LOCUS       NM_001135556            2947 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens dynein cytoplasmic 1 intermediate chain 1 (DYNC1I1),
            transcript variant 2, mRNA.
ACCESSION   NM_001135556
VERSION     NM_001135556.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2947)
  AUTHORS   Ananya,R.G., Pandi,C., Kannan,B., Pandi,A., Prasad,P.,
            Jayaseelan,V.P. and Arumugam,P.
  TITLE     DYNC1I1 acts as a promising prognostic biomarker and is correlated
            with immune infiltration in head and neck squamous cell carcinoma
  JOURNAL   J Stomatol Oral Maxillofac Surg 125 (4), 101734 (2024)
   PUBMED   38072235
  REMARK    GeneRIF: DYNC1I1 acts as a promising prognostic biomarker and is
            correlated with immune infiltration in head and neck squamous cell
            carcinoma.
REFERENCE   2  (bases 1 to 2947)
  AUTHORS   Zhou,J., Zhu,Y., Ma,S., Li,Y., Liu,K., Xu,S., Li,X., Li,L., Hu,J.
            and Liu,Y.
  TITLE     Bioinformatics analysis identifies DYNC1I1 as prognosis marker in
            male patients with liver hepatocellular carcinoma
  JOURNAL   PLoS One 16 (10), e0258797 (2021)
   PUBMED   34679093
  REMARK    GeneRIF: Bioinformatics analysis identifies DYNC1I1 as prognosis
            marker in male patients with liver hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2947)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2947)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2947)
  AUTHORS   Gong,L., Wen,T., Li,Z., Wang,Y., Wang,J., Che,X., Liu,Y. and Qu,X.
  TITLE     TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer
            cell proliferation and inhibits apoptosis
  JOURNAL   Cancer Med 8 (17), 7299-7312 (2019)
   PUBMED   31605449
  REMARK    GeneRIF: TNPO2 operates downstream of DYNC1I1 and promotes gastric
            cancer cell proliferation and inhibits apoptosis.
REFERENCE   6  (bases 1 to 2947)
  AUTHORS   Ligon,L.A., Tokito,M., Finklestein,J.M., Grossman,F.E. and
            Holzbaur,E.L.
  TITLE     A direct interaction between cytoplasmic dynein and kinesin I may
            coordinate motor activity
  JOURNAL   J Biol Chem 279 (18), 19201-19208 (2004)
   PUBMED   14985359
REFERENCE   7  (bases 1 to 2947)
  AUTHORS   Lo,K.W., Naisbitt,S., Fan,J.S., Sheng,M. and Zhang,M.
  TITLE     The 8-kDa dynein light chain binds to its targets via a conserved
            (K/R)XTQT motif
  JOURNAL   J Biol Chem 276 (17), 14059-14066 (2001)
   PUBMED   11148209
REFERENCE   8  (bases 1 to 2947)
  AUTHORS   Horikawa,I., Parker,E.S., Solomon,G.G. and Barrett,J.C.
  TITLE     Upregulation of the gene encoding a cytoplasmic dynein intermediate
            chain in senescent human cells
  JOURNAL   J Cell Biochem 82 (3), 415-421 (2001)
   PUBMED   11500918
REFERENCE   9  (bases 1 to 2947)
  AUTHORS   Crackower,M.A., Sinasac,D.S., Xia,J., Motoyama,J., Prochazka,M.,
            Rommens,J.M., Scherer,S.W. and Tsui,L.C.
  TITLE     Cloning and characterization of two cytoplasmic dynein intermediate
            chain genes in mouse and human
  JOURNAL   Genomics 55 (3), 257-267 (1999)
   PUBMED   10049579
REFERENCE   10 (bases 1 to 2947)
  AUTHORS   King,S.M., Dillman,J.F. 3rd, Benashski,S.E., Lye,R.J.,
            Patel-King,R.S. and Pfister,K.K.
  TITLE     The mouse t-complex-encoded protein Tctex-1 is a light chain of
            brain cytoplasmic dynein
  JOURNAL   J Biol Chem 271 (50), 32281-32287 (1996)
   PUBMED   8943288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA491512.1, AK313148.1, AF123074.1, BC032945.2 and DB343806.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001135556.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (b)
            has the same N- and C-termini but is shorter compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032945.2, SRR1660807.171288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447467.6/ ENSP00000392337.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               DA491512.1         49-572
            525-1668            AK313148.1         571-1714
            1669-1881           AF123074.1         1566-1778
            1882-2224           BC032945.2         1882-2224
            2225-2673           DB343806.1         1-449               c
            2674-2947           BC032945.2         2674-2947
FEATURES             Location/Qualifiers
     source          1..2947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..2947
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /note="dynein cytoplasmic 1 intermediate chain 1"
                     /db_xref="GeneID:1780"
                     /db_xref="HGNC:HGNC:2963"
                     /db_xref="MIM:603772"
     exon            1..220
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..337
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..2116
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /note="isoform b is encoded by transcript variant 2;
                     dynein, cytoplasmic, intermediate polypeptide 1;
                     cytoplasmic dynein 1 intermediate chain 1; DH IC-1; dynein
                     intermediate chain 1, cytosolic; cytoplasmic dynein
                     intermediate chain 1"
                     /codon_start=1
                     /product="cytoplasmic dynein 1 intermediate chain 1
                     isoform b"
                     /protein_id="NP_001129028.1"
                     /db_xref="CCDS:CCDS47645.1"
                     /db_xref="GeneID:1780"
                     /db_xref="HGNC:HGNC:2963"
                     /db_xref="MIM:603772"
                     /translation="MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKE
                     PVQDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSPSSKSVSTPSEAGSQDSGDLGP
                     LTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATH
                     QSEEDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFD
                     RTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCM
                     DWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARF
                     HPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITV
                     STDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTA
                     CRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPL
                     YSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNR
                     VRWAQAGKEVAVGDSEGRIWVYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGTV
                     ELSA"
     exon            338..452
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..543
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..603
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..719
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..809
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..972
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1072
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1198
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1345
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1459
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1593
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1738
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1879
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2005
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2947
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2929..2934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /note="hexamer: AATAAA"
     polyA_site      2947
                     /gene="DYNC1I1"
                     /gene_synonym="DNCI1; DNCIC1"
                     /note="major polyA site"
ORIGIN      
        1 agactgagtg ctccggggag ctgtcagtgt caggctctgg gagagaggaa gtgatcgctc
       61 ccggaggagc gcgagccgag cggccggcgc agcgtgagac agcacatcct gcccgcgccg
      121 gccccgccac cttcgggagc cgcctgcacc aacgctgccg ccgcccagga gccgccgccg
      181 gctcggggag cccagttccg ccgctgccga gcgcgtccag gaaaccaaca tgtctgacaa
      241 aagtgactta aaagctgagc tagagcgcaa aaagcagcgc ttagcacaga taagagaaga
      301 gaagaaacgg aaggaagagg agaggaaaaa gaaagaggct gatatgcagc agaagaaaga
      361 acccgttcag gacgactctg atctggatcg caaacgacga gagacagagg ctttgctgca
      421 aagcattggt atctcaccgg agccgcctct agtcccaacc cctatgtctc cctcctcgaa
      481 atcagtgagc actcccagtg aagctggaag ccaagactca ggcgatctgg ggccattaac
      541 aaggaccctg cagtgggaca cagacccctc agtgctccag ctgcagtcag actcagaact
      601 tggaagaaga ctgcataaac tgggcgtgtc aaaggtcacc caagtggatt tcctgccaag
      661 ggaagtagtg tcctactcaa aggagaccca gactcctctt gccacgcatc agtctgaaga
      721 ggatgaggaa gatgaggaaa tggtggaatc taaagttggc caggactcag aactggaaaa
      781 tcaggacaaa aaacaggaag tgaaggaagc ccctccaaga gagttgacag aggaagaaaa
      841 acagcagatc cttcattcag aggaatttct catctttttt gaccggacaa tacgggtaat
      901 tgaaagagcc ctggctgaag attccgacat cttttttgac tacagcggcc gagagttaga
      961 ggaaaaagat ggggatgttc aggctggagc caatctttct ttcaatcgtc agttctatga
     1021 tgaacattgg tccaagcatc gagtggtcac ttgtatggac tggtccctcc agtaccctga
     1081 gctgatggtg gcttcttaca acaacaatga agatgctccc catgaaccag atggagtggc
     1141 cttggtttgg aacatgaagt ttaagaaaac cacaccagaa tacgtcttcc actgtcagtc
     1201 ctctgtgatg tcggtctgct tcgcccgttt ccatcctaac ttggtggttg gtgggactta
     1261 ctcgggccag attgtcctct gggacaatcg cagtcatcga aggactccag tgcagcggac
     1321 acccttatca gctgctgcac acacgcatcc cgtgtactgt gtaaatgttg ttgggaccca
     1381 gaatgctcat aacctcatca ctgtctccac tgatggcaaa atgtgttcct ggagcctgga
     1441 catgctctca actccacagg agagcatgga gctggtgtac aataagtcca agcctgtcgc
     1501 tgttaccgga atggctttcc caacgggaga cgtcaataac ttcgtggttg gcagtgagga
     1561 aggtacagtc tacacggctt gtcgtcatgg aagcaaagca ggtattggtg aggtctttga
     1621 aggtcaccaa gggccagtga caggaattaa ctgccacatg gcagtgggcc caatcgactt
     1681 ttctcacctg tttgtcacat catcatttga ctggactgtc aaactgtgga ccaccaagca
     1741 caacaagccg ctctactcct ttgaagacaa tgcagactat gtgtacgatg tcatgtggtc
     1801 ccccgtgcat cctgcgcttt ttgcctgcgt ggacgggatg gggcgcttgg acctctggaa
     1861 cctcaacaat gacaccgagg ttccaacagc aagtgtggcc attgaggggg catccgccct
     1921 aaaccgtgtt cgttgggccc aagctggcaa agaagttgct gttggggact cggaaggccg
     1981 tatttgggtc tatgacgttg gagagcttgc agttccccac aatgatgaat ggacccgatt
     2041 tgccaggacc cttgtggaaa ttcgtgctaa cagagctgat agcgaggagg aaggcactgt
     2101 tgagttatct gcctagtgga aatgagccac ccccactgca gcccccacct ttgtgtccta
     2161 gagctcagcg tctgcagtca agtctcttgt attcggtgtc cattcagtat cagtattgct
     2221 gtgatatttt gggtgccata ttgtgccagc tttgctccaa gtattctaaa tgtgtcccat
     2281 catgctttcc actgacccaa aattcaccac agcatttcta tctttatatt tctgtctcaa
     2341 aaatgaagag aagggggtta tgggttaagt tgctgccttt taactacttt gtagctgtat
     2401 ttaatagctg gaaacctctg gttaaatttg tgcttacatg cactcctggc atagtcctat
     2461 taaatccata tgaagccaga tatgattggg tgcagatgtg gtgttcctca tattatggta
     2521 cagggccaaa gacttgagac gtggtgtttt acatggtgac tcacattatg aatggattta
     2581 ctagaagaac attgctgctc cttatttatt gtagtgtgct gcatggaacg tatttatttg
     2641 aaagcattaa aataaatgat cctagagcat gtgcataatg agaggactgt attctctctg
     2701 ctgctgttga ggttatatta agttccacat agcaattaca gtatgccagt tccactgaag
     2761 acatgaaatc tttagaggtt tcttgcagtg aacgaaatga attttaatgc ctattatttc
     2821 tgggtacttt aacaatattt caaatatcat tgaccactaa tacttctcac tgaagctaac
     2881 acagtctgac aaaagtctat ggttcctaaa tatgacatca gtgttgccaa taaaatgttt
     2941 caaacca
//
