LOCUS       NM_016141               2485 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens dynein cytoplasmic 1 light intermediate chain 1
            (DYNC1LI1), transcript variant 1, mRNA.
ACCESSION   NM_016141
VERSION     NM_016141.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2485)
  AUTHORS   Kumari,A., Kumar,C., Pergu,R., Kumar,M., Mahale,S.P., Wasnik,N. and
            Mylavarapu,S.V.S.
  TITLE     Phosphorylation and Pin1 binding to the LIC1 subunit selectively
            regulate mitotic dynein functions
  JOURNAL   J Cell Biol 220 (12) (2021)
   PUBMED   34709360
  REMARK    GeneRIF: Phosphorylation and Pin1 binding to the LIC1 subunit
            selectively regulate mitotic dynein functions.
REFERENCE   2  (bases 1 to 2485)
  AUTHORS   Chang,C.C., Chao,K.C., Huang,C.J., Hung,C.S. and Wang,Y.C.
  TITLE     Association between aberrant dynein cytoplasmic 1 light
            intermediate chain 1 expression levels, mucins and chemosensitivity
            in colorectal cancer
  JOURNAL   Mol Med Rep 22 (1), 185-192 (2020)
   PUBMED   32319648
  REMARK    GeneRIF: Association between aberrant dynein cytoplasmic 1 light
            intermediate chain 1 expression levels, mucins and chemosensitivity
            in colorectal cancer.
REFERENCE   3  (bases 1 to 2485)
  AUTHORS   Sakthikumar,S., Roy,A., Haseeb,L., Pettersson,M.E., Sundstrom,E.,
            Marinescu,V.D., Lindblad-Toh,K. and Forsberg-Nilsson,K.
  TITLE     Whole-genome sequencing of glioblastoma reveals enrichment of
            non-coding constraint mutations in known and novel genes
  JOURNAL   Genome Biol 21 (1), 127 (2020)
   PUBMED   32513296
  REMARK    GeneRIF: Whole-genome sequencing of glioblastoma reveals enrichment
            of non-coding constraint mutations in known and novel genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2485)
  AUTHORS   Tan,S.C., Scherer,J. and Vallee,R.B.
  TITLE     Recruitment of dynein to late endosomes and lysosomes through light
            intermediate chains
  JOURNAL   Mol Biol Cell 22 (4), 467-477 (2011)
   PUBMED   21169557
  REMARK    GeneRIF: using a variety of complementary approaches, our results
            indicate a novel specific role for the LICs in dynein recruitment
            to components of the late endocytic pathway.
REFERENCE   5  (bases 1 to 2485)
  AUTHORS   Horgan,C.P., Hanscom,S.R. and McCaffrey,M.W.
  TITLE     Dynein LIC1 localizes to the mitotic spindle and midbody and LIC2
            localizes to spindle poles during cell division
  JOURNAL   Cell Biol Int 35 (2), 171-178 (2011)
   PUBMED   20964624
REFERENCE   6  (bases 1 to 2485)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2485)
  AUTHORS   Sivaram,M.V., Wadzinski,T.L., Redick,S.D., Manna,T. and Doxsey,S.J.
  TITLE     Dynein light intermediate chain 1 is required for progress through
            the spindle assembly checkpoint
  JOURNAL   EMBO J 28 (7), 902-914 (2009)
   PUBMED   19229290
  REMARK    GeneRIF: Dynein light intermediate chain 1 is required for progress
            through the spindle assembly checkpoint
REFERENCE   8  (bases 1 to 2485)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   9  (bases 1 to 2485)
  AUTHORS   Bielli,A., Thornqvist,P.O., Hendrick,A.G., Finn,R., Fitzgerald,K.
            and McCaffrey,M.W.
  TITLE     The small GTPase Rab4A interacts with the central region of
            cytoplasmic dynein light intermediate chain-1
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1141-1153 (2001)
   PUBMED   11243854
REFERENCE   10 (bases 1 to 2485)
  AUTHORS   Tynan,S.H., Purohit,A., Doxsey,S.J. and Vallee,R.B.
  TITLE     Light intermediate chain 1 defines a functional subfraction of
            cytoplasmic dynein which binds to pericentrin
  JOURNAL   J Biol Chem 275 (42), 32763-32768 (2000)
   PUBMED   10893222
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK074348.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_016141.3.
            
            Summary: The protein encoded by this gene belongs to light
            intermediate subunit family, whose members are components of the
            multiprotein cytoplasmic dynein complex, which is involved in
            intracellular trafficking and chromosome segregation during
            mitosis. The protein plays a role in moving the spindle assembly
            checkpoint (SAC) from kinetochores to spindle poles. The protein
            may also mediate binding to other cargo molecules to facilitate
            intracellular vesicle trafficking. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074348.1, SRR1660809.260396.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273130.9/ ENSP00000273130.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2485              AK074348.1         1-2485
FEATURES             Location/Qualifiers
     source          1..2485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..2485
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /note="dynein cytoplasmic 1 light intermediate chain 1"
                     /db_xref="GeneID:51143"
                     /db_xref="HGNC:HGNC:18745"
                     /db_xref="MIM:615890"
     exon            1..234
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1660
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dynein, cytoplasmic, light intermediate polypeptide 1;
                     dynein light chain A; dynein light intermediate chain 1,
                     cytosolic"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 light intermediate chain 1
                     isoform 1"
                     /protein_id="NP_057225.2"
                     /db_xref="CCDS:CCDS2654.1"
                     /db_xref="GeneID:51143"
                     /db_xref="HGNC:HGNC:18745"
                     /db_xref="MIM:615890"
                     /translation="MAAVGRVGSFGSSPPGLSSTYTGGPLGNEIASGNGGAAAGDDED
                     GQNLWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYL
                     YLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALD
                     SLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQED
                     KDDSVVLPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCL
                     QYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIG
                     ILHENFQTLKAEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAG
                     RPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNS
                     LLSKKTGSPGGPGVSGGSPAGGAGGGSSGLPPSTKKSGQKPVLDVHAELDRITRKPVT
                     VSPTTPTSPTEGEAS"
     exon            235..308
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..425
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..656
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..826
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..920
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1056
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1168
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1228
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1273
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1394
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1550
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..2485
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1669..1674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /note="major polyA site"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
                     /note="hexamer: AATAAA"
     polyA_site      2485
                     /gene="DYNC1LI1"
                     /gene_synonym="DLC-A; DLIC-1; DNCLI1; LIC1"
ORIGIN      
        1 atatccgggt tcccgccgcc tccaccgcca ccgcctcagc cgcctcgcac atttagtctt
       61 gccgggagtg gtgtgattcc cgaccaagat ggcggccgtg gggcgagtcg gctccttcgg
      121 ttcttctccg ccgggattat cctcgactta cactggcggc cccttgggca acgagatagc
      181 gtcgggcaac ggtggcgccg cggcaggcga cgacgaggac gggcagaacc tttggtcctg
      241 catcctcagc gaggtctcca cccgctcgcg ctccaagctc cctgcgggga agaacgtgct
      301 actgctgggt gaagatggag ctggaaaaac aagcttaata agaaaaattc agggaataga
      361 ggagtataag aaaggaagag gattggaata tttgtactta aatgtgcatg atgaagacag
      421 ggatgatcaa acaagatgta atgtttggat cttagatgga gacctatatc acaaaggcct
      481 ccttaaattt tcactggatg ccgtatctct gaaggatact ctagttatgc tggttgttga
      541 catgtcaaag ccttggactg ctttggattc tttacagaaa tgggcaagtg ttgttagaga
      601 acatgttgac aaactgaaaa tccctcctga agaaatgaaa caaatggaac aaaagttgat
      661 tagagacttc caagaatatg tagagccagg agaagacttc ccggcttctc cccagagaag
      721 aaatactgcg tcacaagaag acaaagatga cagtgtagtt ttacctctgg gtgcggatac
      781 acttacacat aacttgggca ttccagtact agtagtttgc acaaagtgtg atgccattag
      841 tgtattggag aaagaacatg actacagaga tgaacatttt gattttattc agtcacatat
      901 ccggaagttt tgtttacagt atggtgcagc acttatttac acttcagtaa aagaaaacaa
      961 aaatatagac ttagtatata aatacatcgt tcagaaacta tatggatttc cctataagat
     1021 tcctgctgtt gttgtggaaa aggatgcagt atttattcca gcagggtggg ataatgataa
     1081 gaaaatagga atattacatg aaaattttca aacattaaaa gcagaagata attttgaaga
     1141 catcataact aaaccacctg ttcgaaagtt tgtacatgag aaggaaatta tggcagaaga
     1201 tgatcaggtg tttcttatga agctacagtc ccttttagca aagcaaccac caactgcagc
     1261 tggaaggcct gtggatgcct caccaagagt cccaggaggc tccccacgaa caccaaatag
     1321 atctgtatca tctaatgttg ccagcgtgtc acccattcct gctgggtcaa aaaaaattga
     1381 tccaaacatg aaagctggag ctacaagtga aggcgttctg gcaaatttct tcaacagttt
     1441 gttgagtaaa aagactggct ctccaggagg ccctggtgtg agtggtggta gccctgcagg
     1501 tggggctgga ggtggaagca gtggtttacc accatccacc aaaaagtcag gccagaagcc
     1561 tgtcttagat gttcatgcag aactagacag aattacacga aaaccagtta cagtttctcc
     1621 cacaacacct acatctccta cggaaggaga agcttcttga agataccaaa taaagccatt
     1681 tattctgttt tctgggataa tgtaaacatg cctctgcctt ttccttcaaa agtggaatta
     1741 gaaagctgga gtgcttcttc agatggacta aatttatgtc gtgtgtgtgt gtgtgtgtgt
     1801 gtgtggttac ccatttttta gaaggagccg tacagaagaa aaattattct acattatgta
     1861 ggattgctgt ttgcattgcc attttgcata agaaagtaat ttttgatttt gaaaatctca
     1921 aaacttttag atctgaaata cagccatgtg atcgatcata ttctaaaggc tatttaaaac
     1981 atgtaaaagg atttggggaa cggcagaaaa catgcagttt gggcatttga ctgacttgga
     2041 agtctaagct tattttagtt ataactatta aaatcatttt taaaaatttg ttagttttgc
     2101 tgacagagaa aaatcgtcag ttgtcagatt ttgcacacca caataaatgt accaccacac
     2161 acggaatatg ctaagaaaac tatcagatag cgtttgatac actagtcatt gtctcaatca
     2221 ctgatcctgt aagttgtcat caaaatatga tttagaaata ttggccaagg tgttgcttta
     2281 actgaggaga aaagaaagca cactgcctaa atgtgtaaaa gaaaaatgca gaggttatta
     2341 aaatgtaaag aagtaacaat ctttggattt gtctatacat atatatatat atatatggct
     2401 ttgccttaat ataccccctt ttttgtttgt gactttcaac tgtaatcagt taataaagta
     2461 tttattctct gcattcaggt tcaaa
//
