LOCUS       NM_203394               5725 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens E2F transcription factor 7 (E2F7), mRNA.
ACCESSION   NM_203394 XM_084871
VERSION     NM_203394.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5725)
  AUTHORS   Jin,Z., Xu,W., Yu,K., Luo,C., Luo,X., Lian,T. and Liu,C.
  TITLE     The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a
            regulatory network in breast cancer
  JOURNAL   Hereditas 161 (1), 27 (2024)
   PUBMED   39192374
  REMARK    GeneRIF: The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a
            regulatory network in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5725)
  AUTHORS   Jiang,B., Yan,B., Yang,H., Geng,H. and Li,P.
  TITLE     Transcription Factor E2F7 Hampers the Killing Effect of NK Cells
            against Colorectal Cancer Cells via Activating RAD18 Transcription
  JOURNAL   J Microbiol Biotechnol 34 (4), 920-929 (2024)
   PUBMED   38073330
  REMARK    GeneRIF: Transcription Factor E2F7 Hampers the Killing Effect of NK
            Cells against Colorectal Cancer Cells via Activating RAD18
            Transcription.
REFERENCE   3  (bases 1 to 5725)
  AUTHORS   Meng,J., Qian,W., Yang,Z., Gong,L., Xu,D., Huang,H., Jiang,X.,
            Pu,Z., Yin,Y. and Zou,J.
  TITLE     p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma
            multiforme
  JOURNAL   BMC Cancer 24 (1), 317 (2024)
   PUBMED   38454344
  REMARK    GeneRIF: p53/E2F7 axis promotes temozolomide chemoresistance in
            glioblastoma multiforme.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5725)
  AUTHORS   Lin,S., Yu,X., Yan,H., Xu,Y., Ma,K., Wang,X., Liu,Y., Xie,A. and
            Yu,Z.
  TITLE     E2F7 serves as a potential prognostic biomarker for lung
            adenocarcinoma
  JOURNAL   Medicine (Baltimore) 103 (3), e34342 (2024)
   PUBMED   38241554
  REMARK    GeneRIF: E2F7 serves as a potential prognostic biomarker for lung
            adenocarcinoma.
REFERENCE   5  (bases 1 to 5725)
  AUTHORS   Wang,L., Wang,Y., Wang,C., Yang,K. and Ye,G.
  TITLE     CISD2 transcriptional activated by transcription factor E2F7
            promotes the malignant progression of cervical cancer
  JOURNAL   J Mol Histol 54 (5), 489-498 (2023)
   PUBMED   37615745
  REMARK    GeneRIF: CISD2 transcriptional activated by transcription factor
            E2F7 promotes the malignant progression of cervical cancer.
REFERENCE   6  (bases 1 to 5725)
  AUTHORS   Reimer,D., Sadr,S., Wiedemair,A., Stadlmann,S., Concin,N.,
            Hofstetter,G., Muller-Holzner,E., Marth,C. and Zeimet,A.G.
  TITLE     Clinical relevance of E2F family members in ovarian cancer--an
            evaluation in a training set of 77 patients
  JOURNAL   Clin Cancer Res 13 (1), 144-151 (2007)
   PUBMED   17200349
  REMARK    GeneRIF: down-regulation of E2F7 may contribute to mechanisms
            underlying platinum resistance in ovarian neoplasms
REFERENCE   7  (bases 1 to 5725)
  AUTHORS   Logan,N., Graham,A., Zhao,X., Fisher,R., Maiti,B., Leone,G. and La
            Thangue,N.B.
  TITLE     E2F-8: an E2F family member with a similar organization of
            DNA-binding domains to E2F-7
  JOURNAL   Oncogene 24 (31), 5000-5004 (2005)
   PUBMED   15897886
  REMARK    GeneRIF: The similarities between E2F-7 and E2F-8 define a new
            subgroup of the E2F family, and further imply that E2F-7 and E2F-8
            may act through overlapping mechanisms in mediating cell cycle
            control.
REFERENCE   8  (bases 1 to 5725)
  AUTHORS   Logan,N., Delavaine,L., Graham,A., Reilly,C., Wilson,J.,
            Brummelkamp,T.R., Hijmans,E.M., Bernards,R. and La Thangue,N.B.
  TITLE     E2F-7: a distinctive E2F family member with an unusual organization
            of DNA-binding domains
  JOURNAL   Oncogene 23 (30), 5138-5150 (2004)
   PUBMED   15133492
REFERENCE   9  (bases 1 to 5725)
  AUTHORS   Di Stefano,L., Jensen,M.R. and Helin,K.
  TITLE     E2F7, a novel E2F featuring DP-independent repression of a subset
            of E2F-regulated genes
  JOURNAL   EMBO J 22 (23), 6289-6298 (2003)
   PUBMED   14633988
  REMARK    GeneRIF: Plays an essential role in the regulation of cell cycle
            progression.
REFERENCE   10 (bases 1 to 5725)
  AUTHORS   de Bruin,A., Maiti,B., Jakoi,L., Timmers,C., Buerki,R. and Leone,G.
  TITLE     Identification and characterization of E2F7, a novel mammalian E2F
            family member capable of blocking cellular proliferation
  JOURNAL   J Biol Chem 278 (43), 42041-42049 (2003)
   PUBMED   12893818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB159890.1, BC017481.1, AC025161.18, AK097677.1 and AI380315.1.
            
            On Nov 22, 2018 this sequence version replaced NM_203394.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.104644.1, BC136366.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322886.12/ ENSP00000323246.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DB159890.1         12-162
            152-438             BC017481.1         150-436
            439-439             AC025161.18        76402-76402         c
            440-1193            BC017481.1         438-1191
            1194-1194           AC025161.18        65048-65048         c
            1195-3180           AK097677.1         797-2782
            3181-5345           AC025161.18        42023-44187         c
            5346-5725           AI380315.1         7-386               c
FEATURES             Location/Qualifiers
     source          1..5725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..5725
                     /gene="E2F7"
                     /note="E2F transcription factor 7"
                     /db_xref="GeneID:144455"
                     /db_xref="HGNC:HGNC:23820"
                     /db_xref="MIM:612046"
     exon            1..225
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2961
                     /gene="E2F7"
                     /note="E2F-7"
                     /codon_start=1
                     /product="transcription factor E2F7"
                     /protein_id="NP_976328.2"
                     /db_xref="CCDS:CCDS9016.1"
                     /db_xref="GeneID:144455"
                     /db_xref="HGNC:HGNC:23820"
                     /db_xref="MIM:612046"
                     /translation="MEVNCLTLKDLISPRQPRLDFAVEDGENAQKENIFVDRSRMAPK
                     TPIKNEPIDLSKQKKFTPERNPITPVKFVDRQQAEPWTPTANLKMLISAASPDIRDRE
                     KKKGLFRPIENKDDAFTDSLQLDVVGDSAVDEFEKQRPSRKQKSLGLLCQKFLARYPS
                     YPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKT
                     LRNLQRLGEEQKYEEQMAYLQQKELDLIDYKFGERKKDGDPDSQEQQLLDFSEPDCPS
                     SSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDAPDHSKFKTKVRR
                     LYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSSDEELVDVSASVLPELKRE
                     TYGQIQVCAKQKLARHGSFNTVQASERIQRKVNSEPSSPYREEQGSGGYSLEIGSLAA
                     VYRQKIEDNSQGKAFASKRVVPPSSSLDPVAPFPVLSVDPEYCVNPLAHPVFSVAQTD
                     LQAFSMQNGLNGQVDVSLASAASAVESLKPALLAGQPLVYVPSASLFMLYGSLQEGPA
                     SGSGSERDDRSSEAPATVELSSAPSAQKRLCEERKPQEEDEPATKRQSREYEDGPLSL
                     VMPKKPSDSTDLASPKTMGNRASIPLKDIHVNGQLPAAEEISGKATANSLVSSEWGNP
                     SRNTDVEKPSKENESTKEPSLLQYLCVQSPAGLNGFNVLLSGSQTPPTVGPSSGQLPS
                     FSVPCMVLPSPPLGPFPVLYSPAMPGPVSSTLGALPNTGPVNFSLPGLGSIAQLLVGP
                     TAVVNPKSSTLPSADPQLQSQPSLNLSPVMSRSHSVVQQPESPVYVGHPVSVVKLHQS
                     PVPVTPKSIQRTHRETFFKTPGSLGDPVLKRRERNQSRNTSSAQRRLEIPSGGAD"
     exon            226..318
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            319..594
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            595..763
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1054
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1213
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1348
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1534
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1607
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..2109
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2365
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2790
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..5725
                     /gene="E2F7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5705..5710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F7"
                     /note="hexamer: AATAAA"
     polyA_site      5725
                     /gene="E2F7"
                     /note="major polyA site"
ORIGIN      
        1 gactacgatc caggctggag ttgcgctcgg ccggtctgag cgctggcgct gcccggacgc
       61 cgcggggtcc ccgccagccc agggcactcg gcgcggggat ctgcgcgcct cgctctccct
      121 tcccgatgcc gccgcccggc tgctgatcgc cgcaccacct tccctcatcg gcttgggtcc
      181 gtggaggtcc ctgcagaggc aggaagcctc cttaggaaag cagggatgga ggtaaattgt
      241 ttaacactaa aagacctgat cagccccagg cagcccagac tagattttgc agttgaagat
      301 ggggaaaatg cacaaaagga aaatatattt gttgatcgat caaggatggc cccgaagact
      361 ccaataaaaa atgaaccaat tgatttatcg aagcaaaaaa aatttactcc agaaagaaat
      421 cccattactc cagttaagtt tgttgacaga cagcaagcgg aaccatggac acccacagct
      481 aacctgaaga tgctcattag tgctgccagc ccagatataa gggaccggga gaagaaaaag
      541 ggactattcc gacccattga aaacaaggac gatgcattta cagattctct acagcttgat
      601 gttgttgggg acagtgctgt ggacgaattt gaaaagcaaa ggccaagcag aaaacagaaa
      661 agtttaggac tcctgtgcca gaagtttcta gctcgctatc caagttatcc cttgtcaact
      721 gagaaaacta ccatctccct agatgaagtt gctgtcagtc ttggtgtgga aaggagacgc
      781 atctatgaca ttgtaaatgt gctggagtcg ctgcatctgg tcagccgggt ggctaagaat
      841 cagtatggct ggcatggacg gcacagcctg ccaaaaaccc tgaggaacct ccagagacta
      901 ggagaggagc agaaatatga agagcaaatg gcctacctcc aacagaaaga gctggacctg
      961 atagattata aatttggaga acgtaaaaaa gatggtgatc cagattccca ggaacaacag
     1021 ttactggatt tctctgaacc cgactgtccc tcttcatctg caaacagtag aaaagacaag
     1081 tctctgagaa ttatgagcca gaagtttgtc atgctgttcc tcgtctccaa aaccaagatt
     1141 gtcactctgg atgtggctgc caaaatactg atagaagaaa gccaagatgc cccagaccat
     1201 agtaaattta aaacaaaggt acgacgcctc tatgacatag ccaatgttct gaccagcttg
     1261 gctctgataa agaaagtgca tgtaacagaa gagcgaggtc gtaaaccagc cttcaagtgg
     1321 atcgggcctg tggacttcag ctcaagtgat gaagaactgg tggatgtttc tgcatctgtc
     1381 ttaccagaat tgaaaagaga aacatatggc cagattcaag tctgtgcaaa acagaagctg
     1441 gctcgccatg gttcttttaa cacagttcag gcttctgaga ggatccagag gaaagtgaac
     1501 tcagaaccga gcagcccgta cagagaagaa caaggatcag gtggctactc tttagaaatt
     1561 ggaagcctgg cagctgtcta tagacagaaa atagaagaca attcacaggg aaaagccttt
     1621 gccagtaaga gagtggtgcc tccatcaagc agcttggacc ctgttgctcc tttccctgtc
     1681 ctctctgttg acccagaata ttgtgttaat cctttagccc acccagtatt ttctgttgct
     1741 cagacggacc tgcaggcatt ctccatgcag aacggtctga atggacaagt ggatgtctca
     1801 cttgcttctg cagcctctgc tgtggagagc ctgaagccag cactccttgc tggccagcct
     1861 ctagtgtatg tgccctctgc ctcactgttc atgctgtatg gaagtctgca ggagggacca
     1921 gcgtcagggt cagggtcaga gagggatgac agaagctcag aagccccagc cacagtagag
     1981 ctgtcatctg caccctcagc tcagaagcgc ctctgtgagg agaggaaacc tcaggaggag
     2041 gatgagccag ccactaaaag gcaaagtagg gaatatgaag acggcccgct gtcgcttgtc
     2101 atgcccaaga aaccctcaga ttccacagac cttgcctctc ccaagactat gggtaacagg
     2161 gcatctatac ccctcaaaga cattcatgtg aatggccaac tccctgctgc agaagagatt
     2221 tcaggaaagg caacagcaaa ctctcttgtt tcttctgagt ggggaaatcc ttcaagaaat
     2281 acagatgttg aaaagccttc aaaagaaaat gaaagcacca aagagccttc tttgctacaa
     2341 tatctttgtg tgcagtctcc tgcaggatta aatggtttca atgtactttt atctggcagt
     2401 caaacccccc ctactgtggg cccgtcctca ggtcagctgc cgtctttcag tgtcccttgc
     2461 atggtcttac catctccacc tctgggccct tttcctgttc tctattctcc tgcaatgccg
     2521 ggcccggttt cttctactct tggtgctctc ccaaacacag gacctgtgaa tttcagcttg
     2581 cctggccttg gatcaatagc ccagcttctc gtcggcccca cagctgtggt taatccaaag
     2641 tcgtccacac tcccttctgc agaccctcag cttcagagtc agccctcact aaacctaagt
     2701 ccagtgatgt caaggtcaca cagtgtcgtc caacaacctg agtcccccgt ttacgtggga
     2761 catccagtct cagtagtaaa attacatcag tcaccagttc cagtgacccc caagagcatc
     2821 caacgcacac atcgtgagac gtttttcaag acacccggca gccttggaga ccctgtcctg
     2881 aagagaagag aaaggaacca gtcacgaaac accagctcgg cccagaggag actagaaatc
     2941 cccagcggcg gcgctgacta acctgccgct ttgccaggtg ggggtgggat caaacgccct
     3001 gagagtcccg gatgtccgag gcgggatgca aaccatcccg tcctgagcac gggtccttcc
     3061 tctctctttc atccacactt ctgttaactt cccaccacca tcaatcatct gatttcctga
     3121 aagtaattaa ttgtgcattt aataccagtt agagttccga ctctgcatgg tgtcacagtg
     3181 aaagcgccga ctgacttatg gttttgattc aagaatcgtc ttattctgga agtagatctg
     3241 aataggctac cggagccttg tttttctaaa ggggggcgct gtctagcact taactagggt
     3301 aagcattctt aacatgtatt tccacttgcc ctgagtaaat ctgtggtgag agaagcttcc
     3361 tttctgcagt ttaaaaaagc tactgcttcc ttaggcttca tcaggaagcc accttcagtt
     3421 gtgaatccta tggtgttatt tattttgttc ctgaaatggg atttagtgca aaaagtttac
     3481 aactacagtc tttaacacat ttttttcagg gtatgacgac ttgaatgttt atacttttat
     3541 tctataattt gccctgcact tattttacaa cctagtaata atgtggataa atgtatctac
     3601 atgacacatg tcaagaccaa aataactgtg aatgacacac cttgctgtaa atgaactgtg
     3661 ctaaccctga ctgtgggctt gagaacaaag atgaactcta gaactctagc agcctaactg
     3721 ctgcttctca aataactgtg tgaacagtga gatattactg tttgtttcta aaaatcctac
     3781 tgtgcccagt ttccttcact acatgccctg cattttttat ttaaatattt agctgtagcg
     3841 ccatcagata tggatgcctt ctaacaattg ctgtttgtaa aataaatcag gatggtagaa
     3901 agtgattata tggaaaattg gaacctggat gagacctttt cgttgaattc tgaagagtaa
     3961 tgatgtgaaa attgatacag ggcaagagat gattcttttg tttttcttct acttcatgtc
     4021 cagaagagta agagggaaaa tggacatatg tttcatatcc aagggtattc aaactgtagt
     4081 tagttggtac ctctgaaaaa tgagaatggt gagcgcacgg gttggttgtt ctagcatgaa
     4141 tacaattctg gaaactgtta tgcaatttcc cttttttaac ccacattact ttaggggtgc
     4201 attaagtcgc caaactatac tagttctttg tattcctaga cttgctgata tttacctctc
     4261 tcttgtctct tcagagtaaa tggttccctt ctttccttcc tactttcctt cattctctct
     4321 tccttccctc cttcctactt cttttcttcc ttcctcttcc tctcttaaaa ctatcttaga
     4381 tgtagaatcc tggtgtaggg ttttatttta tttttatttt ttgacccaat aaaatgttat
     4441 atgaaagaat gaaaatatta atttaagaga ctctgggagt ctgaataaag tagctttata
     4501 ttaactacag gataatatta gccttattac ccccacaaga ttttttaaaa cttgaggtag
     4561 gtagctacat taaataaatt tgctacttat ataaaaattt ttatcaacac taaactttta
     4621 aagtttacaa gttttttttt tcttttttac agtcttctat agagttaggt taaaaatgtg
     4681 gttctaacca tcaacaattg catggttaaa tgaccctgaa ctaaaactga tgggttccct
     4741 atcaaaacaa ataaaaatat acctttttca ggtttcaatc tgtgcagggt atatgcatgt
     4801 taattctacc atgcttaaga acttccacaa aatatttcat ggagaggtct gcatttagac
     4861 ggaaacagaa attgcttttc ccctcactgt tcctgaatgc tctatacttg ttttaacatt
     4921 tttgctatct ttttttatta ttctgatcat gatatgacca tttaacctca gaattcataa
     4981 ttcctgaggg gtgttaagaa gcagtcccat tggtgaggat attatgactt ggtgaccatt
     5041 cttaggagta gaaaaccaag gacaattgct tctgtattca gtatccactt cttaatgtgg
     5101 ctttatatgt aaaaataata atgcagtggt tgtttctgtc aggaaaataa atcttacaga
     5161 acaactggtg gaattgaagc tgctgcgcta gacttggata ttttgggtag tgaagaagca
     5221 atggcaatct tgagtctatt attgtataat ttagtaaaag aaaaaaataa tcgttggtgg
     5281 tcctactaag agaatgcagc ttttttgagt tgtcacagag gctgtgtgtg ccctacactg
     5341 accagggttt gtaaaaccct ttcattctgg tacaagagtc gggggtataa cttttatact
     5401 tgaatctacc taccaagttt acatttctca attccttttt gtaaggtgct atttctgtat
     5461 ttaaataact ttcttttaac gtaaagctgc tttctgctta tcttattgca ctgctagttg
     5521 tatgtaggta ttaattttat tgctgcttac tgcttttgtt ttcttattat ttagctctgc
     5581 tctttttcct aatggctata ttatctatag ctatttactt gtaactgtac tacatgtaaa
     5641 ctgatttttt gttctgattt tttttctaat atttttagga aaatattaag ctttataaaa
     5701 tagcaataaa aaataattca tttaa
//
