LOCUS       NM_006141               4326 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens dynein cytoplasmic 1 light intermediate chain 2
            (DYNC1LI2), transcript variant 1, mRNA.
ACCESSION   NM_006141
VERSION     NM_006141.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4326)
  AUTHORS   Rahman,F., Johnson,J.L., Zhang,J., He,J., Pestonjamasp,K.,
            Cherqui,S. and Catz,S.D.
  TITLE     DYNC1LI2 regulates localization of the chaperone-mediated autophagy
            receptor LAMP2A and improves cellular homeostasis in cystinosis
  JOURNAL   Autophagy 18 (5), 1108-1126 (2022)
   PUBMED   34643468
  REMARK    GeneRIF: DYNC1LI2 regulates localization of the chaperone-mediated
            autophagy receptor LAMP2A and improves cellular homeostasis in
            cystinosis.
REFERENCE   2  (bases 1 to 4326)
  AUTHORS   Sharma,A., Dagar,S. and Mylavarapu,S.V.S.
  TITLE     Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein
            govern mitotic spindle orientation
  JOURNAL   J Cell Sci 133 (12) (2020)
   PUBMED   32467330
  REMARK    GeneRIF: Transgelin-2 and phosphoregulation of the LIC2 subunit of
            dynein govern mitotic spindle orientation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4326)
  AUTHORS   Mahale,S., Kumar,M., Sharma,A., Babu,A., Ranjan,S.,
            Sachidanandan,C. and Mylavarapu,S.V.S.
  TITLE     The Light Intermediate Chain 2 Subpopulation of Dynein Regulates
            Mitotic Spindle Orientation
  JOURNAL   Sci Rep 6 (1), 22 (2016)
   PUBMED   28003657
  REMARK    GeneRIF: Cortically localized dynein, essential for maintaining
            correct spindle orientation, consists majorly of LIC2-dynein, which
            interacts with cortical 14-3-3 epsilon- zeta and Par3, conserved
            proteins required for orienting the spindle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4326)
  AUTHORS   Malik,S., Saito,H., Takaoka,M., Miki,Y. and Nakanishi,A.
  TITLE     BRCA2 mediates centrosome cohesion via an interaction with
            cytoplasmic dynein
  JOURNAL   Cell Cycle 15 (16), 2145-2156 (2016)
   PUBMED   27433848
  REMARK    GeneRIF: These results suggest that cytoplasmic dynein 1 binds to
            BRCA2 through the latter's centrosomal localization signal and
            BRCA2 mediates the cohesion between centrosomes during the S phase,
            potentially serving as a cell-cycle checkpoint.
REFERENCE   5  (bases 1 to 4326)
  AUTHORS   Mahale,S.P., Sharma,A. and Mylavarapu,S.V.
  TITLE     Dynein Light Intermediate Chain 2 Facilitates the Metaphase to
            Anaphase Transition by Inactivating the Spindle Assembly Checkpoint
  JOURNAL   PLoS One 11 (7), e0159646 (2016)
   PUBMED   27441562
  REMARK    GeneRIF: This study uncovers a novel functional hierarchy during
            mitotic checkpoint inactivation between the closely related but
            homologous LIC subunits of cytoplasmic dynein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4326)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 4326)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   8  (bases 1 to 4326)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 4326)
  AUTHORS   Chagnon,P., Michaud,J., Mitchell,G., Mercier,J., Marion,J.F.,
            Drouin,E., Rasquin-Weber,A., Hudson,T.J. and Richter,A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
REFERENCE   10 (bases 1 to 4326)
  AUTHORS   Hughes,S.M., Vaughan,K.T., Herskovits,J.S. and Vallee,R.B.
  TITLE     Molecular analysis of a cytoplasmic dynein light intermediate chain
            reveals homology to a family of ATPases
  JOURNAL   J Cell Sci 108 (Pt 1), 17-24 (1995)
   PUBMED   7738094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL708642.1, AF035812.1, BM805417.1, BC022934.1, BX648863.1 and
            AC018557.9.
            
            On Nov 22, 2018 this sequence version replaced NM_006141.2.
            
            Summary: Cytoplasmic dynein is a microtubule-associated motor
            protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM
            600112) for general information about dyneins.[supplied by OMIM,
            Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.16809.1,
                                           SRR1803612.262817.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258198.7/ ENSP00000258198.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL708642.1         14-25
            13-1634             AF035812.1         1-1622
            1635-1996           BM805417.1         418-779
            1997-2875           BC022934.1         315-1193
            2876-3408           BX648863.1         1675-2207
            3409-4323           BC022934.1         1727-2641
            4324-4326           AC018557.9         159550-159552       c
FEATURES             Location/Qualifiers
     source          1..4326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4326
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /note="dynein cytoplasmic 1 light intermediate chain 2"
                     /db_xref="GeneID:1783"
                     /db_xref="HGNC:HGNC:2966"
                     /db_xref="MIM:611406"
     exon            1..125
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1497
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dynein, cytoplasmic, light intermediate polypeptide 2;
                     cytoplasmic dynein 1 light intermediate chain 2; LIC-2;
                     LIC53/55; dynein light intermediate chain 2, cytosolic"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 light intermediate chain 2
                     isoform 1"
                     /protein_id="NP_006132.1"
                     /db_xref="CCDS:CCDS10818.1"
                     /db_xref="GeneID:1783"
                     /db_xref="HGNC:HGNC:2966"
                     /db_xref="MIM:611406"
                     /translation="MAPVGVEKKLLLGPNGPAVAAAGDLTSEEEEGQSLWSSILSEVS
                     TRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHT
                     RCNVWILDGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHI
                     DKMKIPPEKMRELERKFVKDFQDYMEPEEGCQGSPQRRGPLTSGSDEENVALPLGDNV
                     LTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAALIYTSVKE
                     EKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPED
                     AYEDFIVKPPVRKLVHDKELAAEDEQVFLMKQQSLLAKQPATPTRASESPARGPSGSP
                     RTQGRGGPASVPSSSPGTSVKKPDPNIKNNAASEGVLASFFNSLLSKKTGSPGSPGAG
                     GVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVTNSSTENEA"
     exon            126..199
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..316
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..547
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            548..717
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            718..811
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..947
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1059
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1119
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1161
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1279
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1396
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..4326
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4299..4304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /note="hexamer: AATAAA"
     polyA_site      4326
                     /gene="DYNC1LI2"
                     /gene_synonym="DNCLI2; LIC2"
                     /note="major polyA site"
ORIGIN      
        1 gtggctgcag ttggcaagat ggcgccggtg ggggtggaga agaagctgct gctaggtccc
       61 aacgggcccg cggtggcggc cgccggcgac ctgaccagtg aggaggagga aggccagagc
      121 ctatggtcct ccattctgag cgaagtgtcc acccgcgcca ggtccaagct gccgtccggc
      181 aagaacatcc tggtcttcgg tgaagatggt tctggtaaaa caaccctcat gactaaacta
      241 caaggagctg agcatggcaa aaaaggaaga ggcctagaat atctctacct cagtgtccat
      301 gatgaggacc gagatgatca cacgcgctgc aacgtgtgga ttctggatgg agacttgtac
      361 cacaaaggcc tgctgaaatt tgcagtttct gctgaatcct tgccagagac cctcgtcatt
      421 tttgttgcag acatgtctag accttggact gtgatggaat ctctgcagaa atgggctagt
      481 gttttacgtg agcacattga taaaatgaaa attccaccag aaaaaatgag ggagctggaa
      541 cggaagtttg tgaaagattt tcaagactat atggaacctg aagaaggttg tcaaggttcc
      601 ccacagagaa gaggccctct gacctcaggc tccgatgaag aaaatgttgc cctgcctctg
      661 ggtgacaatg tgctgactca taacctgggg atcccggtgt tggtggtgtg cacaaagtgt
      721 gatgcggtga gtgtcctgga gaaggagcac gattacaggg atgagcattt ggactttatc
      781 cagtcacacc tgcggaggtt ctgccttcag tatggagctg ccttgattta cacatcagtg
      841 aaagaagaga aaaacctcga cttgttgtat aagtatattg ttcataaaac atacggtttc
      901 cacttcacca cacctgcctt agttgtggaa aaggatgccg tttttatacc tgcaggctgg
      961 gacaatgaaa agaaaatagc tattttacat gaaaatttta caaccgtgaa gccggaagat
     1021 gcatatgaag actttattgt gaaacctccc gtgagaaagc tggtccacga caaagagttg
     1081 gcagcagaag atgagcaggt gttcctaatg aagcaacagt cactccttgc caagcaacca
     1141 gccactccca cgagagcttc tgaatctcct gcaagaggac cctctggctc tccaaggacc
     1201 cagggtcggg gagggccagc cagtgtgcct agctcctccc caggcacgtc agtaaaaaag
     1261 ccggacccaa acatcaaaaa taatgcagca agtgaagggg tgttggccag cttcttcaac
     1321 agtctgttga gtaaaaagac aggctctcct ggaagtcctg gtgctggtgg ggtgcagagc
     1381 acagccaaga agtcaggaca aaagactgtg ttgtcaaatg ttcaggaaga actggataga
     1441 atgactcgaa agccagactc tatggtaaca aactcttcaa cagaaaatga agcctgaacc
     1501 tccttaaaaa gtgcatatgt cgaatgacca aataactatg tatattgatc tgctaagacc
     1561 aggatttttc tgatatggca catgctatca gttttttggg gcaggggaga tgaactttaa
     1621 aaaaaaaaaa aaaacttcat tggcttgtcc gagtgtgaaa tgcacattta ggaaggttac
     1681 atgtcagacc ctttgttaag gataaccctt ggactctggg gcatgtggct cttttgtggg
     1741 aggcaagcac atctgggctt cttgtggagg ggaaggtaga gtgaaagaaa gagggcccac
     1801 tttctaacag ggtggagcaa atgagaccaa gaaatcattg gtaagatgat ggttagtctg
     1861 accagtttca tgttagtaaa ttcacttgtt cttgggaagc agattaagta gcagaaagtc
     1921 caggaaagaa agaccagaag gagtaatgag acaagtgatg gtggggaagc tgaatgttga
     1981 gggaggtgga ggaaggagga gatgagcagt gtcagtaaat actgtgcatt cagtagaagt
     2041 tgaagaatca ttgttagaag catttccaaa caaaacacta agcaaaatgg gaattaggct
     2101 tattttgaat gcatctttaa cttacgaaag atgtactaat tgtgggggtg cctgagtcag
     2161 gcggagctga cccaggggtg ggaacgatgg cagctgccca ggacccatgt gcttggccca
     2221 ggctatgtcc tcgtgagagg tactggggtc cacggatatg tgttgtgggg cagacagtca
     2281 ctgtgggatg tcttcaaagt cagcagttac agaattagtt tactttgaat tttgttgtct
     2341 aaatagctcc tgctttattt tttaaattaa attttttgtt tttactatca caggctggcc
     2401 taactaatac aaaataggtg atgaacctct ggttttacca taatgcaatg tgccacggaa
     2461 agtttggggg aggtttttaa tgtaattgca ctctggttaa ttggctcgta ccaagccctg
     2521 ccttatgact tgtggaaagc ttcaaggagt tccactgatg caaaagggtc ttttcctagc
     2581 ttcctggtct gatcagtgct atgagatgga cagataagtg tgaatgtttt atacagaaaa
     2641 tggaaatgat acatttctct tgttaggtgt tttcataaaa tgtagcattt tttttcttat
     2701 ggaaataaga gtttcaggtg tctccccacc tagggcaaat tcatgcacat tgtcatgtta
     2761 taccaccatt ctggaaatga tttctgtgga tttgaaattg cacttttaat tttatatatg
     2821 acagcattta aatgcaaaca ctaccatgaa tttaatgtat aaaatgttgt caaaccaagg
     2881 gaaaaaacca cagttcacca tgtggagttt acttttttta tatgaatgtt tgttgtactg
     2941 tgtctaagca taacttccct aatgtcatta cttttacata ccagatttga ctgaccacta
     3001 atgtagtact ggggataact taatatccta tgttgtgtca agactctttg aagactttct
     3061 tgaattgctt tcgtaaaggt ctgaacactg ttaaggagaa agctgagtat caacttgcct
     3121 ttctgataga aatgtttctt gtgccagttt tattgttgag atatactatt tttttccttt
     3181 tttaattcag ttttttaaaa aaacaaatgt attgtggctt ccagttacca ggttgtctag
     3241 gtaatgacag taaactgact gtagaatgat aattgtggta tagtgaccaa tagatgccaa
     3301 acagcttgtg gcctcactaa aggtggggtc gcttagtccc cgggagtaaa atgagtgacc
     3361 tcagaaacaa gaattcctgg aaaggcacat gccgaagagg aatatggtat aattttaaat
     3421 tttaatgcaa aattttaatt tgtctttatt ttttatcatt tgaactgata agcacttttt
     3481 gtgtcaatat aaaatatact aaaactgatg aaatgctaag acatgtcttg tgaaggaagg
     3541 tttcttggag accactttta tttactcatg agaagtggaa gctcctagta tcagaagaag
     3601 ctgatacata gtgtcatgtg ctcagtggtt gccaaagtct accaactttg gggagctgca
     3661 gggttctttt tgggaggtgg gaggaaggga gatgagtttt gttattttgg ggttttcaag
     3721 cattggaacc aaaggccaaa taataaacag cctttagttt ttaaagtaaa attcatttta
     3781 tttgcagagt acacttgtat ggtagactgt taaagacaat tttatgacta tttatgcaca
     3841 ttataatggt tacatctgct ttttgtcttt aaaataaaaa aaaaaatcag agaaaagccc
     3901 acctttgaat acgtggctga agataacagc caagaattgg tctttcctaa aaatgcaaca
     3961 gataatgctg ctagattgtt attttgtttg cacttttttt tgattggcat tttaaaatcg
     4021 gtatttaaac tgaagacatt gtcatgtttt attaatttaa caaagttgaa agtgactgct
     4081 ctgtacatca tgaccttaac aatgttaatg ctgtaagtga aagttcactg tcgtctgtat
     4141 actaaattta ttggtgtttc taacttaaaa gtaagactgc agattatccc ccaccagcct
     4201 tagtccaggg gtgtggctct gtccgggtgc agtatgcagt catgtggaac cttgctttct
     4261 agtcctggga aaaaaagatg tctctaatta ctggcttcaa taaacacgaa tccagactgc
     4321 ttacaa
//
