LOCUS       NM_003746                663 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens dynein light chain LC8-type 1 (DYNLL1), transcript
            variant 3, mRNA.
ACCESSION   NM_003746
VERSION     NM_003746.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 663)
  AUTHORS   Greenwood,M., Gillard,B.T., Murphy,D. and Greenwood,M.P.
  TITLE     Dimerization of hub protein DYNLL1 and bZIP transcription factor
            CREB3L1 enhances transcriptional activation of CREB3L1 target genes
            like arginine vasopressin
  JOURNAL   Peptides 179, 171269 (2024)
   PUBMED   38960286
  REMARK    GeneRIF: Dimerization of hub protein DYNLL1 and bZIP transcription
            factor CREB3L1 enhances transcriptional activation of CREB3L1
            target genes like arginine vasopressin.
REFERENCE   2  (bases 1 to 663)
  AUTHORS   Swift,M.L., Zhou,R., Syed,A., Moreau,L.A., Tomasik,B., Tainer,J.A.,
            Konstantinopoulos,P.A., D'Andrea,A.D., He,Y.J. and Chowdhury,D.
  TITLE     Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and
            recruitment of Shieldin to DSBs
  JOURNAL   Nat Struct Mol Biol 30 (10), 1456-1467 (2023)
   PUBMED   37696958
REFERENCE   3  (bases 1 to 663)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 663)
  AUTHORS   Lee,G.R., Lee,H.I., Kim,N., Lee,J., Kwon,M., Kang,Y.H., Song,H.J.,
            Yeo,C.Y. and Jeong,W.
  TITLE     Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by
            inhibiting NF-kappaB signaling and reducing oxidative stress
  JOURNAL   J Cell Physiol 237 (9), 3554-3564 (2022)
   PUBMED   35696549
  REMARK    GeneRIF: Dynein light chain LC8 alleviates nonalcoholic
            steatohepatitis by inhibiting NF-kappaB signaling and reducing
            oxidative stress.
REFERENCE   5  (bases 1 to 663)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 663)
  AUTHORS   Crepieux,P., Kwon,H., Leclerc,N., Spencer,W., Richard,S., Lin,R.
            and Hiscott,J.
  TITLE     I kappaB alpha physically interacts with a cytoskeleton-associated
            protein through its signal response domain
  JOURNAL   Mol Cell Biol 17 (12), 7375-7385 (1997)
   PUBMED   9372968
REFERENCE   7  (bases 1 to 663)
  AUTHORS   Jaffrey,S.R. and Snyder,S.H.
  TITLE     PIN: an associated protein inhibitor of neuronal nitric oxide
            synthase
  JOURNAL   Science 274 (5288), 774-777 (1996)
   PUBMED   8864115
REFERENCE   8  (bases 1 to 663)
  AUTHORS   Dick,T., Ray,K., Salz,H.K. and Chia,W.
  TITLE     Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects
            and apoptotic cell death in Drosophila melanogaster
  JOURNAL   Mol Cell Biol 16 (5), 1966-1977 (1996)
   PUBMED   8628263
REFERENCE   9  (bases 1 to 663)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   10 (bases 1 to 663)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU598428.1 and AC063943.23.
            
            On Nov 22, 2018 this sequence version replaced NM_003746.2.
            
            Summary: Cytoplasmic dyneins are large enzyme complexes with a
            molecular mass of about 1,200 kD. They contain two force-producing
            heads formed primarily from dynein heavy chains, and stalks linking
            the heads to a basal domain, which contains a varying number of
            accessory intermediate chains. The complex is involved in
            intracellular transport and motility. The protein described in this
            record is a light chain and exists as part of this complex but also
            physically interacts with and inhibits the activity of neuronal
            nitric oxide synthase. Binding of this protein destabilizes the
            neuronal nitric oxide synthase dimer, a conformation necessary for
            activity, and it may regulate numerous biologic processes through
            its effects on nitric oxide synthase activity. Alternate
            transcriptional splice variants have been characterized. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) contains a distinct 5' UTR,
            including an alternate, downstream transcription initiation site.
            Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV759540.1, BM765041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242577.11/ ENSP00000242577.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BU598428.1         58-87
            31-104              AC063943.23        20689-20762
            105-242             AC063943.23        20962-21099
            243-663             AC063943.23        22619-23039
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..663
                     /gene="DYNLL1"
                     /gene_synonym="DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8;
                     LC8a; PIN"
                     /note="dynein light chain LC8-type 1"
                     /db_xref="GeneID:8655"
                     /db_xref="HGNC:HGNC:15476"
                     /db_xref="MIM:601562"
     exon            1..104
                     /gene="DYNLL1"
                     /gene_synonym="DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8;
                     LC8a; PIN"
                     /inference="alignment:Splign:2.1.0"
     exon            105..242
                     /gene="DYNLL1"
                     /gene_synonym="DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8;
                     LC8a; PIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..380
                     /gene="DYNLL1"
                     /gene_synonym="DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8;
                     LC8a; PIN"
                     /note="protein inhibitor of neuronal nitric oxide
                     synthase; dynein, cytoplasmic, light polypeptide 1; 8 kDa
                     dynein light chain; cytoplasmic dynein light polypeptide"
                     /codon_start=1
                     /product="dynein light chain 1, cytoplasmic"
                     /protein_id="NP_003737.1"
                     /db_xref="CCDS:CCDS9200.1"
                     /db_xref="GeneID:8655"
                     /db_xref="HGNC:HGNC:15476"
                     /db_xref="MIM:601562"
                     /translation="MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKK
                     EFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG"
     exon            243..663
                     /gene="DYNLL1"
                     /gene_synonym="DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8;
                     LC8a; PIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      643..648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNLL1"
                     /gene_synonym="DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8;
                     LC8a; PIN"
                     /note="hexamer: AATAAA"
     polyA_site      663
                     /gene="DYNLL1"
                     /gene_synonym="DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8;
                     LC8a; PIN"
                     /note="major polyA site"
ORIGIN      
        1 agatgcgcca cggtttcggt agcgacggta tctctagccg ggcctgagct gtgctagcac
       61 ctcccccagg agaccgttgc agtcggccag cccccttctc cacggtaacc atgtgcgacc
      121 gaaaggccgt gatcaaaaat gcggacatgt cggaagagat gcaacaggac tcggtggagt
      181 gcgctactca ggcgctggag aaatacaaca tagagaagga cattgcggct catatcaaga
      241 aggaatttga caagaagtac aatcccacct ggcattgcat cgtggggagg aacttcggta
      301 gttatgtgac acatgaaacc aaacacttca tctacttcta cctgggccaa gtggccattc
      361 ttctgttcaa atctggttaa aagcatggac tgtgccacac acccagtgat ccatccaaaa
      421 acaaggactg cagcctaaat tccaaatacc agagactgaa attttcagcc ttgctaaggg
      481 aacatctcga tgtttgaacc tttgttgtgt tttgtacagg gcattctctg tactagtttg
      541 tcgtggttat aaaacaatta gcagaatagc ctacatttgt atttattttc tattccatac
      601 ttctgcccac gttgttttct ctcaaaatcc attcctttaa aaaataaatc tgatgcagat
      661 gtg
//
