LOCUS       NM_173629               1941 bp    mRNA    linear   PRI 12-FEB-2024
DEFINITION  Homo sapiens dynactin associated protein (DYNAP), transcript
            variant 1, mRNA.
ACCESSION   NM_173629
VERSION     NM_173629.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1941)
  AUTHORS   Kunoh,T., Noda,T., Koseki,K., Sekigawa,M., Takagi,M., Shin-ya,K.,
            Goshima,N., Iemura,S., Natsume,T., Wada,S., Mukai,Y., Ohta,S.,
            Sasaki,R. and Mizukami,T.
  TITLE     A novel human dynactin-associated protein, dynAP, promotes
            activation of Akt, and ergosterol-related compounds induce
            dynAP-dependent apoptosis of human cancer cells
  JOURNAL   Mol Cancer Ther 9 (11), 2934-2942 (2010)
   PUBMED   20978158
  REMARK    GeneRIF: DynAP, which promotes activation of Akt, can be a new
            target for cancer therapy.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091135.9.
            
            On Sep 6, 2019 this sequence version replaced NM_173629.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096425.1, DA764456.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2153031
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648945.2/ ENSP00000496812.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC091135.9         49340-49434
            96-260              AC091135.9         53034-53198
            261-1941            AC091135.9         55908-57588
FEATURES             Location/Qualifiers
     source          1..1941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..1941
                     /gene="DYNAP"
                     /gene_synonym="C18orf26"
                     /note="dynactin associated protein"
                     /db_xref="GeneID:284254"
                     /db_xref="HGNC:HGNC:26808"
                     /db_xref="MIM:619421"
     exon            1..95
                     /gene="DYNAP"
                     /gene_synonym="C18orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..593
                     /gene="DYNAP"
                     /gene_synonym="C18orf26"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="dynactin-associated protein isoform 1"
                     /protein_id="NP_775900.2"
                     /db_xref="CCDS:CCDS11957.2"
                     /db_xref="GeneID:284254"
                     /db_xref="HGNC:HGNC:26808"
                     /db_xref="MIM:619421"
                     /translation="MDRKHGKYILNVEHSENQPPITHPNDQEAHSSICWCLPSNDITS
                     DVSPNLTGVCVNPGILAHSRCLQSESCNTQVKEYCRNDWSMWKVFLACLLACVIMTAI
                     GVLIICLVNNKGSANSSIVIQLSTNDGECVTVKPGTPSPACPPTMTTTSTVPASTATE
                     STTSTATAATTSTEPITVAPTDHL"
     exon            96..260
                     /gene="DYNAP"
                     /gene_synonym="C18orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            261..1941
                     /gene="DYNAP"
                     /gene_synonym="C18orf26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcttggag agaagcttgt gatactggca gctcaagaat ggacagaaag catggaaaat
       61 acatattgaa cgttgagcac tctgaaaacc agccgccaat cacacatcca aatgaccaag
      121 aggctcacag ttccatatgc tggtgtctac cttcaaatga tataaccagt gatgtctctc
      181 ccaacttaac tggggtctgc gtgaacccag gaatccttgc acattcaaga tgtctacagt
      241 cagaatcctg taacacacag gtaaaagaat attgccgcaa tgactggtct atgtggaaag
      301 tcttcctggc ttgtctctta gcctgtgtga taatgacagc aattggagta cttataatat
      361 gcttggtgaa taacaaagga tcggccaatt cctccattgt tatccagcta tccacaaatg
      421 atggagagtg tgtgactgtc aaacctggaa caccctctcc tgcttgtcca cctacaatga
      481 ccaccacttc aactgtacct gcaagtacag ccactgaatc tacaacttca acagctacag
      541 ctgccaccac ttccacagaa cctataactg ttgcacctac cgatcattta taatttgaac
      601 agccatagcc atcacttcaa ctgaaacttc aacctctacc acttcaactc agtttgcaac
      661 tataatagct actcctatca cttcaagtgg aatcatggct gcagtcactt taacagactc
      721 tataaccgtt acaacttcaa caaaatcaag tcctacttca acttaaactt acttgacaac
      781 tcaaataatc accacttcga ccatctcttt gactgaatca acaactacat tcccttcaac
      841 tgaatctgca accacttcca cttaacctat aactactgta acttctactt agcctacagt
      901 aacaatgctc atcactcttt tccaacaatg tataatctcc acctattcat ctgaggacta
      961 agctctgatt tttcatcttg cccaaattcc tttctaaggg gtatggggag tcatgcccta
     1021 caaaccataa attctcatca gatgggtttt atttaaccct gtatattgtg acttactttc
     1081 taatctgact ctggcataac aagggaaaaa aatcaaaatg ttttacccca aaatatattt
     1141 ccttgccata ccttgaaatt gtcctgcaaa gtctcttgtg gagaaactcc acattctgta
     1201 gagaatatcc tttccccttt gttttccttc ctttctttcc agatccagga gataatcaac
     1261 taagagccag gcaccctttt aggtctaata agaaacactt tacaacctgc tctctctctg
     1321 aagtctgctt tctgagagat tcctctgcac aataaaactt gatctccaca atcctttatc
     1381 ttaacctgaa cattcctttc catggatctc aggtcttcag ataaactaaa ccaattgtca
     1441 accagaacat gtttaaattt acctatagcc tggaagcccc aactttgagt tgtcctgcct
     1501 ttctgaacca agccaatgta tttcttaaat gtatttgatt gatgtctcat gtctccctaa
     1561 aaatatataa aaccaaactg taccttagcc actttggaca catgttctca ggacctcctg
     1621 agggctatgt catgagccat ggtcactcat atttggctca gaattaatct cttaaaatat
     1681 tttacagagt ttgactcttt ttgtcaacac atccgaacct gcaactacaa atgccaccat
     1741 taccacttaa aacttgatag aactagcatc agtcatcaaa ataacctgtt ctatattaag
     1801 ttaactttta gttatcacca gtaatactag cctacaacta ctcgccacac tggctcttcc
     1861 ccaaaattga aattgtacaa tatgtgagtc taattcttgc taacataaca ttattgccta
     1921 cattaaaagc ttctgcaaag c
//
