LOCUS       NM_001949               5036 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens E2F transcription factor 3 (E2F3), transcript variant
            1, mRNA.
ACCESSION   NM_001949
VERSION     NM_001949.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5036)
  AUTHORS   Xie,W., Shao,Y., Bo,Q., Li,Z., Yu,Q., Wang,L. and Wu,G.
  TITLE     FTO promotes the progression of retinoblastoma through
            YTHDF2-dependent N6-methyladenosine modification in E2F3
  JOURNAL   Mol Carcinog 63 (5), 926-937 (2024)
   PUBMED   38380957
  REMARK    GeneRIF: FTO promotes the progression of retinoblastoma through
            YTHDF2-dependent N6-methyladenosine modification in E2F3.
REFERENCE   2  (bases 1 to 5036)
  AUTHORS   Zhang,X.B., Song,Y., Lai,Y.T., Qiu,S.Z., Hu,A.K., Li,D.X.,
            Zheng,N.S., Zeng,H.Q. and Lin,Q.C.
  TITLE     MiR-210-3p enhances intermittent hypoxia-induced tumor progression
            via inhibition of E2F3
  JOURNAL   Sleep Breath 28 (2), 607-617 (2024)
   PUBMED   37775619
  REMARK    GeneRIF: MiR-210-3p enhances intermittent hypoxia-induced tumor
            progression via inhibition of E2F3.
REFERENCE   3  (bases 1 to 5036)
  AUTHORS   Pan,X., Xu,C., Cheng,G., Chen,Z., Liu,M. and Mei,Y.
  TITLE     Transcription factor E2F3 activates CDC25B to regulate DNA damage
            and promote mitoxantrone resistance in stomach adenocarcinoma
  JOURNAL   Mol Biol Rep 51 (1), 90 (2024)
   PUBMED   38194158
  REMARK    GeneRIF: Transcription factor E2F3 activates CDC25B to regulate DNA
            damage and promote mitoxantrone resistance in stomach
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5036)
  AUTHORS   Chen,H.Z., Tsai,S.Y. and Leone,G.
  TITLE     Emerging roles of E2Fs in cancer: an exit from cell cycle control
  JOURNAL   Nat Rev Cancer 9 (11), 785-797 (2009)
   PUBMED   19851314
  REMARK    Review article
REFERENCE   5  (bases 1 to 5036)
  AUTHORS   He,Y., Armanious,M.K., Thomas,M.J. and Cress,W.D.
  TITLE     Identification of E2F-3B, an alternative form of E2F-3 lacking a
            conserved N-terminal region
  JOURNAL   Oncogene 19 (30), 3422-3433 (2000)
   PUBMED   10918599
REFERENCE   6  (bases 1 to 5036)
  AUTHORS   Leone,G., Nuckolls,F., Ishida,S., Adams,M., Sears,R., Jakoi,L.,
            Miron,A. and Nevins,J.R.
  TITLE     Identification of a novel E2F3 product suggests a mechanism for
            determining specificity of repression by Rb proteins
  JOURNAL   Mol Cell Biol 20 (10), 3626-3632 (2000)
   PUBMED   10779352
REFERENCE   7  (bases 1 to 5036)
  AUTHORS   Magae,J., Wu,C.L., Illenye,S., Harlow,E. and Heintz,N.H.
  TITLE     Nuclear localization of DP and E2F transcription factors by
            heterodimeric partners and retinoblastoma protein family members
  JOURNAL   J Cell Sci 109 (Pt 7), 1717-1726 (1996)
   PUBMED   8832394
REFERENCE   8  (bases 1 to 5036)
  AUTHORS   Karlseder,J., Rotheneder,H. and Wintersberger,E.
  TITLE     Interaction of Sp1 with the growth- and cell cycle-regulated
            transcription factor E2F
  JOURNAL   Mol Cell Biol 16 (4), 1659-1667 (1996)
   PUBMED   8657141
REFERENCE   9  (bases 1 to 5036)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
REFERENCE   10 (bases 1 to 5036)
  AUTHORS   Lees,J.A., Saito,M., Vidal,M., Valentine,M., Look,T., Harlow,E.,
            Dyson,N. and Helin,K.
  TITLE     The retinoblastoma protein binds to a family of E2F transcription
            factors
  JOURNAL   Mol Cell Biol 13 (12), 7813-7825 (1993)
   PUBMED   8246996
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132775.29, Y10479.1,
            AL136303.15 and BU633769.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001949.4.
            
            Summary: This gene encodes a member of a small family of
            transcription factors that function through binding of DP
            interaction partner proteins. The encoded protein recognizes a
            specific sequence motif in DNA and interacts directly with the
            retinoblastoma protein (pRB) to regulate the expression of genes
            involved in the cell cycle. Altered copy number and activity of
            this gene have been observed in a number of human cancers. There
            are pseudogenes for this gene on chromosomes 2 and 17. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1, also known as a) represents
            the longer transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346618.8/ ENSP00000262904.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AL132775.29        96313-96600
            289-1803            Y10479.1           1-1515
            1804-5032           AL136303.15        75114-78342
            5033-5036           BU633769.1         19-22               c
FEATURES             Location/Qualifiers
     source          1..5036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.3"
     gene            1..5036
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /note="E2F transcription factor 3"
                     /db_xref="GeneID:1871"
                     /db_xref="HGNC:HGNC:3115"
                     /db_xref="MIM:600427"
     exon            1..747
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1752
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor E2F3"
                     /codon_start=1
                     /product="transcription factor E2F3 isoform 1"
                     /protein_id="NP_001940.1"
                     /db_xref="CCDS:CCDS4545.1"
                     /db_xref="GeneID:1871"
                     /db_xref="HGNC:HGNC:3115"
                     /db_xref="MIM:600427"
                     /translation="MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGF
                     AAAAAAAAAPGAYIQILTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTT
                     PHGPSSRAGLLQQPPALGRGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAA
                     LRSPDSPKTPKSPSEKTRYDTSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRI
                     YDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDEL
                     IQSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVIVVKAPPETRLEVPDSIES
                     LQIHLASTQGPIEVYLCPEETETHSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSV
                     SMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDLFDA
                     YDLEKLPLVEDFMCS"
     exon            748..859
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1079
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1238
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1353
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1489
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..5036
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5012..5017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /note="hexamer: AATAAA"
     polyA_site      5036
                     /gene="E2F3"
                     /gene_synonym="E2F-3"
                     /note="major polyA site"
ORIGIN      
        1 attcattgtc agcagcagct tcctggagcc atttttcagc tgccggccgc agcacccggg
       61 ctgccgccgc cgcctcgcaa tccgttgcat cggccgcccc cgacgcctcc atccccgctt
      121 ggggcccgat atccgtgcgg ccgggaccct cctctctcca gagccccgat tatttttggc
      181 ccccggggcc tgtgcggtgc ggaaaaataa aaagaaaaga gagagagggg gctcggaagc
      241 gccgggcggg gaggagagaa ggaggagaga cttggaaact ccgactgcaa ataataaaga
      301 aattgaaaac aatacattaa tataccataa cactaaaaag agcaggagcg agagatgaga
      361 aagggaatcc agcccgctct ggagcagtac ctggtgaccg ccgggggtgg ggagggggcg
      421 gctgtcgtcg ccgccgccgc tgcagcctcc atggacaaaa gggcactgct agccagcccc
      481 ggcttcgccg ccgccgccgc cgctgccgcc gccccgggcg cgtacatcca gatcctcacc
      541 acgaacactt ccaccacctc ctgttcctcc tccctccaaa gcggcgccgt agccgccggc
      601 cccctcctcc ccagtgcccc cggcgcggag cagaccgccg gcagcctcct ctacaccacg
      661 ccgcacggac cctccagcag agccgggctg ctgcagcagc caccagcgct gggacgcggc
      721 ggcagcggcg gcggcggcgg ccctccggca aagcgaaggc tggagctagg agaaagcggt
      781 catcagtacc tctcagatgg tttaaaaacc cccaagggca aaggaagagc tgcactacga
      841 agtccagata gtccaaaaac tccaaaatct ccctcagaaa aaacgcggta tgatacgtct
      901 cttggtctgc tcaccaagaa gttcattcag ctcctgagcc agtcacccga tggggtattg
      961 gatttgaaca aggcagcaga agtgctaaaa gtgcaaaaga gaaggattta tgatatcacc
     1021 aacgttctgg aaggcatcca cctcattaag aagaagtcta aaaacaacgt ccaatggatg
     1081 ggctgcagtc tgtctgagga tgggggcatg ctggcccagt gtcaaggcct gtcaaaagaa
     1141 gtgaccgagc tcagtcagga agagaagaaa ttagatgaac tgatccaaag ctgcaccctg
     1201 gacctcaaac tgttaaccga ggattcagag aatcaaaggt tagcttatgt tacatatcaa
     1261 gatattcgaa aaattagtgg ccttaaagac caaactgtta tagttgtgaa agcccctcca
     1321 gaaacaagac ttgaagtgcc tgactcaata gagagcctac aaatacattt ggcaagtacc
     1381 caagggccca ttgaggttta cttatgtcca gaagagactg aaacacacag tccaatgaaa
     1441 acaaacaacc aagaccacaa tgggaatatc cctaaacccg cttccaaaga cttggcttca
     1501 accaactcag gacatagcga ttgctcagtt tctatgggaa acctttctcc tctggcctcc
     1561 ccagccaacc tcttacagca gactgaggac caaattcctt ccaacctaga aggaccgttt
     1621 gtgaacttac tgcctcccct gctgcaagag gactatctcc tgagcctcgg ggaggaggaa
     1681 ggcatcagcg atctcttcga tgcttacgat ttggaaaagc tcccactggt ggaagacttc
     1741 atgtgtagtt gattatgctt cgtgtgaact ctccttaaaa accgatattt ttttatcatg
     1801 gaaccagaac atctgtcatg cagtgttgtc ccttcctacc ttcttcctcc aagagagtat
     1861 catgaagtaa actacaaact tcagaagaaa gctgacattt taatgaattt tttaaaaaat
     1921 taataaacaa attgtctaaa cgcacagttg caggctccct tgggaaagcc ctgctttgct
     1981 ccaggctcca agatctcctg gctaagtcag caagtgagaa aatgtgcaat caggtgtctc
     2041 tcaccccgaa ttgtccttcc tccttcctcc ccggattggc ttgctgtgcc tgacggatgg
     2101 gctgtagaat ggggtctggc cacctggcct gctgggaaac agcaatcttc cttaatagca
     2161 tttcaagccg tgccttctcc gcagaatgca tgtctttgag gtctgctaat atggaatgga
     2221 actgcagcaa atgcaaactt gaagtcatgc aaaagtatga aatggatttc ttcagctctt
     2281 cttaggaata tttaaattac tgtcataatt cagtttaagc tatgaactgt gtgtcccagt
     2341 aggaggtcaa gaaaacctcc acagccttct ggatgaagaa cctgttttca aatatacttg
     2401 ttgcagatac agaagactag tagagttctg ccactctaag ctgttgtgga ttttcctgtc
     2461 tccatgaacc actcccattc ccccgtcccc aatgtgtttg tgagtttcca gttgatttgt
     2521 agcaaatgcc tacttagttc tttgtggatt gttctagact tttaattttt ttagctgcca
     2581 tttaagcatt cctgtggcac ccatcaccat ttcaatttaa ttgtttactt tgaagcggtt
     2641 tttgcaaatt catattactt aagcagaggg agagaacctc tactgatcag agcatctaaa
     2701 cctgtgtgat ctaaggttta tcagcctctg caaggagctt tgtcccatcg tgcttccatt
     2761 cccaggaggg ggagcttgga gcgagtcagt cctggggctt gctgacatgg gtggcccatt
     2821 ggaaaggaga accaggtcag atgatgtaac agccccaagg agcagcaggc atgggtccct
     2881 ccatccttgg gcttcccggg cccctgtgac aggggaaagg gctctcttac accgcactca
     2941 gggagaccac ttctcaggat ggggtcagat ggagagacct ctagggagaa agacatcccc
     3001 attgtgtgag tggcatttcc ttaagctggc aggaacaggg agcagccctg tgtcgggggc
     3061 tggaatagtt ctggccagac cccgttcccc ttcctctatg aaggaataag ttggaccaag
     3121 ggaagtcggg gacgtaaaaa atgaagcaaa acaatgccag ggtgtctccc gctttactct
     3181 tcaggaatgg tgtcccaagt tggaggcttt gtgtcagctg caaatcctac cagttatgtc
     3241 caagaatggc tttccctcgg gcaggtggca gcggccatct cccactggga atatggcgta
     3301 gtatctccgg tccattcctt ggatgctaag gactgcggga atgagggagt cagataaaga
     3361 acaaacctcg aaacgaacag ttaaattgaa atgctatgtg cctgacccaa tggtaggcac
     3421 atagtaggca ctcaactcat atgtttaatt gaattgaaaa tatcccttag gaaaaaaaaa
     3481 aaacacacaa aaaaccacaa gagccccagc cagtttactc caggtagatt tccacaatat
     3541 gcaaagtggt ggtggggtca agacagatga caccagcact ttaaactctt tgtgtgggta
     3601 tgcgtgggtg tatgtttggg aagaaaaaca aaggtgcaga ctatcttcct ttttttcttc
     3661 ttcagcctcc atccctggcc tcctcccctc acacacactg gacttggtac aaaatgtcgg
     3721 tgtggtccta gatgaagcat tggggtgggg gagggagagg gagctttgtg ttaagtgcct
     3781 actggaaatg cactgtgggg ttttttcctg tatgggaaac catttatgcc aagcttttcc
     3841 ccatttccca tatttatctc atctggttag ctgcctctgc ttccagcttt gtgtaattct
     3901 ctttgccagc tgcacaaagc tgattttttc caaagtctaa agactgagct cacctggcta
     3961 gattgttgtg tgttttgttg aattttttca taatgtaatg ccgtatttat tgtttttaaa
     4021 atgaaaggaa tactaataag tcttaaaagt tccttcatgc ataagatttt tttccagtta
     4081 ctgggtttaa ctggtgtaca ttaattagat gtccatactg tattttgttt gcattaagta
     4141 attttctttt tgacttagta tccggcacac aaagtgggtt agtactacag tatttgcgtt
     4201 actttaagta ctaagtatgc aggtttcctg gtaccattga gttgctgcta ttaaagctca
     4261 cacacgaaat ggctaaaagt tacaagtgtg caaattatga ctgcgtgagc cttagaaaat
     4321 aaaatgtata aagggcaaca catgagctgt caaacagtgt taggagtgtg tttatatgta
     4381 cagagttgtg catagcaatc gttttattta agttgatatg tagtctactc acattttcat
     4441 tatttagcaa ttttgtacaa aaatagcaat taatttgtaa acactgccag aatactttct
     4501 agctgctttg taatttttta agagtgttat tttgtttttg tttttctgtt ctttgttgtg
     4561 gctcttgttt tcatttttgt tgtacgtgta gatctgtaaa taaaattgca gtatttaaag
     4621 cttaagcttt caggaaaaag aaaataagaa ttcagtgtgt gcatgacaac tcgtgtgtat
     4681 gagaaggagg gatatgaagg aagatggctt gcagagtaag tcgggtggca attgtcaggg
     4741 tgtgggaatt tcttttccta cggggtacgt gattttgtaa aaaggaagta tttctcccaa
     4801 aattgggagt aggcaaacta ctaatcagtt tagctttgtg ttgtatgcta gtttaaaaaa
     4861 gaaaatatgt aatataatgt aaaaaaaaac aaaaaaaagc ttttatgatg gattttgtaa
     4921 atagatttgt tacagggtga cctgttctct agctgtgatc ttaccacttc aaatgggtgt
     4981 aatttgaata aattttgtat ggtaaaggat caataaaatg atttttttta agagtt
//
