LOCUS       NM_198256               3230 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens E2F transcription factor 6 (E2F6), transcript variant
            a, mRNA.
ACCESSION   NM_198256 NM_001952
VERSION     NM_198256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Wang,Y., Huang,X., Zhang,Q., Cheng,C., Qin,Z., Lu,L. and Huang,Q.
  TITLE     The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates
            EN1 expression by modulating DNA methylation and E2F6 binding
  JOURNAL   J Mol Med (Berl) 102 (2), 273-284 (2024)
   PUBMED   38153509
  REMARK    GeneRIF: The osteoporosis susceptibility SNP rs188303909 at 2q14.2
            regulates EN1 expression by modulating DNA methylation and E2F6
            binding.
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Ai,J., Zhang,W., Deng,W., Yan,L., Zhang,L., Huang,Z., Wu,Z., Ai,J.
            and Jiang,H.
  TITLE     A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis
            of hepatocellular carcinoma
  JOURNAL   BMC Cancer 24 (1), 14 (2024)
   PUBMED   38166853
  REMARK    GeneRIF: A hsa_circ_001726 axis regulated by E2F6 contributes to
            metastasis of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Fang,D., Zhang,Q., Mu,M., Deng,Q., Wang,Y. and Li,Q.
  TITLE     lncRNA ENST00000585827 Contributes to the Progression of
            Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis
  JOURNAL   Appl Biochem Biotechnol 195 (5), 3096-3108 (2023)
   PUBMED   36525235
  REMARK    GeneRIF: lncRNA ENST00000585827 Contributes to the Progression of
            Endometrial Carcinoma via Regulating miR-424/E2F6/E2F7 Axis.
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Kherrouche,Z., De Launoit,Y. and Monte,D.
  TITLE     Human E2F6 is alternatively spliced to generate multiple protein
            isoforms
  JOURNAL   Biochem Biophys Res Commun 317 (3), 749-760 (2004)
   PUBMED   15081404
  REMARK    GeneRIF: contains nine exons distributed along 20.4kbp of genomic
            DNA on chromosome 2 leading to the transcription of six
            alternatively spliced E2F6 mRNAs that encode four different E2F6
            proteins
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Oberley,M.J., Inman,D.R. and Farnham,P.J.
  TITLE     E2F6 negatively regulates BRCA1 in human cancer cells without
            methylation of histone H3 on lysine 9
  JOURNAL   J Biol Chem 278 (43), 42466-42476 (2003)
   PUBMED   12909625
  REMARK    GeneRIF: results suggest that E2F6 represses transcription of the
            brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of
            E2F6 resulted in the recruitment of E2F1 to the target promoters
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Ogawa,H., Ishiguro,K., Gaubatz,S., Livingston,D.M. and Nakatani,Y.
  TITLE     A complex with chromatin modifiers that occupies E2F- and
            Myc-responsive genes in G0 cells
  JOURNAL   Science 296 (5570), 1132-1136 (2002)
   PUBMED   12004135
  REMARK    GeneRIF: data suggest that E2F- and Myc-responsive genes are
            coregulated by E2F6 complex in quiescent cells
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Trimarchi,J.M., Fairchild,B., Wen,J. and Lees,J.A.
  TITLE     The E2F6 transcription factor is a component of the mammalian
            Bmi1-containing polycomb complex
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1519-1524 (2001)
   PUBMED   11171983
REFERENCE   8  (bases 1 to 3230)
  AUTHORS   Cartwright,P., Muller,H., Wagener,C., Holm,K. and Helin,K.
  TITLE     E2F-6: a novel member of the E2F family is an inhibitor of
            E2F-dependent transcription
  JOURNAL   Oncogene 17 (5), 611-623 (1998)
   PUBMED   9704927
REFERENCE   9  (bases 1 to 3230)
  AUTHORS   Gaubatz,S., Wood,J.G. and Livingston,D.M.
  TITLE     Unusual proliferation arrest and transcriptional control properties
            of a newly discovered E2F family member, E2F-6
  JOURNAL   Proc Natl Acad Sci U S A 95 (16), 9190-9195 (1998)
   PUBMED   9689056
REFERENCE   10 (bases 1 to 3230)
  AUTHORS   Trimarchi,J.M., Fairchild,B., Verona,R., Moberg,K., Andon,N. and
            Lees,J.A.
  TITLE     E2F-6, a member of the E2F family that can behave as a
            transcriptional repressor
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2850-2855 (1998)
   PUBMED   9501179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU142999.1, BC008348.1 and
            AC099344.4.
            
            On Nov 23, 2018 this sequence version replaced NM_198256.3.
            
            Summary: This gene encodes a member of a family of transcription
            factors that play a crucial role in the control of the cell cycle.
            The protein encoded by this gene lacks the transactivation and
            tumor suppressor protein association domains found in other family
            members, and contains a modular suppression domain that functions
            in the inhibition of transcription. It interacts in a complex with
            chromatin modifying factors. There are pseudogenes for this gene on
            chromosomes 22 and X. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223407.1, BC107740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381525.8/ ENSP00000370936.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AU142999.1         11-400
            391-1837            BC008348.1         366-1812
            1838-3230           AC099344.4         111461-112853       c
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..3230
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /note="E2F transcription factor 6"
                     /db_xref="GeneID:1876"
                     /db_xref="HGNC:HGNC:3120"
                     /db_xref="MIM:602944"
     exon            1..390
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1128
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /note="isoform 1 is encoded by transcript variant a;
                     transcription factor E2F6"
                     /codon_start=1
                     /product="transcription factor E2F6 isoform 1"
                     /protein_id="NP_937987.2"
                     /db_xref="CCDS:CCDS1680.2"
                     /db_xref="GeneID:1876"
                     /db_xref="HGNC:HGNC:3120"
                     /db_xref="MIM:602944"
                     /translation="MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINL
                     EDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRR
                     VYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDEL
                     IKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPRED
                     SITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEEL
                     LEVSN"
     exon            391..445
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /inference="alignment:Splign:2.1.0"
     exon            446..662
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /inference="alignment:Splign:2.1.0"
     exon            663..818
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /inference="alignment:Splign:2.1.0"
     exon            819..933
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1081
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..3230
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3205..3210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /note="hexamer: AATGAA"
     polyA_site      3230
                     /gene="E2F6"
                     /gene_synonym="E2F-6"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtactgc gcatgcggga agatggcggg ccgggcgact tgagatccgc gggtctccct
       61 cctctttttc cgtctgcgtc gggagctccc gggcacgtga ggccgtgccg cgtttactgg
      121 cgggcgggac ggcctagccg ggcggcgcct cggaggaagc cgcggacccc ttaggtgctg
      181 ggcccttgga aatcggcgcg tggggggcgg tgctcgagct gagcgcgaga gggcgggaga
      241 gctcgtgggg tgcgagggga gcaggacgcc cggccgggca gcatgagtca gcagcggccg
      301 gcgaggaagt tacccagtct cctcctggac ccgacggagg agacggttcg ccgtcggtgc
      361 cgagacccca tcaacgtgga gggcctgctg ccatcaaaaa taaggattaa tttagaagat
      421 aatgtacaat atgtgtccat gagaaaagct ctaaaagtga agagacctcg ttttgatgta
      481 tcgctggttt atttaactcg aaaatttatg gatcttgtca gatctgctcc cgggggtatt
      541 cttgacttaa acaaggttgc aacgaaactg ggagtccgaa agcggagagt gtatgacatc
      601 accaatgtct tagatggaat cgacctcgtt gaaaagaaat ccaagaacca tattagatgg
      661 ataggatctg atcttagcaa ttttggagca gttccccaac aaaagaagct acaggaggaa
      721 ctttctgact tatcagcaat ggaagatgct ttggatgagt taattaagga ttgtgctcag
      781 cagctgtttg agttaacaga tgacaaagaa aatgaaagac tagcatatgt gacctatcaa
      841 gacattcata gcattcaggc cttccatgaa cagatcgtca ttgcagttaa agctccagca
      901 gaaaccagat tggatgttcc agctcccaga gaagactcta tcacagtgca cataaggagc
      961 accaacggac ctatcgatgt ctatttgtgt gaagtggagc agggtcagac cagtaacaaa
     1021 aggtctgaag gtgtcgggac ctcttcatct gagagcactc atccagaagg ccctgaggaa
     1081 gaagaaaatc ctcagcaaag tgaagaattg cttgaagtaa gcaactgatg gcatttgaga
     1141 atttatgtat cactgagttt tttgggaata tcttcgtgga gaattacgca tcaaatttga
     1201 ttctcagagc aataaattat ccatgaagtg ctctcgttct cagtagcggc atcatggcca
     1261 gtagtgtctt tgaggagttc accacttaga ttactgagta attgtggttt ccacatttga
     1321 aaacaactcc ttttataatt attcactgct ttttgtcagt gaaatagaca tcttgcctcc
     1381 tgaagtagct tcatcacaga gtgtcatgaa gacagacagt caggctgaaa tggacagttc
     1441 tttgtggact ctacccttcc cttcaaggag tatgtcatat atcacaaaag aaattgcctt
     1501 acactggttc atgtttgcag ttactgttgt acattgcata gatgtacaca cgaatttaaa
     1561 tgtgatgtct ttgtatatat ctgtataatg ttgagattac ttacgaaata tgtctgagtg
     1621 acacttttca cccttgtaca gccaaaataa tgtatatatg gaaagtgaca gacaaattct
     1681 ctaatctctt tggtacctat aacttattag aatcctctgg atgagggtta gaagagactt
     1741 tttccaaact tctacatgta gaagtatcat aaatgtgcta cacatttatg tttgtggatt
     1801 taattaaagt attttaatat ggttttcagt gctaaaattg gagtcagata cttcttggtt
     1861 ttaagctgtc tacctaattg ctgtctccca gcagactggt ggcatgccca gtggctttgg
     1921 gggcaaggat agaaatgcca tcaggaaata gctgaattca ttgtgaaaca tgaattcagt
     1981 catggtgata attggaaact cctttcaggt ttttgcaagt agattttgta atgtttgtgt
     2041 atgcagcctt gctgttgagt cagtccaagg ggttttactt aggacaagtt gtaccttgcc
     2101 ctctctccag ctctgctccc acattttcac atacctagct gtttctacct cattgggtaa
     2161 gtcatttacc actctgtgcc tcagtttact ctgtagttta ccattagact gtgagctcct
     2221 tgagggactt tgtcataatc actgttacat cccagtgcct cacaccatgc ctggccctta
     2281 agaagtgctc aataaatgtc tgaacaaata agtgagtgga gtgagtgaat tgtaagatca
     2341 gaataataat atttggtttg tctatcgtac aagattcctg tatcgtttga atattgcttt
     2401 taaagaaata tttgaagcga cttcaaattc agactgtgtt taaaaagatt taaaatcgga
     2461 atccaaaatc aaagtattaa aaaataatgc tgagtgttta ggattcacat acctctgagc
     2521 tctggtggct tttgccagtc ctgtccctct gctgagcacc agcccttcct gcagcagtcc
     2581 tgccggtgtg tttctgtgca cctggggatg aagtgtgctc ctcccccagc ggttagcctc
     2641 aatgcttttc ctccctctgt tttattattt gaaattagcc aaagaaaagc tgcagggggc
     2701 actgctgatc atcactggac tggtgggtcg tactgtttga cagaataggg aatacaggag
     2761 gaggagcaag cctagggtaa aacttaggtt tgggacatgc ttgatgaaag caagagttga
     2821 gcaggttgtt gtgtgtatgt aggtcaggtg ctcagcggaa aagtctgagc tgtgtagtac
     2881 gtcaggcaga tgtcagttta gatgcgatag tttaagccac aagagtagga gaggtcatct
     2941 aaagagtaca gcaggcctaa gggcatctat atttaaggag aaatacagaa gaagtctcct
     3001 gagaaggaat aatggggcgg gtggggaggg agaaggcagt gtcccaaaaa ccaacaaagg
     3061 ttttaccaaa ggtaatacca tcatttctga gcagcagttc cttaacttgt gaatgtggca
     3121 aatgttctcc tttacaaatt gttctgaagg taaaatgaga tcatgtaaac gaaaatcctt
     3181 tgtaaattac agatgtgtgt tataaatgaa gtatctctcg agtcactcca
//
