LOCUS       NM_001951               1964 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens E2F transcription factor 5 (E2F5), transcript variant
            1, mRNA.
ACCESSION   NM_001951
VERSION     NM_001951.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Wang,Z., Zhang,H., Li,F. and Huang,C.
  TITLE     Knockdown of RNA-binding protein IMP3 suppresses oral squamous cell
            carcinoma proliferation by destabilizing E2F5 transcript
  JOURNAL   Aging (Albany NY) 16 (2), 1897-1910 (2024)
   PUBMED   38271139
  REMARK    GeneRIF: Knockdown of RNA-binding protein IMP3 suppresses oral
            squamous cell carcinoma proliferation by destabilizing E2F5
            transcript.
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Li,F., Qiu,F., Fan,X., Yu,Q., Liu,S., Guo,Y., Zhu,Y., Xi,X. and
            Du,B.
  TITLE     Expression of CD44 is regulated by ELF3 in 5-FU treated colorectal
            cancer cells
  JOURNAL   Gene 892, 147896 (2024)
   PUBMED   37832805
  REMARK    GeneRIF: Expression of CD44 is regulated by ELF3 in 5-FU treated
            colorectal cancer cells.
REFERENCE   3  (bases 1 to 1964)
  AUTHORS   Pflug,K.M., Lee,D.W., McFadden,K., Herrera,L. and Sitcheran,R.
  TITLE     Transcriptional induction of NF-kappaB-inducing kinase by E2F4/5
            facilitates collective invasion of GBM cells
  JOURNAL   Sci Rep 13 (1), 13093 (2023)
   PUBMED   37567906
  REMARK    GeneRIF: Transcriptional induction of NF-kappaB-inducing kinase by
            E2F4/5 facilitates collective invasion of GBM cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1964)
  AUTHORS   Tang,Y., Gao,G., Xia,W.W. and Wang,J.B.
  TITLE     METTL3 promotes the growth and metastasis of pancreatic cancer by
            regulating the m6A modification and stability of E2F5
  JOURNAL   Cell Signal 99, 110440 (2022)
   PUBMED   35985439
  REMARK    GeneRIF: METTL3 promotes the growth and metastasis of pancreatic
            cancer by regulating the m6A modification and stability of E2F5.
REFERENCE   5  (bases 1 to 1964)
  AUTHORS   Li,L., Liu,J. and Huang,W.
  TITLE     E2F5 promotes proliferation and invasion of gastric cancer through
            directly upregulating UBE2T transcription
  JOURNAL   Dig Liver Dis 54 (7), 937-945 (2022)
   PUBMED   34583905
  REMARK    GeneRIF: E2F5 promotes proliferation and invasion of gastric cancer
            through directly upregulating UBE2T transcription.
REFERENCE   6  (bases 1 to 1964)
  AUTHORS   Hijmans,E.M., Voorhoeve,P.M., Beijersbergen,R.L., van 't Veer,L.J.
            and Bernards,R.
  TITLE     E2F-5, a new E2F family member that interacts with p130 in vivo
  JOURNAL   Mol Cell Biol 15 (6), 3082-3089 (1995)
   PUBMED   7760804
REFERENCE   7  (bases 1 to 1964)
  AUTHORS   Sardet,C., Vidal,M., Cobrinik,D., Geng,Y., Onufryk,C., Chen,A. and
            Weinberg,R.A.
  TITLE     E2F-4 and E2F-5, two members of the E2F family, are expressed in
            the early phases of the cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2403-2407 (1995)
   PUBMED   7892279
REFERENCE   8  (bases 1 to 1964)
  AUTHORS   Itoh,A., Levinson,S.F., Morita,T., Kourembanas,S., Brody,J.S. and
            Mitsialis,S.A.
  TITLE     Structural characterization and specificity of expression of E2F-5:
            a new member of the E2F family of transcription factors
  JOURNAL   Cell Mol Biol Res 41 (3), 147-154 (1995)
   PUBMED   8589754
REFERENCE   9  (bases 1 to 1964)
  AUTHORS   Beijersbergen,R.L., Kerkhoven,R.M., Zhu,L., Carlee,L.,
            Voorhoeve,P.M. and Bernards,R.
  TITLE     E2F-4, a new member of the E2F gene family, has oncogenic activity
            and associates with p107 in vivo
  JOURNAL   Genes Dev 8 (22), 2680-2690 (1994)
   PUBMED   7958925
REFERENCE   10 (bases 1 to 1964)
  AUTHORS   Ginsberg,D., Vairo,G., Chittenden,T., Xiao,Z.X., Xu,G.,
            Wydner,K.L., DeCaprio,J.A., Lawrence,J.B. and Livingston,D.M.
  TITLE     E2F-4, a new member of the E2F transcription factor family,
            interacts with p107
  JOURNAL   Genes Dev 8 (22), 2665-2679 (1994)
   PUBMED   7958924
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011773.9, U15642.1,
            AI740797.1, Z78409.1, DB534924.2 and U31556.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001951.3.
            
            Summary: The protein encoded by this gene is a member of the E2F
            family of transcription factors. The E2F family plays a crucial
            role in the control of cell cycle and action of tumor suppressor
            proteins and is also a target of the transforming proteins of small
            DNA tumor viruses. The E2F proteins contain several evolutionarily
            conserved domains that are present in most members of the family.
            These domains include a DNA binding domain, a dimerization domain
            which determines interaction with the differentiation regulated
            transcription factor proteins (DP), a transactivation domain
            enriched in acidic amino acids, and a tumor suppressor protein
            association domain which is embedded within the transactivation
            domain. This protein is differentially phosphorylated and is
            expressed in a wide variety of human tissues. It has higher
            identity to E2F4 than to other family members. Both this protein
            and E2F4 interact with tumor suppressor proteins p130 and p107, but
            not with pRB. Alternative splicing results in multiple variants
            encoding different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.165558.1,
                                           SRR1163657.34181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416274.7/ ENSP00000398124.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AC011773.9         79592-79821
            231-266             U15642.1           162-197
            267-398             U15642.1           203-334
            399-930             AI740797.1         70-601
            931-1501            Z78409.1           698-1268
            1502-1679           DB534924.2         251-428
            1680-1964           U31556.1           1446-1730
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.2"
     gene            1..1964
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /note="E2F transcription factor 5"
                     /db_xref="GeneID:1875"
                     /db_xref="HGNC:HGNC:3119"
                     /db_xref="MIM:600967"
     exon            1..501
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1308
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor E2F5; E2F transcription factor 5,
                     p130-binding"
                     /codon_start=1
                     /product="transcription factor E2F5 isoform 1"
                     /protein_id="NP_001942.2"
                     /db_xref="CCDS:CCDS47885.1"
                     /db_xref="GeneID:1875"
                     /db_xref="HGNC:HGNC:3119"
                     /db_xref="MIM:600967"
                     /translation="MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGA
                     GGGSSRHEKSLGLLTTKFVSLLQEAKDGVLDLKAAADTLAVRQKRRIYDITNVLEGID
                     LIEKKSKNSIQWKGVGAGCNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSIKN
                     VMDDSINNRFSYVTHEDICNCFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLK
                     SHSGPIHVLLINKESSSSKPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQH
                     VSERSQALQQTSATDISSAGSISGDIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEG
                     VCDLFDVQILNY"
     exon            502..611
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            612..773
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            774..817
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            818..882
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1150
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1198
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1964
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /note="hexamer: AATAAA"
     polyA_site      1964
                     /gene="E2F5"
                     /gene_synonym="E2F-5"
                     /note="major polyA site"
ORIGIN      
        1 cttctcctcg tttccacccc tcccccctcg gtcgtgggcc tcattcacgc ttccccgggc
       61 ttggggaggg ggcggaggcc cggcgtgaca agcggcccag actcccgtgg gcgccgcaca
      121 cctgttgttt gcagcagcca gcgacccgca ctaccgctct cggcgggcgg ggaagcggcc
      181 gcagcggagc cgacccggca ggtggccgcg ggcggggccg gcgagcgaaa gtgcgcgggg
      241 gcccgaccac cgcggggccg ggacgcgatg gcggcggcag agcccgcgag ctcgggccag
      301 caggcgccgg cagggcaggg gcagggccag cggccgccgc cgcagcctcc gcaggcgcaa
      361 gccccgcagc cgcccccgcc gccgcagctc gggggcgccg ggggcggcag cagcaggcac
      421 gagaagagcc tggggctgct cactaccaag ttcgtgtcgc tgctgcagga ggccaaggac
      481 ggcgttctgg atctcaaagc ggctgctgat actttggctg tgaggcaaaa aaggagaatt
      541 tatgatatca ccaatgtctt agagggaatt gacttgattg aaaaaaagtc aaaaaacagt
      601 atccagtgga aaggtgtagg tgctggctgt aatactaaag aagtcataga tagattaaga
      661 tatcttaaag ctgaaattga agatctagaa ctgaaggaaa gagaacttga tcagcagaag
      721 ttgtggctac agcaaagcat caaaaatgtg atggacgatt ccattaataa tagattttcc
      781 tatgtaactc atgaagacat ctgtaattgc tttaatggtg atacactttt ggccattcag
      841 gcaccttctg gtacacaact ggaggtaccc attccagaaa tgggtcagaa tggacaaaag
      901 aaataccaga tcaatctaaa gagtcattca ggacctatcc atgtgctgct tataaataaa
      961 gagtcgagtt catctaagcc cgtggttttt cctgttcccc cacctgatga cctcacacag
     1021 ccttcctccc agtccttgac tccagtgact ccacagaaat ccagcatggc aactcaaaat
     1081 ctgcctgagc aacatgtctc tgaaagaagc caggctctgc agcagacatc agctacagat
     1141 atatcttcag caggatctat tagtggagat atcattgatg agttaatgtc ttctgacgtg
     1201 tttcctctct taaggctttc tcctaccccg gcagatgact acaactttaa tttagatgat
     1261 aacgaaggag tttgtgatct gtttgatgtc cagatactaa attattagat tccatggaaa
     1321 cttgggactg ttatctacct ctaactgtgt aacattttag acttcttaat aacctaaata
     1381 tttaaaataa tgaatgtaac acctttttta gttcactgat tctgaagtgt tcttccctaa
     1441 tactttcttt acttcacaaa acttcaacca taaaaacaaa gggctctgat tgctttaggg
     1501 gataagtgat ttaatatcca caaacgtccc cactcccaaa agtaactata ttctggattt
     1561 caacttttct tctaattgtg aatccttctg ttttttcttc ttaaggagga aagttaaagg
     1621 acactacagg tcatcaaaaa caagttggcc aaggactcat tacttgtctt atatttttac
     1681 tgccactaaa ctgcctgtat ttctgtatgt ccttctatcc aaacagacgt tcactgccac
     1741 ttgtaaagtg aaggatgtaa acgaggatat ataactgttt cagtgaacag attttgtgaa
     1801 gtgccttctg ttttagcact ttaagtttat cacattttgt tgacttctga cattccactt
     1861 tcctaggtta taggaaagat ctgtttatgt agtttgtttt taaaatgtgc caatgcctgt
     1921 acattaacaa gatttttaaa aataaaattg tataaaacat tcaa
//
