LOCUS       NM_001367614            3420 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens double zinc ribbon and ankyrin repeat domains 1
            (DZANK1), transcript variant 8, mRNA.
ACCESSION   NM_001367614
VERSION     NM_001367614.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3420)
  AUTHORS   Dona,M., Bachmann-Gagescu,R., Texier,Y., Toedt,G., Hetterschijt,L.,
            Tonnaer,E.L., Peters,T.A., van Beersum,S.E., Bergboer,J.G.,
            Horn,N., de Vrieze,E., Slijkerman,R.W., van Reeuwijk,J., Flik,G.,
            Keunen,J.E., Ueffing,M., Gibson,T.J., Roepman,R., Boldt,K.,
            Kremer,H. and van Wijk,E.
  TITLE     NINL and DZANK1 Co-function in Vesicle Transport and Are Essential
            for Photoreceptor Development in Zebrafish
  JOURNAL   PLoS Genet 11 (10), e1005574 (2015)
   PUBMED   26485514
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3420)
  AUTHORS   Sedgwick,S.G. and Smerdon,S.J.
  TITLE     The ankyrin repeat: a diversity of interactions on a common
            structural framework
  JOURNAL   Trends Biochem Sci 24 (8), 311-316 (1999)
   PUBMED   10431175
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121893.21 and AL049646.19.
            
            Summary: This gene contains two ankyrin repeat-encoding regions.
            Ankyrin repeats are tandemly repeated modules of about 33 amino
            acids described as L-shaped structures consisting of a beta-hairpin
            and two alpha-helices. Ankyrin repeats occur in a large number of
            functionally diverse proteins, mainly from eukaryotes, and are
            known to function as protein-protein interaction domains. [provided
            by RefSeq, Dec 2018].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.120225.1,
                                           SRR1660805.136063.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000699568.1/ ENSP00000514442.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL121893.21        57532-57566         c
            36-163              AL121893.21        55786-55913         c
            164-317             AL121893.21        50689-50842         c
            318-432             AL121893.21        45783-45897         c
            433-529             AL121893.21        44267-44363         c
            530-654             AL121893.21        43151-43275         c
            655-740             AL121893.21        39520-39605         c
            741-858             AL121893.21        33883-34000         c
            859-972             AL121893.21        24188-24301         c
            973-1065            AL121893.21        17603-17695         c
            1066-1188           AL121893.21        5863-5985           c
            1189-1353           AL121893.21        4884-5048           c
            1354-1561           AL121893.21        3182-3389           c
            1562-1665           AL049646.19        155044-155147       c
            1666-1740           AL049646.19        152993-153067       c
            1741-1837           AL049646.19        150775-150871       c
            1838-1938           AL049646.19        150232-150332       c
            1939-2019           AL049646.19        146900-146980       c
            2020-2147           AL049646.19        146222-146349       c
            2148-2222           AL049646.19        141537-141611       c
            2223-3420           AL049646.19        139888-141085       c
FEATURES             Location/Qualifiers
     source          1..3420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3420
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /note="double zinc ribbon and ankyrin repeat domains 1"
                     /db_xref="GeneID:55184"
                     /db_xref="HGNC:HGNC:15858"
                     /db_xref="MIM:620905"
     exon            1..35
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            36..163
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2388
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /note="isoform 7 is encoded by transcript variant 8;
                     ankyrin repeat-containing protein C20orf12; ankyrin repeat
                     domain 64; double zinc ribbon and ankyrin
                     repeat-containing protein 1"
                     /codon_start=1
                     /product="double zinc ribbon and ankyrin repeat-containing
                     protein 1 isoform 7"
                     /protein_id="NP_001354543.1"
                     /db_xref="CCDS:CCDS93014.1"
                     /db_xref="GeneID:55184"
                     /db_xref="HGNC:HGNC:15858"
                     /db_xref="MIM:620905"
                     /translation="MTAGSVCVPQIIPLRVPQPGKANHEIDNNTLLEMKSDTPDVNIY
                     YTLDGSKPEFLKRIGYGENNTFKYIKPITLPDGKIQVKAIAVSKDCRQSGIVTKVFHV
                     DYEPPNIVSPEDNVENVLKDSSRQEFKNGFVGSKLKKKYKNSENQRSWNVNLRKFPDV
                     QVGERTDPKTLKDLHFSESPLEIPAYGGGSGSRPPTRQSQSPGFAHVSGQKCLTSTEI
                     MRIQRETDFLKCAHCLAPRPSDPFARFCQECGSPVPPIFGCRLPPPEGAQMGLCAECR
                     SLVPMNTPICVVCEAPLALQLQPQASLHLKEKVICRACGTGNPAHLRYCVTCEGALPS
                     SQESMCSGDKAPPPPTQKGGTISCYRCGRWNLWEASFCGWCGAMLGIPAGCSVCPKCG
                     ASNHLSARFCGSCGICVKSLVKLSLDRSLALAAEEPRPFSEPRCAWQSLNIPLPRSDV
                     GTKRDIGTQTVGLFYPSGKLLAKKEQELASQKQRQEKMSDHKPLLTAISPGRGYWRRQ
                     LDHISAHLRCYAQNNPEFRALIAEPRMGKLISATVHEDGCEVSIRLNYSQVSNKNLYL
                     NKAVNFSDHLLSSAAEGDGGLCGSRSSWVSDYSQSTSDTIEKIKRIKNFKTKTFQEKK
                     EQLIPENRLLLKEVGPTGEGRVSVIEQLLDEGADPNCCDEDNRPVITVAVMNKHHEAI
                     PVLVQRGADIDQQWGPLRNTALHEATLLGLAGRESTATLLGCNASIQKKNAGGQTAYD
                     LALNTGDDLVTSLFAAKFGQGLEDQLAQTRSLSLDDC"
     exon            164..317
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            318..432
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            433..529
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            530..654
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            655..740
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            741..858
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            859..972
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1065
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1188
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1353
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1561
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1665
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1740
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1837
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1938
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2019
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2147
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2222
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..3420
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3395..3400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /note="hexamer: AATAAA"
     polyA_site      3420
                     /gene="DZANK1"
                     /gene_synonym="ANKRD64; C20orf12; C20orf84"
                     /note="major polyA site"
ORIGIN      
        1 aacccgggcg gcggcgaagg aggaggcaag aggcgagaga gagagagaga gaaaatgact
       61 gctggttcag tgtgtgtccc tcagatcata ccattacgag tgcctcagcc tggaaaagct
      121 aaccatgaaa ttgataacaa tacgcttttg gaaatgaaat cagacactcc agatgtcaac
      181 atatattata ctctggatgg cagcaaacct gaatttctaa agagaattgg ttatggggaa
      241 aataacacat ttaagtatat aaaacctatt actctgcctg atggaaaaat acaagttaaa
      301 gctattgctg tctctaaaga ctgcagacag agtggcattg tgacaaaggt gtttcacgta
      361 gactatgaac caccaaatat agtctctcct gaagacaatg ttgaaaatgt tctcaaagat
      421 tcttcaaggc aggaattcaa aaatggattt gttggatcaa aactaaagaa aaaatataag
      481 aactctgaaa atcaacgcag ctggaatgtt aaccttagaa agtttccaga cgtccaggta
      541 ggtgaaagaa ctgaccctaa aactttgaaa gatcttcact tttcagagag tccattggaa
      601 atcccagctt atggtggagg atcaggttct agaccaccca cccgccagtc ccagtccccc
      661 ggttttgcac acgtaagcgg tcagaagtgt ttgacaagca cggagataat gagaattcaa
      721 agggagacag actttctcaa gtgtgcccac tgccttgccc cccggccatc agatcccttt
      781 gctcgcttct gtcaagaatg tggctctcct gtcccaccca tatttggctg tcgtctccca
      841 cccccagaag gagctcagat gggcttgtgt gcagaatgca gaagcttggt acccatgaac
      901 actcccatct gtgtggtgtg tgaggcccct cttgctctac agctgcagcc acaggcaagc
      961 ctccacttga aggagaaggt aatttgccgg gcctgtggta caggaaatcc tgctcacctg
     1021 agatactgtg tcacctgtga gggggccctg ccttcatcac aagagtcgat gtgcagtggg
     1081 gataaagccc ctcctccgcc cactcagaaa ggggggacca tttcctgcta cagatgtggt
     1141 cgctggaatc tctgggaggc gtccttctgc ggctggtgtg gagccatgct cggcattcct
     1201 gctggctgtt ctgtttgccc taaatgtggg gccagcaatc acctgtctgc ccgattctgt
     1261 ggctcctgtg gtatttgtgt gaagtcccta gtgaaactta gcttggacag aagcctggct
     1321 ctagctgctg aggaacctcg ccctttttct gagccccgat gtgcctggca gtccctgaat
     1381 attcctttgc ccagatctga tgttgggact aagagggaca taggaacaca gactgttggc
     1441 ctcttctacc catctggcaa gctgctagca aaaaaggaac aggaactagc ctctcaaaag
     1501 cagaggcagg agaaaatgag tgaccataaa cccctcctga cagccatcag cccaggaaga
     1561 gggtactgga gaagacagct ggatcacatc tctgctcacc tcaggtgtta tgctcagaac
     1621 aaccctgaat tccgggcctt gattgcagaa cccaggatgg gaaagcttat ctctgctact
     1681 gtccacgaag atggttgtga agttagcatc agactgaatt atagtcaagt ctcaaacaag
     1741 aacctttacc tgaacaaggc agtgaatttc agcgatcacc ttctgagcag tgctgccgag
     1801 ggtgatgggg ggctgtgcgg cagcaggtcc agctgggtga gtgactacag ccagagtacc
     1861 tcagatacta ttgaaaaaat caaaaggata aagaatttca agaccaaaac ttttcaagaa
     1921 aagaaggagc agcttatacc tgaaaacaga ctcctgctga aggaagtcgg acccacgggg
     1981 gaaggaagag tctctgtgat tgaacagctg ctggatgagg gagcagaccc caactgctgt
     2041 gatgaagaca atcgacccgt cataaccgtg gctgttatga ataagcacca tgaagcgatt
     2101 ccagttctcg tgcagagagg agcagacatc gaccagcagt gggggccgct cagaaataca
     2161 gctcttcatg aagcaactct gcttggcctt gcaggaagag agagcaccgc cactttactg
     2221 ggatgcaatg caagcatcca aaagaagaat gcaggaggcc agacagcata cgacctggct
     2281 ctgaacactg gagatgacct tgtcacctca ctctttgctg ccaagtttgg ccaagggctt
     2341 gaggaccaac tcgctcaaac taggagcctc agcctggatg actgttagcc ctgaggcctc
     2401 cacgggactt catttaagaa tacgtgcatg gctggcacag tggcttacgc ctgtaatccc
     2461 agcactttgg gaggctgagg ctggcgtatc acctgaggtt gggagttcaa gaccagcctg
     2521 accaacatgg agaaaccccg tctctactaa aaatacaaaa ttagtcgggc gtagtggtgc
     2581 atgcctgtaa tcccagttac tcgagaggct gaggcaggaa aatcgcttga acccgggagg
     2641 cagaggttac agtgagccaa gatcgcgcca tcgcactcca gcctgggcaa caagagcaaa
     2701 actccatctc aaaaaaaaaa aagaatatgt gcagctctgg ctattcttta atcatgtctt
     2761 tctgaaatgt gtatttgaga ttagaaattg aggttgagag gaactcagga gatttttttt
     2821 ttaaatcata tgacagtata agccatcagt actaaatgga cagctcccag tatactgtgg
     2881 actgtgataa actgaatgta tgttttttaa tggtttattg ctgcaggttt tttgtgtatt
     2941 tgatttttag tttttaactt atttttcaat aggtaataat tgcacatggt tcaaagctaa
     3001 aaggtatgaa gtattatgta gggatacgtc cctcccattc tgtcccacag ccaccacctc
     3061 tctcctcagc cagcaatgac atcagcgtcg acttgccttt cccggggttg tgcagagtta
     3121 gatatgcaca tacatgtggt ataagcacat gtacagagga gtacacatag catataaaca
     3181 tgtctgtagc acatatatat tctttcccct cttttaaaac aaatggtagc aaaccaacca
     3241 cacactgttc tgtatcttgc tctgtttgct tgatacatct tgtaagtggc tcctaattac
     3301 tatgtaaaga ttgaccttat ttaaattttt ttatgttgaa atcatcaata ttcccatcat
     3361 tatggtgtgt tctttgattg acaaatcagc tctcaataaa ccacttataa gaatgtgtaa
//
