LOCUS       NM_001318503            2434 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dual specificity phosphatase 9 (DUSP9), transcript
            variant 1, mRNA.
ACCESSION   NM_001318503 XM_005274655
VERSION     NM_001318503.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Binjawhar,D.N., Ansari,M.G.A., Sabico,S., Hussain,S.D.,
            Alenad,A.M., Alokail,M.S., Al-Masri,A.A. and Al-Daghri,N.M.
  TITLE     Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are
            Associated with Prediabetes Susceptibility and Inflammatory Markers
            in the Saudi Arabian Population
  JOURNAL   Genes (Basel) 14 (3), 536 (2023)
   PUBMED   36980809
  REMARK    GeneRIF: Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6
            Genes Are Associated with Prediabetes Susceptibility and
            Inflammatory Markers in the Saudi Arabian Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Khoubai,F.Z. and Grosset,C.F.
  TITLE     DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell
            Biology and Human Diseases
  JOURNAL   Int J Mol Sci 22 (21), 11538 (2021)
   PUBMED   34768967
  REMARK    GeneRIF: DUSP9, a Dual-Specificity Phosphatase with a Key Role in
            Cell Biology and Human Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2434)
  AUTHORS   Jeong,D.G., Yoon,T.S., Jung,S.K., Park,B.C., Park,H., Ryu,S.E. and
            Kim,S.J.
  TITLE     Exploring binding sites other than the catalytic core in the
            crystal structure of the catalytic domain of MKP-4
  JOURNAL   Acta Crystallogr D Biol Crystallogr 67 (Pt 1), 25-31 (2011)
   PUBMED   21206059
  REMARK    GeneRIF: 2.7 A resolution crystal structure of the catalytic domain
            of MKP-4 (MKP-4C) is presented
REFERENCE   7  (bases 1 to 2434)
  AUTHORS   Voight,B.F., Scott,L.J., Steinthorsdottir,V., Morris,A.P., Dina,C.,
            Welch,R.P., Zeggini,E., Huth,C., Aulchenko,Y.S., Thorleifsson,G.,
            McCulloch,L.J., Ferreira,T., Grallert,H., Amin,N., Wu,G.,
            Willer,C.J., Raychaudhuri,S., McCarroll,S.A., Langenberg,C.,
            Hofmann,O.M., Dupuis,J., Qi,L., Segre,A.V., van Hoek,M.,
            Navarro,P., Ardlie,K., Balkau,B., Benediktsson,R., Bennett,A.J.,
            Blagieva,R., Boerwinkle,E., Bonnycastle,L.L., Bengtsson Bostrom,K.,
            Bravenboer,B., Bumpstead,S., Burtt,N.P., Charpentier,G.,
            Chines,P.S., Cornelis,M., Couper,D.J., Crawford,G., Doney,A.S.,
            Elliott,K.S., Elliott,A.L., Erdos,M.R., Fox,C.S., Franklin,C.S.,
            Ganser,M., Gieger,C., Grarup,N., Green,T., Griffin,S., Groves,C.J.,
            Guiducci,C., Hadjadj,S., Hassanali,N., Herder,C., Isomaa,B.,
            Jackson,A.U., Johnson,P.R., Jorgensen,T., Kao,W.H., Klopp,N.,
            Kong,A., Kraft,P., Kuusisto,J., Lauritzen,T., Li,M., Lieverse,A.,
            Lindgren,C.M., Lyssenko,V., Marre,M., Meitinger,T., Midthjell,K.,
            Morken,M.A., Narisu,N., Nilsson,P., Owen,K.R., Payne,F.,
            Perry,J.R., Petersen,A.K., Platou,C., Proenca,C., Prokopenko,I.,
            Rathmann,W., Rayner,N.W., Robertson,N.R., Rocheleau,G., Roden,M.,
            Sampson,M.J., Saxena,R., Shields,B.M., Shrader,P., Sigurdsson,G.,
            Sparso,T., Strassburger,K., Stringham,H.M., Sun,Q., Swift,A.J.,
            Thorand,B., Tichet,J., Tuomi,T., van Dam,R.M., van Haeften,T.W.,
            van Herpt,T., van Vliet-Ostaptchouk,J.V., Walters,G.B.,
            Weedon,M.N., Wijmenga,C., Witteman,J., Bergman,R.N., Cauchi,S.,
            Collins,F.S., Gloyn,A.L., Gyllensten,U., Hansen,T., Hide,W.A.,
            Hitman,G.A., Hofman,A., Hunter,D.J., Hveem,K., Laakso,M.,
            Mohlke,K.L., Morris,A.D., Palmer,C.N., Pramstaller,P.P., Rudan,I.,
            Sijbrands,E., Stein,L.D., Tuomilehto,J., Uitterlinden,A.,
            Walker,M., Wareham,N.J., Watanabe,R.M., Abecasis,G.R., Boehm,B.O.,
            Campbell,H., Daly,M.J., Hattersley,A.T., Hu,F.B., Meigs,J.B.,
            Pankow,J.S., Pedersen,O., Wichmann,H.E., Barroso,I., Florez,J.C.,
            Frayling,T.M., Groop,L., Sladek,R., Thorsteinsdottir,U.,
            Wilson,J.F., Illig,T., Froguel,P., van Duijn,C.M., Stefansson,K.,
            Altshuler,D., Boehnke,M. and McCarthy,M.I.
  CONSRTM   MAGIC investigators; GIANT Consortium
  TITLE     Twelve type 2 diabetes susceptibility loci identified through
            large-scale association analysis
  JOURNAL   Nat Genet 42 (7), 579-589 (2010)
   PUBMED   20581827
  REMARK    Erratum:[Nat Genet. 2011 Apr;43(4):388]
REFERENCE   8  (bases 1 to 2434)
  AUTHORS   Liu,Y., Lagowski,J., Sundholm,A., Sundberg,A. and Kulesz-Martin,M.
  TITLE     Microtubule disruption and tumor suppression by mitogen-activated
            protein kinase phosphatase 4
  JOURNAL   Cancer Res 67 (22), 10711-10719 (2007)
   PUBMED   18006813
  REMARK    GeneRIF: microtubule disruption by MKP4 provides a novel mechanism
            for tumor suppression by a cytosolic MKP
REFERENCE   9  (bases 1 to 2434)
  AUTHORS   Dickinson,R.J., Williams,D.J., Slack,D.N., Williamson,J.,
            Seternes,O.M. and Keyse,S.M.
  TITLE     Characterization of a murine gene encoding a developmentally
            regulated cytoplasmic dual-specificity mitogen-activated protein
            kinase phosphatase
  JOURNAL   Biochem J 364 (Pt 1), 145-155 (2002)
   PUBMED   11988087
REFERENCE   10 (bases 1 to 2434)
  AUTHORS   Muda,M., Boschert,U., Smith,A., Antonsson,B., Gillieron,C.,
            Chabert,C., Camps,M., Martinou,I., Ashworth,A. and Arkinstall,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mitogen-activated protein kinase phosphatase, MKP-4
  JOURNAL   J Biol Chem 272 (8), 5141-5151 (1997)
   PUBMED   9030581
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC060837.1, U52111.3 and
            AI253132.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001318503.1.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily. These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues. They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated
            with cellular proliferation and differentiation. Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli. This
            gene product shows selectivity for members of the ERK family of MAP
            kinases and is localized to the cytoplasm and nucleus. Aberrant
            expression of this gene is associated with type 2 diabetes and
            cancer progression in several cell types. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060837.1, ERR3218378.212083.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342782.4/ ENSP00000345853.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-714               BC060837.1         1-714
            715-715             U52111.3           32524-32524
            716-1107            BC060837.1         716-1107
            1108-1108           U52111.3           33209-33209
            1109-1890           BC060837.1         1109-1890
            1891-2155           BC060837.1         1892-2156
            2156-2434           AI253132.1         15-293              c
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2434
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /note="dual specificity phosphatase 9"
                     /db_xref="GeneID:1852"
                     /db_xref="HGNC:HGNC:3076"
                     /db_xref="MIM:300134"
     exon            1..223
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /inference="alignment:Splign:2.1.0"
     exon            224..631
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1413
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="serine/threonine specific protein phosphatase; map
                     kinase phosphatase 4; mitogen-activated protein kinase
                     phosphatase 4"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 9"
                     /protein_id="NP_001305432.1"
                     /db_xref="CCDS:CCDS14724.1"
                     /db_xref="GeneID:1852"
                     /db_xref="HGNC:HGNC:3076"
                     /db_xref="MIM:300134"
                     /translation="MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSV
                     ALPALLLRRLRRGSLSVRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEA
                     ESVLGTLLQKLREEGYLAYYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVV
                     GLGSLCLGSDCSDAESEADRDSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARD
                     SANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFI
                     DEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFM
                     GQLLDFERSLRLEERHSQEQGSGGQASAASNPPSFFTTPTSDGAFELAPT"
     exon            632..1087
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..2434
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /note="hexamer: AATAAA"
     polyA_site      2434
                     /gene="DUSP9"
                     /gene_synonym="MKP-4; MKP4"
                     /note="major polyA site"
ORIGIN      
        1 aaggtggaag ctgggtccgg ctgccaggaa gcggccggtg cgcgggctgc gcgggctgcg
       61 cggggctcgg cttccacgtg cgagcctgca ccgccgcccc gccctctcct ggcggccagg
      121 cctggggact ctctgccgcg ggacggcgcc tcgcgttccg ccgtggcagt ggccgtggcc
      181 agaacgtcca cgcgcggtcg tccaccgccg gatctcgctc cagcgcccgt ggtccagcgt
      241 gtagggagcc gatcgcccat ggagggtctg ggccgctcgt gcctgtggct gcgtcgggag
      301 ctgtcgcccc cgcggccgcg gctcctgctc ctggactgcc gcagccgcga gctgtacgag
      361 tcggcgcgca tcggtggggc gctgagcgtg gccctgccgg cgctcctgct gcgccgcctg
      421 cggaggggca gcctgtcggt gcgcgcgctc ctgcctgggc cgccgctgca gccgcccccg
      481 cctgcccccg tgctcctgta cgaccagggc gggggccggc gccggcgcgg ggaggccgag
      541 gccgaggccg aggagtggga ggccgagtcg gtgctgggca ccctgctgca gaagctgcga
      601 gaggaaggct acctggccta ctacctccag ggaggcttca gcagattcca ggccgagtgc
      661 cctcacctgt gtgagaccag ccttgctggc cgtgccggct ccagcatggc gccggtgccc
      721 ggtccagtgc ccgtggtggg gttgggcagc ctgtgcctgg gctccgactg ctctgatgcg
      781 gaatccgagg ctgaccgcga ctccatgagc tgtggcctgg attcggaggg tgccacaccc
      841 ccaccagtgg ggctgcgggc atccttccct gtccagatcc tgcccaacct ctatctgggc
      901 agtgcccggg attccgccaa tttggagagc ctggccaaac tgggcatccg ctacatcctc
      961 aatgtcaccc ccaacctccc aaacttcttc gagaagaatg gtgactttca ctacaagcag
     1021 atccccatct ccgaccactg gagccagaac ctgtcgcggt tctttccgga ggccattgag
     1081 ttcattgatg aggccttgtc ccagaactgc ggggtgctcg tccactgctt ggcgggggtc
     1141 agccgttctg tcaccgtcac tgtggcctac ctcatgcaga agctccacct ctctctcaac
     1201 gatgcctatg acctggtcaa gaggaagaag tctaacatct cccccaactt caacttcatg
     1261 gggcagttgc tggactttga gcgcagcttg cggctggagg agcgccactc gcaggagcag
     1321 ggcagtgggg ggcaggcatc tgcggcctcc aacccgccct ccttcttcac cacccccacc
     1381 agtgatggcg ccttcgagct ggcccccacc tagggccccg tggccggcag gccggcccct
     1441 gccccacccc cacccacggg tgtccctgcc cactcgtgtg gcaagggagg ggagggcagg
     1501 agggctcggc ctgagcaggg tgctgggggg agagcgcaat acctcacgcg ggctgccgtc
     1561 ctaatcaacg tgcctatggc gggaccacgc tcggagcctg cctcttctgc gactgttact
     1621 ttttctttgc gggatggggg tgggggttcc ctctccaggt ggttgtccag gcccaggtcc
     1681 cggccctggg tgctcagcca gctcggctag gccctgcgcc tccctgcgct tcccccttca
     1741 ggaagggtgt gtgccacctc gttgcactgg atcccagtgg ctgcttgggg gagaggcgtt
     1801 tgccatcact ggtgttgtca cctccctgtt tctccaccaa gggcttgggc ctctcggggc
     1861 tggggcctcc caggggatgg ggacccagag tgcagtggcc gcccacatcc atggcctagg
     1921 agctactggg caggttcccg gccacacatc tggtgggctg ttttgttttt tttttttcct
     1981 cttcccccag atgtcttgac gggatcactg gggctctttg tgagtgaggg tggccaaact
     2041 accgccggag gagatggggt ctcagagcga gagctgcgga gggggagggg aagaagaagg
     2101 cctcactttt gctgctgcgg ggcccacaca gccgctgcta ctttgggggg tggggaaggg
     2161 gccaagctgc agacacacac agtcattcat ttctgtccac acccctgtgg gtggcgggtg
     2221 tgcgtgtgtg tgcttgtgtg tgcgcacgtg tcggcgctca cacacacatg ctagcccact
     2281 gatgcaccca gcccagggct ggcagtcttt gcagcgtggg gccgtctcac cctggagcct
     2341 ggagaggatc tatgcttgtt tgtttttgta atccatatca tagttgcttt ctttaattgt
     2401 tccttctgaa taaacagttt atttaagata ctga
//
