LOCUS       NM_174910                787 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens dynein light chain Tctex-type 2 (DYNLT2), transcript
            variant 1, mRNA.
ACCESSION   NM_174910
VERSION     NM_174910.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 787)
  AUTHORS   Saberiyan,M., Mirfakhraie,R., Moghni,M. and Teimori,H.
  TITLE     Study of Linc00574 Regulatory Effect on the TCTE3 Expression in
            Sperm Motility
  JOURNAL   Reprod Sci 28 (1), 159-165 (2021)
   PUBMED   32749594
  REMARK    GeneRIF: Study of Linc00574 Regulatory Effect on the TCTE3
            Expression in Sperm Motility.
REFERENCE   2  (bases 1 to 787)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 787)
  AUTHORS   Zhao,C.L., Hui,Y., Wang,L.J., Lombardo,K., Yang,D., Mangray,S.,
            Yakirevich,E., Amin,A., Huang,C.K. and Lu,S.
  TITLE     T-complex-associated-testis-expressed 3 (TCTE3) is a novel marker
            for pancreatobiliary carcinomas
  JOURNAL   Hum Pathol 70, 62-69 (2017)
   PUBMED   29079176
  REMARK    GeneRIF: TCTE3 is a useful marker of pancreatobiliary
            differentiation and may aid in the diagnosis of pancreatobiliary
            adenocarcinomas.
REFERENCE   4  (bases 1 to 787)
  AUTHORS   Sanchez-Castro,M., Eldjouzi,H., Charpentier,E., Busson,P.F.,
            Hauet,Q., Lindenbaum,P., Delasalle-Guyomarch,B., Baudry,A.,
            Pichon,O., Pascal,C., Lefort,B., Bajolle,F., Pezard,P.,
            Schott,J.J., Dina,C., Redon,R., Gournay,V., Bonnet,D. and Le
            Caignec,C.
  TITLE     Search for Rare Copy-Number Variants in Congenital Heart Defects
            Identifies Novel Candidate Genes and a Potential Role for FOXC1 in
            Patients With Coarctation of the Aorta
  JOURNAL   Circ Cardiovasc Genet 9 (1), 86-94 (2016)
   PUBMED   26643481
REFERENCE   5  (bases 1 to 787)
  AUTHORS   Teshiba,R., Masumoto,K., Esumi,G., Nagata,K., Kinoshita,Y.,
            Tajiri,T., Taguchi,T. and Yamamoto,K.
  TITLE     Identification of TCTE3 as a gene responsible for congenital
            diaphragmatic hernia using a high-resolution single-nucleotide
            polymorphism array
  JOURNAL   Pediatr Surg Int 27 (2), 193-198 (2011)
   PUBMED   21085971
  REMARK    GeneRIF: Because TCTE3 encodes a putative light chain of the outer
            dynein arm of cilia and human diseases caused by ciliary
            dysfunction show various phenotypes including skeletal defect,
            TCTE3 may be a genetic candidate influencing CDH.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 787)
  AUTHORS   Neesen,J., Drenckhahn,J.D., Tiede,S., Burfeind,P., Grzmil,M.,
            Konietzko,J., Dixkens,C., Kreutzberger,J., Laccone,F. and Omran,H.
  TITLE     Identification of the human ortholog of the t-complex-encoded
            protein TCTE3 and evaluation as a candidate gene for primary
            ciliary dyskinesia
  JOURNAL   Cytogenet Genome Res 98 (1), 38-44 (2002)
   PUBMED   12584439
REFERENCE   7  (bases 1 to 787)
  AUTHORS   DiBella,L.M., Benashski,S.E., Tedford,H.W., Harrison,A.,
            Patel-King,R.S. and King,S.M.
  TITLE     The Tctex1/Tctex2 class of dynein light chains. Dimerization,
            differential expression, and interaction with the LC8 protein
            family
  JOURNAL   J Biol Chem 276 (17), 14366-14373 (2001)
   PUBMED   11278908
REFERENCE   8  (bases 1 to 787)
  AUTHORS   Rappold,G.A., Trowsdale,J. and Lichter,P.
  TITLE     Assignment of the human homologue of the mouse t-complex gene TCTE3
            to human chromosome 6q27
  JOURNAL   Genomics 13 (4), 1337-1339 (1992)
   PUBMED   1505969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX089062.1, AF519569.1 and AL354892.19.
            
            On Nov 23, 2018 this sequence version replaced NM_174910.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.329011.1, BX089062.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366774.4/ ENSP00000355736.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-527               BX089062.1         12-538
            528-777             AF519569.1         498-747
            778-782             BX089062.1         787-791
            783-787             AL354892.19        17311-17315         c
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..787
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /note="dynein light chain Tctex-type 2"
                     /db_xref="GeneID:6991"
                     /db_xref="HGNC:HGNC:11695"
                     /db_xref="MIM:186977"
     exon            1..234
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..711
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /note="Tctex1 domain containing 3; tctex1
                     domain-containing protein 3; T-complex testis-specific
                     protein 3; T-complex-associated testis-expressed protein
                     3; t-complex-associated-testis-expressed 3"
                     /codon_start=1
                     /product="dynein light chain Tctex-type protein 2"
                     /protein_id="NP_777570.1"
                     /db_xref="CCDS:CCDS5310.1"
                     /db_xref="GeneID:6991"
                     /db_xref="HGNC:HGNC:11695"
                     /db_xref="MIM:186977"
                     /translation="MEKRGRGVKSSPIQTPNQTPQQAPVTPRKERRPSMFEKEAYTQI
                     LRERLRESIHNVQYVEPPFDDSIADIGKEWKSALAKLKFANSYRMEPLKKFQAHSVET
                     KVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQA
                     INIASRWIWDIAWDSWVAAKHEAESYVALVLVFALYYE"
     exon            235..441
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     exon            442..600
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     exon            601..787
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      760..765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /note="hexamer: AATGAA"
     polyA_site      787
                     /gene="DYNLT2"
                     /gene_synonym="oda12; TCTE3; TCTEX1D3; TCTEX2; Tctex4"
                     /note="major polyA site"
ORIGIN      
        1 acttcctacc gtacgaggcg caggtgggag acttccgccc tcgcgggact ggctagggcg
       61 tttgaccgcc ggcggtgaag gggaggcggt gggcgtcttg gagaacagag cgagatggag
      121 aagcgaggcc gaggcgtgaa gtcgagcccc atccagaccc cgaaccagac ccctcagcag
      181 gctccggtga cgcctaggaa agaaaggagg cctagcatgt tcgagaagga ggcatataca
      241 cagattttaa gagaaagact gagagagtca attcacaatg ttcagtatgt ggagcctcct
      301 tttgatgact caattgctga tataggtaaa gaatggaaga gtgccctggc aaaattaaag
      361 tttgctaatt catatagaat ggagccattg aagaaattcc aagctcattc agtagaaact
      421 aaagtccagc agatactaac agaaagtctt aaagatgtca aatatgatga taaagtattc
      481 tctcacttgt cacttgaatt ggcagaccgc atactgttag cagtcaaaga atttgggtac
      541 caccgttata agttcattat aaaagtatta tttattcaaa agactggcca agcaataaat
      601 attgccagca gatggatctg ggacattgca tgggacagct gggtcgcagc taaacacgaa
      661 gcagaatcct acgtggcact ggtcttggtg tttgcccttt attatgaata gctcattaca
      721 ggtactaagg attgtttact tccgaacttt tcaaaaataa atgaaattta catatttgta
      781 aacctca
//
