LOCUS       NM_006482               8888 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens dual specificity tyrosine phosphorylation regulated
            kinase 2 (DYRK2), transcript variant 2, mRNA.
ACCESSION   NM_006482
VERSION     NM_006482.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8888)
  AUTHORS   Yoshida,S., Kawamura,A., Aoki,K., Wiriyasermkul,P., Sugimoto,S.,
            Tomiyoshi,J., Tajima,A., Ishida,Y., Katoh,Y., Tsukada,T.,
            Tsuneoka,Y., Yamada,K., Nagamori,S., Nakayama,K. and Yoshida,K.
  TITLE     Positive regulation of Hedgehog signaling via phosphorylation of
            GLI2/GLI3 by DYRK2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320070121 (2024)
   PUBMED   38968120
  REMARK    GeneRIF: Positive regulation of Hedgehog signaling via
            phosphorylation of GLI2/GLI3 by DYRK2 kinase.
REFERENCE   2  (bases 1 to 8888)
  AUTHORS   Harada,E., Yoshida,S., Imaizumi,Y., Kawamura,A., Ohtsuka,T. and
            Yoshida,K.
  TITLE     Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor
            effects by induction of G1 arrest in lung adenocarcinoma
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (6), 130600 (2024)
   PUBMED   38508285
  REMARK    GeneRIF: Dual-specificity tyrosine-regulated kinase 2 exerts
            anti-tumor effects by induction of G1 arrest in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 8888)
  AUTHORS   Jimenez-Izquierdo,R., Morrugares,R., Suanes-Cobos,L.,
            Correa-Saez,A., Garrido-Rodriguez,M., Cerero-Tejero,L., Khan,O.M.,
            de la Luna,S., Sancho,R. and Calzado,M.A.
  TITLE     FBXW7 tumor suppressor regulation by dualspecificity
            tyrosine-regulated kinase 2
  JOURNAL   Cell Death Dis 14 (3), 202 (2023)
   PUBMED   36934104
  REMARK    GeneRIF: FBXW7 tumor suppressor regulation by dualspecificity
            tyrosine-regulated kinase 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8888)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 8888)
  AUTHORS   Tandon,V., Moreno,R., Allmeroth,K., Quinn,J., Wiley,S.E.,
            Nicely,L.G., Denzel,M.S., Edwards,J., de la Vega,L. and Banerjee,S.
  TITLE     Dual inhibition of HSF1 and DYRK2 impedes cancer progression
  JOURNAL   Biosci Rep 43 (1) (2023)
   PUBMED   36622366
  REMARK    GeneRIF: Dual inhibition of HSF1 and DYRK2 impedes cancer
            progression.
REFERENCE   6  (bases 1 to 8888)
  AUTHORS   Taira,N., Nihira,K., Yamaguchi,T., Miki,Y. and Yoshida,K.
  TITLE     DYRK2 is targeted to the nucleus and controls p53 via Ser46
            phosphorylation in the apoptotic response to DNA damage
  JOURNAL   Mol Cell 25 (5), 725-738 (2007)
   PUBMED   17349958
  REMARK    GeneRIF: These findings indicate that DYRK2 regulates p53 to induce
            apoptosis in response to DNA damage.
REFERENCE   7  (bases 1 to 8888)
  AUTHORS   Gwack,Y., Sharma,S., Nardone,J., Tanasa,B., Iuga,A., Srikanth,S.,
            Okamura,H., Bolton,D., Feske,S., Hogan,P.G. and Rao,A.
  TITLE     A genome-wide Drosophila RNAi screen identifies DYRK-family kinases
            as regulators of NFAT
  JOURNAL   Nature 441 (7093), 646-650 (2006)
   PUBMED   16511445
REFERENCE   8  (bases 1 to 8888)
  AUTHORS   Wang,X., Li,W., Parra,J.L., Beugnet,A. and Proud,C.G.
  TITLE     The C terminus of initiation factor 4E-binding protein 1 contains
            multiple regulatory features that influence its function and
            phosphorylation
  JOURNAL   Mol Cell Biol 23 (5), 1546-1557 (2003)
   PUBMED   12588975
REFERENCE   9  (bases 1 to 8888)
  AUTHORS   Woods,Y.L., Cohen,P., Becker,W., Jakes,R., Goedert,M., Wang,X. and
            Proud,C.G.
  TITLE     The kinase DYRK phosphorylates protein-synthesis initiation factor
            eIF2Bepsilon at Ser539 and the microtubule-associated protein tau
            at Thr212: potential role for DYRK as a glycogen synthase kinase
            3-priming kinase
  JOURNAL   Biochem J 355 (Pt 3), 609-615 (2001)
   PUBMED   11311121
REFERENCE   10 (bases 1 to 8888)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461362.1, BC005809.2,
            BC006375.2, DA768075.1, CN303286.1, AK025018.1 and AC078777.15.
            
            On Jun 2, 2019 this sequence version replaced NM_006482.2.
            
            Summary:  DYRK2 belongs to a family of protein kinases whose
            members are presumed to be involved in cellular growth and/or
            development.  The family is defined by structural similarity of
            their kinase domains and their capability to autophosphorylate on
            tyrosine residues.  DYRK2 has demonstrated tyrosine
            autophosphorylation and catalyzed phosphorylation of histones H3
            and H2B in vitro.  Two isoforms of DYRK2 have been isolated.  The
            predominant isoform, isoform 1, lacks a 5' terminal insert.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant:  This variant (2) includes the 149 bp insert in
            the 5' end of the transcript and thus results in a longer
            amino-terminal protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.151541.1,
                                           SRR1660809.228246.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344096.4/ ENSP00000342105.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DB461362.1         19-51
            34-438              BC005809.2         1-405
            439-587             BC006375.2         263-411
            588-1879            BC005809.2         406-1697
            1880-2386           BC006375.2         1704-2210
            2387-2391           BC005809.2         2205-2209
            2392-2613           DA768075.1         35-256
            2614-3176           CN303286.1         35-597
            3177-3853           AK025018.1         531-1207
            3854-6146           AC078777.15        18369-20661         c
            6147-8888           AC078777.15        15627-18368         c
FEATURES             Location/Qualifiers
     source          1..8888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..8888
                     /gene="DYRK2"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 2"
                     /db_xref="GeneID:8445"
                     /db_xref="HGNC:HGNC:3093"
                     /db_xref="MIM:603496"
     exon            1..438
                     /gene="DYRK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..2195
                     /gene="DYRK2"
                     /EC_number="2.7.12.1"
                     /note="isoform 2 is encoded by transcript variant 2; dual
                     specificity tyrosine-(Y)-phosphorylation regulated kinase
                     2"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 2 isoform 2"
                     /protein_id="NP_006473.2"
                     /db_xref="CCDS:CCDS8978.1"
                     /db_xref="GeneID:8445"
                     /db_xref="HGNC:HGNC:3093"
                     /db_xref="MIM:603496"
                     /translation="MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGT
                     GPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRT
                     VLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAM
                     KQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHV
                     AYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQ
                     DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQ
                     CLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPE
                     VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK
                     RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLF
                     LDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKL
                     PPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS"
     exon            439..587
                     /gene="DYRK2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..8888
                     /gene="DYRK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6122..6127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK2"
                     /note="hexamer: AATAAA"
     polyA_site      6146
                     /gene="DYRK2"
                     /note="major polyA site"
     regulatory      7342..7347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK2"
                     /note="hexamer: AATAAA"
     polyA_site      7365
                     /gene="DYRK2"
                     /note="major polyA site"
     regulatory      8622..8627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK2"
                     /note="hexamer: AATAAA"
     polyA_site      8646
                     /gene="DYRK2"
                     /note="major polyA site"
     regulatory      8871..8876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK2"
                     /note="hexamer: AATAAA"
     polyA_site      8888
                     /gene="DYRK2"
ORIGIN      
        1 gcgcgcgggc ccgggagagg ctcccgagcc aggcggtctt cggtcctcgc agcgcttcca
       61 gctccccgcg cccctatgtg agggagacgg ggaggcccgc ggcgcgcagg ggagggcgag
      121 gcatgtgcac gggccggagg gtgctgcagc cgcccgagga agaggaggac ggcggcgagg
      181 aggagagcgg ggggctcgcg gcggcgggcc ccggccgagg ggatgcagtg gactgtgtgt
      241 gtctggctgt agcagacgcg aggcggcgac gaggcgccgg ggacccgcgc gaggggcggc
      301 cgggaggcgg cggcggcggc cgccagaagt agcagcagga ccggcggcgg cgacggcagc
      361 cctgaaatgc attttcctct ccagcggcca tgttaaccag gaaaccttcg gccgccgctc
      421 ccgccgccta cccgaccggc cgaggtgggg acagcgccgt tcgtcagctt caggcttccc
      481 cggggctcgg tgcaggggcc acccggagcg gagtggggac tggcccgccc tcccccatcg
      541 ccctgccgcc tctccgggcc agcaacgctg ccgccgcagc ccacacgatt ggcggcagta
      601 agcacacaat gaatgatcac ctgcatgtcg gcagccacgc tcacggacag atccaggttc
      661 aacagttgtt tgaggataac agtaacaagc ggacagtgct cacgacacaa ccaaatgggc
      721 ttacaacagt gggcaaaacg ggcttgccag tggtgccaga gcggcagctg gacagcattc
      781 atagacggca ggggagctcc acctctctaa agtccatgga aggcatgggg aaggtgaaag
      841 ccacccccat gacacctgaa caagcaatga agcaatacat gcaaaaactc acagccttcg
      901 aacaccatga gattttcagc taccctgaaa tatatttctt gggtctaaat gctaagaagc
      961 gccagggcat gacaggtggg cccaacaatg gtggctatga tgatgaccag ggatcatatg
     1021 tgcaggtgcc ccacgatcac gtggcttaca ggtatgaggt cctcaaggtc attgggaagg
     1081 ggagctttgg gcaggtggtc aaggcctacg atcacaaagt ccaccagcac gtggccctaa
     1141 agatggtgcg gaatgagaag cgcttccacc ggcaagcagc ggaggagatc cgaatcctgg
     1201 aacacctgcg gaagcaggac aaggataaca caatgaatgt catccatatg ctggagaatt
     1261 tcaccttccg caaccacatc tgcatgacgt ttgagctgct gagcatgaac ctctatgagc
     1321 tcatcaagaa gaataaattc cagggcttca gtctgccttt ggttcgcaag tttgcccact
     1381 cgattctgca gtgcttggat gctttgcaca aaaacagaat aattcactgt gaccttaagc
     1441 ccgagaacat tttgttaaag cagcagggta gaagcggtat taaagtaatt gattttggct
     1501 ccagttgtta cgagcatcag cgtgtctaca cgtacatcca gtcgcgtttt taccgggctc
     1561 cagaagtgat ccttggggcc aggtatggca tgcccattga tatgtggagc ctgggctgca
     1621 ttttagcaga gctcctgacg ggttaccccc tcttgcctgg ggaagatgaa ggggaccagc
     1681 tggcctgtat gattgaactg ttgggcatgc cctcacagaa actgctggat gcatccaaac
     1741 gagccaaaaa ttttgtgagc tccaagggtt atccccgtta ctgcactgtc acgactctct
     1801 cagatggctc tgtggtccta aacggaggcc gttcccggag ggggaaactg aggggcccac
     1861 cggagagcag agagtggggg aacgcgctga aggggtgtga tgatcccctt ttccttgact
     1921 tcttaaaaca gtgtttagag tgggatcctg cagtgcgcat gaccccaggc caggctttgc
     1981 ggcacccctg gctgaggagg cggttgccaa agcctcccac cggggagaaa acgtcagtga
     2041 aaaggataac tgagagcacc ggtgctatca catctatatc caagttacct ccaccttcta
     2101 gctcagcttc caaactgagg actaatttgg cgcagatgac agatgccaat gggaatattc
     2161 agcagaggac agtgttgcca aaacttgtta gctgagctca cgtcccctga tgctggtaac
     2221 ctgaaagata cgacattgct gagccttact gggttgaaaa ggagtagctc agacctgttt
     2281 ttatttgctc aataactcta ctcatttgta tcttttcagc acttaatttt aatgtaagaa
     2341 agttgttcat tttgttttta taaaatacat gaggacaatg ctttaagttt ttatactttc
     2401 agaaactttt tgtgttctaa aagtacaatg agccttactg tatttagtgt ggcagaataa
     2461 taacatcagt ggcaggccac tgattacttc atgactgcca cgcatttaca gattggtgtc
     2521 aaagacattc actatgtttt tatggttcat gttatatcct ccccagggtg acagcccctt
     2581 aaggccctcc ttttccctcc atgctccagg tccatgcaca ggtgtagcat gtcctgcttc
     2641 cgtttttcat aaattaatct gggtgttggg ggtagtggga ggagaacggt cagaatcaaa
     2701 gtgacattct aagaaaaact gtaccttaga gattttcctc tagtgctcaa acaaatacaa
     2761 aataagatcc ccaaggttta aactgcccag ttagcattct gacattctaa aagccggcaa
     2821 agcagctttt agtggataaa tgggaatgga aacgtgtgtg ttcctccaaa ttttctagta
     2881 tgatcggtga gctgttttgt aaagaagcct catattacag agttgctttt gcacctaaat
     2941 ttagaattgt attccatgaa ctgttcctcc cttttctctg cttttctcct ctctgttcct
     3001 cttttaatac cacacgtctg ttgcttgcat ttagtttgtc ttcttccttc agctgtgtat
     3061 cccagactgt taatacagaa aagagacatt tcagctgtga ttatgaccat tgtttcatat
     3121 tccaattaaa aaaagaacag cagcctagct acttaaggtg gggatttcca tagttccaaa
     3181 gaagatttag cagattagag tgagttcaca cttttcaggt gccactgtaa ggttctctca
     3241 gcctgggaaa ctatcaactc tttctttaaa aagaaagagg gttgaaaatc ctctggacga
     3301 acagaagtca ctttggctgt tcagtaaggc caatgttaac aacacgttta gaggaggaaa
     3361 agttcaacct caagttaaat ggtttgactt attcttcgta tcattagaag aaccccagag
     3421 atagcattcc tctattttat tttactttct tttggattgc actgattgtt tttgtgggaa
     3481 tgacacttta tctggcaaag taactgagag tttggtaaaa gaatattttc ttctctgaat
     3541 aataattatt ttcacagtga aaatttcagt attttatcac taatgtatga gcaatgatct
     3601 atatcaattt caaggcacgt gaaaaaaatt ttttagtatg tgcaatttaa tatagaaaga
     3661 tttctgcctg tttggacaat aggttttggg tagtacagat taggataagt aagcttatat
     3721 atgcacagag attattgtat tacctgtaaa ttgatttaca agtacttaaa agcgtggtcc
     3781 ccagtgaggc caagaaagtt tccggttaag ttctttaata ataatcctac agtttatctt
     3841 aagaaaaaaa aaaaggtttg aaaaaaacac tttaatttag gcttcgttgg ttgatggtgg
     3901 aaaaaaatgc tcaggaaata tttcagatat ttgccaaaaa accagtaata aggttacctt
     3961 attaaaatag tgatatttgc tttactattt aaggtgtcac tgataaatta atttgtactt
     4021 ctgtgtttag aaattatagc ttcttttccc ttagtcaaat tttttagcat attatacaca
     4081 tttctgtgta atctgtggaa gtgcaataat atgttagtaa gttacatttt aaataatgct
     4141 catgtgacaa tactcccaat caatggctta tagaatttaa agatctgtat attagatttt
     4201 ggcttaaagg catgagaagt ataagacttg gtttggtggc tttgtaagac caccagcctc
     4261 ttaatgatgg ttagcttctt taggtcatta aatcaataaa aacatataat gctgttttgc
     4321 tcttctaatg ctcctcttcc atttccagtt atcttcacat ttacatttaa atatacaaac
     4381 ctgagcctgc cattattaat ttccctataa aatgacgata catgtgaaca tttataaatg
     4441 gactaatact gcttgtcttt cccccaccgc acaaaactgg ttcttaagat gccagcaatg
     4501 aatttgagac tatctttatt tataaatgga aaccggaaac ttttatacca aactataata
     4561 atgtgcagca ctgtagggct tttttttttt tccctccaaa tacagtgaaa tttttttatt
     4621 cacaagagct gccacatctc agcatttagt aatagagctg ctttaataaa attctagttt
     4681 gattgtcatg tcaaaaaaag aaaaatgttg catctttgtg attttaaaac ataaattaat
     4741 gaaggctctg ataggctatt aggagttggc ttggaaacag tttttggtct cacaggttac
     4801 cattgtttgg ggatgtctga gctgttttca gatctaggaa tagcacagtg ttgtcttgtc
     4861 tttggcagtc tcatttggct ctgtttcttg caccaccagc gtgttcatta ccacttaaat
     4921 atattgctac agcagtggaa caacagagtg gtgcaagaca ctgtagatta acggtagagg
     4981 agaaattgtg cccttagtgt taacaatgtg ccttttgttc tgaatgccat gttgtagggc
     5041 atgcattttt tggcctcttt aactcttcga attctagtca gtaagaatgg aacccatctc
     5101 tgcaaagata catctgtctt aaatatctag ttacaggcct taatagaaac cataaggcat
     5161 gactcatctt caggcactga aaaaagataa ccatcaggta gtgttacaca aggacttcct
     5221 atatttaagg ggttaaagat ggtctttgtt gtatcttaac atcagactga tttttacatt
     5281 ttttttttgt tatgctaaca ctagacaaaa atcaactgta tttgtaaaaa tttacctcaa
     5341 accatttaat tttatagtgt gattaatccc agggcatttg gtatgaacca aagtgcattc
     5401 cttttatatg tgcctggctc tagtaaggat ggccagggat ttttacaatt tgggtgcaag
     5461 gcacttaagc cacttttaaa cttaatgggt ggtttggggt cgtgttaaat gactccatca
     5521 gaatgttaga aaacacttta ggcatcagta gcattgggcc atattggaat cctaaagtgt
     5581 gaattatttt aaggagagca ttcatttttg taattttttt catcaaaaat atttctggta
     5641 agcagaagac tttttaaaaa aactgatctg gtctcggtaa aggttttaat attgcccaac
     5701 ataatgctgt aatagcatta aaaaaagtat ttgtgaactc tgtttcttag gggcttgtac
     5761 atctctctgc tatggacata cataaaatta attgtaatta tactcagctc aactgctaca
     5821 gttctgtcta ggcagtggct tgggttttta tcgagcaaca acttagacac gtgactgtaa
     5881 tatgctgcaa ctgtgtgtac tgaaaatatg tgaaaatggt tgaatgtgga ctgtgtatat
     5941 atgtatgtaa aaatttctgt gagatgctgc tgtcgccact taacattaaa tatgttctag
     6001 tggattttaa tcctagtggc cagttctatg atactgtatg tattatacag ctgatgacag
     6061 gagtaagact gtttagtgaa tatctgttaa attttattgt tgtggccaga gataatttca
     6121 gaataaaatt ttaatgtcct accttacttc tctccccttt ctaactataa tttaactcct
     6181 gatctatttc tggtattatc ctttgtcaat tagcctggag agggtttaga atgcaaaatg
     6241 gatagctcta tatcagggtc ttgagaagtt aaaataattc attctactag tttgttcata
     6301 gcaatacttt attagttcaa tataagtatg cagattccaa gtggaaaaac aaaggtttta
     6361 gtaagtagtt cttgcttttc ccaggatatt ctattccttc acctgtcaga tttttatgtt
     6421 aactttttta tatatagcct ctgctgtgtt ctttattatg ctagagcttc atatcttctt
     6481 ttattttaac cttcacaatg atagttaagc tgggggagca gaacctgtca attattcccc
     6541 accagtcttc attcttttct ctgcacaagt tctggtaaat tattctaatg tgctctaacc
     6601 agttccaccc aatgtttttt aatgcttatg agtttgcagt ttttgtactt ggtggtctct
     6661 gtggttcaca tttttttgtg ttgtagtgtc tcctgcctcg gttggctcag aaaataaggc
     6721 ctaggaactg caattagctc atgatttgtc aagttcagtt agtaccaagc taagagttta
     6781 cttacagatg acagcaagca gatgctctag taattcgtca gacattgcag ggatattgtg
     6841 tagtcagata ttaccctctt gtggaaagaa ctacctcaca tcattattta tttcccttct
     6901 gttaccaaca gccaaggaat tacttagtgt ggctccctgc atcaatactg ggatatgctt
     6961 aaacaaggga atgccataag agttcccaat tgcctcgtca tagcctgggc catagatttt
     7021 tgttactgct aatcttgctt cttaaagttc acacccagtg caaaaaaccc aatcagcaaa
     7081 ctaaccccaa aatccaatat atttagaaat gtaagtgtta agagatgtgc attatgtaca
     7141 aaattgaaaa ttggtgctaa agtggcaatg tcaatttaaa atttcttgtc cagatctgac
     7201 tgactgactc aggagattat agttcctact cattctcttt ccttttatca gatctttcaa
     7261 aagcgctttt taaaattgat caatgtgcaa ttctgtttga gtctctacag tcctatccct
     7321 tttggaatga acagctacac aaataaatat tcttggaact tcgaagttgt cttcaaacta
     7381 gctctagaaa atgtccctag ttgacattag tgttggtctg ttagaagggg aaattgattt
     7441 gactgcttca tgttttgaaa agagcattaa gagggatttg aggaaggtat atgtggcttt
     7501 cttttttttt cttaagtttg aattacactt gatttccttt gggttattag gcagataaac
     7561 ccttgtcatt agtaatactt agcactgtcc aaaatgaaaa atgactgcca gtgtgttgca
     7621 catacataag aaaattacat cttactgcga agtctttggt ttgtttcctt atttggtttg
     7681 actttgactt actattttgc tatggtcata tccttaatat ctgcggtaca tttcatatat
     7741 atatatgggg tgggagcata attgccattc ccatgtgtct caaggaagct taatgaggaa
     7801 actaatgagt taatattaac tcttctgaag aaagctgaca ttttaggagt attaagtcat
     7861 ctgtcgttaa ggagcagcaa gaatatatta tgattgtatc acatgttcca gaagagcatt
     7921 accccttaca tagaaagctc cttggagatt tcatgatgtt ggatgaacat cagtttatcc
     7981 ttatacatcc ctatgagcta taattatcct catttgatac ttgaggaaac tgaagtgact
     8041 tgctccaaag ttgactacaa aaacattgca gtttgaggct taggttgtaa tcaggtaatt
     8101 ttggtcttgg acagtaaggg aaaatccata atacataaaa cacaaaagtt tagaaagggg
     8161 gggaagttga gctagcaatg ggcatttcta ttatttaagt tacatatcag tttccaggaa
     8221 tatttttcaa atgggacaaa ctaaaaagtt gaggactaga gcatcgtagt gtctaagtgc
     8281 acctaataac ttaatgcatg tgcacacacc ctcagttaat ttgtaagaga gtgacttctc
     8341 attgttattt gtggagaggc taattatagt agcttcattc tttattttct gtgttcttaa
     8401 attttttttt acatttgaaa gtatgaaaat actatttttg acactttact gatactcagg
     8461 gattaaaagt taaattttac tgactgtagc agcaggtaaa tctcttaaat ttactcaggt
     8521 ttcctatcct ttgcctccat atttaagaaa atatagaatg cctgccaggg aaatatataa
     8581 aaataaaaat ttcaaataca attttaaaat accaatttgt aaataaacca attttacaaa
     8641 ctaaaatatt gtgtctttcc ttgcttttta tcccaattta tctcccctcc taagtttgag
     8701 gagttttata tattaaggct atttcttcat ttgtaaaaat gaagtatgct atttgcaaag
     8761 caaaagccca tgaaaagccc caaatcattt aagtaaagct tactgaattg ttttcaattg
     8821 ttttgggaga aatgtaacta attataagca atttatgtgg accagcagca aataaatgta
     8881 tgagtaca
//
