LOCUS       NM_004091               5196 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens E2F transcription factor 2 (E2F2), mRNA.
ACCESSION   NM_004091
VERSION     NM_004091.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5196)
  AUTHORS   Jakstas,T., Bartnykaite,A., Padervinskis,E., Vegiene,A.,
            Juozaityte,E., Uloza,V. and Ugenskiene,R.
  TITLE     The association of E2F1 and E2F2 single nucleotide polymorphisms
            with laryngeal squamous cell carcinoma pathomorphological features
  JOURNAL   BMC Cancer 24 (1), 214 (2024)
   PUBMED   38360622
  REMARK    GeneRIF: The association of E2F1 and E2F2 single nucleotide
            polymorphisms with laryngeal squamous cell carcinoma
            pathomorphological features.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5196)
  AUTHORS   Hua,R., Chu,Q., Guo,F., Chen,Q., Li,M., Zhou,X. and Zhu,Y.
  TITLE     DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia
            Associated with Nonobstructive Azoospermia by Providing miR-214-5p
            and Decreasing E2F2 Expression
  JOURNAL   Anal Cell Pathol (Amst) 2023, 1477658 (2023)
   PUBMED   38152068
  REMARK    GeneRIF: DNM3OS Enhances the Apoptosis and Senescence of
            Spermatogonia Associated with Nonobstructive Azoospermia by
            Providing miR-214-5p and Decreasing E2F2 Expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5196)
  AUTHORS   Liu,S., Wang,J., Chen,S., Han,Z., Wu,H., Chen,H. and Duan,Y.
  TITLE     C/EBPbeta Coupled with E2F2 Promoted the Proliferation of
            hESC-Derived Hepatocytes through Direct Binding to the Promoter
            Regions of Cell-Cycle-Related Genes
  JOURNAL   Cells 12 (3), 497 (2023)
   PUBMED   36766839
  REMARK    GeneRIF: C/EBPbeta Coupled with E2F2 Promoted the Proliferation of
            hESC-Derived Hepatocytes through Direct Binding to the Promoter
            Regions of Cell-Cycle-Related Genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5196)
  AUTHORS   Liu,T.T., Yang,H., Zhuo,F.F., Yang,Z., Zhao,M.M., Guo,Q., Liu,Y.,
            Liu,D., Zeng,K.W. and Tu,P.F.
  TITLE     Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2
            transcription factor degradation for cancer therapy
  JOURNAL   EBioMedicine 86, 104353 (2022)
   PUBMED   36375317
  REMARK    GeneRIF: Atypical E3 ligase ZFP91 promotes small-molecule-induced
            E2F2 transcription factor degradation for cancer therapy.
REFERENCE   5  (bases 1 to 5196)
  AUTHORS   Ye,Q., Taleb,S.J., Wang,H., Parinandi,N.L., Kass,D.J., Rojas,M.,
            Wang,C., Ma,Q., Zhao,J. and Zhao,Y.
  TITLE     Molecular Regulation of Heme Oxygenase-1 Expression by E2F
            Transcription Factor 2 in Lung Fibroblast Cells: Relevance to
            Idiopathic Pulmonary Fibrosis
  JOURNAL   Biomolecules 12 (10), 1531 (2022)
   PUBMED   36291740
  REMARK    GeneRIF: Molecular Regulation of Heme Oxygenase-1 Expression by E2F
            Transcription Factor 2 in Lung Fibroblast Cells: Relevance to
            Idiopathic Pulmonary Fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5196)
  AUTHORS   Lin,S.Y., Black,A.R., Kostic,D., Pajovic,S., Hoover,C.N. and
            Azizkhan,J.C.
  TITLE     Cell cycle-regulated association of E2F1 and Sp1 is related to
            their functional interaction
  JOURNAL   Mol Cell Biol 16 (4), 1668-1675 (1996)
   PUBMED   8657142
REFERENCE   7  (bases 1 to 5196)
  AUTHORS   Karlseder,J., Rotheneder,H. and Wintersberger,E.
  TITLE     Interaction of Sp1 with the growth- and cell cycle-regulated
            transcription factor E2F
  JOURNAL   Mol Cell Biol 16 (4), 1659-1667 (1996)
   PUBMED   8657141
REFERENCE   8  (bases 1 to 5196)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
REFERENCE   9  (bases 1 to 5196)
  AUTHORS   Lees,J.A., Saito,M., Vidal,M., Valentine,M., Look,T., Harlow,E.,
            Dyson,N. and Helin,K.
  TITLE     The retinoblastoma protein binds to a family of E2F transcription
            factors
  JOURNAL   Mol Cell Biol 13 (12), 7813-7825 (1993)
   PUBMED   8246996
REFERENCE   10 (bases 1 to 5196)
  AUTHORS   Ivey-Hoyle,M., Conroy,R., Huber,H.E., Goodhart,P.J., Oliff,A. and
            Heimbrook,D.C.
  TITLE     Cloning and characterization of E2F-2, a novel protein with the
            biochemical properties of transcription factor E2F
  JOURNAL   Mol Cell Biol 13 (12), 7802-7812 (1993)
   PUBMED   8246995
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021154.1, L22846.1 and
            AF086395.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004091.3.
            
            Summary: The protein encoded by this gene is a member of the E2F
            family of transcription factors. The E2F family plays a crucial
            role in the control of cell cycle and action of tumor suppressor
            proteins and is also a target of the transforming proteins of small
            DNA tumor viruses. The E2F proteins contain several evolutionally
            conserved domains found in most members of the family. These
            domains include a DNA binding domain, a dimerization domain which
            determines interaction with the differentiation regulated
            transcription factor proteins (DP), a transactivation domain
            enriched in acidic amino acids, and a tumor suppressor protein
            association domain which is embedded within the transactivation
            domain. This protein and another 2 members, E2F1 and E2F3, have an
            additional cyclin binding domain. This protein binds specifically
            to retinoblastoma protein pRB in a cell-cycle dependent manner, and
            it exhibits overall 46% amino acid identity to E2F1. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053676.1, SRR18074967.3546383.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361729.3/ ENSP00000355249.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL021154.1         80986-80998         c
            14-1778             L22846.1           2-1766
            1779-4649           AL021154.1         56750-59620         c
            4650-5196           AF086395.1         1-547
FEATURES             Location/Qualifiers
     source          1..5196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..5196
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /note="E2F transcription factor 2"
                     /db_xref="GeneID:1870"
                     /db_xref="HGNC:HGNC:3114"
                     /db_xref="MIM:600426"
     exon            1..692
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..1754
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /codon_start=1
                     /product="transcription factor E2F2"
                     /protein_id="NP_004082.1"
                     /db_xref="CCDS:CCDS236.1"
                     /db_xref="GeneID:1870"
                     /db_xref="HGNC:HGNC:3114"
                     /db_xref="MIM:600426"
                     /translation="MLQGPRALASAAGQTPKVVPAMSPTELWPSGLSSPQLCPATATY
                     YTPLYPQTAPPAAAPGTCLDATPHGPEGQVVRCLPAGRLPAKRKLDLEGIGRPVVPEF
                     PTPKGKCIRVDGLPSPKTPKSPGEKTRYDTSLGLLTKKFIYLLSESEDGVLDLNWAAE
                     VLDVQKRRIYDITNVLEGIQLIRKKAKNNIQWVGRGMFEDPTRPGKQQQLGQELKELM
                     NTEQALDQLIQSCSLSFKHLTEDKANKRLAYVTYQDIRAVGNFKEQTVIAVKAPPQTR
                     LEVPDRTEDNLQIYLKSTQGPIEVYLCPEEVQEPDSPSEEPLPSTSTLCPSPDSAQPS
                     SSTDPSIMEPTASSVPAPAPTPQQAPPPPSLVPLEATDSLLELPHPLLQQTEDQFLSP
                     TLACSSPLISFSPSLDQDDYLWGLEAGEGISDLFDSYDLGDLLIN"
     exon            693..798
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1018
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1177
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1292
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1485
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..5196
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5179..5184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /note="hexamer: ATTAAA"
     polyA_site      5196
                     /gene="E2F2"
                     /gene_synonym="E2F-2"
                     /note="major polyA site"
ORIGIN      
        1 agagaaagac tcaaggacta gagagcgagc cgcaaggaag tcggtgcagt cgagaccccc
       61 ctccccatcc cagcgcatcg cgtctccgcc gagcttgagg gcacgccggg gacccctccc
      121 cagagccggc cggaccccag gtgccgaggc cttggggagc gcggggcgtc ccgggtcgcg
      181 gtgccctcgg gacgagacag cccctggcag tgccaccacc gcagccgccg ggcgatctcc
      241 aagcggcgat ctctaagcgc tgctctctgc tcggccgcgg gccaggaggg gagggtccgg
      301 ccttgccccg caggcgtcca ttggcggctt cccccggcct ccgcgccatg ccgcgggccg
      361 tgtgaaaggc ggcagcaccg gaacccgcag gtgtccgcgg gcgcgccaag cccttttggg
      421 tagggggcgc cttactcgct atgctgcaag ggccccgggc cttggcttcg gccgctgggc
      481 agaccccgaa ggtggtgccc gcgatgagcc ccacagagct gtggccatcc ggcctcagca
      541 gcccccagct ctgcccagct actgctacct actacacacc gctgtacccg cagacggcgc
      601 ctcccgcagc ggcgccaggc acctgcctcg acgccactcc ccacggaccc gagggccaag
      661 ttgtgcgatg cctgccggca ggccggctgc cggccaaaag gaagctggat ctggagggga
      721 ttgggaggcc cgtcgtccct gagttcccaa cccccaaggg gaagtgcatc agagtggatg
      781 gcctccccag ccccaaaacc cccaaatccc ccggggagaa gactcggtat gacacttcgc
      841 tggggctgct caccaagaag ttcatttacc tcctgagcga gtcagaggat ggggtcctgg
      901 acctgaactg ggccgctgag gtgctggacg tgcagaagcg gcgcatctat gacatcacca
      961 acgtgctgga aggcatccag ctcatccgca agaaggccaa gaacaacatc cagtgggtag
     1021 gcaggggaat gtttgaagac cccaccagac ctgggaagca gcaacagctg gggcaggagc
     1081 tgaaggagct gatgaacacg gagcaggcct tggaccagct catccagagc tgctctctga
     1141 gcttcaagca cctgactgag gacaaggcca acaagaggct ggcctatgtg acttaccagg
     1201 atatccgtgc tgttggcaac tttaaggagc agacagtgat tgccgtcaag gcccctccgc
     1261 agacgagact ggaagtgccc gacaggactg aggacaacct gcagatatat ctcaagagca
     1321 cccaagggcc catcgaagtc tacctgtgcc cagaggaggt gcaggagccg gacagtcctt
     1381 ccgaggagcc tctcccctct acctccaccc tctgccccag ccctgactct gcccagccca
     1441 gcagcagcac cgaccctagc atcatggagc ccacagcatc ctcagtgcca gcaccagcgc
     1501 caacccccca gcaggcccca ccgcctccat ccctggtccc cttggaggct actgacagcc
     1561 tgctggagct gccgcaccca ctcctgcagc agactgagga ccagttcctg tccccgaccc
     1621 tggcgtgcag ctcccctctg atcagcttct ccccatcctt ggaccaggac gactacctgt
     1681 ggggcttgga ggcgggtgag ggcatcagcg atctcttcga ctcctacgac cttggggacc
     1741 tgttgattaa ttgagtggcc ctgcctgccc ccagcagcct gcccccgact ctacctcctc
     1801 acagacaggc tgacagcccc tctgcctgca cagggacatt ggacactagg tgctgccctc
     1861 agggcatggg gtctcctcgc ctttcctgcc ccagccggca gaagctgtgt ggggagatat
     1921 gaatggtacg ggtgaggagt ggataagggg tggtcctcac cttcctaatg gaagctgggc
     1981 ctagggaggc ccatccagtc ttctgacttc tgacctctca caagaaggct gcaggtgagg
     2041 tggccaagtc cagggaaagg ccctgctacc tccttttgag gggtaattag gaccctcgac
     2101 gtaccaagaa gcacataatg cctttgtatt tatttcaggt tgagttgttt gtttgtcctc
     2161 cctgagtttt agcagggagg ttgttctagt ttttagtgag acctctgcag acaggcccat
     2221 cactgtccat gttccagggc aggtctgggt ttccaaggga ggggcccagg ctacatcctt
     2281 ggtttcccca ctgtggtggg ggctgggact ctgaggggct gtccagtctg ctagaatgct
     2341 aattgcactt aggcctcatg gttctagtaa acggcagctg tgggcccttt tgcctcttcc
     2401 cctgttcttg gcctcacatc tccagctgag ctgccggtct tggcttcctg gtcgcctctg
     2461 tcccagagat ggtcccaggg agccatccta gggcaggtag cactgaggct cctgtggaaa
     2521 caggagccac ctgctcagga gacccctttc ctgaggaagt ccttacctct ccccttgaga
     2581 tgtaaaaatg gtccagcaga gacaagctcc cgtggaaaac agacaggagc atgggggcag
     2641 ctgtcatggc tgtggcgggc acttttcctc agagtttctg ccttgcgctg gtccaggagc
     2701 cattttgcac caaggacttg gtaggcagag gcagccccac tgtaaagaag ggtcagatta
     2761 aaacaaaaaa ctgccaaaag catcccctct gccccccatg tggcactggc atcattctct
     2821 gcttccctgg gaggaatttt ttcaccatgt tattgaaggg gatggttcat taaggactcc
     2881 acccctcaga gctcactcag accccaagga cagaggtgac tggggcttgg tgacttgttc
     2941 actccttttt tcccaggtat actgaagggg tgacagagag aggtcttcat ggcagaccag
     3001 gccttcacag ctaatgggga gaggaactca tgttacctct gcaggcctgg ggtcctgagg
     3061 gggtcttttg gcttcagcct gttcccccag aggcttgatc atcccacatt gtcccttcag
     3121 ctcagctgct cttctccccc acccaccctg ggatgtgggt gctctgggct gaaccaaggc
     3181 tatgacttct ggagagaggc tcaggggttg gtctgagagg cctgccatcc acccctcagg
     3241 gagctaggtt ttctcagagg ctcagctgga cagcactttt tagaaaagtt tgtagcatta
     3301 agctggttta aaatatgaag ttggttttgt tggatggctc ctgagctgac tgactgatgt
     3361 ctgaagtttg agacgaggga ttatttcagg gtggggccca atgtgatcta atgcccagct
     3421 ggggacaatt gtgcctcatc atttgctcaa attcctgggc ccccaagtta gccccctccc
     3481 aggagtggtc agcgggtcac agctgccccc actctataag cagggctaat tgtgtaccct
     3541 ttgcagaaat gcttttggtc tcctacccaa atactcacaa gggtcttatc agacgcccgt
     3601 cttaaagtcc agcatgctca gggaccctgt gtaggatctc gtttgtggtg agtgggctgc
     3661 tctgaggtct ccactgggct gccatttagc catgtgccat ctctgaagtc agaggtgttt
     3721 gactcccatt ccttgggctc tggagctttc cccaagaatt acatcagaga aaaggaagaa
     3781 ggggcctgca ggacccattg ggaatgagtt taatactgaa gtctggaatg taagctcatg
     3841 ccctagaggc ctctccatat ggctggtcag gggagctgcc ttcaggcttg tgccccgtgt
     3901 gctcagcagc tgcctctgtc cccctctact gtccctttca caccttgcct ggccaagggg
     3961 ctagacctcc caggctaagc ctcagattca gtgcaggaca caagctcatg cccccgtctt
     4021 gccagtgaca cttgaagcct cccgacttcc acagagtgct tcaggacaca ttttgagtgg
     4081 tattttcttt tctttttttc ttcttttttt ttttttttga gatggagtct cgctctgttg
     4141 cccaggctgg agtgcagtgg cctgatctcg gctcactgca acctctgcct cccaggttca
     4201 agcgattctt ctgcctcagc ctccagagta gctgggacta tagacatgca ccaccacgcc
     4261 cggctaattt tgtatttttg gtcgagacgg ggttttgcca tgttagtcag gctggtcttg
     4321 aactcctgac ctcaagtgat ccaccacctc ggcctcccaa agtgttgaga tgacaggcac
     4381 gagccaccag gcccagcctg agtggtattt tctttaggga ccaggtagac tttaaaacga
     4441 gggtaagaga aaagccagtg tctttctgag gtaaataatt tctgccagga aacttcccag
     4501 ccccaccagc agccccccta aaaaaatcac tcgtgtcccc agggacttct aaagcttggg
     4561 gctccaggaa atcatccagt agagttggag attcagagat ttcttgaagc cagggacatg
     4621 ctcctaactc ctttcccatt aaaggtgtta gaatagacca gagggtgtcc cttttccaca
     4681 gtaatgggat cggctggtgt gccttcaggg aggaagaggg aggtggtcaa gcttgaaaaa
     4741 ctggctttag gatggttctg actttgttct ccctccccaa gtgttctcaa cctccattct
     4801 gcagtgttca gagttttagg gaaagggttt gggtgcccca gcatccaggt gttgtgtggc
     4861 ttagcgcatg tgaagtgaaa accttctggg gttgtttgga agcagctttc tggttcttgt
     4921 gattgtatcc tgaggtccca gaaccctatt ctcccacgag gatcctcagt gaccatggtg
     4981 gccacacgcc tggccagcct gctggctcct gggtgagctg aagaaccttg cctgtggcac
     5041 ttttcgaggg tgagctggaa ccgagagaac atggtccccg tgctgggact catgcgggtc
     5101 atttcctgcc ggcctggttt cgcctggtcg tgtctttatg agcaccatgt aagcctcctt
     5161 gtattgagat aattgggcat taaacattaa actgca
//
