LOCUS       NM_018051               3789 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dynein 2 intermediate chain 1 (DYNC2I1), transcript
            variant 1, mRNA.
ACCESSION   NM_018051
VERSION     NM_018051.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3789)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3789)
  AUTHORS   Toropova,K., Zalyte,R., Mukhopadhyay,A.G., Mladenov,M., Carter,A.P.
            and Roberts,A.J.
  TITLE     Structure of the dynein-2 complex and its assembly with
            intraflagellar transport trains
  JOURNAL   Nat Struct Mol Biol 26 (9), 823-829 (2019)
   PUBMED   31451806
REFERENCE   3  (bases 1 to 3789)
  AUTHORS   Tsurumi,Y., Hamada,Y., Katoh,Y. and Nakayama,K.
  TITLE     Interactions of the dynein-2 intermediate chain WDR34 with the
            light chains are required for ciliary retrograde protein
            trafficking
  JOURNAL   Mol Biol Cell 30 (5), 658-670 (2019)
   PUBMED   30649997
REFERENCE   4  (bases 1 to 3789)
  AUTHORS   Vuolo,L., Stevenson,N.L., Heesom,K.J. and Stephens,D.J.
  TITLE     Dynein-2 intermediate chains play crucial but distinct roles in
            primary cilia formation and function
  JOURNAL   Elife 7, e39655 (2018)
   PUBMED   30320547
  REMARK    GeneRIF: loss of function of dynein-2 WDR34 and WDR60 subunits
            leads to defects in transition zone architecture, as well as
            intraflagellar transport.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3789)
  AUTHORS   Hamada,Y., Tsurumi,Y., Nozaki,S., Katoh,Y. and Nakayama,K.
  TITLE     Interaction of WDR60 intermediate chain with TCTEX1D2 light chain
            of the dynein-2 complex is crucial for ciliary protein trafficking
  JOURNAL   Mol Biol Cell 29 (13), 1628-1639 (2018)
   PUBMED   29742051
  REMARK    GeneRIF: WDR60 plays a major role and TCTEX1D2 plays an auxiliary
            role in the dynein-2 complex to mediate retrograde ciliary protein
            trafficking.
REFERENCE   6  (bases 1 to 3789)
  AUTHORS   Asante,D., Stevenson,N.L. and Stephens,D.J.
  TITLE     Subunit composition of the human cytoplasmic dynein-2 complex
  JOURNAL   J Cell Sci 127 (Pt 21), 4774-4787 (2014)
   PUBMED   25205765
REFERENCE   7  (bases 1 to 3789)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   8  (bases 1 to 3789)
  AUTHORS   McInerney-Leo,A.M., Schmidts,M., Cortes,C.R., Leo,P.J., Gener,B.,
            Courtney,A.D., Gardiner,B., Harris,J.A., Lu,Y., Marshall,M.,
            Scambler,P.J., Beales,P.L., Brown,M.A., Zankl,A., Mitchison,H.M.,
            Duncan,E.L. and Wicking,C.
  CONSRTM   UK10K Consortium
  TITLE     Short-rib polydactyly and Jeune syndromes are caused by mutations
            in WDR60
  JOURNAL   Am J Hum Genet 93 (3), 515-523 (2013)
   PUBMED   23910462
  REMARK    GeneRIF: These findings show that WDR60 mutations can cause
            skeletal ciliopathies and suggest a role for WDR60 in ciliogenesis.
REFERENCE   9  (bases 1 to 3789)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   10 (bases 1 to 3789)
  AUTHORS   Lettre,G., Jackson,A.U., Gieger,C., Schumacher,F.R., Berndt,S.I.,
            Sanna,S., Eyheramendy,S., Voight,B.F., Butler,J.L., Guiducci,C.,
            Illig,T., Hackett,R., Heid,I.M., Jacobs,K.B., Lyssenko,V., Uda,M.,
            Boehnke,M., Chanock,S.J., Groop,L.C., Hu,F.B., Isomaa,B., Kraft,P.,
            Peltonen,L., Salomaa,V., Schlessinger,D., Hunter,D.J., Hayes,R.B.,
            Abecasis,G.R., Wichmann,H.E., Mohlke,K.L. and Hirschhorn,J.N.
  CONSRTM   Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung
            Colorectal and Ovarian Cancer Screening Trial; Nurses' Health
            Study; SardiNIA
  TITLE     Identification of ten loci associated with height highlights new
            biological pathways in human growth
  JOURNAL   Nat Genet 40 (5), 584-591 (2008)
   PUBMED   18391950
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124833.1, BC014491.1,
            DB072968.1, BM718580.1 and AL137660.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018051.4.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD)
            and may facilitate the formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. The encoded protein
            contains four WD repeats and may play a role in the formation of
            cilia. Mutations in this gene have been associated with short-rib
            polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.120757.1, BC014491.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407559.8/ ENSP00000384290.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC124833.1         24828-24847
            21-852              BC014491.1         1-832
            853-853             AC124833.1         48055-48055
            854-1099            DB072968.1         310-555
            1100-2250           BC014491.1         1080-2230
            2251-2709           BM718580.1         54-512
            2710-3789           AL137660.1         1690-2769
FEATURES             Location/Qualifiers
     source          1..3789
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.3"
     gene            1..3789
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /note="dynein 2 intermediate chain 1"
                     /db_xref="GeneID:55112"
                     /db_xref="HGNC:HGNC:21862"
                     /db_xref="MIM:615462"
     exon            1..193
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..3379
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat-containing protein 60; testicular secretory protein
                     Li 66; WD repeat domain 60; cytoplasmic dynein 2
                     intermediate chain 1"
                     /codon_start=1
                     /product="cytoplasmic dynein 2 intermediate chain 1
                     isoform a"
                     /protein_id="NP_060521.4"
                     /db_xref="CCDS:CCDS47757.1"
                     /db_xref="GeneID:55112"
                     /db_xref="HGNC:HGNC:21862"
                     /db_xref="MIM:615462"
                     /translation="MEPGKRRTKDDTWKADDLRKHLWAIQSGGSKEERKHREKKLRKE
                     SEMDLPEHKEPRCRDPDQDARSRDRVAEVHTAKESPRGERDRDRQRERRRDAKDREKE
                     KLKEKHREAEKSHSRGKDREKEKDRRARKEELRQTVAHHNLLGQETRDRQLLERAERK
                     GRSVSKVRSEEKDEDSERGDEDRERRYRERKLQYGDSKDNPLKYWLYKEEGERRHRKP
                     REPDRDNKHREKSSTREKREKYSKEKSNSFSDKGEERHKEKRHKEGFHFDDERHQSNV
                     DRKEKSAKDEPRKRESQNGEHRNRGASSKRDGTSSQHAENLVRNHGKDKDSRRKHGHE
                     EGSSVWWKLDQRPGGEETVEIEKEETDLENARADAYTASCEDDFEDYEDDFEVCDGDD
                     DESSNEPESREKLEELPLAQKKEIQEIQRAINAENERIGELSLKLFQKRGRTEFEKEP
                     RTDTNSSPSRASVCGIFVDFASASHRQKSRTQALKQKMRSTKLLRLIDLDFSFTFSLL
                     DLPPVNEYDMYIRNFGKKNTKQAYVQCNEDNVERDIQTEEIETREVWTQHPGESTVVS
                     GGSEQRDTSDAVVMPKIDTPRLCSFLRAACQVMAVLLEEDRLAAEPSWNLRAQDRALY
                     FSDSSSQLNTSLPFLQNRKVSSLHTSRVQRQMVVSVHDLPEKSFVPLLDSKYVLCVWD
                     IWQPSGPQKVLICESQVTCCCLSPLKAFLLFAGTAHGSVVVWDLREDSRLHYSVTLSD
                     GFWTFRTATFSTDGILTSVNHRSPLQAVEPISTSVHKKQSFVLSPFSTQEEMSGLSFH
                     IASLDESGVLNVWVVVELPKADIAGSISDLGLMPGGRVKLVHSALIQLGDSLSHKGNE
                     FWGTTQTLNVKFLPSDPNHFIIGTDMGLISHGTRQDLRVAPKLFKPQQHGIRPVKVNV
                     IDFSPFGEPIFLAGCSDGSIRLHQLSSAFPLLQWDSSTDSHAVTGLQWSPTRPAVFLV
                     QDDTSNIYIWDLLQSDLGPVAKQQVSPNRLVAMAAVGEPEKAGGSFLALVLARASGSI
                     DIQHLKRRWAAPEVDECNRLRLLLQEALWPEGKLHK"
     exon            194..247
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            248..668
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            669..751
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1057
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1113
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1168
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1237
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1315
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1535
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1638
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1768
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1880
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1969
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2099
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2272
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2435
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2549
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2611
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2663
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2724
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2824
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2956
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3180
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3789
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3765..3770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /note="hexamer: ATTAAA"
     polyA_site      3789
                     /gene="DYNC2I1"
                     /gene_synonym="CFAP163; DIC6; FAP163; SRPS6; SRTD8; WDR60"
                     /note="major polyA site"
ORIGIN      
        1 gggagaggcc gcagggcacg ctgggcagtg cttctgggcc ctctgctgct cctgcttgtc
       61 ggttgctagg cgctgggacg cgcctcccga agggtgcggg gcacaggtgg cctcttcggg
      121 gtggaccgcg cctggccggg gccgaggaca ccgcggccgc ccgggcctgc gggaagcgat
      181 ggagcccggg aagagaagaa ccaaagatga tacctggaaa gcagatgacc tcagaaaaca
      241 tctctgggcc atacagtcag gtggttccaa ggaagaaaga aagcacagag agaagaagct
      301 gcgtaaggag tctgagatgg accttcctga acataaggag ccgaggtgca gggatcccga
      361 ccaggatgcc aggagcagag acagggtggc cgaagtccac accgctaagg agagtcctcg
      421 tggggagagg gacagagaca gacagaggga gaggagaaga gacgcaaaag accgggagaa
      481 agaaaagctg aaggagaaac atcgagaggc agaaaagtct cacagcagag gaaaggacag
      541 ggaaaaagaa aaagacagaa gggcccggaa ggaagagctc cggcagaccg tggcccacca
      601 caacctgctg ggccaggaga cacgcgaccg gcagctcctg gagcgggcgg agaggaaagg
      661 ccgctcagta agtaaagtaa gaagtgaaga gaaagatgaa gactctgaaa gaggagatga
      721 agatagagaa agaagatacc gagaaagaaa gctgcagtac ggagacagca aggacaaccc
      781 tctcaagtac tggctttata aagaagaagg cgagaggaga cacaggaagc ccagagagcc
      841 agatcgagac aacaaacacc gagaaaaaag cagcacaagg gaaaaaagag agaaatattc
      901 caaagagaaa agtaattcat tctctgacaa aggggaagaa agacataaag aaaagcgaca
      961 caaagaaggt tttcattttg atgatgagag gcaccaaagc aacgtggata gaaaagagaa
     1021 atcggcaaaa gatgagccca ggaaaaggga atcccagaat ggtgaacaca gaaatcgagg
     1081 tgcaagctca aaaagagatg ggaccagcag ccagcatgct gagaatttag taaggaatca
     1141 tggaaaagat aaagattcaa gacggaagca tggccacgag gaaggctctt ctgtgtggtg
     1201 gaagctggac cagaggccgg gaggcgagga aaccgtggaa attgaaaagg aagaaactga
     1261 tttagaaaat gctagagctg atgcatatac agccagttgt gaagatgatt ttgaagacta
     1321 tgaagatgac tttgaggttt gtgatggtga tgatgatgaa agcagtaatg aacctgagtc
     1381 aagagaaaaa ctggaagaac ttcctctagc tcaaaaaaag gaaatacaag aaattcaaag
     1441 agctattaat gcagaaaatg aaaggattgg cgagttatct ttgaaactgt ttcagaagcg
     1501 aggtagaaca gaatttgaaa aggagcccag gacagataca aacagttccc cttccagagc
     1561 ctctgtttgt ggaatttttg tggattttgc ctcagcttca caccgtcaaa agagtcggac
     1621 tcaggccctt aagcaaaaga tgcgaagtac aaaactgctt cggctcattg acttagattt
     1681 ttcatttact ttctctctct tggatctacc accagtaaat gaatatgaca tgtatatcag
     1741 aaactttggg aaaaaaaata ccaagcaggc atatgttcag tgtaacgaag ataatgttga
     1801 aagagacatt caaacggagg aaatagagac cagggaagtg tggacccagc acccgggaga
     1861 aagtactgtt gtatctggag gcagtgaaca aagagatacc tctgatgctg tagttatgcc
     1921 aaagattgat actccaaggt tatgtagctt tctgcgggct gcttgtcagg tgatggccgt
     1981 tttgctggaa gaggatcgct tggcagctga acccagctgg aatcttaggg ctcaagacag
     2041 ggccctgtat tttagtgaca gctcatctca gctgaacacc agtctaccat tccttcaaaa
     2101 tcgaaaagta tcctccttgc acacctcccg agttcagagg cagatggtgg tctccgttca
     2161 cgacttaccc gagaagagct ttgtgcccct gctggacagc aaatacgtcc tctgtgtgtg
     2221 ggatatttgg cagccttcag ggccacagaa agttctgata tgtgagtccc aggtcacgtg
     2281 ttgctgcttg agccctttga aagcattttt actgtttgcc ggaacagcgc acggctcagt
     2341 tgtcgtctgg gatttgagag aagactcaag gctgcattac tctgtgacgc tgagcgatgg
     2401 cttctggacg ttccggaccg ccacgttttc caccgatgga atccttacct cagtaaacca
     2461 ccgaagccct cttcaagcag tagaacctat ctcaacgtcc gtccacaaaa agcagagctt
     2521 tgtgctttca cccttttcta ctcaagaaga aatgtcaggt ttgtccttcc acatcgcttc
     2581 cttggatgag agtggggttc tcaatgtatg ggtggttgtt gaattaccaa aggcagacat
     2641 cgcaggttca ataagtgatt taggtctgat gcctggaggg agggtcaagc tggtacatag
     2701 tgctctgatc cagttgggtg acagtctttc ccataaaggt aatgaatttt ggggcactac
     2761 acaaacactg aatgttaaat ttctgccttc agatcctaat cactttatta ttggcacaga
     2821 catgggtctc ataagccatg gcacaagaca agatttgaga gtggctccca aactattcaa
     2881 acctcagcaa catggtataa gaccagtgaa agttaatgtc attgattttt caccatttgg
     2941 agaaccaata tttttggccg gctgttcgga cggaagcatc aggctgcacc agctgagctc
     3001 cgcgtttccg ctcctgcagt gggacagcag cacggacagc catgcggtca ccggcctgca
     3061 gtggtcccca accaggcctg ccgtgttcct ggtgcaggac gacacatcca acatctacat
     3121 ctgggacctc ctccagagcg atctgggtcc tgtcgccaaa cagcaggtct cccccaacag
     3181 gctggtggcc atggctgcgg tgggtgagcc tgagaaggct ggtggcagct tcctggccct
     3241 ggtgctggcc agggcgtctg gctccatcga catccagcac ctgaagaggc ggtgggcggc
     3301 cccggaggtg gacgagtgca acaggctgcg tctgcttttg caggaagccc tgtggccaga
     3361 gggaaaactg cacaagtagc gggtgtggct gagaggaccg cgtttctgta atgacccaga
     3421 tttaaaagac ataaggtgga taattctaca tttgtgtgca agtatattta tgtatataga
     3481 ctatgtatat tctgtatata atttatttta catgaatatg tctttggtat tcccagtaaa
     3541 tagatgacta cttttgagtg gaaacaaaga acattctagc atttacaaaa cttccagggg
     3601 aatgtagagc cacgtccagg gtgctctttt ctgagagtat ttcgagttat ttttagaaca
     3661 gtttaaatat tgtcacatta ctgctagatt ttaaacagcc taccatgaaa atgtatctta
     3721 atgaactatt ttcttatgca taaagtatgt gaacacatgt ctaaattaaa aggaattact
     3781 ccaccgaaa
//
