LOCUS       NM_001378               4354 bp    mRNA    linear   PRI 12-JUN-2025
DEFINITION  Homo sapiens dynein cytoplasmic 1 intermediate chain 2 (DYNC1I2),
            transcript variant 1, mRNA.
ACCESSION   NM_001378
VERSION     NM_001378.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4354)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4354)
  AUTHORS   Habu,T. and Kim,J.
  TITLE     Dynein intermediate chain 2c (DNCI2c) complex is essential for
            exiting Mad2-dependent spindle assembly checkpoint
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (12), 119120 (2021)
   PUBMED   34400173
  REMARK    GeneRIF: Dynein intermediate chain 2c (DNCI2c) complex is essential
            for exiting Mad2-dependent spindle assembly checkpoint.
REFERENCE   3  (bases 1 to 4354)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4354)
  AUTHORS   Canty,J.T., Tan,R., Kusakci,E., Fernandes,J. and Yildiz,A.
  TITLE     Structure and Mechanics of Dynein Motors
  JOURNAL   Annu Rev Biophys 50, 549-574 (2021)
   PUBMED   33957056
  REMARK    Review article
REFERENCE   5  (bases 1 to 4354)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4354)
  AUTHORS   Palmer,K.J., Hughes,H. and Stephens,D.J.
  TITLE     Specificity of cytoplasmic dynein subunits in discrete
            membrane-trafficking steps
  JOURNAL   Mol Biol Cell 20 (12), 2885-2899 (2009)
   PUBMED   19386764
REFERENCE   7  (bases 1 to 4354)
  AUTHORS   Pfister,K.K., Fisher,E.M., Gibbons,I.R., Hays,T.S., Holzbaur,E.L.,
            McIntosh,J.R., Porter,M.E., Schroer,T.A., Vaughan,K.T.,
            Witman,G.B., King,S.M. and Vallee,R.B.
  TITLE     Cytoplasmic dynein nomenclature
  JOURNAL   J Cell Biol 171 (3), 411-413 (2005)
   PUBMED   16260502
REFERENCE   8  (bases 1 to 4354)
  AUTHORS   Davies,T.H., Ning,Y.M. and Sanchez,E.R.
  TITLE     A new first step in activation of steroid receptors:
            hormone-induced switching of FKBP51 and FKBP52 immunophilins
  JOURNAL   J Biol Chem 277 (7), 4597-4600 (2002)
   PUBMED   11751894
REFERENCE   9  (bases 1 to 4354)
  AUTHORS   Crackower,M.A., Sinasac,D.S., Xia,J., Motoyama,J., Prochazka,M.,
            Rommens,J.M., Scherer,S.W. and Tsui,L.C.
  TITLE     Cloning and characterization of two cytoplasmic dynein intermediate
            chain genes in mouse and human
  JOURNAL   Genomics 55 (3), 257-267 (1999)
   PUBMED   10049579
REFERENCE   10 (bases 1 to 4354)
  AUTHORS   Vaughan,K.T. and Vallee,R.B.
  TITLE     Cytoplasmic dynein binds dynactin through a direct interaction
            between the intermediate chains and p150Glued
  JOURNAL   J Cell Biol 131 (6 Pt 1), 1507-1516 (1995)
   PUBMED   8522607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA435365.1, AK055491.1,
            BC091498.1 and AC068039.6.
            
            On Jun 2, 2019 this sequence version replaced NM_001378.2.
            
            Summary: This gene encodes a member of the dynein intermediate
            chain family. The encoded protein is a non-catalytic component of
            the cytoplasmic dynein 1 complex, which acts as a retrograde
            microtubule motor to transport organelles and vesicles. A
            pseudogene of this gene is located on chromosome 10. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Nov 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.43162.1,
                                           SRR1660805.83421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397119.8/ ENSP00000380308.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DA435365.1         61-63
            4-816               AK055491.1         1-813
            817-2607            BC091498.1         727-2517
            2608-4354           AC068039.6         43771-45517
FEATURES             Location/Qualifiers
     source          1..4354
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..4354
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="dynein cytoplasmic 1 intermediate chain 2"
                     /db_xref="GeneID:1781"
                     /db_xref="HGNC:HGNC:2964"
                     /db_xref="MIM:603331"
     exon            1..159
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            160..276
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2085
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dynein, cytoplasmic, intermediate polypeptide 2; DH IC-2;
                     dynein intermediate chain 2, cytosolic; testis tissue
                     sperm-binding protein Li 66n"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 intermediate chain 2
                     isoform 1"
                     /protein_id="NP_001369.1"
                     /db_xref="CCDS:CCDS46450.1"
                     /db_xref="GeneID:1781"
                     /db_xref="HGNC:HGNC:2964"
                     /db_xref="MIM:603331"
                     /translation="MSDKSELKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAV
                     APVQEESDLEKKRREAEALLQSMGLTPESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQ
                     DSGDGAVGSRTLHWDTDPSVLQLHSDSDLGRGPIKLGMAKITQVDFPPREIVTYTKET
                     QTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILH
                     SEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERW
                     SKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSA
                     VMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGT
                     QNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVG
                     SEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKL
                     WTTKNNKPLYSFEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASIS
                     VEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINAN
                     RADAEEEAATRIPA"
     exon            277..394
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            395..412
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            413..503
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            504..563
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            564..679
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            680..775
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            776..938
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1038
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1164
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1311
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1425
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1559
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1704
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1845
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1971
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..4354
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2586..2591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="hexamer: AATAAA"
     regulatory      2592..2597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="hexamer: AACAAA"
     polyA_site      2607
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="major polyA site"
     polyA_site      2616
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="major polyA site"
     regulatory      3877..3882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="hexamer: AATAAA"
     polyA_site      3899
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
     regulatory      4334..4339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
                     /note="hexamer: AATAAA"
     polyA_site      4354
                     /gene="DYNC1I2"
                     /gene_synonym="DIC74; DNCI2; IC2; NEDMIBA"
ORIGIN      
        1 cttctcgatc gtgtcagttt gtaaggcgag ggcggaagtt ggattcctgg cctgagaata
       61 ttaggcgtag ttttccagtt tttggcaaag cggaaatact taaggcccct gggttgactg
      121 ggttctttgt tttatctacc ggcttctgct ttacgacagg tcacaaacat gtcagacaaa
      181 agtgaattaa aggctgagtt ggaacgtaag aagcagcgac tggcccaaat cagagaggaa
      241 aagaagagaa aagaagaaga aaggaaaaaa aaagaaacag accagaagaa ggaagctgtt
      301 gctcctgtgc aagaagaatc agatcttgaa aaaaaaagga gagaagctga agcattgctt
      361 caaagcatgg ggctaactcc agaatccccc attgtttttt ctgaatactg ggtccctcct
      421 cctatgtctc catcctccaa atctgtgagc actccaagtg aagctggaag ccaagactct
      481 ggagatggcg ccgtgggatc taggacgctg cattgggata cagatccatc agttcttcag
      541 cttcactcag attccgattt gggacgagga cctattaaac ttggaatggc taaaatcacg
      601 caagtcgact ttcctcctcg agaaattgtc acgtatacaa aggaaactca gactccagtt
      661 atggctcaac ccaaagaaga tgaagaggaa gatgatgatg tagtggctcc taaaccacct
      721 attgaacctg aagaagagaa aactttaaag aaagatgagg aaaatgatag taaagctccc
      781 cctcatgagc tgactgaaga agaaaagcaa caaatcttgc actctgagga atttttaagt
      841 ttctttgacc attctacaag aattgtagaa agagctcttt ctgagcagat taacatcttc
      901 tttgactata gtgggagaga tttggaagac aaagaaggag agattcaagc aggtgctaaa
      961 ctgtcattaa atcgacaatt ttttgacgaa cgttggtcaa agcatcgggt ggttagttgt
     1021 ttggattggt catctcagta tccggagtta ctcgtggctt cctataacaa caatgaagat
     1081 gcccctcatg agcctgatgg tgtggccctt gtatggaata tgaaatacaa aaaaactacc
     1141 ccagagtatg tgtttcactg ccagtcagct gtgatgtctg ccacatttgc aaaatttcat
     1201 ccaaatcttg ttgttggtgg tacatattca ggccaaattg tgctttggga taaccgtagc
     1261 aataaaagaa ctccagtgca aagaactcca ctgtcagcag ctgcacacac acaccctgta
     1321 tattgtgtaa atgttgttgg aacacaaaat gctcacaatc tgattagcat ctctactgat
     1381 ggaaaaattt gttcatggag tctggacatg ctttcccatc cacaggatag catggagttg
     1441 gttcataaac agtcaaaagc agtagctgtg acatctatgt ccttccctgt tggagatgtc
     1501 aacaactttg ttgttgggag tgaagaaggt tctgtgtaca cagcatgccg ccatggcagc
     1561 aaagctggaa tcagtgagat gtttgagggg catcaaggac caatcactgg catccattgt
     1621 catgcagctg ttggagcagt agacttctca catctttttg tcacttcatc gtttgactgg
     1681 acagtaaagc tttggacaac taagaataac aagcctttgt attcatttga agataatgca
     1741 gactatgttt atgatgttat gtggtcacct acccacccag ccctgtttgc ctgtgtggat
     1801 ggcatgggga gattggattt gtggaatctc aataatgaca cagaggtacc aactgccagc
     1861 atttctgtgg agggtaatcc tgctcttaat cgtgtgagat ggacccattc tggcagagag
     1921 attgctgtgg gtgattctga aggacagatt gttatatacg atgtgggaga gcagattgct
     1981 gttccccgca atgatgaatg ggcacggttt ggccgaacac ttgcagaaat taatgcaaac
     2041 cgagctgatg cagaggagga agcagctacc cgaatacctg cttagttcct gaaaagggga
     2101 gtgtaactag tggatttggg aaaggttctt aagtagatcc tgagactatt tgcatgcttc
     2161 tgtctaaatg ataattaaaa ggaaatttca tggattaaac catgggttta atgcagcaag
     2221 gaaacttaca atgtcccttt atatataaca tgcatcttgt tttggatttg tgtcattttt
     2281 taatatagct gattgacttc acagaaagca gcttttttga attctaatac ataggtgtat
     2341 atttggtatt agttattttg agttcttttc aacttataac actgtataca gttatttcta
     2401 aagcacagat gaaataagtt ctgcatattt ttaaataatc acagttccct gttatacaga
     2461 taatgttctc actacccata atatgtagga acattgtttc tccttagccg tagtatgcat
     2521 acacctatcc atgttcattc tgacatcctt tgttgtcttt ataattcatg tggtagttac
     2581 ctataaataa aaacaaatat gcgttaactt ttcaaatttt catttttact ccttacaact
     2641 tgaatttttc catcttttat aaaatatatt ttttccatat ctttctttaa gctcctgctg
     2701 tgagcagcca tctcaaatcc tatagagctg tgtaccctaa atataccatg tggtatatac
     2761 tatagatctc ccagtgcatt atgaattgat gtctagataa tctgttggtg aaaaaatttc
     2821 ccctaggtta acttttgctt tactacttta tattctttcc atctaagaca tatttccttt
     2881 aaaggataaa tagaaagctg cctataattt tcactgatta agaactatgt atgtgacctc
     2941 actgagagta aaatctttga gagaaattga tttcatgatt tcagtagcca taaaggcaaa
     3001 gtgctcaaat ggacccatac tttggcatta aaatctacat cttgagatct gttgccacag
     3061 cattgtctac aagtccgaaa ggtaggtgac aaatatctaa gaatcagtat tgaaatcagt
     3121 gaatttcagg aatagaggaa aggactatga tcagatcttg attttatcta ctttaaattg
     3181 tctatttatt tgatcccaac cttttgtact tctgaagtgt aactgtcttt tattcaacag
     3241 aacatgaact aggaagagag attagaaaac agaatgtgaa catttttctt ttaataattg
     3301 taacaaagat ttgttgggag agaaatttcc aaataatgag tagtgtatag tgtaaggaat
     3361 aattgacctg gaattattgg ccccaaactc tgattcttgc tgaagcatct atgagaagtg
     3421 tgattttagc caagtctgtg ccgcattctt tatatgtagg aattaagttt tgatttaatg
     3481 atttctgaat tttctttcag ctctactcaa ttaaggggta tcagtatgtg aaatggaata
     3541 tagaaaagta ggcaattctt tacttttcta tattcagttt cataaattaa taccccataa
     3601 ttgcccatta tataccaaag acaatatctc aagttatctc attgtagcag tgtctgtgag
     3661 tcaaaacttc aattttagta gagtcacact ttctttatat agaaaaattc atgtactcac
     3721 tactcatgta gttactgtat ctttaccttc agtttgtaaa aatgactaaa agtagggaaa
     3781 acaagtgtta aaacataatg gataagaaaa ggttggaaat catatggcaa atcacatgtt
     3841 cctcagcctc aaggtgtgtt tagttgtgaa agaaagaata aaattgttta aatatttcac
     3901 tttttgggaa tgacttctcc cctactcccc cagaaaatgc gatgtatacc tttgcccatt
     3961 caactttagt ccatattttt aggaacacac aaatttactt taaggaatta cctttaaagt
     4021 tgactatata atagcaaaag agaaagtatt gagactgtca gtgttgataa agcttctagc
     4081 aagattaggt tgactagaag tgcatcacag ttctttatac ttttagaact aaaagcctta
     4141 taattttgaa aaatatccag ttacagaaat tgtaccttat cagttatact ttttttctga
     4201 gtaagaaaac aagctatagc tttctggtta atttcttatt tttcgttgtt tggtttttgt
     4261 ctttttgagt ggaacgttaa agtttattac cttcatgtta aggaatatcc agcttcacag
     4321 acaattaact tgcaataaat ctctgaaata atca
//
