LOCUS       NM_006519                730 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dynein light chain Tctex-type 1 (DYNLT1), transcript
            variant 1, mRNA.
ACCESSION   NM_006519
VERSION     NM_006519.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 730)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 730)
  AUTHORS   Rosseto,S.M., Alarcon,T.A., Rocha,D.M.C., Ribeiro,F.M.,
            Ferguson,S.S.G., Martins-Silva,C., Muniz,M.R., Costa,P.F.,
            Guimaraes,D.A. and Pires,R.G.W.
  TITLE     DYNLT1 gene expression is downregulated in whole blood of patients
            at different Huntington's disease stages
  JOURNAL   Neurol Sci 42 (5), 1963-1967 (2021)
   PUBMED   32995988
  REMARK    GeneRIF: DYNLT1 gene expression is downregulated in whole blood of
            patients at different Huntington's disease stages.
REFERENCE   3  (bases 1 to 730)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 730)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 730)
  AUTHORS   Schwarzer,C., Barnikol-Watanabe,S., Thinnes,F.P. and Hilschmann,N.
  TITLE     Voltage-dependent anion-selective channel (VDAC) interacts with the
            dynein light chain Tctex1 and the heat-shock protein PBP74
  JOURNAL   Int J Biochem Cell Biol 34 (9), 1059-1070 (2002)
   PUBMED   12009301
REFERENCE   6  (bases 1 to 730)
  AUTHORS   Mueller,S., Cao,X., Welker,R. and Wimmer,E.
  TITLE     Interaction of the poliovirus receptor CD155 with the dynein light
            chain Tctex-1 and its implication for poliovirus pathogenesis
  JOURNAL   J Biol Chem 277 (10), 7897-7904 (2002)
   PUBMED   11751937
  REMARK    GeneRIF: Association with Tctex-1 and, hence, with the dynein motor
            complex may offer an explanation for how poliovirus hijacks the
            cellular transport machinery to retrogradely ascend along the axon
            to the neuronal cell body.
REFERENCE   7  (bases 1 to 730)
  AUTHORS   Strovel,E.T., Wu,D. and Sussman,D.J.
  TITLE     Protein phosphatase 2Calpha dephosphorylates axin and activates
            LEF-1-dependent transcription
  JOURNAL   J Biol Chem 275 (4), 2399-2403 (2000)
   PUBMED   10644691
REFERENCE   8  (bases 1 to 730)
  AUTHORS   Nagano,F., Orita,S., Sasaki,T., Naito,A., Sakaguchi,G., Maeda,M.,
            Watanabe,T., Kominami,E., Uchiyama,Y. and Takai,Y.
  TITLE     Interaction of Doc2 with tctex-1, a light chain of cytoplasmic
            dynein. Implication in dynein-dependent vesicle transport
  JOURNAL   J Biol Chem 273 (46), 30065-30068 (1998)
   PUBMED   9804756
REFERENCE   9  (bases 1 to 730)
  AUTHORS   King,S.M., Dillman,J.F. 3rd, Benashski,S.E., Lye,R.J.,
            Patel-King,R.S. and Pfister,K.K.
  TITLE     The mouse t-complex-encoded protein Tctex-1 is a light chain of
            brain cytoplasmic dynein
  JOURNAL   J Biol Chem 271 (50), 32281-32287 (1996)
   PUBMED   8943288
REFERENCE   10 (bases 1 to 730)
  AUTHORS   Watanabe,T.K., Fujiwara,T., Shimizu,F., Okuno,S., Suzuki,M.,
            Takahashi,E., Nakamura,Y. and Hirai,Y.
  TITLE     Cloning, expression, and mapping of TCTEL1, a putative human
            homologue of murine Tcte1, to 6q
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 153-156 (1996)
   PUBMED   8646886
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY171700.1, AL589931.14,
            BC105588.1 and BU675683.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006519.3.
            
            Summary: This gene encodes a component of the motor complex,
            cytoplasmic dynein, which transports cellular cargo along
            microtubules in the cell. The encoded protein regulates the length
            of primary cilia which are sensory organelles found on the surface
            of cells. The protein encoded by this gene interacts with viral
            proteins, like the minor capsid protein L2 of human papillomavirus,
            and is required for dynein-mediated delivery of the viral nucleic
            acid to the host nucleus. This protein interacts with oncogenic
            nucleoporins to disrupt gene regulation and cause leukemic
            transformation. Pseudogenes of this gene are present on chromosomes
            4 and 17. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Apr
            2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.123843.1,
                                           SRR5189661.171423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367089.8/ ENSP00000356056.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                HY171700.1         47-63
            18-18               AL589931.14        7969-7969           c
            19-728              BC105588.1         11-720
            729-730             BU675683.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..730
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /note="dynein light chain Tctex-type 1"
                     /db_xref="GeneID:6993"
                     /db_xref="HGNC:HGNC:11697"
                     /db_xref="MIM:601554"
     exon            1..62
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..377
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     t-complex-associated-testis-expressed 1-like 1; T-complex
                     testis-specific protein 1 homolog"
                     /codon_start=1
                     /product="dynein light chain Tctex-type 1 isoform 1"
                     /protein_id="NP_006510.1"
                     /db_xref="CCDS:CCDS5257.1"
                     /db_xref="GeneID:6993"
                     /db_xref="HGNC:HGNC:11697"
                     /db_xref="MIM:601554"
                     /translation="MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTT
                     NVVEQTLSQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTM
                     YCIVSAFGLSI"
     exon            63..104
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..228
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..306
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..730
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      710..715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /note="hexamer: AATAAA"
     polyA_site      730
                     /gene="DYNLT1"
                     /gene_synonym="CW-1; TCTEL1; tctex-1; TCTEX1"
                     /note="major polyA site"
ORIGIN      
        1 actcagggag ccggagggga cgcgccggag gaaagatgga agactaccag gctgcggagg
       61 agactgcttt tgttgttgat gaagtgagca acattgtaaa agaggctata gaaagcgcaa
      121 ttggtggtaa cgcttatcaa cacagcaaag tgaaccagtg gaccacaaat gtagtagaac
      181 aaactttaag ccaactcacc aagctgggaa aaccatttaa atacatcgtg acctgtgtaa
      241 ttatgcagaa gaatggagct ggattacaca cagcaagttc ctgcttctgg gacagctcta
      301 ctgacgggag ctgcactgtg cgatgggaga ataagaccat gtactgcatc gtcagtgcct
      361 tcggactgtc tatttgacct gcagtccagc ctatggcctt tctccttttg tctctagttc
      421 atcctctaac caccagccat gaattcagtg aactcttttc tcattctctt tgttttgtgg
      481 cactttcaca atgtagagga aaaaaccaaa tgaccgcact gtgatgtgaa tggcaccgaa
      541 gtcagatgag tatccctgta ggtcacctgc agcctgcgtt gccacttgtc ttaactctga
      601 atatttcatt tcaaaggtgc taaaatctga aatctgctag tgtgaaactt gctctactct
      661 ctgaaatgat tcaaatacac taattttcca tactttatac ttttgttaga ataaattatt
      721 caaatctaaa
//
