LOCUS       NM_001269053             638 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens DPY30 domain containing 1 (DYDC1), transcript variant
            2, mRNA.
ACCESSION   NM_001269053
VERSION     NM_001269053.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 638)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 638)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 638)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 638)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 638)
  AUTHORS   Li,S., Qiao,Y., Di,Q., Le,X., Zhang,L., Zhang,X., Zhang,C.,
            Cheng,J., Zong,S., Koide,S.S., Miao,S. and Wang,L.
  TITLE     Interaction of SH3P13 and DYDC1 protein: a germ cell component that
            regulates acrosome biogenesis during spermiogenesis
  JOURNAL   Eur J Cell Biol 88 (9), 509-520 (2009)
   PUBMED   19545932
  REMARK    Erratum:[Eur J Cell Biol. 2019 Jan;98(1):51-52. doi:
            10.1016/j.ejcb.2018.11.002.. PMID: 30497823]
REFERENCE   6  (bases 1 to 638)
  AUTHORS   Kuhl,A., Melberg,A., Meinl,E., Nurnberg,G., Nurnberg,P.,
            Kehrer-Sawatzki,H. and Jenne,D.E.
  TITLE     Myofibrillar myopathy with arrhythmogenic right ventricular
            cardiomyopathy 7: corroboration and narrowing of the critical
            region on 10q22.3
  JOURNAL   Eur J Hum Genet 16 (3), 367-373 (2008)
   PUBMED   18197198
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359195.24, BI828082.1 and
            BC019250.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001269053.1.
            
            Summary: This gene encodes a member of a family of proteins that
            contains a DPY30 domain. The encoded protein is involved in
            acrosome formation during spermatid development. This gene locus
            overlaps with a closely related gene on the opposite strand.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jun 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. Variants 1-4 all encode the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI828082.1, DRR138524.1153727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372202.6/ ENSP00000361276.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL359195.24        112126-112136       c
            12-61               BI828082.1         10-59
            62-64               AL359195.24        107972-107974       c
            65-614              BI828082.1         63-612
            615-638             BC019250.1         732-755
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.1"
     gene            1..638
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /note="DPY30 domain containing 1"
                     /db_xref="GeneID:143241"
                     /db_xref="HGNC:HGNC:23460"
                     /db_xref="MIM:615154"
     exon            1..44
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..200
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..587
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /note="isoform a is encoded by transcript variant 2; DPY30
                     domain-containing protein 1"
                     /codon_start=1
                     /product="DPY30 domain-containing protein 1 isoform a"
                     /protein_id="NP_001255982.1"
                     /db_xref="CCDS:CCDS7366.1"
                     /db_xref="GeneID:143241"
                     /db_xref="HGNC:HGNC:23460"
                     /db_xref="MIM:615154"
                     /translation="MESIYLQKHLGACLTQGLAEVARVRPVDPIEYLALWIYKYKENV
                     TMEQLRQKEMAKLERERELALMEQEMMERLKAEELLLQQQQLALQLELEMQEKERQRI
                     QELQRAQEQLGKEMRMNMENLVRNEDILHSEEATLDSGKTLAEISDRYGAPNLSRVEE
                     LDEPMFSDIALNIDQDL"
     exon            201..302
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..395
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..452
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..557
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /inference="alignment:Splign:2.1.0"
     exon            558..638
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      607..612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /note="hexamer: AATAAA"
     polyA_site      638
                     /gene="DYDC1"
                     /gene_synonym="DPY30D1"
                     /note="major polyA site"
ORIGIN      
        1 aacgggacgc cgctcctggg tggcgagcag gcgcgtgtgt aggggagtta gaaatggagt
       61 caatatatct tcaaaagcac cttggggcct gtttaactca aggtcttgca gaagtggcaa
      121 gagttcgccc agtggatccg atagaatatt tagcattgtg gatttacaag tataaggaaa
      181 atgtgaccat ggaacaactg agacaaaagg aaatggccaa gctggagcgt gaaagagaat
      241 tagctctgat ggagcaggaa atgatggaga ggctcaaagc agaggagctc ttacttcagc
      301 agcaacagct ggcattgcag ctagagttgg aaatgcaaga aaaggagagg cagagaatac
      361 aagaactaca gagagctcaa gaacaattag gcaaggagat gagaatgaat atggaaaatc
      421 tagttaggaa tgaagatatt ctacattcag aggaagcaac actagactca ggcaaaacac
      481 tagctgaaat cagcgatcgt tatggagcac ctaacttgag cagagtggaa gaacttgatg
      541 aaccaatgtt ttctgatatt gcattaaaca ttgatcaaga tttgtaggac caaccaacct
      601 aagagcaata aatgtttttg tttgtttcaa atttcaaa
//
