LOCUS       NM_004423               5269 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens dishevelled segment polarity protein 3 (DVL3), mRNA.
ACCESSION   NM_004423
VERSION     NM_004423.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5269)
  AUTHORS   Zhao,H., Wu,G., Luo,Y., Xie,Y., Han,Y., Zhang,D., Han,Q., Zhao,X.,
            Qin,Y., Li,Q. and Wang,E.
  TITLE     WNT5B promotes the malignant phenotype of non-small cell lung
            cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway
  JOURNAL   Cell Signal 122, 111330 (2024)
   PUBMED   39094673
  REMARK    GeneRIF: WNT5B promotes the malignant phenotype of non-small cell
            lung cancer via the FZD3-DVL3-RAC1-PCP-JNK pathway.
REFERENCE   2  (bases 1 to 5269)
  AUTHORS   Zhang,Y., Lin,N., Liu,X. and Yao,T.
  TITLE     Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial
            LPS Promotes the Proliferation and Migration of Prostate Cancer
            Cells through the TLR4 Pathway
  JOURNAL   Arch Esp Urol 77 (2), 193-201 (2024)
   PUBMED   38583012
  REMARK    GeneRIF: Dishevelled Segment Polarity Protein 3 (DVL3) Induced by
            Bacterial LPS Promotes the Proliferation and Migration of Prostate
            Cancer Cells through the TLR4 Pathway.
REFERENCE   3  (bases 1 to 5269)
  AUTHORS   Li,Z., Yang,Z., Liu,W., Zhu,W., Yin,L., Han,Z., Xian,Y., Wen,J.,
            Tang,H., Lin,X., Yang,Y., Wang,J. and Zhang,K.
  TITLE     Disheveled3 enhanced EMT and cancer stem-like cells properties via
            Wnt/beta-catenin/c-Myc/SOX2 pathway in colorectal cancer
  JOURNAL   J Transl Med 21 (1), 302 (2023)
   PUBMED   37147666
  REMARK    GeneRIF: Disheveled3 enhanced EMT and cancer stem-like cells
            properties via Wnt/beta-catenin/c-Myc/SOX2 pathway in colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5269)
  AUTHORS   Yang,P., Zhang,P. and Zhang,S.
  TITLE     RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes
            Wnt/beta-Catenin Signaling in Endometrial Carcinoma
  JOURNAL   Int J Mol Sci 24 (1), 592 (2022)
   PUBMED   36614043
  REMARK    GeneRIF: RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes
            Wnt/beta-Catenin Signaling in Endometrial Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5269)
  AUTHORS   Pruller,J., Figeac,N. and Zammit,P.S.
  TITLE     DVL1 and DVL3 require nuclear localisation to regulate
            proliferation in human myoblasts
  JOURNAL   Sci Rep 12 (1), 8388 (2022)
   PUBMED   35589804
  REMARK    GeneRIF: DVL1 and DVL3 require nuclear localisation to regulate
            proliferation in human myoblasts.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5269)
  AUTHORS   Kishida,S., Yamamoto,H., Hino,S., Ikeda,S., Kishida,M. and
            Kikuchi,A.
  TITLE     DIX domains of Dvl and axin are necessary for protein interactions
            and their ability to regulate beta-catenin stability
  JOURNAL   Mol Cell Biol 19 (6), 4414-4422 (1999)
   PUBMED   10330181
REFERENCE   7  (bases 1 to 5269)
  AUTHORS   Bui,T.D., Beier,D.R., Jonssen,M., Smith,K., Dorrington,S.M.,
            Kaklamanis,L., Kearney,L., Regan,R., Sussman,D.J. and Harris,A.L.
  TITLE     cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27,
            and expression in human breast and colon carcinomas
  JOURNAL   Biochem Biophys Res Commun 239 (2), 510-516 (1997)
   PUBMED   9344861
REFERENCE   8  (bases 1 to 5269)
  AUTHORS   Semenov,M.V. and Snyder,M.
  TITLE     Human dishevelled genes constitute a DHR-containing multigene
            family
  JOURNAL   Genomics 42 (2), 302-310 (1997)
   PUBMED   9192851
REFERENCE   9  (bases 1 to 5269)
  AUTHORS   Pizzuti,A., Amati,F., Calabrese,G., Mari,A., Colosimo,A.,
            Silani,V., Giardino,L., Ratti,A., Penso,D., Calza,L., Palka,G.,
            Scarlato,G., Novelli,G. and Dallapiccola,B.
  TITLE     cDNA characterization and chromosomal mapping of two human
            homologues of the Drosophila dishevelled polarity gene
  JOURNAL   Hum Mol Genet 5 (7), 953-958 (1996)
   PUBMED   8817329
REFERENCE   10 (bases 1 to 5269)
  AUTHORS   Roifman,M., Brunner,H., Lohr,J., Mazzeu,J. and Chitayat,D.
  TITLE     Autosomal Dominant Robinow Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25577943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131235.4, U75651.1 and
            D86963.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 6, 2018 this sequence version replaced NM_004423.3.
            
            Summary: This gene is a member of a multi-gene family which shares
            strong similarity with the Drosophila dishevelled gene, dsh. The
            Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein
            that regulates cell proliferation. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86963.1, U75651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313143.9/ ENSP00000316054.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC131235.4         56312-56430         c
            120-480             U75651.1           254-614
            481-2303            D86963.1           362-2184
            2304-2950           U75651.1           2438-3084
            2951-3203           D86963.1           2832-3084
            3204-3271           U75651.1           3336-3403
            3272-5181           D86963.1           3153-5062
            5182-5269           AC131235.4         38193-38280         c
FEATURES             Location/Qualifiers
     source          1..5269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..5269
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /note="dishevelled segment polarity protein 3"
                     /db_xref="GeneID:1857"
                     /db_xref="HGNC:HGNC:3087"
                     /db_xref="MIM:601368"
     exon            1..420
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2410
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /note="dishevelled 3 (homologous to Drosophila dsh);
                     dishevelled, dsh homolog 3"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-3"
                     /protein_id="NP_004414.3"
                     /db_xref="CCDS:CCDS3253.1"
                     /db_xref="GeneID:1857"
                     /db_xref="HGNC:HGNC:3087"
                     /db_xref="MIM:601368"
                     /translation="MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKF
                     FFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPP
                     MERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNG
                     TAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHK
                     RRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGI
                     YIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVA
                     KCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSIT
                     SSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDW
                     LYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHD
                     HDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSAS
                     SQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSER
                     SGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAP
                     PGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM"
     exon            421..490
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            491..612
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            613..722
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..858
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..952
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1022
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1162
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1239
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1307
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1457
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1589
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1757
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1973
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..5269
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /note="hexamer: AATAAA"
     polyA_site      2531
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /note="major polyA site"
     polyA_site      2601
                     /gene="DVL3"
                     /gene_synonym="DRS3"
     regulatory      5243..5248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DVL3"
                     /gene_synonym="DRS3"
                     /note="hexamer: AATAAA"
     polyA_site      5266
                     /gene="DVL3"
                     /gene_synonym="DRS3"
ORIGIN      
        1 gggccgggag ggccgcggcc accggaagag tcgcggtcgc cagtccagtc gggagagtgg
       61 ggagcggaag cggcggccgc ggcggcggcg ggcggcgctg ggacccggta gcggccggag
      121 aacaagggag ctggcgccgc cagcagccgc cgagctgggt tgagccgctg ggccgcgccg
      181 cgcgccgccg ccgtctggga ggctcggccc ggccgcccga gcaggccgcg cgcgggccgc
      241 cgggcccgag gccagagcca tgggcgagac caagatcatc taccacttgg atgggcagga
      301 gacgccgtac cttgtgaagc tgcccctgcc cgccgagcgc gtcaccttgg cggactttaa
      361 gggcgttttg cagcgaccca gctataagtt cttcttcaag tctatggacg acgatttcgg
      421 agtggtgaag gaggagatct cggatgacaa tgccaagcta ccatgcttca atggccgggt
      481 ggtgtcctgg ctggtgtcag ctgagggctc acacccagac ccagccccct tctgtgctga
      541 taacccatcg gagctgccac cacctatgga gcgcacggga ggcatcgggg actcccgacc
      601 cccatccttc caccctcatg ctggtggggg cagccaggag aacctggaca atgacacaga
      661 gacggactct ttggtgtctg cccagcgaga gcggccacgc cggagggatg gcccagagca
      721 tgcaacccgg ctaaatggaa ctgcgaaggg ggaacggcgg cgagaaccag ggggttatga
      781 tagctcatcc acccttatga gcagtgagct ggagaccacc agcttctttg actcagatga
      841 ggatgactcc accagcaggt tcagcagctc cacagaacag agcagtgcct cacgcctgat
      901 gagaagacac aagcggcggc ggcggaagca gaaggtttct cggattgagc ggtcctcgtc
      961 cttcagcagc atcacggact ccaccatgtc actcaacatc atcacggtca ctctcaacat
     1021 ggaaaaatat aacttcttgg gcatctccat tgtgggccaa agcaacgagc gtggtgacgg
     1081 cggcatctac attggctcta tcatgaaggg tggggccgtg gctgctgatg gacgcatcga
     1141 gccaggagat atgttgttac aggtaaacga gatcaacttt gagaacatga gtaatgacga
     1201 tgcagtccgg gtactgcggg agattgtgca caaaccgggg cccatcaccc tgactgtagc
     1261 caagtgctgg gacccaagtc cacgtggttg cttcacattg cccaggagcg agcccatccg
     1321 gcccattgac cctgcggcct gggtctccca cactgcagcc atgaccggca ccttccctgc
     1381 atacggcatg agcccctccc tgagcaccat cacctccacc agctcctcca tcaccagttc
     1441 catccctgac acagagcgcc tagacgactt ccacttgtcc atccacagtg acatggctgc
     1501 catcgtaaaa gccatggcct cccctgaatc agggttggag gtccgtgacc gcatgtggct
     1561 caagattacc atccctaatg ctttcatcgg ctcagatgtg gtggactggc tgtaccacaa
     1621 tgtggaaggc ttcacggacc ggagggaggc ccgcaagtat gccagcaacc tgctgaaagc
     1681 tggcttcatc cgccataccg tcaacaagat caccttctcc gagcagtgct actacatctt
     1741 cggtgacctc tgcggcaaca tggccaacct gtctctccac gatcacgatg gctccagtgg
     1801 cgcctctgac caggacacac tggccccttt gccgcacccg ggggccgccc cttggcccat
     1861 ggctttcccg taccagtacc cgccaccccc gcacccatac aacccgcacc cgggcttccc
     1921 ggagctgggc tacagctacg gcgggggcag cgccagcagt cagcacagcg aaggcagtcg
     1981 gagcagtggc tccaaccgta gcggcagcga tcggaggaag gagaaggacc cgaaggccgg
     2041 ggactccaag tccgggggca gcggcagcga atcggaccac accacacgca gcagcctgcg
     2101 ggggccgcgg gagcgggcgc ccagcgagcg ctcagggccg gcggccagcg agcacagcca
     2161 ccgcagccac cattccctgg ccagcagcct tcgcagccac cacacacacc cgagctacgg
     2221 tcctcccgga gtgccccctc tctacggccc ccccatgctg atgatgcccc cgccgcccgc
     2281 ggccatgggg cccccaggag cccctccggg ccgcgacctg gcctcagtgc ccccggaact
     2341 gaccgccagc agacagtcct tccgcatggc catgggaaac cccagtgagt tctttgtgga
     2401 tgtgatgtga gcagggcccc tcccccagct ccattccgct cccaccccag ccggctgcgt
     2461 tcctctctcc atccgtccgt cttttttact ttgtctggta cctgaaaggg aaataaaagg
     2521 aactaaatcc aggtgcgcta actgctcgca gggtgctgcg agggtggggt gcacctaccg
     2581 attggctctg cagcccccta acctgcctct ggccccagtt cgtttcctct gcccactaat
     2641 ccctgcgcag gacttcccag gacccctttt gtctctggga ccagacttgt tggtgctacc
     2701 ccttactccc ctctgcaacc cccattttgg gagttgaccc cagcaatgac cttggtggca
     2761 cgctcactcc ctcattctct cgtttcccct ttagctccct ttcaccattt attcagctac
     2821 atcatccctc tattaacccc accccatcag gcacgtgtgc aaacctcttg actttacccc
     2881 acattactga aaccaaaata tatttgcttc atctgcccct actaaccatc cccctgcctg
     2941 ctgcctcagt cctgcaacct aaagctgtag tcgcctccaa tagccatcca tgccatccct
     3001 gcctgtgcct agatcagagg cccagagggc cccctcagtt gcctgagcag ctggtggctt
     3061 ccagggagca tctctgctct acccctgccc catgcctgcc ctgcgtgctg gttccttcag
     3121 acccctaacc ctactaacca gcaggctcat ctcacctcca ggcctgaaac atttcttttc
     3181 tttctttttt cctcccccaa tttaccctgg gcctggagca gccaagaatt tcgggctgtt
     3241 tgactttctg tgagccccca gcgaggggag gcccagcctc cgaggagacc aggaaccctg
     3301 cttcagcagc ccctcagggc ttcccaagga tgtccagccc ccacacccac acgttaacat
     3361 aatgagtcac taggcttctg gggagggccc aacttcaccc atgcatgaga gactctcctc
     3421 ctttccagag agaatcggat cgcaccacgt gtggcagcct gcggcggggg gaggggggcc
     3481 tctttagctc tctttatctt tctctctcac tcatgtatgc atacatgcac agagatgcat
     3541 acacaggtgc ctatgcaagt tcatttaagc ctcagggctg gtccctgccc aaagggctgg
     3601 accctcctaa tcctctccta ggttgtgggg ctggtcccct gacacccttc tccccttcct
     3661 ggtagacctt aaacctcgca cacatgtccc cagcattttc tcacctggat aaagcccata
     3721 agctgggtct caggctgggc tcagcaaagg actcgccttg caaccgacag gccattccca
     3781 cccccacaca caacctcccc tgttttcaca ttcaccatgg catcccagag caaggacaca
     3841 ggagcccaca ggccagttga ggttgggcaa ggagacttcc aggacttcca gacagagtac
     3901 caggttttat ttttcacctt attctctact ttaaacaaat cataactttc tctttaagcc
     3961 tctgctataa attctcctgg ctctcctggg cttccatatt ttgggggctg gggtgtcaaa
     4021 agtgagatga agttcttagc tccaggtttt ggggtaaacc aaggtaggaa cattttggca
     4081 tttatttcaa ttaacaatac ttccttggac gggtgcggtg gctcacgtct gtaatcccag
     4141 cactttggga ggctgagaca ggtggatcac ttgaggtcgg gagttcgaga ccagcctggc
     4201 caacatagca aaaccctgtc tctactaaaa atacaaaaat tagatgggtg ttttggcacc
     4261 tgcctgtaat ctcagctact caggaggctg aggcacaaga atcgcttgaa tccaggaagc
     4321 aagcggaggt tgcagtgagt tgagatcgca ctccagcctg ggtgacagag tgagattctg
     4381 tctcaaaagc aaactaacaa agaaaaacaa tacttcctgg ggttttggtg tgcagagggc
     4441 tttgttggaa gtgtgactca atcttgcctg ccttctggga gctctagaat tgttcccaac
     4501 ccagtccatg gcttctagcc accactacag ggctgtttca tgtacttctc tctctgactc
     4561 tgtcttgtcc gactctcttg agaatttctc aacgattgct catgcctgtc agtatcagtg
     4621 cttccatcgt tccatctttg attcacttct ctttcctttc tatttactcc caaaatggag
     4681 tcattcatcc tgatgtcctc aattgctgct gatatgctgg tgattcccaa atacatagct
     4741 ccaaccccca acttccccca gactttagat ctgtattggt attacctact ggacatctct
     4801 atggacagtt ccgtatagac tcaactcatc tgcccaacca agtatgttcc tcctgaattc
     4861 ctctcctggt tacttcatca caatctacat aggctcacca gctagaaaca tttatgagct
     4921 tacattcctt cttcccatat cttatcagca tatcatatcc atttcactcc aacactctgt
     4981 cttgaatttg gccctccctc tcccctctct actttaattc attggagcat gggatttgga
     5041 gttaggtggt tttgggtttg aattccagct ctactatttt tggttgtgtg atagagttat
     5101 ttaacctctc tgagcctcag ttccctcgta tgtaaaatga tgataataat acctacctca
     5161 cagggttgtt gtgaggattt aaattagata ttgtacgaaa agtgcctagc acagtgcctg
     5221 gcacacagta gagtaggtgc tcaataaatg gtagctatta ttattatta
//
