LOCUS       NM_001377534             869 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens dynein light chain Tctex-type 4 (DYNLT4), transcript
            variant 2, mRNA.
ACCESSION   NM_001377534 XM_011541376
VERSION     NM_001377534.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Freitas,M.J., Korrodi-Gregorio,L., Morais-Santos,F., Cruz e
            Silva,Ed. and Fardilha,M.
  TITLE     TCTEX1D4 interactome in human testis: unraveling the function of
            dynein light chain in spermatozoa
  JOURNAL   OMICS 18 (4), 242-253 (2014)
   PUBMED   24606217
  REMARK    GeneRIF: 40 novel TCTEX1D4 interactors in human spermatozoa have
            been identified.
REFERENCE   3  (bases 1 to 869)
  AUTHORS   Korrodi-Gregorio,L., Vieira,S.I., Esteves,S.L., Silva,J.V.,
            Freitas,M.J., Brauns,A.K., Luers,G., Abrantes,J., Esteves,P.J., da
            Cruz E Silva,O.A., Fardilha,M. and da Cruz E Silva,E.F.
  TITLE     TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the
            phosphatase to the microtubule network
  JOURNAL   Biol Open 2 (5), 453-465 (2013)
   PUBMED   23789093
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 869)
  AUTHORS   Fardilha,M., Esteves,S.L., Korrodi-Gregorio,L., Vintem,A.P.,
            Domingues,S.C., Rebelo,S., Morrice,N., Cohen,P.T., da Cruz e
            Silva,O.A. and da Cruz e Silva,E.F.
  TITLE     Identification of the human testis protein phosphatase 1
            interactome
  JOURNAL   Biochem Pharmacol 82 (10), 1403-1415 (2011)
   PUBMED   21382349
REFERENCE   5  (bases 1 to 869)
  AUTHORS   Meng,Q., Lux,A., Holloschi,A., Li,J., Hughes,J.M., Foerg,T.,
            McCarthy,J.E., Heagerty,A.M., Kioschis,P., Hafner,M. and
            Garland,J.M.
  TITLE     Identification of Tctex2beta, a novel dynein light chain family
            member that interacts with different transforming growth
            factor-beta receptors
  JOURNAL   J Biol Chem 281 (48), 37069-37080 (2006)
   PUBMED   16982625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592166.16.
            
            On Jan 21, 2020 this sequence version replaced XM_011541376.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.402436.1,
                                           DRR138524.79148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339355.3/ ENSP00000341803.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AL592166.16        71353-71379         c
            28-82               AL592166.16        70812-70866         c
            83-869              AL592166.16        69921-70707         c
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..869
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /note="dynein light chain Tctex-type 4"
                     /db_xref="GeneID:343521"
                     /db_xref="HGNC:HGNC:32315"
                     /db_xref="MIM:611713"
     exon            1..27
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /inference="alignment:Splign:2.1.0"
     exon            28..82
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /inference="alignment:Splign:2.1.0"
     exon            83..869
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..759
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /note="tctex1 domain-containing protein 4; Tctex2 beta;
                     novel Tctex-1 family domain-containing protein;
                     tctex-2-beta; Tctex1 domain containing 4; protein N22.1"
                     /codon_start=1
                     /product="dynein light chain Tctex-type 4"
                     /protein_id="NP_001364463.1"
                     /db_xref="CCDS:CCDS30699.1"
                     /db_xref="GeneID:343521"
                     /db_xref="HGNC:HGNC:32315"
                     /db_xref="MIM:611713"
                     /translation="MASRPLPPGRQEEENAKDSGRKPSPVRPRGCLPSIDEARPAGPG
                     PAPASRRGSMLGLAASFSRRNSLVGPGAGPGGQRPSLGPVPPLGSRVSFSGLPLAPAR
                     WVAPSYRTEPVPGERWEAARAQRALEAALAAGLHDACYSSDEAARLVRELCEQVHVRL
                     RELSPPRYKLVCSVVLGPRAGQGVHVVSRALWDVARDGLASVSYTNTSLFAVATVHGL
                     YCE"
     regulatory      826..831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /note="hexamer: AATAAA"
     polyA_site      845
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /note="major polyA site"
     regulatory      848..853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /note="hexamer: AATAAA"
     polyA_site      869
                     /gene="DYNLT4"
                     /gene_synonym="TCTEX1D4"
                     /note="major polyA site"
ORIGIN      
        1 agaagccaaa gcctgcgggt gactcagcac ctaggaaccc aggcagcctg ggactatctg
       61 atccacttgt tctaaaacac agccagcagg tccatggcca gcaggcctct gcccccggga
      121 cgccaggagg aggagaatgc caaagactcc gggcggaaac cctcaccggt gcggccccga
      181 ggctgcctgc ccagcattga tgaggcccga ccggcaggtc caggtccagc cccggcctcg
      241 cgccggggct ccatgctggg cctggccgcg tccttctccc gccgcaactc gctggtcggg
      301 ccaggcgcgg gtcctggggg tcagcggcca tccctgggcc cggtgccccc tctgggctca
      361 agggtcagct tctcagggtt gcccctggcg cccgcccgtt gggtggcgcc ctcctaccgc
      421 acggagccag tgcccgggga gcgctgggag gctgcgcgtg cacagcgtgc cctggaggcg
      481 gcgctggccg cagggctgca cgacgcgtgc tactccagcg acgaggccgc gcggctggtg
      541 cgggagctct gcgagcaggt gcacgttcgc ctgcgcgagc tcagcccgcc acgctacaag
      601 ctggtatgca gtgtggtgct ggggccgcgc gcgggccagg gcgttcacgt ggtcagccgt
      661 gcgctctggg acgtggcgcg cgatgggctg gcctcggtct cctacaccaa cacctcgctc
      721 ttcgcggtgg ccacggtcca cgggctctac tgcgagtgag ggggagtcca attctgcaaa
      781 attgtttatt atcctaggag gaggcccccc tggggctcac atcccaataa ataagtgtct
      841 gacaataaat aaaagtggtc cataaataa
//
