LOCUS       NM_004422               2989 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens dishevelled segment polarity protein 2 (DVL2), mRNA.
ACCESSION   NM_004422
VERSION     NM_004422.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Omble,A., Mahajan,S., Bhoite,A. and Kulkarni,K.
  TITLE     Dishevelled2 activates WGEF via its interaction with a unique
            internal peptide motif of the GEF
  JOURNAL   Commun Biol 7 (1), 543 (2024)
   PUBMED   38714795
  REMARK    GeneRIF: Dishevelled2 activates WGEF via its interaction with a
            unique internal peptide motif of the GEF.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   He,R., Chen,Y., Qian,C., Hu,Y., Huang,X. and Tao,R.
  TITLE     Dishevelled segment polarity protein 2 promotes gastric cancer
            progression through Wnt/beta-catenin pathway
  JOURNAL   Tissue Cell 82, 102119 (2023)
   PUBMED   37257286
  REMARK    GeneRIF: Dishevelled segment polarity protein 2 promotes gastric
            cancer progression through Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Demirci,U., Orenay-Boyacioglu,S., Kasap,E., Gerceker,E., Bilgic,F.,
            Yuceyar,H., Yildirim,H., Baykan,A.R., Ellidokuz,E.B. and Korkmaz,M.
  TITLE     Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes
            enhance gastric cancer development in the presence of Helicobacter
            pylori
  JOURNAL   Arab J Gastroenterol 24 (2), 91-97 (2023)
   PUBMED   36720664
  REMARK    GeneRIF: Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5
            genes enhance gastric cancer development in the presence of
            Helicobacter pylori.
REFERENCE   4  (bases 1 to 2989)
  AUTHORS   Shen,J., Zha,Q., Yang,Q.H., Zhou,Y.Q., Liang,X., Chen,Y.J.,
            Qi,G.X., Zhang,X.J., Yao,W.B., Gao,X.D. and Chen,S.
  TITLE     Inhibiting von Hippel-Lindau protein-mediated Dishevelled
            ubiquitination protects against experimental parkinsonism
  JOURNAL   Acta Pharmacol Sin 44 (5), 940-953 (2023)
   PUBMED   36357669
  REMARK    GeneRIF: Inhibiting von Hippel-Lindau protein-mediated Dishevelled
            ubiquitination protects against experimental parkinsonism.
REFERENCE   5  (bases 1 to 2989)
  AUTHORS   Kang,K., Shi,Q., Wang,X. and Chen,Y.G.
  TITLE     Dishevelled phase separation promotes Wnt signalosome assembly and
            destruction complex disassembly
  JOURNAL   J Cell Biol 221 (12) (2022)
   PUBMED   36342472
  REMARK    GeneRIF: Dishevelled phase separation promotes Wnt signalosome
            assembly and destruction complex disassembly.
REFERENCE   6  (bases 1 to 2989)
  AUTHORS   Strovel,E.T., Wu,D. and Sussman,D.J.
  TITLE     Protein phosphatase 2Calpha dephosphorylates axin and activates
            LEF-1-dependent transcription
  JOURNAL   J Biol Chem 275 (4), 2399-2403 (2000)
   PUBMED   10644691
REFERENCE   7  (bases 1 to 2989)
  AUTHORS   Semenov,M.V. and Snyder,M.
  TITLE     Human dishevelled genes constitute a DHR-containing multigene
            family
  JOURNAL   Genomics 42 (2), 302-310 (1997)
   PUBMED   9192851
REFERENCE   8  (bases 1 to 2989)
  AUTHORS   Klingensmith,J., Yang,Y., Axelrod,J.D., Beier,D.R., Perrimon,N. and
            Sussman,D.J.
  TITLE     Conservation of dishevelled structure and function between flies
            and mice: isolation and characterization of Dvl2
  JOURNAL   Mech Dev 58 (1-2), 15-26 (1996)
   PUBMED   8887313
REFERENCE   9  (bases 1 to 2989)
  AUTHORS   Pizzuti,A., Amati,F., Calabrese,G., Mari,A., Colosimo,A.,
            Silani,V., Giardino,L., Ratti,A., Penso,D., Calza,L., Palka,G.,
            Scarlato,G., Novelli,G. and Dallapiccola,B.
  TITLE     cDNA characterization and chromosomal mapping of two human
            homologues of the Drosophila dishevelled polarity gene
  JOURNAL   Hum Mol Genet 5 (7), 953-958 (1996)
   PUBMED   8817329
REFERENCE   10 (bases 1 to 2989)
  AUTHORS   Greco,T.L., Sussman,D.J. and Camper,S.A.
  TITLE     Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and
            vestigial tail (vt) on mouse chromosome 11
  JOURNAL   Mamm Genome 7 (6), 475-476 (1996)
   PUBMED   8662242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG716400.1, CB994349.1,
            BC014844.1 and AK026019.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004422.2.
            
            Summary: This gene encodes a member of the dishevelled (dsh)
            protein family. The vertebrate dsh proteins have approximately 40%
            amino acid sequence similarity with Drosophila dsh. This gene
            encodes a 90-kD protein that undergoes posttranslational
            phosphorylation to form a 95-kD cytoplasmic protein, which may play
            a role in the signal transduction pathway mediated by multiple Wnt
            proteins. The mechanisms of dishevelled function in Wnt signaling
            are likely to be conserved among metazoans. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014844.1, SRR1660803.149730.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000005340.10/ ENSP00000005340.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BG716400.1         38-86
            50-160              CB994349.1         77-187
            161-2784            BC014844.1         1-2624
            2785-2989           AK026019.1         2338-2542
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2989
                     /gene="DVL2"
                     /note="dishevelled segment polarity protein 2"
                     /db_xref="GeneID:1856"
                     /db_xref="HGNC:HGNC:3086"
                     /db_xref="MIM:602151"
     exon            1..449
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2466
                     /gene="DVL2"
                     /note="dishevelled 2 (homologous to Drosophila dsh);
                     dishevelled, dsh homolog 2"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-2"
                     /protein_id="NP_004413.1"
                     /db_xref="CCDS:CCDS11091.1"
                     /db_xref="GeneID:1856"
                     /db_xref="HGNC:HGNC:3086"
                     /db_xref="MIM:602151"
                     /translation="MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFK
                     SVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPP
                     VHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLR
                     RERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMS
                     RFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYN
                     FLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAV
                     RVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPA
                     YPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIP
                     NAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDL
                     SGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPP
                     PYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEP
                     SSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMV
                     VMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM"
     exon            450..519
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..665
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..775
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..911
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1002
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1072
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1212
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1289
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1357
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1486
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1618
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1798
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..2017
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2989
                     /gene="DVL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2967..2972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DVL2"
                     /note="hexamer: AATAAA"
     polyA_site      2989
                     /gene="DVL2"
                     /note="major polyA site"
ORIGIN      
        1 gggtacctgg aggaagctcg cggcgtcggt ggcggtggcg cgcggcggcc gctgagaccg
       61 gggctttgag tcgcaccccg cggcccgccc cccgccgcca ccctcgcaga tccgtgcttt
      121 ttcccctttg cttctctccc gtactgggtc agtcctgtcc gcgctcgcgc gtcggtttgc
      181 gggtgtgcgc aggcgcggca ggggccatta gccctttggg tgggcggtgg agcccgggag
      241 cgcgcgggcg agaccatggc gggtagcagc actgggggcg gtggggttgg ggagacgaag
      301 gtgatttacc acctggatga ggaagagact ccctacctgg tgaagatccc tgtccccgcc
      361 gagcgcatca ccctcggcga tttcaagagc gtcctgcagc ggcccgcggg cgccaagtac
      421 tttttcaagt ctatggatca ggatttcggg gtggtgaagg aagaaatttc agatgacaac
      481 gcccgcctcc cctgcttcaa cggaagggtg gtatcctggc tggtgtcctc agataatccc
      541 caacccgaga tggcccctcc agtccatgag cctcgggcag aactggcgcc tccagcccca
      601 cctttacctc ctttgccacc cgagaggacc agcggcattg gggactcaag gcctccatcc
      661 ttccacccta atgtgtccag cagccatgag aatctggagc ctgagacaga aaccgagtca
      721 gtagtgtcac tgaggcggga gcggcctcgc aggagagaca gcagtgagca tggcgctggg
      781 ggccacagga ctggtggccc ctcaaggctg gagcgccacc tggccggata cgagagctcc
      841 tctaccctca tgaccagcga gctggagagt accagcctgg gggactcgga cgaggaggac
      901 accatgagca ggttcagcag ctccacggag cagagcagtg cctcccgcct ccttaagcgc
      961 caccggcggc gaaggaagca gaggccaccc cgcctggaga ggacgtcatc cttcagcagc
     1021 gtcacagatt ccacaatgtc tctcaatatc atcacagtca cgctaaacat ggagaagtac
     1081 aacttcctgg gtatctccat tgttggccag agcaatgagc ggggagacgg aggcatctac
     1141 attggctcca tcatgaaggg tggggctgtg gcggccgacg ggcgcattga gccaggggac
     1201 atgcttttgc aggtgaatga catgaacttt gagaacatga gcaacgatga cgctgtgcgg
     1261 gtgctgaggg acattgtgca caagcctggc cccattgtgc tgactgtggc caagtgctgg
     1321 gatccctctc ctcaggccta tttcactctc ccccgaaatg agcccatcca gccaattgac
     1381 cctgctgcct gggtgtccca ttccgcggct ctgactggca ccttcccagc ctatccaggt
     1441 tcctcctcca tgagcaccat tacatctgga tcgtctttgc ctgatggctg tgaaggccgg
     1501 ggtctctccg tccatacgga catggcatcg gtgaccaagg ccatggcagc tccagagtct
     1561 ggactggaag tccgggaccg catgtggctc aagatcacca tccctaatgc ctttctgggc
     1621 tcggatgtgg ttgactggct ctaccatcac gtggagggct ttcctgagcg gcgggaggcc
     1681 cgcaagtatg ccagcgggct gctcaaagca ggcctgatcc gacacaccgt caacaagatc
     1741 accttctctg agcagtgcta ttacgtcttc ggagacctca gtggtggctg tgagagctac
     1801 ctagtcaacc tgtctctcaa tgacaacgat ggctccagtg gggcttcaga ccaggatacc
     1861 ctggctcctc tgcctggggc caccccctgg cccctgctgc ccactttctc ctaccaatac
     1921 cctgccccac acccctacag cccgcagcct ccaccctacc atgagctttc atcttacacc
     1981 tatggtgggg gcagtgccag cagccagcat agtgagggca gccggagcag tgggtcgaca
     2041 cggagtgatg ggggggcagg gcgcacgggg aggcccgagg agcgggcccc cgagtccaag
     2101 tccggcagtg gcagtgagtc tgagccctcc agccgagggg gcagccttcg gcggggtggg
     2161 gaagcaagtg ggactagcga tgggggccct cctccatcca gaggctcaac tgggggtgcc
     2221 cctaatctcc gagcccaccc agggctccat ccctatggac cgccccctgg catggccctc
     2281 ccctacaacc ccatgatggt ggtcatgatg cccccacctc cacctccagt ccctccagca
     2341 gtgcagcctc cgggggcccc tccagtcaga gacctgggct ctgtgccccc agaactgaca
     2401 gccagccgcc aaagcttcca catggccatg ggcaatccca gcgagttctt tgtggatgtt
     2461 atgtagccca ctgtggggcc aggctgggcc gggcgctcct ggtgtgtgac tgggtgtcct
     2521 ggccgtcatg tgcttgctct tacagtgcct gggctcagcc taccagctgc tgccatacag
     2581 gagattgtgg ccactgtgac tctcaccagc agtgcctggt tcctccccct tccctcaggg
     2641 gtagacaagg gacctttgat tatttttagc tttgtttttt tataagcctt tttgggggtt
     2701 aaaatagagt ttcttacatt tttgggactt ttttaatagg catttcctct tttatatgaa
     2761 gaattcccat ccattgggcc ccttctaacc ccagaatgtg acctcctcct ccagttaccc
     2821 acagccctgc cctttgcagg gttgggggtg gtcagcggta ccccggggtt aggcatccta
     2881 gacagcagcc tgaggaagct gggagatttg ggccatgtag ctgcctttgt tactctattt
     2941 attttagtca cttgtataaa acaccaaata aagcaataga ggcaaactc
//
