LOCUS       NM_001351307            1117 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens double homeobox B (DUXB), transcript variant 1, mRNA.
ACCESSION   NM_001351307
VERSION     NM_001351307.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1117)
  AUTHORS   Madissoon,E., Jouhilahti,E.M., Vesterlund,L., Tohonen,V.,
            Krjutskov,K., Petropoulos,S., Einarsdottir,E., Linnarsson,S.,
            Lanner,F., Mansson,R., Hovatta,O., Burglin,T.R., Katayama,S. and
            Kere,J.
  TITLE     Characterization and target genes of nine human PRD-like homeobox
            domain genes expressed exclusively in early embryos
  JOURNAL   Sci Rep 6, 28995 (2016)
   PUBMED   27412763
  REMARK    Erratum:[Sci Rep. 2016 Sep 02;6:32053. doi: 10.1038/srep32053..
            PMID: 27586261]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1117)
  AUTHORS   Tohonen,V., Katayama,S., Vesterlund,L., Jouhilahti,E.M.,
            Sheikhi,M., Madissoon,E., Filippini-Cattaneo,G., Jaconi,M.,
            Johnsson,A., Burglin,T.R., Linnarsson,S., Hovatta,O. and Kere,J.
  TITLE     Novel PRD-like homeodomain transcription factors and
            retrotransposon elements in early human development
  JOURNAL   Nat Commun 6, 8207 (2015)
   PUBMED   26360614
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1117)
  AUTHORS   Clapp,J., Mitchell,L.M., Bolland,D.J., Fantes,J., Corcoran,A.E.,
            Scotting,P.J., Armour,J.A. and Hewitt,J.E.
  TITLE     Evolutionary conservation of a coding function for D4Z4, the tandem
            DNA repeat mutated in facioscapulohumeral muscular dystrophy
  JOURNAL   Am J Hum Genet 81 (2), 264-279 (2007)
   PUBMED   17668377
REFERENCE   4  (bases 1 to 1117)
  AUTHORS   Booth,H.A. and Holland,P.W.
  TITLE     Annotation, nomenclature and evolution of four novel homeobox genes
            expressed in the human germ line
  JOURNAL   Gene 387 (1-2), 7-14 (2007)
   PUBMED   17005330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025287.8.
            
            On May 17, 2019 this sequence version replaced NM_001351307.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LN651084.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148874 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000633875.4/ ENSP00000491301.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC025287.8         16409-16476
            69-223              AC025287.8         17701-17855
            224-329             AC025287.8         20927-21032
            330-484             AC025287.8         21755-21909
            485-1117            AC025287.8         23345-23977
FEATURES             Location/Qualifiers
     source          1..1117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..1117
                     /gene="DUXB"
                     /note="double homeobox B"
                     /db_xref="GeneID:100033411"
                     /db_xref="HGNC:HGNC:33345"
                     /db_xref="MIM:618698"
     exon            1..68
                     /gene="DUXB"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1081
                     /gene="DUXB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     double homeobox protein B"
                     /codon_start=1
                     /product="double homeobox protein B isoform 1"
                     /protein_id="NP_001338236.1"
                     /db_xref="CCDS:CCDS86542.1"
                     /db_xref="GeneID:100033411"
                     /db_xref="HGNC:HGNC:33345"
                     /db_xref="MIM:618698"
                     /translation="MNLEGTSGGILQKEFWRNRIQYNQSQKDILQSWFQHDPFPDKAA
                     REQLAKEIGVPESNIQVWFKNYRVKQRKLDYKCFSEKDQTQGHDQSQHLTQEYLPKEA
                     RQKQTFITWTQKNRLVQAFERNPFPDIATRKKLAEQTGLQESRIQMWFQKQRSLYLKK
                     SRMEPMNLLVDDPNERPDATVGWHPINLFLPTDSSHYFSCSHSSSGHETLPPVLPSTQ
                     APWDPFRFHVSQGPNVMIMQPTQAVQEGEKSDQPLIIPNHLLTLPILTKDLDTPTPFW
                     LQYQEEHQNHKEHSGSGVPQVKSHSQPEPEHREQQPLNLGQFDISNILQRWDEICQAL
                     LAEWDPLKGTH"
     exon            69..223
                     /gene="DUXB"
                     /inference="alignment:Splign:2.1.0"
     exon            224..329
                     /gene="DUXB"
                     /inference="alignment:Splign:2.1.0"
     exon            330..484
                     /gene="DUXB"
                     /inference="alignment:Splign:2.1.0"
     exon            485..1117
                     /gene="DUXB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttactcgc tgatctccgt ggagtccagg tcttctgccc aagatgaatt tggagggcac
       61 ttcaggtggc atacttcaaa aagaattctg gagaaacaga attcagtata accagagtca
      121 aaaggatatc ctccaatcat ggtttcaaca tgaccctttc cctgataaag ctgccagaga
      181 acaactggcc aaagaaattg gggttccaga atctaatatt caggtttggt ttaaaaatta
      241 cagagtaaaa cagagaaaac tggattataa gtgcttctca gaaaaagatc aaacccaggg
      301 gcatgaccag tcccagcatc tgactcaaga atacttacct aaagaagccc gacaaaaaca
      361 gacattcatc acatggactc aaaaaaacag gctagtgcaa gcctttgaga ggaacccatt
      421 ccctgatatt gctaccagaa aaaaactggc tgaacaaaca ggcctgcagg aatcaagaat
      481 tcaaatgtgg tttcagaaac aaagatctct gtacctcaag aagagcagaa tggagcccat
      541 gaatttattg gtagacgacc caaatgagag accagatgca actgttgggt ggcatccaat
      601 caacctgttc ctccccacag acagctctca ttatttttct tgctcacatt cttccagcgg
      661 gcatgaaact cttccacctg ttcttccttc aacccaggct ccttgggatc ccttcaggtt
      721 ccatgtgagc caaggaccaa atgtcatgat catgcagccc acacaggctg tgcaggaagg
      781 agagaagtct gatcagcctc tgataattcc gaatcacctc ctgacactgc caattctgac
      841 aaaggactta gatactccga ctcccttctg gctccaatac caagaagaac accaaaatca
      901 caaagaacac tctggctcgg gagtaccaca ggtcaagagc cattctcagc ctgaacctga
      961 gcacagggag caacaacctc taaatctggg tcagtttgac atatcgaaca ttttgcaaag
     1021 gtgggacgag atctgccagg ctctgcttgc tgaatgggac cctctcaaag ggacacactg
     1081 agacagactt gtggcagcag taggcacact cagctga
//
