LOCUS       NM_005225               2690 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens E2F transcription factor 1 (E2F1), mRNA.
ACCESSION   NM_005225
VERSION     NM_005225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2690)
  AUTHORS   Huang,Y., Zeng,J., Liu,T., Xu,Q., Song,X. and Zeng,J.
  TITLE     ARHGEF39 targeted by E2F1 fosters hepatocellular carcinoma
            metastasis by mediating fatty acid metabolism
  JOURNAL   Clin Res Hepatol Gastroenterol 48 (8), 102446 (2024)
   PUBMED   39128592
  REMARK    GeneRIF: ARHGEF39 targeted by E2F1 fosters hepatocellular carcinoma
            metastasis by mediating fatty acid metabolism.
REFERENCE   2  (bases 1 to 2690)
  AUTHORS   Chen,J.H., Ye,L., Zhu,S.L., Yang,Y. and Xu,N.
  TITLE     DNMT1-Mediated the Downregulation of FOXF1 Promotes High
            Glucose-induced Podocyte Damage by Regulating the miR-342-3p/E2F1
            Axis
  JOURNAL   Cell Biochem Biophys 82 (3), 2957-2975 (2024)
   PUBMED   39014186
  REMARK    GeneRIF: DNMT1-Mediated the Downregulation of FOXF1 Promotes High
            Glucose-induced Podocyte Damage by Regulating the miR-342-3p/E2F1
            Axis.
REFERENCE   3  (bases 1 to 2690)
  AUTHORS   Liu,Q., Li,Y., Tan,B., Zhao,Q., Fan,L., Zhang,Z., Wang,D., Zhao,X.,
            Liu,Y. and Liu,W.
  TITLE     LncRNA HAGLR regulates gastric cancer progression by regulating the
            miR-20a-5p/E2F1 axis
  JOURNAL   Aging (Albany NY) 16 (16), 11843-11856 (2024)
   PUBMED   39172101
  REMARK    GeneRIF: LncRNA HAGLR regulates gastric cancer progression by
            regulating the miR-20a-5p/E2F1 axis.
REFERENCE   4  (bases 1 to 2690)
  AUTHORS   Liu,C., Zhuo,Y., Yang,X., Yang,C., Shu,M., Hou,B., Hou,J., Chen,X.,
            Wang,L. and Wu,X.
  TITLE     Epigenetically associated IGF2BP3 upregulation promotes cell
            proliferation by regulating E2F1 expression in hepatocellular
            carcinoma
  JOURNAL   Sci Rep 14 (1), 16051 (2024)
   PUBMED   38992083
  REMARK    GeneRIF: Epigenetically associated IGF2BP3 upregulation promotes
            cell proliferation by regulating E2F1 expression in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2690)
  AUTHORS   Xiong,Y., Shi,L., Li,L., Yang,W., Zhang,H., Zhao,X. and Shen,N.
  TITLE     CDCA5 accelerates progression of breast cancer by promoting the
            binding of E2F1 and FOXM1
  JOURNAL   J Transl Med 22 (1), 639 (2024)
   PUBMED   38978058
  REMARK    GeneRIF: CDCA5 accelerates progression of breast cancer by
            promoting the binding of E2F1 and FOXM1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2690)
  AUTHORS   Shan,B., Zhu,X., Chen,P.L., Durfee,T., Yang,Y., Sharp,D. and
            Lee,W.H.
  TITLE     Molecular cloning of cellular genes encoding
            retinoblastoma-associated proteins: identification of a gene with
            properties of the transcription factor E2F
  JOURNAL   Mol Cell Biol 12 (12), 5620-5631 (1992)
   PUBMED   1448092
REFERENCE   7  (bases 1 to 2690)
  AUTHORS   Nevins,J.R.
  TITLE     E2F: a link between the Rb tumor suppressor protein and viral
            oncoproteins
  JOURNAL   Science 258 (5081), 424-429 (1992)
   PUBMED   1411535
REFERENCE   8  (bases 1 to 2690)
  AUTHORS   Huang,S., Shin,E., Sheppard,K.A., Chokroverty,L., Shan,B.,
            Qian,Y.W., Lee,E.Y. and Yee,A.S.
  TITLE     The retinoblastoma protein region required for interaction with the
            E2F transcription factor includes the T/E1A binding and
            carboxy-terminal sequences
  JOURNAL   DNA Cell Biol 11 (7), 539-548 (1992)
   PUBMED   1388726
REFERENCE   9  (bases 1 to 2690)
  AUTHORS   Helin,K., Lees,J.A., Vidal,M., Dyson,N., Harlow,E. and Fattaey,A.
  TITLE     A cDNA encoding a pRB-binding protein with properties of the
            transcription factor E2F
  JOURNAL   Cell 70 (2), 337-350 (1992)
   PUBMED   1638634
REFERENCE   10 (bases 1 to 2690)
  AUTHORS   Hiebert,S.W., Chellappan,S.P., Horowitz,J.M. and Nevins,J.R.
  TITLE     The interaction of RB with E2F coincides with an inhibition of the
            transcriptional activity of E2F
  JOURNAL   Genes Dev 6 (2), 177-185 (1992)
   PUBMED   1531329
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050369.2, BC005098.1 and
            AL121906.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005225.2.
            
            Summary: The protein encoded by this gene is a member of the E2F
            family of transcription factors. The E2F family plays a crucial
            role in the control of cell cycle and action of tumor suppressor
            proteins and is also a target of the transforming proteins of small
            DNA tumor viruses. The E2F proteins contain several evolutionally
            conserved domains found in most members of the family. These
            domains include a DNA binding domain, a dimerization domain which
            determines interaction with the differentiation regulated
            transcription factor proteins (DP), a transactivation domain
            enriched in acidic amino acids, and a tumor suppressor protein
            association domain which is embedded within the transactivation
            domain.  This protein and another 2 members, E2F2 and E2F3, have an
            additional cyclin binding domain. This protein binds preferentially
            to retinoblastoma protein pRB in a cell-cycle dependent manner. It
            can mediate both cell proliferation and p53-dependent/independent
            apoptosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050369.2, M96577.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343380.6/ ENSP00000345571.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2487              BC050369.2         20-2506
            2488-2681           BC005098.1         1346-1539
            2682-2690           AL121906.18        51914-51922         c
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..2690
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /note="E2F transcription factor 1"
                     /db_xref="GeneID:1869"
                     /db_xref="HGNC:HGNC:3113"
                     /db_xref="MIM:189971"
     exon            1..382
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1435
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /note="retinoblastoma-associated protein 1; PBR3; RBAP-1;
                     RBBP-3; PRB-binding protein E2F-1; retinoblastoma-binding
                     protein 3; retinoblastoma-binding protein 3 (E2F-like)"
                     /codon_start=1
                     /product="transcription factor E2F1"
                     /protein_id="NP_005216.1"
                     /db_xref="CCDS:CCDS13224.1"
                     /db_xref="GeneID:1869"
                     /db_xref="HGNC:HGNC:3113"
                     /db_xref="MIM:189971"
                     /translation="MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASA
                     PPAPTGPAAPAAGPCDPDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLA
                     ESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVL
                     KVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQ
                     QLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAV
                     DSSENFQISLKSKQGPIDVFLCPEETVGGISPGKTPSQEVTSEEENRATDSATIVSPP
                     PSSPPSSLTTDPSQSLLSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDFS
                     GLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFDCDFGDLTPLDF"
     exon            383..473
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..693
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            694..846
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            847..961
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1187
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..2690
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1979
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /note="major polyA site"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
                     /note="hexamer: AGTAAA"
     polyA_site      2690
                     /gene="E2F1"
                     /gene_synonym="E2F-1; RBAP1; RBBP3; RBP3"
ORIGIN      
        1 gggactttgc aggcagcggc ggccgggggc ggagcgggat cgagccctcg ccgaggcctg
       61 ccgccatggg cccgcgccgc cgccgccgcc tgtcacccgg gccgcgcggg ccgtgagcgt
      121 catggccttg gccggggccc ctgcgggcgg cccatgcgcg ccggcgctgg aggccctgct
      181 cggggccggc gcgctgcggc tgctcgactc ctcgcagatc gtcatcatct ccgccgcgca
      241 ggacgccagc gccccgccgg ctcccaccgg ccccgcggcg cccgccgccg gcccctgcga
      301 ccctgacctg ctgctcttcg ccacaccgca ggcgccccgg cccacaccca gtgcgccgcg
      361 gcccgcgctc ggccgcccgc cggtgaagcg gaggctggac ctggaaactg accatcagta
      421 cctggccgag agcagtgggc cagctcgggg cagaggccgc catccaggaa aaggtgtgaa
      481 atccccgggg gagaagtcac gctatgagac ctcactgaat ctgaccacca agcgcttcct
      541 ggagctgctg agccactcgg ctgacggtgt cgtcgacctg aactgggctg ccgaggtgct
      601 gaaggtgcag aagcggcgca tctatgacat caccaacgtc cttgagggca tccagctcat
      661 tgccaagaag tccaagaacc acatccagtg gctgggcagc cacaccacag tgggcgtcgg
      721 cggacggctt gaggggttga cccaggacct ccgacagctg caggagagcg agcagcagct
      781 ggaccacctg atgaatatct gtactacgca gctgcgcctg ctctccgagg acactgacag
      841 ccagcgcctg gcctacgtga cgtgtcagga ccttcgtagc attgcagacc ctgcagagca
      901 gatggttatg gtgatcaaag cccctcctga gacccagctc caagccgtgg actcttcgga
      961 gaactttcag atctccctta agagcaaaca aggcccgatc gatgttttcc tgtgccctga
     1021 ggagaccgta ggtgggatca gccctgggaa gaccccatcc caggaggtca cttctgagga
     1081 ggagaacagg gccactgact ctgccaccat agtgtcacca ccaccatcat ctcccccctc
     1141 atccctcacc acagatccca gccagtctct actcagcctg gagcaagaac cgctgttgtc
     1201 ccggatgggc agcctgcggg ctcccgtgga cgaggaccgc ctgtccccgc tggtggcggc
     1261 cgactcgctc ctggagcatg tgcgggagga cttctccggc ctcctccctg aggagttcat
     1321 cagcctttcc ccaccccacg aggccctcga ctaccacttc ggcctcgagg agggcgaggg
     1381 catcagagac ctcttcgact gtgactttgg ggacctcacc cccctggatt tctgacaggg
     1441 cttggaggga ccagggtttc cagagatgct caccttgtct ctgcagccct ggagccccct
     1501 gtccctggcc gtcctcccag cctgtttgga aacatttaat ttatacccct ctcctctgtc
     1561 tccagaagct tctagctctg gggtctggct accgctagga ggctgagcaa gccaggaagg
     1621 gaaggagtct gtgtggtgtg tatgtgcatg cagcctacac ccacacgtgt gtaccggggg
     1681 tgaatgtgtg tgagcatgtg tgtgtgcatg taccggggaa tgaaggtgaa catacacctc
     1741 tgtgtgtgca ctgcagacac gccccagtgt gtccacatgt gtgtgcatga gtccatgtgt
     1801 gcgcgtgggg gggctctaac tgcactttcg gcccttttgc tctgggggtc ccacaaggcc
     1861 cagggcagtg cctgctccca gaatctggtg ctctgaccag gccaggtggg gaggctttgg
     1921 ctggctgggc gtgtaggacg gtgagagcac ttctgtctta aaggtttttt ctgattgaag
     1981 ctttaatgga gcgttattta tttatcgagg cctctttggt gagcctgggg aatcagcaaa
     2041 ggggaggagg ggtgtggggt tgatacccca actccctcta cccttgagca agggcagggg
     2101 tccctgagct gttcttctgc cccatactga aggaactgag gcctgggtga tttatttatt
     2161 gggaaagtga gggagggaga cagactgact gacagccatg ggtggtcaga tggtggggtg
     2221 ggccctctcc agggggccag ttcagggccc cagctgcccc ccaggatgga tatgagatgg
     2281 gagaggtgag tgggggacct tcactgatgt gggcaggagg ggtggtgaag gcctccccca
     2341 gcccagaccc tgtggtccct cctgcagtgt ctgaagcgcc tgcctcccca ctgctctgcc
     2401 ccaccctcca atctgcactt tgatttgctt cctaacagct ctgttccctc ctgctttggt
     2461 tttaataaat attttgatga cgtttgggcc gggttttggg actctgttgg gaacatttcg
     2521 gggcgggaga ggccaaggtt gctggggaaa tgcccattct ccacttccct tctccctgtc
     2581 cgtgcccgat ttgatttgag cctcataact cgaagaaagg tcagcttcct cgctgttttg
     2641 gtcctaactc aaaagcagat ccagtaaagg tttttgttgt agaaagccaa
//
