LOCUS       NM_004714               2496 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens dual specificity tyrosine phosphorylation regulated
            kinase 1B (DYRK1B), transcript variant 1, mRNA.
ACCESSION   NM_004714
VERSION     NM_004714.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2496)
  AUTHORS   Folon,L., Baron,M., Scherrer,V., Toussaint,B., Vaillant,E.,
            Loiselle,H., Dechaume,A., De Pooter,F., Boutry,R., Boissel,M.,
            Diallo,A., Ning,L., Balkau,B., Charpentier,G., Franc,S., Marre,M.,
            Derhourhi,M., Froguel,P. and Bonnefond,A.
  TITLE     Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic
            Obesity Associated With Type 2 Diabetes
  JOURNAL   Diabetes Care 47 (3), 444-451 (2024)
   PUBMED   38170957
  REMARK    GeneRIF: Pathogenic, Total Loss-of-Function DYRK1B Variants Cause
            Monogenic Obesity Associated With Type 2 Diabetes.
REFERENCE   2  (bases 1 to 2496)
  AUTHORS   Beckers,C., Vasilikos,L., Sanchez Fernandez,A., Moor,L. and
            Pruschy,M.
  TITLE     Targeting the survival kinase DYRK1B: A novel approach to overcome
            radiotherapy-related treatment resistance
  JOURNAL   Radiother Oncol 190, 110039 (2024)
   PUBMED   38040123
  REMARK    GeneRIF: Targeting the survival kinase DYRK1B: A novel approach to
            overcome radiotherapy-related treatment resistance.
REFERENCE   3  (bases 1 to 2496)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 2496)
  AUTHORS   Armanmehr,A., Jafari Khamirani,H., Zoghi,S. and Dianatpour,M.
  TITLE     Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in
            Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and
            Healthy Individuals During Adipogenesis
  JOURNAL   Metab Syndr Relat Disord 20 (10), 576-583 (2022)
   PUBMED   36318489
  REMARK    GeneRIF: Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns
            in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C
            and Healthy Individuals During Adipogenesis.
REFERENCE   5  (bases 1 to 2496)
  AUTHORS   Leder,S., Czajkowska,H., Maenz,B., De Graaf,K., Barthel,A.,
            Joost,H.G. and Becker,W.
  TITLE     Alternative splicing variants of dual specificity tyrosine
            phosphorylated and regulated kinase 1B exhibit distinct patterns of
            expression and functional properties
  JOURNAL   Biochem J 372 (Pt 3), 881-888 (2003)
   PUBMED   12633499
REFERENCE   6  (bases 1 to 2496)
  AUTHORS   Lim,S., Zou,Y. and Friedman,E.
  TITLE     The transcriptional activator Mirk/Dyrk1B is sequestered by
            p38alpha/beta MAP kinase
  JOURNAL   J Biol Chem 277 (51), 49438-49445 (2002)
   PUBMED   12384504
  REMARK    GeneRIF: p38 MAP Kinase suppresses the function of Mirk as a
            transcriptional activator only when cells are proliferating
REFERENCE   7  (bases 1 to 2496)
  AUTHORS   Lim,S., Jin,K. and Friedman,E.
  TITLE     Mirk protein kinase is activated by MKK3 and functions as a
            transcriptional activator of HNF1alpha
  JOURNAL   J Biol Chem 277 (28), 25040-25046 (2002)
   PUBMED   11980910
  REMARK    GeneRIF: activation by MKK2 and role as transcriptional activator
            of HNF1alpha
            Erratum:[J Biol Chem. 2004 Feb 6;279(6):5047]
REFERENCE   8  (bases 1 to 2496)
  AUTHORS   Lee,K., Deng,X. and Friedman,E.
  TITLE     Mirk protein kinase is a mitogen-activated protein kinase substrate
            that mediates survival of colon cancer cells
  JOURNAL   Cancer Res 60 (13), 3631-3637 (2000)
   PUBMED   10910078
REFERENCE   9  (bases 1 to 2496)
  AUTHORS   Leder,S., Weber,Y., Altafaj,X., Estivill,X., Joost,H.G. and
            Becker,W.
  TITLE     Cloning and characterization of DYRK1B, a novel member of the DYRK
            family of protein kinases
  JOURNAL   Biochem Biophys Res Commun 254 (2), 474-479 (1999)
   PUBMED   9918863
REFERENCE   10 (bases 1 to 2496)
  AUTHORS   Becker,W., Weber,Y., Wetzel,K., Eirmbter,K., Tejedor,F.J. and
            Joost,H.G.
  TITLE     Sequence characteristics, subcellular localization, and substrate
            specificity of DYRK-related kinases, a novel family of dual
            specificity protein kinases
  JOURNAL   J Biol Chem 273 (40), 25893-25902 (1998)
   PUBMED   9748265
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y17999.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004714.2.
            
            Summary: This gene encodes a member of a family of
            nuclear-localized protein kinases. The encoded protein participates
            in the regulation of the cell cycle. Expression of this gene may be
            altered in tumor cells, and mutations in this gene were found to
            cause abdominal obesity-metabolic syndrome 3. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2014].
            
            Transcript Variant: This variant (1, also known as 'a') represents
            the longest transcript and encodes the longest isoform (p69, also
            known as isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018751.1, Y17999.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323039.10/ ENSP00000312789.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2496              Y17999.1           40-2535
FEATURES             Location/Qualifiers
     source          1..2496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2496
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /note="dual specificity tyrosine phosphorylation regulated
                     kinase 1B"
                     /db_xref="GeneID:9149"
                     /db_xref="HGNC:HGNC:3092"
                     /db_xref="MIM:604556"
     exon            1..140
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            141..304
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2131
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /EC_number="2.7.12.1"
                     /note="isoform p69 is encoded by transcript variant 1;
                     minibrain-related kinase; mirk protein kinase; dual
                     specificity tyrosine-(Y)-phosphorylation regulated kinase
                     1B"
                     /codon_start=1
                     /product="dual specificity
                     tyrosine-phosphorylation-regulated kinase 1B isoform p69"
                     /protein_id="NP_004705.1"
                     /db_xref="CCDS:CCDS12543.1"
                     /db_xref="GeneID:9149"
                     /db_xref="HGNC:HGNC:3092"
                     /db_xref="MIM:604556"
                     /translation="MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAP
                     LRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVR
                     SGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE
                     LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLA
                     QQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQS
                     RFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPA
                     AMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAG
                     EPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSAST
                     SPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVP
                     PSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDV
                     SLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQS
                     TAASS"
     exon            305..424
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            425..613
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            614..761
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1048
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1195
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1336
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1652
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1759
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..2496
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /note="hexamer: AGTAAA"
     polyA_site      2496
                     /gene="DYRK1B"
                     /gene_synonym="AOMS3; MIRK"
                     /note="major polyA site"
ORIGIN      
        1 gttgtggtcg ccattttgct ggttgcatta ctgggtaatc ggggccctgg cttgccgcgt
       61 ccgccggata ccctcagcca gtgggcaggt ctgagctcgg gctccccgag cagtttgagt
      121 ccccttgccc gctccttcag gtctcagcgg cggtggcagc cgaggtgcag gatgcaagaa
      181 ggcgcccccc ggccgggctc ccgctccagg cctcgctccc ctgcggccct ctgagcccac
      241 catggccgtc ccaccgggcc atggtccctt ctctggcttc ccagggcccc aggagcacac
      301 gcaggtattg cctgatgtgc ggctactgcc tcggaggctg cccctggcct tccgggatgc
      361 aacctcagcc ccgctgcgta agctctctgt ggacctcatc aagacctaca agcacatcaa
      421 tgaggtatac tatgcgaaga agaagcggcg ggcccagcag gcgccacccc aggattcgag
      481 caacaagaag gagaagaagg tcctgaacca tggttatgat gacgacaacc atgactacat
      541 cgtgcgcagt ggcgagcgct ggctggagcg ctacgaaatt gactcgctca ttggcaaagg
      601 ctcctttggc caggtggtga aagcctatga tcatcagacc caggagcttg tggccatcaa
      661 gatcatcaag aacaaaaagg ctttcctgaa ccaggcccag attgagctgc ggctgctgga
      721 gctgatgaac cagcatgaca cggagatgaa gtactatata gtacacctga agcggcactt
      781 catgttccgg aaccacctgt gcctggtatt tgagctgctg tcctacaacc tgtacgacct
      841 cctgcgcaac acccacttcc gcggcgtctc gctgaacctg acccggaagc tggcgcagca
      901 gctctgcacg gcactgctct ttctggccac gcctgagctc agcatcattc actgcgacct
      961 caagcccgaa aacatcttgc tgtgcaaccc caagcgcagc gccatcaaga ttgtggactt
     1021 cggcagctcc tgccagcttg gccagaggat ctaccagtat atccagagcc gcttctaccg
     1081 ctcacctgag gtgctcctgg gcacacccta cgacctggcc attgacatgt ggtccctggg
     1141 ctgcatcctt gtggagatgc acaccggaga gcccctcttc agtggctcca atgaggtcga
     1201 ccagatgaac cgcattgtgg aggtgctggg catcccaccg gccgccatgc tggaccaggc
     1261 gcccaaggct cgcaagtact ttgaacggct gcctgggggt ggctggaccc tacgaaggac
     1321 gaaagaactc aggaaggatt accagggccc cgggacacgg cggctgcagg aggtgctggg
     1381 cgtgcagacg ggcgggcccg ggggccggcg ggcgggggag ccgggccaca gccccgccga
     1441 ctacctccgc ttccaggacc tggtgctgcg catgctggag tatgagcccg ccgcccgcat
     1501 cagccccctg ggggctctgc agcacggctt cttccgccgc acggccgacg aggccaccaa
     1561 cacgggcccg gcaggcagca gtgcctccac ctcgcccgcg cccctcgaca cctgcccctc
     1621 ttccagcacc gccagctcca tctccagttc tggaggctcc agtggctcct ccagtgacaa
     1681 ccggacctac cgctacagca accgatattg tgggggccct gggcccccta tcacagactg
     1741 tgagatgaac agcccccagg tcccaccctc ccagccgctg cggccctggg cagggggtga
     1801 tgtgccccac aagacacatc aagcccctgc ctctgcctcg tcactgcctg ggaccggggc
     1861 ccagttaccc ccccagcccc gataccttgg tcgtccccca tcaccaacct caccaccacc
     1921 cccggagctg atggatgtga gcctggtggg cggccctgct gactgctccc cacctcaccc
     1981 agcgcctgcc ccccagcacc cggctgcctc agccctccgg actcggatga ctggaggtcg
     2041 tccacccctc ccgcctcctg atgaccctgc cactctgggg cctcacctgg gcctccgtgg
     2101 tgtaccccag agcacagcag ccagctcgtg accctgcccc ctccctgggg cccctcctga
     2161 agccataccc tcccccatct gggggccctg ggctcccatc ctcatctctc tccttgactg
     2221 gaattgctgc tacccagctg gggtgggtga ggcctgcact gattggggcc tggggcaggg
     2281 gggtcaagga gagggttttg gccgctccct ccccactaag gactggaccc ttgggcccct
     2341 ctcccccttt ttttctattt attgtaccaa agacagtggt ggtccggtgg agggaagacc
     2401 ccccctcacc ccaggaccct aggagggggt gggggcaggt agggggagat ggccttgctc
     2461 ctcctcgctg tacccccagt aaagagcttt ctcaca
//
