LOCUS       NM_014648               5304 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DAZ interacting zinc finger protein 3 (DZIP3), mRNA.
ACCESSION   NM_014648
VERSION     NM_014648.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5304)
  AUTHORS   Qiu,R., Zhao,S., Lu,C., Xu,Z., Shu,E., Weng,Q., Chen,W., Fang,S.,
            Chen,W., Zheng,L., Zhao,Z., Yang,Y. and Ji,J.
  TITLE     Proteomic analysis of DZIP3 interactome and its role in
            proliferation and metastasis in gastric cancer cells
  JOURNAL   Exp Cell Res 425 (1), 113525 (2023)
   PUBMED   36841324
  REMARK    GeneRIF: Proteomic analysis of DZIP3 interactome and its role in
            proliferation and metastasis in gastric cancer cells.
REFERENCE   2  (bases 1 to 5304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5304)
  AUTHORS   Kolapalli,S.P., Sahu,R., Chauhan,N.R., Jena,K.K., Mehto,S.,
            Das,S.K., Jain,A., Rout,M., Dash,R., Swain,R.K., Lee,D.Y.,
            Rusten,T.E., Chauhan,S. and Chauhan,S.
  TITLE     RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to
            Drive Cell-Cycle and Cancer Progression
  JOURNAL   Cancer Res 81 (2), 315-331 (2021)
   PUBMED   33067265
  REMARK    GeneRIF: RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin
            D1 to Drive Cell-Cycle and Cancer Progression.
REFERENCE   4  (bases 1 to 5304)
  AUTHORS   Liang,T., Zhou,X., Li,P., You,G., Wang,F., Wang,P. and Feng,E.
  TITLE     DZIP3 is a key factor to stratify IDH1 wild-type lower-grade
            gliomas
  JOURNAL   Aging (Albany NY) 12 (24), 24995-25004 (2020)
   PUBMED   33229627
  REMARK    GeneRIF: DZIP3 is a key factor to stratify IDH1 wild-type
            lower-grade gliomas.
REFERENCE   5  (bases 1 to 5304)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5304)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   7  (bases 1 to 5304)
  AUTHORS   Zhou,W., Zhu,P., Wang,J., Pascual,G., Ohgi,K.A., Lozach,J.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     Histone H2A monoubiquitination represses transcription by
            inhibiting RNA polymerase II transcriptional elongation
  JOURNAL   Mol Cell 29 (1), 69-80 (2008)
   PUBMED   18206970
  REMARK    GeneRIF: By monoubiquitination of H2A at lysine 119, 2A-HUB
            mediates a selective repression of a specific set of chemokine
            genes in macrophages, critically modulating migratory responses to
            TLR activation.
REFERENCE   8  (bases 1 to 5304)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   9  (bases 1 to 5304)
  AUTHORS   Kreft,S.G. and Nassal,M.
  TITLE     hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase
  JOURNAL   J Cell Sci 116 (Pt 4), 605-616 (2003)
   PUBMED   12538761
REFERENCE   10 (bases 1 to 5304)
  AUTHORS   Moore,F.L., Jaruzelska,J., Fox,M.S., Urano,J., Firpo,M.T.,
            Turek,P.J., Dorfman,D.M. and Pera,R.A.
  TITLE     Human Pumilio-2 is expressed in embryonic stem cells and germ cells
            and interacts with DAZ (Deleted in AZoospermia) and DAZ-like
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (2), 538-543 (2003)
   PUBMED   12511597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092693.8 and AC092185.3.
            
            On Nov 23, 2018 this sequence version replaced NM_014648.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023138.1, SRR1660809.157842.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361582.8/ ENSP00000355028.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC092693.8         5270-5387
            119-222             AC092693.8         20883-20986
            223-292             AC092185.3         4041-4110
            293-448             AC092185.3         7126-7281
            449-565             AC092185.3         12493-12609
            566-646             AC092185.3         20396-20476
            647-771             AC092185.3         21797-21921
            772-886             AC092185.3         25014-25128
            887-1006            AC092185.3         28905-29024
            1007-1108           AC092185.3         30823-30924
            1109-1201           AC092185.3         32568-32660
            1202-1254           AC092185.3         33448-33500
            1255-1331           AC092185.3         38390-38466
            1332-1949           AC092185.3         40116-40733
            1950-1982           AC092185.3         42569-42601
            1983-2152           AC092185.3         43895-44064
            2153-2197           AC092185.3         44870-44914
            2198-2223           AC092185.3         47089-47114
            2224-2389           AC092185.3         50097-50262
            2390-2485           AC092185.3         57829-57924
            2486-2613           AC092185.3         58082-58209
            2614-2682           AC092185.3         65633-65701
            2683-2779           AC092185.3         68512-68608
            2780-2883           AC092185.3         70030-70133
            2884-2971           AC092185.3         71738-71825
            2972-3073           AC092185.3         73449-73550
            3074-3199           AC092185.3         80168-80293
            3200-3339           AC092185.3         82397-82536
            3340-3460           AC092185.3         83928-84048
            3461-3604           AC092185.3         84545-84688
            3605-3706           AC092185.3         84775-84876
            3707-3823           AC092185.3         86739-86855
            3824-5304           AC092185.3         89312-90792
FEATURES             Location/Qualifiers
     source          1..5304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.13"
     gene            1..5304
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /note="DAZ interacting zinc finger protein 3"
                     /db_xref="GeneID:9666"
                     /db_xref="HGNC:HGNC:30938"
                     /db_xref="MIM:608672"
     exon            1..118
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..222
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3817
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /EC_number="2.3.2.27"
                     /note="zinc finger DAZ interacting protein 3; RING-type E3
                     ubiquitin transferase DZIP3; human RNA-binding ubiquitin
                     ligase of 138 kDa; UURF2 ubiquitin ligase; DAZ-interacting
                     protein 3; protein phosphatase 1, regulatory subunit 66;
                     DAZ interacting protein 3, zinc finger; RNA-binding
                     RING-H2 protein-ubiquitin ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase DZIP3"
                     /protein_id="NP_055463.1"
                     /db_xref="CCDS:CCDS2952.1"
                     /db_xref="GeneID:9666"
                     /db_xref="HGNC:HGNC:30938"
                     /db_xref="MIM:608672"
                     /translation="MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTD
                     LVPVNLLLEVKKLLNAINTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPA
                     LTLRFLITQLEAALRNIQAGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENK
                     FLVMKMMIQENEICENFMSLVYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFD
                     IDPTEDEDLPTTFKDLLNNFIKTTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQ
                     LMCSKSCCVYFHKICWKKFKNLKYPGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIV
                     KILFEVVRKDEYITIENLGASYRKLISLKITDTDIRPKISLKFNTKDEMPIFKLDYNY
                     FYHLLHIIIISGTDIVRQIFDEAMPPPLLKKELLIHKNVLESYYNHLWTNHPLGGSWH
                     LLYPPNKELPQSKQFDLCLLLALIKHLNVFPAPKKGWNMEPPSSDISKSADILRLCKY
                     RDILLSEILMNGLTESQFNSIWKKVSDILLRLGMMQEDIDKVKENPIENISLDYHQLS
                     VYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIEIEELQNEEEELSPPLMEYNINVKS
                     HPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQRKKKKTKNKKNKDSKEDQVPYVV
                     EKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFYSLDELHILDMIEQGSAGKVT
                     TDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQENQMQIKKKDKIIASLNQQ
                     VAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHNLESTMKTYVSKLNAET
                     SRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNLESLQLKAAVDSWNA
                     IVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVK
                     ESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPS
                     IMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKISQFIDPKK
                     SQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEE
                     PCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGHPSRQ
                     LPKI"
     exon            223..292
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            293..448
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..565
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..646
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..771
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..886
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1006
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1108
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1201
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1254
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1331
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1949
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..1982
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2152
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2197
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2223
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2389
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2485
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2613
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2682
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2779
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2883
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2971
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3073
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3199
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3339
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3460
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3604
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3706
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3823
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..5304
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4478..4483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /note="hexamer: ATTAAA"
     polyA_site      4497
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /note="major polyA site"
     regulatory      4564..4569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /note="hexamer: AATAAA"
     polyA_site      4590
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
     regulatory      5284..5289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
                     /note="hexamer: AATAAA"
     polyA_site      5304
                     /gene="DZIP3"
                     /gene_synonym="hRUL138; PPP1R66; UURF2"
ORIGIN      
        1 actcagctgt gcgctctgat ttcgtgcgct tcctcgtcct tcatgttgga tggccagttt
       61 ttcgtttgtg cgtcatcctc tacctgagaa atggtcgctt gcccctagtc tagacacgca
      121 ttaaagggca gtatttaaag tcagttggca agcagtggaa taagattttt gtaaagaaac
      181 cttgtgcagc atggattctc taccagatga attttttgtg aggcatcctg ctgtggagga
      241 tcagaggaag gaagaaactg agaataagct agaaaaatca tctggtcaac tgaacaaaca
      301 ggaaaatgac atacctactg atcttgtccc tgttaaccta ctattagaag tgaagaagtt
      361 attaaatgca attaatactc taccaaaagg tgtggttcct cacattaaga agttcttaca
      421 agaagatttt tccttccaaa ctatgcagag agaagttgca gctaacagcc agaatggtga
      481 ggaaattgtt cctgctttga ctttacgttt cttgattaca cagctagaag cagcacttag
      541 gaacattcaa gctggcaatt ataccgcaca ccagattaat attggttatt atttgacatt
      601 actgttttta tatggagtag cactcactga aagaggaaag aaagaggatt atacagaagc
      661 tgagaataaa tttctggtga tgaagatgat gatccaagaa aatgaaattt gtgaaaactt
      721 tatgtcttta gtttattttg gacgtggttt actgcgatgt gctcaaaaga gatataatgg
      781 aggactgcta gaatttcata aaagcttaca agaaattgga gacaaaaatg accattggtt
      841 tgacatagat cctacagaag atgaagattt acctacaact tttaaagatc ttcttaataa
      901 ttttatcaag acaactgaaa gcaatataat gaagcagacg atttgtagtt acctagattg
      961 tgaacgatct tgtgaagctg acattttgaa gaacaccagt tataagggat tttttcagtt
     1021 aatgtgcagt aaaagttgct gtgtttattt ccataaaatt tgctggaaaa agttcaagaa
     1081 tttaaagtat ccaggtgaaa atgatcagag ttttagtggg aaaaaatgtt tgaaggaagg
     1141 atgtacaggt gacatggtaa ggatgctgca atgtgatgta cctggaattg ttaaaatttt
     1201 gtttgaagtt gtgagaaagg atgaatatat caccattgaa aatttaggag caagttatag
     1261 aaagttgata tctctgaaaa taactgatac tgatataaga ccgaagatca gtttaaaatt
     1321 taatacaaaa gatgaaatgc ctatcttcaa gcttgattat aattatttct atcatctgct
     1381 tcatataatt attatttctg gtactgacat tgttcgacaa atatttgatg aggctatgcc
     1441 acctcctctt ttgaaaaaag agcttcttat acacaagaat gtgctggaat cctactacaa
     1501 ccatctttgg accaatcatc ctttgggtgg atcatggcat ctgctttatc ctcctaacaa
     1561 ggagttaccg caatccaaac agtttgactt atgcctcctg ttagctctta taaaacattt
     1621 aaatgtgttc cctgcaccca aaaaaggatg gaatatggaa ccgccatctt ctgacatctc
     1681 taaatctgca gacatcctga gactgtgcaa atacagggat atcctcctta gtgagatttt
     1741 gatgaatggt ctcactgagt cacagttcaa ttcaatttgg aaaaaagttt cagatattct
     1801 tctgcgcctt gggatgatgc aagaggatat tgacaaagtg aaggagaatc ccattgagaa
     1861 tatctccctt gattaccatc agctatctgt ctacctaggc ataccagtac cagaaatcat
     1921 acagaggatg ttatcctgct atcaacaagg aattgctcta cagtcaataa caggcagtca
     1981 gcgtattgaa atagaagagt tacagaatga ggaagaagaa ctaagtccac ctctcatgga
     2041 gtacaatata aatgtgaaat cacaccctga gatacagttt gcagaaatta ataaagatgg
     2101 gacctcaata cccagtgaat cttcaacaga atctcttaaa gatctccagg aagttaagag
     2161 taaacaaagg aaaaagaaga agactaagaa taaaaagaat aaagactcaa aagaagacca
     2221 agtcccatat gtggtagaaa aggaagagca gttgaggaaa gaacaagcaa atccacactc
     2281 agtcagtaga cttataaaag atgatgcaag tgatgttcaa gaggattctg caatggaaga
     2341 caagttctat agcctggatg aattgcatat tctggacatg atagagcagg gctcagctgg
     2401 caaagtaact acagactatg gagaaactga aaaggaaagg cttgctcgtc aaaggcagct
     2461 ttataaattg cactatcagt gtgaagattt caaaagacag ttgagaacag tgacttttcg
     2521 gtggcaagaa aaccaaatgc agattaaaaa gaaagacaaa attatcgcat ctcttaatca
     2581 acaagttgct tttggaatca ataaggtttc caaattacag cgtcaaatcc atgctaaaga
     2641 taatgaaatc aagaacctta aagagcaact ttctatgaaa agatctcagt gggaaatgga
     2701 aaaacataat ctggaaagca caatgaaaac atacgtaagc aaactgaacg cagaaactag
     2761 cagagcttta acagccgagg tgtatttctt acagtgtcgt agggattttg gtttgcttca
     2821 tctagagcag actgaaaagg aatgtctcaa tcagcttgcc agggtgactc acatggcagc
     2881 aagcaaccta gaatcacttc aattaaaggc tgcggtagac agttggaatg ccattgtggc
     2941 agatgttaga aacaagattg cattcctcag gacacagtac aatgaacaaa taaacaaagt
     3001 caagcaagga tttgccttga gtaccttgcc tccagtccag cttcctcctc caccacccag
     3061 tcctgagata ctgatgcagc agttcttagg aagacctctt gtgaaagaat ctttctttag
     3121 acccatactt actgttcctc aaatgcctgc agtttgcccg ggagtcgtct ctgcaactgg
     3181 ccaacctaga gcccccctga tgactggcat agcctgggct ctgccagcgc ctgtgggaga
     3241 cgctgtgcct cccagtgcag gtctgcggag tgatccctcc atcatgaatt gggagagaat
     3301 tacagacagg ctgaaaactg cctttccaca gcaaaccaga aaggaactta cagatttctt
     3361 acggaaattg aaggatgctt atggaaaatc cttgtctgaa ctgacatttg atgaaattgt
     3421 ttgcaagatt tcccagttta ttgaccccaa aaagtctcag agtcaaggaa aatcagtgtc
     3481 aaatgttaat tgtgtttcac ctagtcattc tccatcacag cctgatgctg cccagccccc
     3541 aaaaccagcc tggaggccac tcacttcaca gggtcctgcc acatgggaag gagccagtaa
     3601 tccagatgag gaagaggaag aagaagagcc ttgtgtgatc tgtcatgaga atctgtctcc
     3661 agaaaatctt tcagttttgc cttgcgctca caaattccat gctcagtgca ttagaccatg
     3721 gttgatgcaa caggggacat gtccaacgtg cagactccac gttttgctac cagaagaatt
     3781 ccctggtcac cccagccggc agttgcccaa gatctgatac aaggtaccca tgaagagatt
     3841 atgaactact tgaaggtgga gactgtacgg tggtgtgttg gagctggctt gtaatgtctt
     3901 atgagtgaca atcgttagtt tgaggaattt tgtgagacag ttgtcaaatt gttgctagct
     3961 tgaaatctgc ggcaattgga gtatttacac catagaaatg ctataagtga agacctacct
     4021 ttcccttaag agctagttgt taaaccttta ccagcatacc actggacctt gtctaaaatt
     4081 tctttgtgtt cccagtgtct tgcccagtag atacaagata aatattgcca gaatcagata
     4141 tcaggaagta gtaagaaaag gagttaatat gcaaactaaa tcactcgctc aattgaataa
     4201 ttgagatctt ctgttcattt gttccttgga ccttaatcat ttgcattttg gagaaaattt
     4261 tttctgcttt aaaagtctgt aatttcagtt tttgtgtcgg ggagagggaa aaactatttg
     4321 tctgtagttg ctttttgtga caaagtgaat acccactggg ctaagtttca tatctaaagc
     4381 ttgtcactaa gaattttcat ttttaggggt caaaaaccta ttttgaaaat agtgttgtgt
     4441 gaatgctgta agtgttgtac atgtctctgg tttcagaatt aaaagaattc agagttacct
     4501 tgtgagataa atgttctttg cttcatattc acagtttcac ctccatttaa atttatgggg
     4561 aagaataaat gtttcctgac tcagaaacaa ttttgcctcc atatttcagt gcaaatatat
     4621 tttgaagtta cttttaaata tttatttaaa acctctgttt ctgtaactgt atgttaaacg
     4681 tattcttctg taatgagaat agactggaac atgtgaggga aaaatattta aaaaaagatg
     4741 gcagtcatct agacatgtaa aatgccaaga atgtcttaga attgcacaat ttagaattta
     4801 tagagccttt aatcaccttg tctagcacct tgtattagtc cattttcatg ctgctgataa
     4861 agacatacct gagattgggc aatttacaaa agaaagaggt ttaacggact tacagttcca
     4921 catgactaag gaggcctcac aatcatggtg gaaggcaaag aggagcaagt cacatcttac
     4981 atggatggca gcagacaagg agagagagct tgtgcaggga aactcccatt tttaaaacca
     5041 tcagatctca tgaggcttac tatcacgaga acagcatggg aaagacctgc ccccgtgatt
     5101 aaattatttc ccaccaggcc cctcccacaa catggaataa tgggagatac aagatatttg
     5161 ggtggagaca cagagccaaa ccatatcaca ccttaaggtc atggtcatat agctagttat
     5221 cttgtaaaac caatgtttct tagttcatac ttacaactgc aatttcactt tcatttagaa
     5281 aagaataaat gtttcttaat tgaa
//
