctgctcca gcgagggcag ccgtgagaac ctgctgcacc
     1141 aggccatgca gaactccggc atcgtccttg agcgcgctgc tggggaggag ggtgccctgg
     1201 agccagctcc tgctgccggg tccagtcccc agcccctggc agtggcagcc ccgcagctgc
     1261 cggtactgga agtgcagccg ctggagacac aggtggccag cgaggcctca gcggtgccca
     1321 ggacccaccc atgtcctcag tgcagtgaga ccttcccgac agcagccacc ctggaggccc
     1381 acaagagggg ccacaccggg ccgaggccgt tcgcctgcgc gcagtgtggc aaggccttcc
     1441 ccaaggccta cctgctcaag aagcaccagg aggtgcacgt gcgtgagcgc cgcttccgct
     1501 gtggcgactg cgggaagctc tacaagacca ttgcccatgt gcgtggccac cggcgcgtcc
     1561 actcagacga gcggccctac ccttgtccca agtgtggcaa gcgctacaag actaagaacg
     1621 cacagcaggt gcacttcagg acacacctgg aggagaagcc gcacgtgtgc cagttctgca
     1681 gccgtggctt ccgagagaag ggctcactgg tgcggcacgt gcgacaccac acaggcgaga
     1741 agccgttcaa gtgctacaag tgcggccgtg gcttcgccga gcacggcacg ctgaaccggc
     1801 acctgcgcac caaagggggc tgcctgctgg aggtggagga gttgctggtg tctgaggaca
     1861 gccccgcggc agccaccacc gtcctcacgg aagacccgca cacagtgttg gtggagttct
     1921 cgtccgtggt agctgacacc caggagtata tcatcgaggc cactgcggac gatgcggaga
     1981 ccagtgaggc cacggagatc atcgagggca cccagacaga ggtggacagc cacatcatga
     2041 aggtggtgca gcagatcgtg caccaggcta gcgccggcca ccagatcatc gtgcagaacg
     2101 tcaccatgga cgaggagacg gcgctgggcc cagaggcggc tgccgccgac accatcacca
     2161 tcgccacccc cgagagcctg acagagcagg tggccatgac gctggcctcg gccatcagcg
     2221 agggcactgt gcttgccgcc cgggcaggga caagtggcac tgaacaggcc actgtgacca
     2281 tggtgtcatc agaggacatc gagatcctgg agcatgcagg cgagctggtc atcgcctcgc
     2341 cggagggcca gctggaggtg cagacggtca tcgtctagca tgaggtctgc ggggtcctgg
     2401 ccgggcaggg acagggcaga ggactctgag cgccccaccc atgcctgcct ggcctggtag
     2461 agaagatggc acaggatgga ggcgccccaa gacggacagt gtacataaga gtttcttgtt
     2521 gctttacaat aaaacatgag aacctgca
//
