LOCUS       NM_032372               1863 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DPY30 domain containing 2 (DYDC2), transcript variant
            1, mRNA.
ACCESSION   NM_032372
VERSION     NM_032372.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Kuhl,A., Melberg,A., Meinl,E., Nurnberg,G., Nurnberg,P.,
            Kehrer-Sawatzki,H. and Jenne,D.E.
  TITLE     Myofibrillar myopathy with arrhythmogenic right ventricular
            cardiomyopathy 7: corroboration and narrowing of the critical
            region on 10q22.3
  JOURNAL   Eur J Hum Genet 16 (3), 367-373 (2008)
   PUBMED   18197198
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA590784.1, AK093378.1 and
            BC018606.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032372.5.
            
            Summary: This gene encodes a member of a family of proteins that
            contains a DPY30 domain. This gene locus overlaps with a closely
            related gene on the opposite strand. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 2 encode the same protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK093378.1, SRR5189667.285203.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256039.3/ ENSP00000256039.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA590784.1         14-34
            22-1862             AK093378.1         3-1843
            1863-1863           BC018606.2         2254-2254
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..1863
                     /gene="DYDC2"
                     /note="DPY30 domain containing 2"
                     /db_xref="GeneID:84332"
                     /db_xref="HGNC:HGNC:23468"
     exon            1..45
                     /gene="DYDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            46..198
                     /gene="DYDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..354
                     /gene="DYDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..741
                     /gene="DYDC2"
                     /note="isoform 1 is encoded by transcript variant 1; DPY30
                     domain-containing protein 2"
                     /codon_start=1
                     /product="DPY30 domain-containing protein 2 isoform 1"
                     /protein_id="NP_115748.1"
                     /db_xref="CCDS:CCDS7367.1"
                     /db_xref="GeneID:84332"
                     /db_xref="HGNC:HGNC:23468"
                     /translation="METNYLKRCFGNCLAQALAEVAKVRPSDPIEYLAHWLYHYRKTA
                     KAKEENREKKIHLQEEYDSSLKEMEMTEMLKQEEYQIQQNCEKCHKELTSETVSTKKT
                     IFMQEDTNPLEKEALKQEFLPGTSSLIPGMPQQVPPSESAGQIDQNFKMPQEINYKEA
                     FQHEVAHEMPPGSKSPF"
     exon            355..477
                     /gene="DYDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1863
                     /gene="DYDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      926..931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYDC2"
                     /note="hexamer: AATAAG"
     polyA_site      943
                     /gene="DYDC2"
                     /note="major polyA site"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYDC2"
                     /note="hexamer: TATAAA"
     polyA_site      1863
                     /gene="DYDC2"
ORIGIN      
        1 aggagccagt gtaggcgccg caaagcggaa ggggcgcgcg gatagagctc ccagtgtgcc
       61 aagcgtgggc ggtatacagt aaacaaagac aacccctatt cttatcacct tgcctactga
      121 gtgcaagtcc aggaactgtg taagcagacc ctcagaggag ctctgggaaa cactgaaaaa
      181 tagcctctcc ccccattggc tgccaggatg gaaactaact acctgaagag gtgctttgga
      241 aattgcctgg cccaggcact ggcagaggtg gcgaaggttc ggcccagtga cccaatagaa
      301 tacctggctc actggcttta tcattacagg aaaacagcaa aagcaaaaga agagaatagg
      361 gaaaagaaga tccacctgca ggaggaatat gacagtagcc tcaaggaaat ggaaatgaca
      421 gaaatgctga aacaggaaga gtatcagatt caacagaact gtgaaaagtg tcacaaggaa
      481 ctgacttctg aaactgtttc cacgaagaag accatattca tgcaggagga cacaaacccc
      541 cttgagaagg aggccttgaa gcaggaattc ctgccaggta cttccagtct gattccagga
      601 atgcctcaac aggttcctcc ttcagagtct gctggccaga ttgaccagaa cttcaaaatg
      661 ccacaagaaa taaattacaa ggaggctttt cagcatgaag ttgctcatga aatgcctcct
      721 ggctccaaat ctccttttta ggttacagaa ggtagatgct tctgatttac ttctctcaaa
      781 gctagaagcc aagaaaatgg ccagctagaa ccaagattta aggggctgta aaaggcaagt
      841 tcagggactc tccagcctac tccttttctg aaaaaccctt aatcatgtga acatttgaac
      901 tagttatagg ataaaataaa ctcagaataa ggatttaaaa taagtaacca agtggctgtg
      961 actttttcct cttgttttat caacgttttg gagactacac aatgaaaaca catctgttgg
     1021 ggtgatcaga cccaacaccc ggccatgggg gctacaaagt ccagccgagt caaaggaaag
     1081 agaaaagaca agtcaagaga gaaagtggga ccagggggcc aatgctagta tggaggctgt
     1141 gaagtcccca agctctggaa gcccacacta tttgttggtg atcaaacaaa gaaacaggtg
     1201 atgaggatgt gggagttgaa agaaagtggt gtatcaagcg aatgaactac agctgtgagg
     1261 gtttagcatt ttctttgaaa catatggcta cttgagataa tgggagtgct agaagcaagg
     1321 agccagcaag tctggacaca ttacaaaggc cacaaggggt tttatcctgg accccggaca
     1381 tgttccaagc cctgcctcaa cttttctccc aacactaagc tttcctccca acacacatcc
     1441 atctcgtgtg ttcatgtctt aacttttgct tcacttcaca gtcaggcctc tccgagtatt
     1501 ttttacacat atcctggagt ctacctatgt cactgatagc agatattttt cttcaacata
     1561 tattatcaat gttttaatac ttttcttcaa ttttagtaac tggtaaaata catgtaagat
     1621 gtaccatctt aaccattttt aagtgtacag atcagttgta ttaagtagat tcatattctt
     1681 gtgcaaccat catcaccatc cggctgcaaa actctttcat cttgcaaaac tgaaactcta
     1741 cacccattaa aaaataactc gccatttctc tctctcccca gcccctggca accaccattc
     1801 tttctgtctc tgtgatttag attactctgt aagtatgttg tataaataga ctcatacaat
     1861 gtt
//
