LOCUS       NM_006520               2151 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dynein light chain Tctex-type 3 (DYNLT3), mRNA.
ACCESSION   NM_006520
VERSION     NM_006520.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Wang,H., Chen,X., Jin,Y., Liu,T., Song,Y., Zhu,X. and Zhu,X.
  TITLE     The role of DYNLT3 in breast cancer proliferation, migration, and
            invasion via epithelial-to-mesenchymal transition
  JOURNAL   Cancer Med 12 (14), 15289-15303 (2023)
   PUBMED   37260179
  REMARK    GeneRIF: The role of DYNLT3 in breast cancer proliferation,
            migration, and invasion via epithelial-to-mesenchymal transition.
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Gu,X., Wang,B., Zhu,H., Zhou,Y., Horning,A.M., Huang,T.H., Chen,Y.,
            Houghton,P., Lai,Z., Michalek,J.E. and Sun,L.Z.
  TITLE     Age-associated genes in human mammary gland drive human breast
            cancer progression
  JOURNAL   Breast Cancer Res 22 (1), 64 (2020)
   PUBMED   32539762
  REMARK    GeneRIF: Age-associated genes in human mammary gland drive human
            breast cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Douglas,M.W., Diefenbach,R.J., Homa,F.L., Miranda-Saksena,M.,
            Rixon,F.J., Vittone,V., Byth,K. and Cunningham,A.L.
  TITLE     Herpes simplex virus type 1 capsid protein VP26 interacts with
            dynein light chains RP3 and Tctex1 and plays a role in retrograde
            cellular transport
  JOURNAL   J Biol Chem 279 (27), 28522-28530 (2004)
   PUBMED   15117959
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Wilson,M.J., Salata,M.W., Susalka,S.J. and Pfister,K.K.
  TITLE     Light chains of mammalian cytoplasmic dynein: identification and
            characterization of a family of LC8 light chains
  JOURNAL   Cell Motil Cytoskeleton 49 (4), 229-240 (2001)
   PUBMED   11746667
  REMARK    Erratum:[Cell Motil Cytoskeleton. 2002 Jul;52(3):193.]
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Tai,A.W., Chuang,J.Z. and Sung,C.H.
  TITLE     Cytoplasmic dynein regulation by subunit heterogeneity and its role
            in apical transport
  JOURNAL   J Cell Biol 153 (7), 1499-1509 (2001)
   PUBMED   11425878
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   King,S.M., Barbarese,E., Dillman,J.F. 3rd, Benashski,S.E., Do,K.T.,
            Patel-King,R.S. and Pfister,K.K.
  TITLE     Cytoplasmic dynein contains a family of differentially expressed
            light chains
  JOURNAL   Biochemistry 37 (43), 15033-15041 (1998)
   PUBMED   9790665
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Roux,A.F., Rommens,J., McDowell,C., Anson-Cartwright,L., Bell,S.,
            Schappert,K., Fishman,G.A. and Musarella,M.
  TITLE     Identification of a gene from Xp21 with similarity to the tctex-1
            gene of the murine t complex
  JOURNAL   Hum Mol Genet 3 (2), 257-263 (1994)
   PUBMED   8004092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA342302.1 and BC000968.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006520.2.
            
            Summary: This gene encodes a member of a subclass of dynein light
            chains. The encoded protein homodimerizes and forms the light chain
            component of the cytoplasmic dynein motor protein complex. This
            protein may be important for binding dynein to specific cargos
            including the spindle checkpoint protein BUB3. This protein may
            also function independently of dynein as a transcriptional
            modulator. Pseudogenes of this gene are found on chromosomes 2 and
            20.[provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U02556.1, SRR3476690.401720.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378578.9/ ENSP00000367841.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA342302.1         57-82
            27-2151             BC000968.2         20-2144
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..2151
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /note="dynein light chain Tctex-type 3"
                     /db_xref="GeneID:6990"
                     /db_xref="HGNC:HGNC:11694"
                     /db_xref="MIM:300302"
     exon            1..91
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..412
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /note="protein 91/23"
                     /codon_start=1
                     /product="dynein light chain Tctex-type 3"
                     /protein_id="NP_006511.1"
                     /db_xref="CCDS:CCDS14243.1"
                     /db_xref="GeneID:6990"
                     /db_xref="HGNC:HGNC:11694"
                     /db_xref="MIM:300302"
                     /translation="MEEYHRHCDEVGFNAEEAHNIVKECVDGVLGGEDYNHNNINQWT
                     ASIVEQSLTHLVKLGKAYKYIVTCAVVQKSAYGFHTASSCFWDTTSDGTCTVRWENRT
                     MNCIVNVFAIAIVL"
     exon            92..133
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            134..257
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            258..335
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /inference="alignment:Splign:2.1.0"
     exon            336..2151
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1903..1908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /note="hexamer: AATAAA"
     polyA_site      1925
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /note="hexamer: AATAAA"
     polyA_site      2151
                     /gene="DYNLT3"
                     /gene_synonym="RP3; TCTE1L; TCTEX1L"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcggc cgcggtgctc taccggcgtg tcgctccgcc ccagggagag ccggcgctac
       61 catggaggag taccatcgcc actgcgacga ggttggcttc aatgctgagg aagcccacaa
      121 tattgtcaaa gagtgtgtag atggggtttt aggtggtgaa gattataatc acaacaacat
      181 caaccagtgg actgcaagca tagtggaaca atccttaaca cacctggtta agttgggaaa
      241 agcctataaa tatattgtga cctgtgcagt ggtccagaag agcgcatatg gctttcacac
      301 agccagctcc tgtttttggg ataccacatc tgatggaacc tgtaccgtaa gatgggagaa
      361 ccggaccatg aactgtattg tcaacgtttt tgccattgct attgttcttt aactgactaa
      421 aaatgttggg ctaaagccat taacttaaga atttgtcagt gtatcctttc caaaaagagt
      481 aatagttgtt tactagtgtg ctagatgaaa agcgtgcaat atgctttaaa gctatcaaca
      541 aaaactgaat attataagca agcaatatca tagtaattgg cagattagct catattctat
      601 acagcatcgt ttaaatagga aaaatttaat gctagcaaaa aataaattta gaaatatggc
      661 atgacatgaa aatacaatct tatatttaca ccagcttttc actaatattt tgtacctaag
      721 gtgatgggga actccattca gataataaaa ttctctttca gctagagaag ttaacaggaa
      781 taaatatatg aacaaaaaag ctgcaaggat aaatgtggag aaaatgatga gaattagcta
      841 acatttttaa gtttttttaa actttcttcc cctcagttgt acttaatatt tagtggaaag
      901 taataatttt tttaattttc tatcaactaa tagtatagta acaactatga ttaacttgtt
      961 tactttttct gaggattagt aaatcaattt tttttaattt caaatttttg gatttacact
     1021 tgagggtaaa ttaaatctgg taaactgaat ttcctagtta aataaaatta gttgcagtat
     1081 atgatgaaca gtgtatgact caaacagctg ccttacaatt cactcattcc atgtggaaca
     1141 aacatttatc agatgcctat tatgggcata tgtctctgct aagcaccata gttgtcaatg
     1201 tgctgtgcaa atgctaagtt ccttttagca attgttcagt tggaagacgt attaatattt
     1261 ggggaaggaa aagaaagtag ttgttttaca agggaggaaa aaagtgaatc tggttacaca
     1321 tatggaagta agcaaaatga aaagcactta ttgctttctg acagaattat agatgtaatt
     1381 ttaagagttg ctcctagcaa gttaaaagtg catataaaat atgcaactct tagttaaagg
     1441 ccttattatc agtcttacct atacaagtag taaattttgt cattgcttta gttacaacca
     1501 tctgtaaata acttaaaaga cttattatgt ggggttcaaa ttgagtggaa taaagtatag
     1561 attaaaagta tacaatcctt agcacgttat ctcagggctt atgaaatgta attaaattta
     1621 ttaagaaaat agatgaaaaa ttagggtaca cagctggcca ccaaatgcga agtcaatctg
     1681 ctacttaacc ctgaaaacaa aatcagtttt gcatattacc actaacacta atacatatag
     1741 agagcggaac cataactcat tgaattttgg agaggaataa gcttagcgtt aatattgaca
     1801 atattaaggc aatattcttg taggaatact atgtgcatgt ttgatatttt gccaaataac
     1861 aataattaat aattgttcaa tgtttaagaa taatattaac aaaataaagg agtttaatgc
     1921 agtgatcttt gtttttggca catcaaaaat tctcagtcat tattcatgtt tctttatgct
     1981 gctggctttt gtgccctgga agatcataat agtgaccaaa atatacatgc agacttgttt
     2041 tttattattg ttgtttaagc ataatttaag aaaaaaaatt tttacctggt gaacttgcta
     2101 tctgctctgt ttctagttaa aatataataa atattatctt cctgtgctgt a
//
