LOCUS       NM_001330311            3305 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens dishevelled segment polarity protein 1 (DVL1),
            transcript variant 1, mRNA.
ACCESSION   NM_001330311 XM_005244731
VERSION     NM_001330311.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Carr,H.S., Zuo,Y. and Frost,J.A.
  TITLE     The Wnt pathway protein Dvl1 targets somatostatin receptor 2 for
            lysosome-dependent degradation
  JOURNAL   J Biol Chem 299 (5), 104645 (2023)
   PUBMED   36965619
  REMARK    GeneRIF: The Wnt pathway protein Dvl1 targets somatostatin receptor
            2 for lysosome-dependent degradation.
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Caliskan,C., Yuce,Z. and Ogun Sercan,H.
  TITLE     Dvl proteins regulate SMAD1, AHR, mTOR, BRD7 protein expression
            while differentially regulating canonical and non-canonical Wnt
            signaling pathways in CML cell lines
  JOURNAL   Gene 854, 147109 (2023)
   PUBMED   36509295
  REMARK    GeneRIF: Dvl proteins regulate SMAD1, AHR, mTOR, BRD7 protein
            expression while differentially regulating canonical and
            non-canonical Wnt signaling pathways in CML cell lines.
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Pruller,J., Figeac,N. and Zammit,P.S.
  TITLE     DVL1 and DVL3 require nuclear localisation to regulate
            proliferation in human myoblasts
  JOURNAL   Sci Rep 12 (1), 8388 (2022)
   PUBMED   35589804
  REMARK    GeneRIF: DVL1 and DVL3 require nuclear localisation to regulate
            proliferation in human myoblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Bukovac,A., Dragicevic,K., Kafka,A., Oreskovic,D.,
            Cesarec-Augustinovic,S. and Pecina-Slaus,N.
  TITLE     Decoding the Role of DVL1 in Intracranial Meningioma
  JOURNAL   Int J Mol Sci 22 (21), 11996 (2021)
   PUBMED   34769425
  REMARK    GeneRIF: Decoding the Role of DVL1 in Intracranial Meningioma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Chen,Z., Liu,X., Liu,F., Zhang,G., Tu,H., Lin,W. and Lin,H.
  TITLE     Identification of 4-methylation driven genes based prognostic
            signature in thyroid cancer: an integrative analysis based on the
            methylmix algorithm
  JOURNAL   Aging (Albany NY) 13 (16), 20164-20178 (2021)
   PUBMED   34456184
  REMARK    GeneRIF: Identification of 4-methylation driven genes based
            prognostic signature in thyroid cancer: an integrative analysis
            based on the methylmix algorithm.
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Steitz,S.A., Tsang,M. and Sussman,D.J.
  TITLE     Wnt-mediated relocalization of dishevelled proteins
  JOURNAL   In Vitro Cell Dev Biol Anim 32 (7), 441-445 (1996)
   PUBMED   8856345
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Pizzuti,A., Amati,F., Calabrese,G., Mari,A., Colosimo,A.,
            Silani,V., Giardino,L., Ratti,A., Penso,D., Calza,L., Palka,G.,
            Scarlato,G., Novelli,G. and Dallapiccola,B.
  TITLE     cDNA characterization and chromosomal mapping of two human
            homologues of the Drosophila dishevelled polarity gene
  JOURNAL   Hum Mol Genet 5 (7), 953-958 (1996)
   PUBMED   8817329
REFERENCE   8  (bases 1 to 3305)
  AUTHORS   Pizzuti,A., Novelli,G., Mari,A., Ratti,A., Colosimo,A., Amati,F.,
            Penso,D., Sangiuolo,F., Calabrese,G., Palka,G., Silani,V.,
            Gennarelli,M., Mingarelli,R., Scarlato,G., Scambler,P. and
            Dallapiccola,B.
  TITLE     Human homologue sequences to the Drosophila dishevelled
            segment-polarity gene are deleted in the DiGeorge syndrome
  JOURNAL   Am J Hum Genet 58 (4), 722-729 (1996)
   PUBMED   8644734
REFERENCE   9  (bases 1 to 3305)
  AUTHORS   Klingensmith,J., Nusse,R. and Perrimon,N.
  TITLE     The Drosophila segment polarity gene dishevelled encodes a novel
            protein required for response to the wingless signal
  JOURNAL   Genes Dev 8 (1), 118-130 (1994)
   PUBMED   8288125
REFERENCE   10 (bases 1 to 3305)
  AUTHORS   Roifman,M., Brunner,H., Lohr,J., Mazzeu,J. and Chitayat,D.
  TITLE     Autosomal Dominant Robinow Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25577943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139287.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001330311.1.
            
            Summary: DVL1, the human homolog of the Drosophila dishevelled gene
            (dsh) encodes a cytoplasmic phosphoprotein that regulates cell
            proliferation, acting as a transducer molecule for developmental
            processes, including segmentation and neuroblast specification.
            DVL1 is a candidate gene for neuroblastomatous transformation. The
            Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A
            have been mapped to the same region as DVL1. The phenotypes of
            these diseases may be consistent with defects which might be
            expected from aberrant expression of a DVL gene during development.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378888.10/ ENSP00000368166.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               AL139287.24        48849-49371         c
            524-593             AL139287.24        42642-42711         c
            594-715             AL139287.24        42316-42437         c
            716-819             AL139287.24        42006-42109         c
            820-958             AL139287.24        41620-41758         c
            959-1052            AL139287.24        40363-40456         c
            1053-1122           AL139287.24        40200-40269         c
            1123-1262           AL139287.24        39991-40130         c
            1263-1339           AL139287.24        39689-39765         c
            1340-1407           AL139287.24        39535-39602         c
            1408-1560           AL139287.24        39240-39392         c
            1561-1692           AL139287.24        38475-38606         c
            1693-1860           AL139287.24        38222-38389         c
            1861-2067           AL139287.24        37930-38136         c
            2068-3305           AL139287.24        35231-36468         c
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..3305
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /note="dishevelled segment polarity protein 1"
                     /db_xref="GeneID:1855"
                     /db_xref="HGNC:HGNC:3084"
                     /db_xref="MIM:601365"
     exon            1..523
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..2441
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dishevelled 1 (homologous to Drosophila dsh); dishevelled,
                     dsh homolog 1; segment polarity protein dishevelled
                     homolog DVL-1; DSH homolog 1; dishevelled-1"
                     /codon_start=1
                     /product="segment polarity protein dishevelled homolog
                     DVL-1 isoform 1"
                     /protein_id="NP_001317240.1"
                     /db_xref="CCDS:CCDS81252.1"
                     /db_xref="GeneID:1855"
                     /db_xref="HGNC:HGNC:3084"
                     /db_xref="MIM:601365"
                     /translation="MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHA
                     YKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDL
                     PPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTN
                     GHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRK
                     HKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDG
                     GIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLT
                     VAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSS
                     SLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADV
                     VDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLN
                     LNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTG
                     SQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQL
                     SRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQK
                     AMGNPCEFFVDIM"
     exon            524..593
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..715
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..819
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..958
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1052
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1122
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1262
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1339
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1407
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1560
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1692
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1860
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2067
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..3305
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3280..3285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /note="hexamer: ACTAAA"
     polyA_site      3305
                     /gene="DVL1"
                     /gene_synonym="DRS2; DVL; DVL1L1; DVL1P1"
                     /note="major polyA site"
ORIGIN      
        1 gcggccacgc tcaggacccc gggccgggcg gtccctttaa cggcgcggcc cgaggggcgc
       61 aggcgggagg gcggcggggc tgagcgcgcc ctccgtgctg cgtccctcgc gccgctcccg
      121 ggccgggggc ggatgggcgg ccgcgggccg cggggcagca gtcgggacgc gcgcgggagc
      181 cgggggcggc ggccggggcc tgggcggtcg ggcgggggcg cccgggggcc tcggagcgtc
      241 ggggccgaga gcggtgcggg ccgggcgggg cgcaggcggg cgggcgggta gcgccccgcg
      301 tccgagcccc gggccgggcc ctgagcgcgc gggctccgcg ccgccgccgc gccatggcgg
      361 agaccaagat tatctaccac atggacgagg aggagacgcc gtacctggtc aagctgcccg
      421 tggcccccga gcgcgtcacg ctggccgact tcaagaacgt gctcagcaac cggcccgtgc
      481 acgcctacaa attcttcttt aagtccatgg accaggactt cggggtggtg aaggaggaga
      541 tctttgatga caatgccaag cttccctgct tcaacggccg cgtggtctcc tggctggtcc
      601 tggctgaggg tgctcactcg gatgcggggt cccagggcac ggacagccac acagacctgc
      661 ccccgcctct tgagcggaca ggcggcatcg gggactcccg gcccccctcc ttccacccaa
      721 atgtggccag cagccgtgac gggatggaca acgagacagg cacggagtcc atggtcagtc
      781 accggcggga gcgtgcccga cgccggaacc gcgaggaggc cgcccggacc aatgggcacc
      841 caaggggaga ccgacggcgg gatgtggggc tgcccccaga cagcgcgtcc accgccctca
      901 gcagcgagct tgagtccagc agctttgtgg actcggacga ggatggcagc acgagcaggc
      961 tcagcagctc cacggagcag agcacctcat ccagactcat ccggaagcac aaacgccggc
     1021 ggaggaagca gcgccttcgg caggcggacc gggcctcctc cttcagcagc ataaccgact
     1081 ccaccatgtc cctcaacatc gtcactgtca cgctcaacat ggaaagacat cactttctgg
     1141 gcatcagcat cgtggggcag agcaacgacc gtggagacgg cggcatctac attggctcca
     1201 tcatgaaggg cggggctgtg gccgctgacg gccgcatcga gcccggcgac atgttgctgc
     1261 aggtgaatga cgtgaacttt gagaacatga gcaatgacga tgccgtgcgg gtgctgcggg
     1321 agatcgtttc ccagacgggg cccatcagcc tcactgtggc caagtgctgg gacccaacgc
     1381 cccgaagcta cttcaccgtc ccacgggctg acccggtgcg gcccatcgac cccgccgcct
     1441 ggctgtccca cacggcggca ctgacaggag ccctgccccg ctacggtacg agtccctgct
     1501 ccagcgccgt cacgcgcacc agctcctcct cactaaccag ctccgtgcct ggtgctccac
     1561 agctggaaga ggcgccgctg acggtgaaga gtgacatgag cgccgtcgtc cgggtcatgc
     1621 agctgccaga ctcgggactg gagatccgcg accgcatgtg gctcaagatc accatcgcca
     1681 atgccgtcat cggggcggac gtggtggact ggctgtacac acacgtggag ggcttcaagg
     1741 agcggcggga ggcccggaag tacgccagca gcttgctgaa gcacggcttc ctgcggcaca
     1801 cggtcaacaa gatcaccttc tccgagcagt gctactacgt cttcggggat ctctgcagca
     1861 atctcgccac cctgaacctc aacagtggct ccagtgggac ttcggatcag gacacgctgg
     1921 ccccgctgcc ccacccggct gccccctggc ctctgggtca gggctacccc taccagtacc
     1981 cgggaccccc accctgcttc ccgcctgcct accaggaccc gggctttagc tatggcagcg
     2041 gcagcaccgg gagtcagcag agtgaaggga gcaaaagcag tgggtccacc cggagcagcc
     2101 gccgggcccc gggccgtgag aaggagcgtc gggcggcggg agctgggggc agtggcagtg
     2161 aatcggatca cacggcaccg agtggggtgg ggagcagctg gcgagagcgt ccggccggcc
     2221 agctcagccg tggcagcagc ccacgcagtc aggcctcggc taccgccccg gggctccccc
     2281 cgccccaccc cacgaccaag gcctatacag tggtgggggg gccacccggg ggaccccctg
     2341 tccgggagct ggctgccgtc cccccggaat tgacaggcag ccgccagtcc ttccagaagg
     2401 ctatggggaa cccctgcgag ttcttcgtgg acatcatgtg actcgtggcg catgccccag
     2461 ccctgcctga ggtggggagc tggcggtcct gccgcatgca gagctcgcgt gggcttgcct
     2521 tcgtgggggc caggacggga ggcagggtgg ggggcaggct ggaccaccac catctgccct
     2581 ggcagcctgg ctgctccagc tcctgacagc acctgtgtct gagcagccgt gttgggggcg
     2641 ctccctctct gcccctcagc gagagcctcg gacctcccaa ccccttgtgt ctggtgggga
     2701 tccctcctgg gatgaggaag accccctcgg gctctcggct gacccccacc tcctgcacag
     2761 ctgtgcccag gcccccaggg tggtccatgc ggggcaaccc cctgcggtgc acaggccccc
     2821 tgtctggagt agggatctaa tttatttatt tattgcctgg ccggtgactc gggggaggag
     2881 gcgaccctgt catctgtccc acctgctgct gccccttgga gcagcctgca ccttctctcc
     2941 tcccatccgg caacagtctg aaagtacgtg gaggacggga ccggaagacg agagagggct
     3001 ggacatcctg cccaccgtgt cccagccagg gcagggaggg accatggccc gcagggtcaa
     3061 ggggccccga tgtgcacagc tgccacaggg agggaggtct tggggagatg ggcagtcagg
     3121 tggcccgtcc ttggtgagtg cacacactgc gcgcacacat cgcggccttc ctggcttctc
     3181 tggcccccac gtgtctgtgc tgtagatact gtatcaaagt cccagcgttt agatggttaa
     3241 catagagctg cttctgtgta aatgctgctt attttaaaca ctaaaaagcg tttaatttta
     3301 tggga
//
