LOCUS       NM_001950               2110 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens E2F transcription factor 4 (E2F4), mRNA.
ACCESSION   NM_001950
VERSION     NM_001950.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Pflug,K.M., Lee,D.W., McFadden,K., Herrera,L. and Sitcheran,R.
  TITLE     Transcriptional induction of NF-kappaB-inducing kinase by E2F4/5
            facilitates collective invasion of GBM cells
  JOURNAL   Sci Rep 13 (1), 13093 (2023)
   PUBMED   37567906
  REMARK    GeneRIF: Transcriptional induction of NF-kappaB-inducing kinase by
            E2F4/5 facilitates collective invasion of GBM cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Sun,Y.M., Zhang,Y.M., Shi,H.L., Yang,S., Zhao,Y.L., Liu,H.J.,
            Li,C., Liu,H.L., Yang,J.P., Song,J., Sun,G.Z. and Yang,J.K.
  TITLE     Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway
            activation and glioma stem cell characteristics
  JOURNAL   Hereditas 160 (1), 29 (2023)
   PUBMED   37349788
  REMARK    GeneRIF: Enhancer-driven transcription of MCM8 by E2F4 promotes ATR
            pathway activation and glioma stem cell characteristics.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Zheng,Y. and Fei,H.
  TITLE     High Expression of E2F4 Is an Adverse Prognostic Factor and Related
            to Immune Infiltration in Oral Squamous Cell Carcinoma
  JOURNAL   Biomed Res Int 2022, 4731364 (2022)
   PUBMED   36567912
  REMARK    GeneRIF: High Expression of E2F4 Is an Adverse Prognostic Factor
            and Related to Immune Infiltration in Oral Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2110)
  AUTHORS   Qi,L., Ren,Z. and Li,W.
  TITLE     E2F4 transcription factor is a prognostic biomarker related to
            immune infiltration of head and neck squamous cell carcinoma
  JOURNAL   Sci Rep 12 (1), 12132 (2022)
   PUBMED   35840663
  REMARK    GeneRIF: E2F4 transcription factor is a prognostic biomarker
            related to immune infiltration of head and neck squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2110)
  AUTHORS   Yang,H., Qu,X., Huang,J., Zhang,F., Fang,Z., Zhao,B. and Wang,Y.
  TITLE     E2F4 may be a core transcription factor in the lncRNA-TF regulatory
            network in cervical cancer
  JOURNAL   J Clin Lab Anal 36 (4), e24322 (2022)
   PUBMED   35262965
  REMARK    GeneRIF: E2F4 may be a core transcription factor in the lncRNA-TF
            regulatory network in cervical cancer.
REFERENCE   6  (bases 1 to 2110)
  AUTHORS   Xiao,Z.X., Ginsberg,D., Ewen,M. and Livingston,D.M.
  TITLE     Regulation of the retinoblastoma protein-related protein p107 by G1
            cyclin-associated kinases
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4633-4637 (1996)
   PUBMED   8643455
REFERENCE   7  (bases 1 to 2110)
  AUTHORS   Moberg,K., Starz,M.A. and Lees,J.A.
  TITLE     E2F-4 switches from p130 to p107 and pRB in response to cell cycle
            reentry
  JOURNAL   Mol Cell Biol 16 (4), 1436-1449 (1996)
   PUBMED   8657117
REFERENCE   8  (bases 1 to 2110)
  AUTHORS   Sardet,C., Vidal,M., Cobrinik,D., Geng,Y., Onufryk,C., Chen,A. and
            Weinberg,R.A.
  TITLE     E2F-4 and E2F-5, two members of the E2F family, are expressed in
            the early phases of the cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2403-2407 (1995)
   PUBMED   7892279
REFERENCE   9  (bases 1 to 2110)
  AUTHORS   Beijersbergen,R.L., Kerkhoven,R.M., Zhu,L., Carlee,L.,
            Voorhoeve,P.M. and Bernards,R.
  TITLE     E2F-4, a new member of the E2F gene family, has oncogenic activity
            and associates with p107 in vivo
  JOURNAL   Genes Dev 8 (22), 2680-2690 (1994)
   PUBMED   7958925
REFERENCE   10 (bases 1 to 2110)
  AUTHORS   Ginsberg,D., Vairo,G., Chittenden,T., Xiao,Z.X., Xu,G.,
            Wydner,K.L., DeCaprio,J.A., Lawrence,J.B. and Livingston,D.M.
  TITLE     E2F-4, a new member of the E2F transcription factor family,
            interacts with p107
  JOURNAL   Genes Dev 8 (22), 2665-2679 (1994)
   PUBMED   7958924
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC040160.4, BU857680.1 and
            BC021050.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001950.3.
            
            Summary: The protein encoded by this gene is a member of the E2F
            family of transcription factors. The E2F family plays a crucial
            role in the control of cell cycle and action of tumor suppressor
            proteins and is also a target of the transforming proteins of small
            DNA tumor viruses. The E2F proteins contain several evolutionally
            conserved domains found in most members of the family. These
            domains include a DNA binding domain, a dimerization domain which
            determines interaction with the differentiation regulated
            transcription factor proteins (DP), a transactivation domain
            enriched in acidic amino acids, and a tumor suppressor protein
            association domain which is embedded within the transactivation
            domain. This protein binds to all three of the  tumor suppressor
            proteins pRB, p107 and p130, but with higher affinity to the last
            two. It plays an important role in the suppression of
            proliferation-associated genes, and its gene mutation and increased
            expression may be associated with human cancer. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.121195.1,
                                           SRR1660803.141578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379378.8/ ENSP00000368686.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC040160.4         146660-146669       c
            11-586              BU857680.1         16-591
            587-2110            BC021050.1         541-2064
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2110
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /note="E2F transcription factor 4"
                     /db_xref="GeneID:1874"
                     /db_xref="HGNC:HGNC:3118"
                     /db_xref="MIM:600659"
     exon            1..208
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1315
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /note="p107/p130-binding protein; E2F transcription factor
                     4, p107/p130-binding"
                     /codon_start=1
                     /product="transcription factor E2F4"
                     /protein_id="NP_001941.2"
                     /db_xref="CCDS:CCDS32464.1"
                     /db_xref="GeneID:1874"
                     /db_xref="HGNC:HGNC:3118"
                     /db_xref="MIM:600659"
                     /translation="MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLK
                     LAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKA
                     EIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAP
                     SGTSLEVPIPEGLNGQKKYQIHLKSVSGPIEVLLVNKEAWSSPPVAVPVPPPEDLLQS
                     PSAVSTPPPLPKPALAQSQEASRPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGT
                     DSKDSGELSSLPLGPTTLDTRPLQSSALLDSSSSSSSSSSSSSNSNSSSSSGPNPSTS
                     FEPIKADPTGVLELPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDY
                     IYNLDESEGVCDLFDVPVLNL"
     exon            209..318
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            319..480
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            481..524
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            525..586
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            587..881
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1106
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1154
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1199
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..2110
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2088..2093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /note="hexamer: AATAAA"
     polyA_site      2110
                     /gene="E2F4"
                     /gene_synonym="E2F-4"
                     /note="major polyA site"
ORIGIN      
        1 aggaacggaa gcggaagtgg cggcggcgcc ggcctggcct ggcctggctg aggggaggcg
       61 gcgggcgggc gcgatggcgg aggccgggcc acaggcgccg ccgcccccgg gcactccaag
      121 ccggcacgaa aagagcctgg gactgctcac caccaagttc gtgtcccttc tgcaggaggc
      181 caaggacggc gtgcttgacc tcaagctggc agctgacacc ctagctgtac gccagaagcg
      241 gcggatttac gacattacca atgttttgga aggtatcggg ctaatcgaga aaaagtccaa
      301 gaacagcatc cagtggaagg gtgtggggcc tggctgcaat acccgggaga ttgctgacaa
      361 actgattgag ctcaaggcag agatcgagga gctgcagcag cgggagcaag aactagacca
      421 gcacaaggtg tgggtgcagc agagcatccg gaacgtcaca gaggacgtgc agaacagctg
      481 tttggcctac gtcactcatg aggacatctg cagatgcttt gctggagata ccctcttggc
      541 catccgggcc ccatcaggca ccagcctgga ggtgcccatc ccagagggtc tcaatgggca
      601 gaagaagtac cagattcacc tgaagagtgt gagtggtccc attgaggttc tgctggtgaa
      661 caaggaggca tggagctcac cccctgtggc tgtgcctgtg ccaccacctg aagatttgct
      721 ccagagccca tctgctgttt ctacacctcc acctctgccc aagcctgccc tagcccagtc
      781 ccaggaagcc tcacgtccaa atagtcctca gctcactccc actgctgtcc ctggcagtgc
      841 agaagtccag ggaatggctg gcccagcagc tgagatcaca gtgagtggcg gccctgggac
      901 tgatagcaag gacagtggtg agctcagttc actcccactg ggcccaacaa cactggacac
      961 ccggccactg cagtcttctg ccctgctgga cagcagcagc agcagcagca gcagcagcag
     1021 cagcagcagc aacagtaaca gcagcagttc gtccggaccc aacccttcta cctcctttga
     1081 gcccatcaag gcagacccca caggtgtttt ggaactcccc aaagagctgt cagaaatctt
     1141 tgatcccaca cgagagtgca tgagctcgga gctgctggag gagttgatgt cctcagaagt
     1201 gtttgcccct ctgcttcgtc tttctccacc cccgggagac cacgattata tctacaacct
     1261 ggacgagagt gaaggtgtct gtgacctctt tgatgtgcct gttctcaacc tctgactgac
     1321 agggacatgc cctgtgtggc tgggacccag actgtctgac ctgggggttg cctggggacc
     1381 tctcccaccc gacccctaca gagcttgaga gccacagacg cctggcttct ccggcctccc
     1441 ctcaccgcac agttctggcc acagctcccg ctcctgtgct ggcacttctg tgctcgcaga
     1501 gcaggggaac aggactcagc ccccatcacc gtggagccaa agtgtttgct tctccctttc
     1561 tgcggccttc gccagcccag gctcggctgc cacccagtgg cacagaaccg aggagctgcc
     1621 attacccccc atagggggca gtgtcttgtt cctgccagcc tcagtgtctt gcttctgcca
     1681 gctccttccc ctaggaggga agggtggggt ggaactgggc acatgccagc accacttcta
     1741 gcttccttcg ctatccccca ccccctgacc ctccagctcc tcctggccct ctcacgtgcc
     1801 cacttctgct gggcctttag ccctagaacc tgcaggtggt gggggcggct accaagaagg
     1861 aacagaggtc tctggggagg agtctgggtg gtccagccct gatgattggc cccacctcct
     1921 gctgccccat aaccctctct tcatttcggc tttttcattt accctcattt agagccattt
     1981 gcagagattt agaaagattt acagtaacga atggattcct atataaagat tatttttata
     2041 ctttttgcag caaaaggaaa ttgtaatatt tgtacagtgt tcaagtgaat aaaaaccatg
     2101 cctaaggcta
//
