LOCUS       NM_001394779            2065 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens dual specificity tyrosine phosphorylation regulated
            kinase 4 (DYRK4), transcript variant 6, mRNA.
ACCESSION   NM_001394779
VERSION     NM_001394779.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Liu,C.C., Veeraraghavan,J., Tan,Y., Kim,J.A., Wang,X., Loo,S.K.,
            Lee,S., Hu,Y. and Wang,X.S.
  TITLE     A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers
            Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast
            Cancers
  JOURNAL   Clin Cancer Res 27 (3), 785-798 (2021)
   PUBMED   33172895
  REMARK    GeneRIF: A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4,
            Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive
            Breast Cancers.
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Bunyavanich,S., Schadt,E.E., Himes,B.E., Lasky-Su,J., Qiu,W.,
            Lazarus,R., Ziniti,J.P., Cohain,A., Linderman,M., Torgerson,D.G.,
            Eng,C.S., Pino-Yanes,M., Padhukasahasram,B., Yang,J.J.,
            Mathias,R.A., Beaty,T.H., Li,X., Graves,P., Romieu,I., Navarro
            Bdel,R., Salam,M.T., Vora,H., Nicolae,D.L., Ober,C., Martinez,F.D.,
            Bleecker,E.R., Meyers,D.A., Gauderman,W.J., Gilliland,F.,
            Burchard,E.G., Barnes,K.C., Williams,L.K., London,S.J., Zhang,B.,
            Raby,B.A. and Weiss,S.T.
  TITLE     Integrated genome-wide association, coexpression network, and
            expression single nucleotide polymorphism analysis identifies novel
            pathway in allergic rhinitis
  JOURNAL   BMC Med Genomics 7, 48 (2014)
   PUBMED   25085501
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2065)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   6  (bases 1 to 2065)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   7  (bases 1 to 2065)
  AUTHORS   Papadopoulos,C., Arato,K., Lilienthal,E., Zerweck,J.,
            Schutkowski,M., Chatain,N., Muller-Newen,G., Becker,W. and de la
            Luna,S.
  TITLE     Splice variants of the dual specificity tyrosine
            phosphorylation-regulated kinase 4 (DYRK4) differ in their
            subcellular localization and catalytic activity
  JOURNAL   J Biol Chem 286 (7), 5494-5505 (2011)
   PUBMED   21127067
  REMARK    GeneRIF: DYRK4 isoforms resulting from alternative splicing differ
            in subcellular localization and catalytic activity
REFERENCE   8  (bases 1 to 2065)
  AUTHORS   Sacher,F., Moller,C., Bone,W., Gottwald,U. and Fritsch,M.
  TITLE     The expression of the testis-specific Dyrk4 kinase is highly
            restricted to step 8 spermatids but is not required for male
            fertility in mice
  JOURNAL   Mol Cell Endocrinol 267 (1-2), 80-88 (2007)
   PUBMED   17292540
  REMARK    GeneRIF: Dyrk4 is a testis-specific kinase with a very restricted
            expression to stage VIII postmeiotic spermatids.
REFERENCE   9  (bases 1 to 2065)
  AUTHORS   Zhang,D., Li,K., Erickson-Miller,C.L., Weiss,M. and Wojchowski,D.M.
  TITLE     DYRK gene structure and erythroid-restricted features of DYRK3 gene
            expression
  JOURNAL   Genomics 85 (1), 117-130 (2005)
   PUBMED   15607427
REFERENCE   10 (bases 1 to 2065)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005832.1.
            
            Summary: This gene encodes an enzyme that belongs to a conserved
            family of serine/threonine protein kinases. Members of this dual
            specificity kinase family are thought to function in the regulation
            of cell differentiation and proliferation, survival, and in
            development. Alternate splicing results in multiple transcript
            variants. Additional alternatively spliced transcript variants of
            this gene have been described, but their full-length nature is not
            known. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543431.6/ ENSP00000439697.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC005832.1         132823-132898       c
            77-170              AC005832.1         127058-127151       c
            171-251             AC005832.1         106089-106169       c
            252-362             AC005832.1         104666-104776       c
            363-501             AC005832.1         103808-103946       c
            502-665             AC005832.1         101941-102104       c
            666-802             AC005832.1         98821-98957         c
            803-943             AC005832.1         98377-98517         c
            944-1082            AC005832.1         95940-96078         c
            1083-1164           AC005832.1         95318-95399         c
            1165-1337           AC005832.1         90020-90192         c
            1338-1398           AC005832.1         87719-87779         c
            1399-1528           AC005832.1         84822-84951         c
            1529-1704           AC005832.1         82388-82563         c
            1705-2065           AC005832.1         81231-81591         c
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.32"
     gene            1..2065
                     /gene="DYRK4"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 4"
                     /db_xref="GeneID:8798"
                     /db_xref="HGNC:HGNC:3095"
                     /db_xref="MIM:609181"
     exon            1..76
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1943
                     /gene="DYRK4"
                     /EC_number="2.7.12.1"
                     /note="isoform 5 is encoded by transcript variant 6; dual
                     specificity tyrosine-(Y)-phosphorylation regulated kinase
                     4"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 4 isoform 5"
                     /protein_id="NP_001381708.1"
                     /db_xref="CCDS:CCDS91641.1"
                     /db_xref="GeneID:8798"
                     /db_xref="HGNC:HGNC:3095"
                     /db_xref="MIM:609181"
                     /translation="MQLLPPPIRTGTKTQMDAKKPRKCDLTPFLVLKARKKQKFTSAK
                     VGSKLSVQIQKPPSNIKNSRMTQVFHKNTSVTSLPFVDTKGKKNTVSFPHISKKVLLK
                     SSLLYQENQAHNQMPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLF
                     KNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYR
                     YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKD
                     NTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQ
                     MLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVIL
                     GHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQ
                     TFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQ
                     ALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKDEITKETTEKT
                     KDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSL
                     KNTNVLPPIV"
     exon            77..170
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            171..251
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            252..362
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            363..501
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            502..665
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            666..802
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            803..943
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1082
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1164
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1337
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1398
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1528
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1704
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..2065
                     /gene="DYRK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK4"
                     /note="hexamer: CATAAA"
     polyA_site      2065
                     /gene="DYRK4"
                     /note="major polyA site"
ORIGIN      
        1 acagcctccc gcagcggcgg gcggtcagcg ccggcctcat gcagctcctc ccgccgccta
       61 tccgcaccgg aacaaagact caaatggatg ctaaaaagcc aaggaaatgt gatttgactc
      121 ccttcctggt tttgaaagca agaaagaaac aaaagttcac ctctgcgaag gttggaagta
      181 aactttcggt tcagatccag aagccacctt ccaatatcaa gaactccaga atgacccaag
      241 tctttcataa gaacaccagt gttacttcac tcccctttgt ggacaccaag gggaagaaga
      301 atacggtaag cttcccacac attagcaaga aagtcctgct gaagtcatcc ctgctgtatc
      361 aggagaatca agctcacaat cagatgccgg cctcagagct caaggcttca gaaatacctt
      421 tccaccctag cattaaaacc caggatccca aggcagagga gaagtcacca aagaagcaaa
      481 aggtgactct gacagcggca gaggccctaa agctttttaa gaaccagctg tctccatatg
      541 aacaaagtga aatcctgggc tacgcggagc tgtggttcct gggtcttgaa gccaagaagc
      601 tcgacacggc tcctgagaaa tttagcaaga cgagttttga tgatgagcat ggcttctatc
      661 tgaaggtcct gcatgatcac attgcctacc gctatgaagt tctggagaca atcgggaagg
      721 ggtcctttgg acaggtggcc aagtgcttgg atcacaaaaa caatgagctg gtggccctga
      781 aaatcatcag gaacaagaag aggtttcacc agcaggccct gatggagctg aagatcctgg
      841 aagctctcag aaagaaggac aaagacaaca cctacaatgt ggtgcatatg aaggactttt
      901 tctactttcg caatcacttc tgcatcacct ttgagctcct gggaatcaac ttgtatgagt
      961 tgatgaagaa taacaacttt caaggcttca gtctgtccat agttcggcgc ttcactctct
     1021 ctgttttgaa gtgcttgcag atgctttcgg tagagaaaat cattcactgt gatctcaagc
     1081 ccgaaaatat agtgctatac caaaagggcc aagcctctgt taaagtcatt gactttggat
     1141 caagctgtta tgaacaccag aaagtataca cgtacatcca aagccggttc taccgatccc
     1201 cagaagtgat cctgggccac ccctacgacg tggccattga catgtggagc ctgggctgca
     1261 tcacggcgga gttgtacacg ggctaccccc tgttccccgg ggagaatgag gtggagcagc
     1321 tggcctgcat catggaggtg ctgggtctgc cgccagccgg cttcattcag acagcctcca
     1381 ggagacagac attctttgat tccaaaggtt ttcctaaaaa tataaccaac aacaggggga
     1441 aaaaaagata cccagattcc aaggacctca cgatggtgct gaaaacctat gacaccagct
     1501 tcctggactt tctcagaagg tgtttggtat gggaaccttc tcttcgcatg accccggacc
     1561 aggccctcaa gcatgcttgg attcatcagt ctcggaacct caagccacag cccaggcccc
     1621 agaccctgag gaaatccaat tcctttttcc cctctgagac aaggaaggac aaggttcaag
     1681 gctgtcatca ctcgagcaga aaagatgaga tcaccaaaga gactacagag aaaacaaaag
     1741 atagccccac gaagcatgtt cagcattcag gtgatcagca ggactgtctc cagcacggag
     1801 ctgacactgt tcagctgcct caactggtag acgctcccaa gaagtcagag gcagctgtcg
     1861 gggcggaggt gtccatgacc tccccaggac agagcaaaaa cttctccctc aagaacacaa
     1921 acgttttacc ccctattgta tgacctttgc tgagggtatg tcctgctcct ttccaccagt
     1981 gatttgtatt aagacagcac ttatattgta caatacttca gactgttttt tttaaataca
     2041 taaaacttta tgttaaaaaa ctcta
//
