LOCUS       NM_003582               8128 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens dual specificity tyrosine phosphorylation regulated
            kinase 3 (DYRK3), transcript variant 1, mRNA.
ACCESSION   NM_003582
VERSION     NM_003582.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8128)
  AUTHORS   Lee,Y.H., Yoon,A.R., Yun,C.O. and Chung,K.C.
  TITLE     Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269
            residue and promotes melanoma progression
  JOURNAL   J Biol Chem 300 (4), 107206 (2024)
   PUBMED   38519031
  REMARK    GeneRIF: Dual-specificity kinase DYRK3 phosphorylates p62 at the
            Thr-269 residue and promotes melanoma progression.
REFERENCE   2  (bases 1 to 8128)
  AUTHORS   Miyata,Y. and Nishida,E.
  TITLE     Protein quality control of DYRK family protein kinases by the
            Hsp90-Cdc37 molecular chaperone
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (10), 119081 (2021)
   PUBMED   34147560
  REMARK    GeneRIF: Protein quality control of DYRK family protein kinases by
            the Hsp90-Cdc37 molecular chaperone.
REFERENCE   3  (bases 1 to 8128)
  AUTHORS   Ivanova,E., Sharma,S.D., Brichkina,A., Pfefferle,P., Keber,U.,
            Pagenstecher,A. and Lauth,M.
  TITLE     DYRK3 contributes to differentiation and hypoxic control in
            neuroblastoma
  JOURNAL   Biochem Biophys Res Commun 567, 215-221 (2021)
   PUBMED   34171798
  REMARK    GeneRIF: DYRK3 contributes to differentiation and hypoxic control
            in neuroblastoma.
REFERENCE   4  (bases 1 to 8128)
  AUTHORS   Lindberg,M.F. and Meijer,L.
  TITLE     Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases
            (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview
  JOURNAL   Int J Mol Sci 22 (11), 6047 (2021)
   PUBMED   34205123
  REMARK    GeneRIF: Dual-Specificity, Tyrosine Phosphorylation-Regulated
            Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an
            Overview.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8128)
  AUTHORS   Kim,K., Lee,S., Kang,H., Shin,E., Kim,H.Y., Youn,H. and Youn,B.
  TITLE     Dual Specificity Kinase DYRK3 Promotes Aggressiveness of
            Glioblastoma by Altering Mitochondrial Morphology and Function
  JOURNAL   Int J Mol Sci 22 (6), 2982 (2021)
   PUBMED   33804169
  REMARK    GeneRIF: Dual Specificity Kinase DYRK3 Promotes Aggressiveness of
            Glioblastoma by Altering Mitochondrial Morphology and Function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8128)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   7  (bases 1 to 8128)
  AUTHORS   Li,K., Zhao,S., Karur,V. and Wojchowski,D.M.
  TITLE     DYRK3 activation, engagement of protein kinase A/cAMP response
            element-binding protein, and modulation of progenitor cell survival
  JOURNAL   J Biol Chem 277 (49), 47052-47060 (2002)
   PUBMED   12356771
  REMARK    GeneRIF: DYRK3 has roles in kinase activation, binding to CREB, and
            hematopoietic progenitor cell survival
REFERENCE   8  (bases 1 to 8128)
  AUTHORS   Lord,K.A., Creasy,C.L., King,A.G., King,C., Burns,B.M., Lee,J.C.
            and Dillon,S.B.
  TITLE     REDK, a novel human regulatory erythroid kinase
  JOURNAL   Blood 95 (9), 2838-2846 (2000)
   PUBMED   10779429
REFERENCE   9  (bases 1 to 8128)
  AUTHORS   Xia,J., Yang,X., Ruan,Q., Pan,Q., Liu,C., Xie,W. and Deng,H.
  TITLE     [Molecular cloning and characterization of novel protein kinase
            gene DYRK3]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 15 (6), 327-332 (1998)
   PUBMED   9845759
REFERENCE   10 (bases 1 to 8128)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU126055.1, Y12735.2,
            BC015501.1 and AL591846.15.
            
            On Aug 13, 2020 this sequence version replaced NM_003582.3.
            
            Summary: This gene product belongs to the DYRK family of
            dual-specificity protein kinases that catalyze autophosphorylation
            on serine/threonine and tyrosine residues. The members of this
            family share structural similarity, however, differ in their
            substrate specificity, suggesting their involvement in different
            cellular functions. The encoded protein has been shown to
            autophosphorylate on tyrosine residue and catalyze phosphorylation
            of histones H3 and H2B in vitro. Alternatively spliced transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript, but encodes the longer isoform (a), also known as the
            RED-L isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308082.1, AK313245.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367109.8/ ENSP00000356076.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AU126055.1         1-167
            168-1353            Y12735.2           148-1333
            1354-2167           BC015501.1         1405-2218
            2168-8128           AL591846.15        77159-83119
FEATURES             Location/Qualifiers
     source          1..8128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..8128
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 3"
                     /db_xref="GeneID:8444"
                     /db_xref="HGNC:HGNC:3094"
                     /db_xref="MIM:603497"
     exon            1..245
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1935
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /EC_number="2.7.12.1"
                     /note="isoform a is encoded by transcript variant 1;
                     regulatory erythroid kinase; dual-specificity
                     tyrosine-(Y)-phosphorylation regulated kinase 5; dual
                     specificity tyrosine-(Y)-phosphorylation regulated kinase
                     3; protein kinase Dyrk3"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 3 isoform a"
                     /protein_id="NP_003573.2"
                     /db_xref="CCDS:CCDS30999.1"
                     /db_xref="GeneID:8444"
                     /db_xref="HGNC:HGNC:3094"
                     /db_xref="MIM:603497"
                     /translation="MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCP
                     PCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQS
                     DGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKL
                     EIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKG
                     SFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLE
                     SFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHC
                     DLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDI
                     WSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPR
                     YCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPS
                     ARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLK
                     ANLMSETNGSIPLCSVLPKLIS"
     exon            246..357
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /inference="alignment:Splign:2.1.0"
     exon            358..8128
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2140..2145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /note="hexamer: ATTAAA"
     polyA_site      2163
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /note="major polyA site"
     regulatory      6928..6933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /note="hexamer: AATAAA"
     polyA_site      6952
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
     regulatory      8105..8110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /note="hexamer: AATAAA"
     regulatory      8111..8116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
                     /note="hexamer: AATGAA"
     polyA_site      8125
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
     polyA_site      8128
                     /gene="DYRK3"
                     /gene_synonym="DYRK5; hYAK3-2; RED; REDK"
ORIGIN      
        1 acttcccagc cggggccagt cgggagcgaa agtgcgctga gctgcagtgt ctggtcgaga
       61 gtacccgtgg gagcgtcgcg ccgcggaggc agccgtcccg gcgtaggtgg cgtggccgac
      121 cggaccccca actggcgcct ctccccgcgc ggggtcccga gctaggagat gggaggcaca
      181 gctcgtgggc ctgggcggaa ggatgcgggg ccgcctgggg ccgggctccc gccccagcag
      241 cggaggttgg gggatggtgt ctatgacacc ttcatgatga tagatgaaac caaatgtccc
      301 ccctgttcaa atgtactctg caatccttct gaaccacctc cacccagaag actaaatatg
      361 accactgagc agtttacagg agatcatact cagcactttt tggatggagg tgagatgaag
      421 gtagaacagc tgtttcaaga atttggcaac agaaaatcca atactattca gtcagatggc
      481 atcagtgact ctgaaaaatg ctctcctact gtttctcagg gtaaaagttc agattgcttg
      541 aatacagtaa aatccaacag ttcatccaag gcacccaaag tggtgcctct gactccagaa
      601 caagccctga agcaatataa acaccacctc actgcctatg agaaactgga aataattaat
      661 tatccagaaa tttactttgt aggtccaaat gccaagaaaa gacatggagt tattggtggt
      721 cccaataatg gagggtatga tgatgcagat ggggcctata ttcatgtacc tcgagaccat
      781 ctagcttatc gatatgaggt gctgaaaatt attggcaagg ggagttttgg gcaggtggcc
      841 agggtctatg atcacaaact tcgacagtac gtggccctaa aaatggtgcg caatgagaag
      901 cgctttcatc gtcaagcagc tgaggagatc cggattttgg agcatcttaa gaaacaggat
      961 aaaactggta gtatgaacgt tatccacatg ctggaaagtt tcacattccg gaaccatgtt
     1021 tgcatggcct ttgaattgct gagcatagac ctttatgagc tgattaaaaa aaataagttt
     1081 cagggtttta gcgtccagtt ggtacgcaag tttgcccagt ccatcttgca atctttggat
     1141 gccctccaca aaaataagat tattcactgc gatctgaagc cagaaaacat tctcctgaaa
     1201 caccacgggc gcagttcaac caaggtcatt gactttgggt ccagctgttt cgagtaccag
     1261 aagctctaca catatatcca gtctcggttc tacagagctc cagaaatcat cttaggaagc
     1321 cgctacagca caccaattga catatggagt tttggctgca tccttgcaga acttttaaca
     1381 ggacagcctc tcttccctgg agaggatgaa ggagaccagt tggcctgcat gatggagctt
     1441 ctagggatgc caccaccaaa acttctggag caatccaaac gtgccaagta ctttattaat
     1501 tccaagggca taccccgcta ctgctctgtg actacccagg cagatgggag ggttgtgctt
     1561 gtggggggtc gctcacgtag gggtaaaaag cggggtcccc caggcagcaa agactggggg
     1621 acagcactga aagggtgtga tgactacttg tttatagagt tcttgaaaag gtgtcttcac
     1681 tgggacccct ctgcccgctt gaccccagct caagcattaa gacacccttg gattagcaag
     1741 tctgtcccca gacctctcac caccatagac aaggtgtcag ggaaacgggt agttaatcct
     1801 gcaagtgctt tccagggatt gggttctaag ctgcctccag ttgttggaat agccaataag
     1861 cttaaagcta acttaatgtc agaaaccaat ggtagtatac ccctatgcag tgtattgcca
     1921 aaactgatta gctagtggac agagatatgc ccagagatgc atatgtgtat atttttatga
     1981 tcttacaaac ctgcaaatgg aaaaaatgca agcccattgg tggatgtttt tgttagagta
     2041 gacttttttt aaacaagaca aaacattttt atatgattat aaaagaattc ttcaagggct
     2101 aattacctaa ccagcttgta ttggccatct ggaatatgca ttaaatgact ttttataggt
     2161 caatgcatct ttgttattat cgtcagatgt atttcaactg atgtattata ctattggttt
     2221 aaatctcttt ctctcaagat agaaggtgta gcaaaagtat cccaactact cctcgcttct
     2281 agtgtccctc ggcatctgtt ctggaggggt aatttgggat gtggtgttag ttgtggctga
     2341 gagccagtgc taggtccctt gccccactag gccattctct aggctcattc taggtgaaag
     2401 agctcacagc agactgtggg gtgggggagc accaggaagc tgttggtgac ctggacaact
     2461 ggtgtccctg gttttcagtg actcgctcct cttcccttca gttctctgat gtttggtgtt
     2521 attattttat gttgttattt tgcctctgat ttgtttccta gtcactcaaa gcattttaca
     2581 gaagccttac cactttacta aataaccctg taaggtactg atttaaaaac tgagtcatat
     2641 gcatccctcc tcctttcctc tcccatgccc aaggaagata aaacagcttc tctgccacaa
     2701 ttgacccaga gtggtaaaga tagagaatca gcatgaaaac tgcagttccc cagctttgtg
     2761 gtactccacg gaccagcctc cttgctgcat tttcatagaa tctcttcctt ataaaagtaa
     2821 tcactctcgg ataaacctta ctacagttta aaaatgcttc cctcttctct ttacagctac
     2881 ctgccacttc aatgtgccac atttttcccc ccactttcac gttaagctta atgctattcc
     2941 ctagatctga gtgaacttca gttagaagaa gaaaactaaa aatccagaaa ctggtgataa
     3001 tcaagttttc cctttttatg tttcttaatt ttattctctt caacagcttt tctttttctc
     3061 tgctaagatt taaacagtga gggctgataa taaaactaat tgttaagcca gtgtcctact
     3121 tacaagggtg gagacgggac agaagctaac tcactgctac tgggttttgt ttgttgtttc
     3181 ctgtcccttg ctctatttct gtcctcttcc agaacaaaag tatgctcaag ttctatccta
     3241 aatgtgtgct cttggctggg tattagtggc tcatgcctgt aatcccagca ctttgggagg
     3301 ctgaggtggg tggattcctt gagcccagga gttcaagacc agcctgggca acatggtgaa
     3361 accctgcctc tacaaaaaat acaaaaatta gccaggccta gtggcacatg cctgtaatcc
     3421 cagctacttg ggaggctgag gtgggaggat cacttgagct gagatcatgc cactgcactc
     3481 cagcctaggc aacagagtga gactctgtct aaaaaacaaa ccaaaaaaag tgtgttcttt
     3541 aaagtagaat atttgctttt tacaatatag ttctcagaat gatccagttc catttattat
     3601 tctagaatgt ggtgcaaact caatgacatt ggaagagact ctttttgttg ggcagtgtag
     3661 gaacaagaaa agaaaataaa aatgccatga gtatattatt taaggaactt ttgttttatc
     3721 caaaagtagt catgattgct gtagcatagg ctgtgaaaaa tgagagagtg caaatctctc
     3781 tcatttaaat gtccacagtg gctttagtct cccaagtaca agggccagat ggcagagaac
     3841 agcttaaact gagccttcag cctcattaat aggaggaagt cttggtactt ttggtgacta
     3901 agaaactgga ttatttaaaa ccttaattat ctcctttact cctggtttac agaaggcaat
     3961 aaatatacaa ctcctttaga tccctctaac tcctgctgaa ttttctttct ttttttctaa
     4021 gtctgcatcc tatctcttga ttccattgcc tgaagaagct gtgtgaaatt agtctggtta
     4081 ttggttttct tgtctgatag tggcatcttg atctcttcag atgtcacact aaatgctgct
     4141 cataacccat cctcctcttc tttattcatc actgccttct tcaagggagg tcttgaaact
     4201 gcctcatcta cctcatgatc tgctagtcga gatagtgact ctttggaagt tggtagtcca
     4261 atgtctgctt ccccgcatta accacattgc gtaggtttgg gaattttgca ggtgctaaat
     4321 catcatggcc aggaagatga aacaccttga gaaatgggaa catctcttca ctgtgttctt
     4381 ggatcagcct tctttcaact accaagaaat ggatgatttc tctgccaact ccaggaagta
     4441 gtacagcatg attgaatcct tcttcagtga atcttttcat tgtaacttag ggtgtaaaag
     4501 ctcatatcta ctcaaaaaac tcaaatctac tctttcagta gatatgagct tacattgact
     4561 tatgaatggt tttcctgtag gcccaacagt gtcatgaccc tccagttgaa acaaagcatg
     4621 agttattttt atatcgagtc cttgaactgc tagccaggta gatgtttcct tgaagtccag
     4681 agcaggatcc aagtcagatg aaggaggtgg cacacctggc ttaactgcag atcagggagc
     4741 attgaacctc tacaatttgc tgcattggat ttctgcatgg gtttctcact gaatagtaaa
     4801 ttagagaaaa tgctactttt actattttgc attttatatc aacattagca gcctgttccc
     4861 actcaggtgc tgtccaaggc acatgtttcc ttgggatgtt tggacagaat gatctggctt
     4921 gatgtatttc ttgggctctg gtaccacatc atagagttgg ttaaatgtag ccagcagcag
     4981 tgtcaagaca gctgacactg tcttccaaga gtgaatgcat tggcctttgg aactgctgct
     5041 aaagccatgt gtggggtggc gagcacatct ttaggtggca gcaaggctat atctgattga
     5101 cacagatctg aagtctctaa caccatattg ctgttgtcct gaattttcta acttggagaa
     5161 atttaaggat ctcctgcatt atctaggcag agcatatgtt gaggttgttt tgccagttgt
     5221 tatcagtgtt gaagaactgc tcctgtaagc aaactgttaa aagcattact accccatatg
     5281 catctgatgt acactgtgtt ttggtgtttg tgtttttagt gagagttcta gccagtactg
     5341 tgcctgaact tgggagagaa aggggcctgt ggctgaggtt ggtgcgtgct ctatttctgt
     5401 gtatcgaatg gactacaagg ttactgaaac tgggctaagg gaaagtgtat agacaactca
     5461 ttacactgta gacagatttt agaaagctac aggaaggcaa atggatgttt ctgcctcaat
     5521 ttggcaaccg agagagtgat gcagagcaga gtcattgaag ttggcatacc tgtcttctgc
     5581 aggccaattc aagtttgagg agagtgggct gcttaaaaac atggtgctcg tccacatgga
     5641 tttgaggaag tttatggttg ggtttcaagc ttagggacaa gttgtggttt ttagaggcag
     5701 taactctatg ccaccttatt ggccactgtt aaaagtttca cttggatccc tgcccagcca
     5761 tagcaatgag tgactgaatt ggatcagagt tagtacagaa attcagactg tctcttcctc
     5821 agttactgga ttgttcttta gccatttttc ttctagtcat ttcagtcaaa ctggttaggt
     5881 taggtgactt actgagttct aaattgacaa attttaattt ccaagttgtt tctgacacgg
     5941 tgagagttgg gttagaattt ttatttcatt ccccaagtca ttttttcttt ttctttattt
     6001 tttctttttg agacagagtc tcgctctgtc gtccaggctg gagtgaagtg gcgcagtgtt
     6061 gtctgcagcc tcaacctccc aggctcaggt gattctccca tctcaacctc cagagtaact
     6121 gggactacag tcacgtgcta ccatgcctgg ctaatttttt gtatatctgt agagaggggg
     6181 tttcaccatg ttgctcgggc tggtcttgaa ctcctgggct caagtgatcc atgtgcctta
     6241 ccctctcaaa gtgctgggat tataggtgtg agcgaccgtg cccagcctca ttttttcttt
     6301 caatatggaa aattggctaa tccacctaat acctgctcat cttctagtat tctatcctac
     6361 catctaccct cagagttatt gatgtactct ttcatcatgt gctatcatga tttctcctta
     6421 gattagaaag taagcttcaa atgggagtgt gtcttcatat tgttctgaat taacagattt
     6481 tgatgcccgc tgatcatgtg cagatgatgg aagctcattt ccttccatga accaggagca
     6541 tgctcgcctc ttcttttaag ttgacccaca caatctctga tgtcttcttt ttgggaaagg
     6601 gtaatgagat aaggattaag gacattttct tctggtccag tgttagatac agttaccttg
     6661 ataataatga aaaaaaaatg aataccacca aaacctaact atgatgtaag gattctgctt
     6721 ctgccccaca ggggctctga aagagtctag cctggatctt ctttcccaga ggaagtttga
     6781 cttatgacca tattagtatg ctttattcct tggtgtttaa gggagttggg gcagacaggt
     6841 tagctggcta atgtcattac aatttagttt ttgtgacaat ctgttaagaa gggggcttat
     6901 tgcataatca aaaaagaaca ataaaaaaat aaaaatttct actgtgaaac tatttcaatc
     6961 tgtagcagct ggtcatgtta aaacactttc tgttttgctt aattcgtaac taggcataat
     7021 taaagttaaa tgctaaattt taggtagcag ctgataaatg gttctaagct ttcctgacag
     7081 aatactccta ctactttggt gaatcatgga aaactctttc tcctttattt ttaattattt
     7141 cttttccatc tgttattgat gtcatcaaca cggaagttgg aaaggtgaca atgattgttc
     7201 tagactgcct ctgtaatgct ttttctcctc tgagaattaa aaatacatac ttacaccttg
     7261 agccaggtag aattgccaga acatgttttc ctccgtgtct tcggtctaga tgaccaatct
     7321 gtagaacgct ataacttact atgcgtagag cagcggcagg cattcatgct atggaaaacc
     7381 tggagtcagt acaaataagg agtaagaaaa ggccagggat tggcaaatca aagaagagtt
     7441 ctcttctgcc agggattagc ctcctagttt taaatatatt tttaatatcc ccattttaac
     7501 atactccatt ttcaccttca acctatcctt cctgaagccc aaacttttaa agaatttact
     7561 tccagacctg gccttcagcc taatatgatt agggtgtttt tctgagtgtc tgtcaaatta
     7621 tgctggctaa tttcaatgag aaaagatttt agagtcacag tgaacccatc cataaaagga
     7681 ctaaaagctc tctctggtcc ctgagatcca caacccctga gagaagccag aactacaaat
     7741 gcatcgtcta gactttgaag aagcagggta tgattcttaa tatagcccac ccatcgctaa
     7801 gtcaagccta gactctaata tttttctata acaggagaag cctccctgac tggagactag
     7861 agtctcacat cttctgccac cacatgaata gactaaaaag aaaggagagt cccacatcag
     7921 gccaagtggt gacctgtggc tatttcagct cagaatgtca gcctctgaag catcaggttt
     7981 gaatgacttt ggtgtcatgg gattctgtcc attgtccgtt tgagtctgct gacatgcttc
     8041 ctctggaaag tgcagtttgg catggatgag tcagtggttt tttattttgg ggtgtttttt
     8101 aaaaaataaa aatgaattgc tttgagaa
//
