LOCUS       NM_004420               4824 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dual specificity phosphatase 8 (DUSP8), mRNA.
ACCESSION   NM_004420
VERSION     NM_004420.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4824)
  AUTHORS   Turkowski,K., Herzberg,F., Gunther,S., Weigert,A., Haselbauer,T.,
            Fink,L., Brunn,D., Grimminger,F., Seeger,W., Sultmann,H.,
            Stiewe,T., Pullamsetti,S.S. and Savai,R.
  TITLE     miR-147b mediated suppression of DUSP8 promotes lung cancer
            progression
  JOURNAL   Oncogene 43 (16), 1178-1189 (2024)
   PUBMED   38396293
  REMARK    GeneRIF: miR-147b mediated suppression of DUSP8 promotes lung
            cancer progression.
REFERENCE   2  (bases 1 to 4824)
  AUTHORS   Chuang,H.C., Hsueh,C.H., Hsu,P.M., Tsai,C.Y., Shih,Y.C., Chiu,H.Y.,
            Chen,Y.M., Yu,W.K., Chen,M.H. and Tan,T.H.
  TITLE     DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha
  JOURNAL   J Clin Invest 133 (21), e166269 (2023)
   PUBMED   37909329
  REMARK    GeneRIF: DUSP8 induces TGF-beta-stimulated IL-9 transcription and
            Th9-mediated allergic inflammation by promoting nuclear export of
            Pur-alpha.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4824)
  AUTHORS   Zhang,H., Wang,M., Chen,D. and Luo,C.
  TITLE     Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in
            breast cancer by regulating MAPK pathways
  JOURNAL   J Investig Med 70 (5), 1293-1300 (2022)
   PUBMED   35428675
  REMARK    GeneRIF: Dual-specificity phosphatase 8 (DUSP8) induces drug
            resistance in breast cancer by regulating MAPK pathways.
REFERENCE   4  (bases 1 to 4824)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4824)
  AUTHORS   Baumann,P., Schriever,S.C., Kullmann,S., Zimprich,A., Peter,A.,
            Gailus-Durner,V., Fuchs,H., Hrabe de Angelis,M., Wurst,W.,
            Tschop,M.H., Heni,M., Holter,S.M. and Pfluger,P.T.
  TITLE     Diabetes type 2 risk gene Dusp8 is associated with altered sucrose
            reward behavior in mice and humans
  JOURNAL   Brain Behav 11 (1), e01928 (2021)
   PUBMED   33131190
  REMARK    GeneRIF: Diabetes type 2 risk gene Dusp8 is associated with altered
            sucrose reward behavior in mice and humans.
REFERENCE   6  (bases 1 to 4824)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   7  (bases 1 to 4824)
  AUTHORS   Berger,I.R., Buschbeck,M., Bange,J. and Ullrich,A.
  TITLE     Identification of a transcriptionally active hVH-5 pseudogene on
            10q22.2
  JOURNAL   Cancer Genet Cytogenet 159 (2), 155-159 (2005)
   PUBMED   15899389
  REMARK    GeneRIF: Because this variant of hVH-5 lacked intronic sequences in
            its genomic structure, we suggest it might be a processed
            pseudogene of hVH-5.
REFERENCE   8  (bases 1 to 4824)
  AUTHORS   Hink,R.L., Hokanson,J.E., Shah,I., Long,J.C., Goldman,D. and
            Sikela,J.M.
  TITLE     Investigation of DUSP8 and CALCA in alcohol dependence
  JOURNAL   Addict Biol 8 (3), 305-312 (2003)
   PUBMED   13129832
  REMARK    GeneRIF: DUSP8 is genetically linked to alcohol dependence and was
            found on chromosome 11p15.5
REFERENCE   9  (bases 1 to 4824)
  AUTHORS   Nesbit,M.A., Hodges,M.D., Campbell,L., de Meulemeester,T.M.,
            Alders,M., Rodrigues,N.R., Talbot,K., Theodosiou,A.M.,
            Mannens,M.A., Nakamura,Y., Little,P.F. and Davies,K.E.
  TITLE     Genomic organization and chromosomal localization of a member of
            the MAP kinase phosphatase gene family to human chromosome 11p15.5
            and a pseudogene to 10q11.2
  JOURNAL   Genomics 42 (2), 284-294 (1997)
   PUBMED   9192849
REFERENCE   10 (bases 1 to 4824)
  AUTHORS   Martell,K.J., Seasholtz,A.F., Kwak,S.P., Clemens,K.K. and
            Dixon,J.E.
  TITLE     hVH-5: a protein tyrosine phosphatase abundant in brain that
            inactivates mitogen-activated protein kinase
  JOURNAL   J Neurochem 65 (4), 1823-1833 (1995)
   PUBMED   7561881
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP006285.2, U27193.1,
            BC045110.1, AK124467.1 and BU740880.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004420.2.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily. These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues. They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated
            with cellular proliferation and differentiation. Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli. This
            gene product inactivates SAPK/JNK and p38, is expressed
            predominantly in the adult brain, heart, and skeletal muscle, is
            localized in the cytoplasm, and is induced by nerve growth factor
            and insulin. An intronless pseudogene for DUSP8 is present on
            chromosome 10q11.2. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038231.1, DRR138524.1225501.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152798, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397374.8/ ENSP00000380530.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AP006285.2         67333-67683         c
            352-1374            U27193.1           7-1029
            1375-2731           BC045110.1         897-2253
            2732-3603           AK124467.1         27-898
            3604-4192           AP006285.2         50095-50683         c
            4193-4824           BU740880.1         19-650              c
FEATURES             Location/Qualifiers
     source          1..4824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..4824
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /note="dual specificity phosphatase 8"
                     /db_xref="GeneID:1850"
                     /db_xref="HGNC:HGNC:3074"
                     /db_xref="MIM:602038"
     exon            1..371
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /inference="alignment:Splign:2.1.0"
     exon            372..710
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..2357
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="serine/threonine specific protein phosphatase; H1
                     phosphatase, vaccinia virus homolog; dual specificity
                     protein phosphatase hVH-5"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 8"
                     /protein_id="NP_004411.2"
                     /db_xref="CCDS:CCDS7724.1"
                     /db_xref="GeneID:1850"
                     /db_xref="HGNC:HGNC:3074"
                     /db_xref="MIM:602038"
                     /translation="MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVL
                     SSVNICCSKLVKRRLQQGKVTIAELIQPAARSQVEATEPQDVVVYDQSTRDASVLAAD
                     SFLSILLSKLDGCFDSVAILTGGFATFSSCFPGLCEGKPAALLPMSLSQPCLPVPSVG
                     LTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYC
                     EKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFV
                     KDRRPSISPNFNFLGQLLEYERSLKLLAALQGDPGTPSGTPEPPPSPAAGAPLPRLPP
                     PTSESAATGNAAAREGGLSAGGEPPAPPTPPATSALQQGLRGLHLSSDRLQDTNRLKR
                     SFSLDIKSAYAPSRRPDGPGPPDPGEAPKLCKLDSPSGAALGLSSPSPDSPDAAPEAR
                     PRPRRRPRPPAGSPARSPAHSLGLNFGDAARQTPRHGLSALSAPGLPGPGQPAGPGAW
                     APPLDSPGTPSPDGPWCFSPEGAQGAGGVLFAPFGRAGAPGPGGGSDLRRREAARAEP
                     RDARTGWPEEPAPETQFKRRSCQMEFEEGMVEGRARGEELAALGKQASFSGSVEVIEV
                     S"
     exon            711..849
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1016
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1176
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1300
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..4824
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /note="hexamer: AGTAAA"
     polyA_site      2489
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /note="major polyA site"
     regulatory      4800..4805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /note="hexamer: AATAAA"
     polyA_site      4824
                     /gene="DUSP8"
                     /gene_synonym="C11orf81; HB5; HVH-5; HVH8"
                     /note="major polyA site"
ORIGIN      
        1 actcgcggcc gagcgcggcg gccgagccgg ctccccccac gacgccccgc cggacgccgg
       61 acgcccgagc ccgagcccga gcccgagccc gagccgcgcc ggaacctccc ggccgcgccc
      121 gccgagccgc ggggctggga tgcgcgccgc gagcgcgcgt gcccgcccgc agtgcgcgcg
      181 ccccggcccg agcgagcgct ccccgcggcg ttggcggcgg cgacggcggc gacggcgacg
      241 cggcccgcgc gctcccccgg cccctgcccc ggctgcgcgg gcccccgccg ggcccatgga
      301 cggcgcggcc gagcgggcgc cctgagcgcg gcgcgggtcc ccggagcgcc cccgaggcga
      361 gcgcgagcga ggtccagcac catgtgctag gtcactccca gcgcgaggcc acacctgggc
      421 cgtcggagca gcccctcctc acttcagggg tcaccctccc cagcacccat tgccccacca
      481 tggctgggga ccggctcccg aggaaggtga tggatgccaa gaagctggcc agcctgctgc
      541 ggggcgggcc tggggggccg ctggtcatcg acagccgctc cttcgtggag tacaacagct
      601 ggcatgtgct cagctccgtc aacatctgct gctccaagct ggtgaagcgg cggctgcagc
      661 agggcaaggt gaccattgcg gagctcatcc agccggctgc acgcagccag gtggaggcta
      721 cggagccaca ggacgtggtg gtctatgacc agagcacgcg ggacgccagc gtgctggccg
      781 cagacagctt cctctccatc ctgctgagca agctggacgg ctgcttcgac agcgtggcca
      841 tcctcactgg gggcttcgcc accttctcct cctgcttccc cggcctctgc gagggcaagc
      901 ctgctgccct gctacccatg agcctctccc agccctgcct gcctgtgccc agcgtgggcc
      961 tgacccgcat cctgcctcac ctctacctgg gctcgcagaa ggacgtccta aacaaggatc
     1021 tgatgacgca aaatggaata agctacgtcc tcaacgccag caactcctgc cccaagcctg
     1081 acttcatctg cgagagccgc ttcatgcggg tccccatcaa cgacaactac tgtgaaaaac
     1141 tgctgccctg gctggacaag tccatcgagt tcatcgataa agccaagctc tccagctgcc
     1201 aagtcatcgt ccactgtctg gctggcatct cccgctctgc caccatcgcc atcgcctaca
     1261 tcatgaagac catgggcatg tcctccgacg acgcctacag gttcgtgaag gacaggcgcc
     1321 cgtccatctc gcccaacttc aacttcctgg gccagctgct ggagtacgag cgcagcctga
     1381 agctgctggc cgccctgcag ggcgacccgg gcaccccctc agggacgccg gagcctccgc
     1441 ccagtcctgc cgccggggcc ccgctgccac ggctgccacc acctacctca gagagcgctg
     1501 ccacagggaa tgcggctgcc agggagggcg gcctgagcgc gggcggggag ccccccgcgc
     1561 cccccacgcc cccggcgacc agcgcactgc agcagggcct gcgcggcctg cacctctcct
     1621 cggaccgcct gcaggacact aaccgcctca agcgctcctt ctccctggac atcaagtctg
     1681 cctacgcccc tagcaggcgg cccgacggcc ccgggccccc cgaccccggc gaggccccga
     1741 agctctgcaa gctggacagc ccgtcggggg ccgcgctggg cctgtcctcg cccagcccgg
     1801 acagcccgga cgccgcgcct gaggcgcgcc cacggccccg ccggcggccc cggccccccg
     1861 ccggctcccc cgcgcgctcc cccgcgcaca gcctcggcct gaacttcggc gatgcggccc
     1921 ggcagactcc gcggcacggc ctctcggccc tgtcggcgcc cgggctgccc ggccctggcc
     1981 agccggccgg ccccggggcc tgggcaccgc cgctcgactc cccaggcacg ccgtcgcccg
     2041 acgggccctg gtgcttcagc cccgagggcg cacagggggc gggcggggtg ctgtttgcgc
     2101 ccttcggccg ggcgggcgcc ccgggaccag gcggcggcag cgacctgcgg cggcgggagg
     2161 cagcgagggc tgagccccgg gacgcgcgga ccggctggcc cgaggagccg gccccggaga
     2221 cgcagttcaa gcgccgcagc tgccagatgg agttcgagga gggcatggtg gaggggcgcg
     2281 cgcgcggcga ggagctggcc gccctgggca agcaggcgag cttctcgggc agcgtggagg
     2341 tcatcgaggt gtcctgaccc ctccgctgcc ctcggccccg ccgcccgcag ccaggcccgt
     2401 tataaatgta tattatatat aatgcaaaga aaggtaaatg gttttactgg gatttttatc
     2461 gagaagtaaa tatttcgatt ttttatttat ttaagctgtt cattctggca atgatttggc
     2521 aacagtgcgg gtggtcctcg agctctattt ttactgtctg gtatttaaac tgaaacatac
     2581 gtttctaagc aatacgaggc caccttcagt cgcaagctgg gtgccaggcc tggggcccct
     2641 cccagttccc ccgccccagg aaacactgct gacctttgca aaggctgccg agctttcgtg
     2701 cactttttac ataacaaaaa ggtgaaaaaa aggaaaaaaa aacttctttg ccacaaactg
     2761 agccgcagaa ccccccttct ccccccaccc acctcccctg ctccctccct tctctgcgcc
     2821 ggcctagggc tctgcaccaa agccatagga tggaggagca ggagctggtg tgccccggag
     2881 aggtgcggcc agccctccat cagctccagg caccaaatct tggtggcaag gagggcaccc
     2941 cgctgcccgt tgccccagag ctgttctctg gcaggggagg acaggcattg ggcttcatgg
     3001 tgccagggtg ttcagagggg ctgagaaata gaacagtgtg tgtaggggct tcgggcaggg
     3061 ggttctggaa cgtcagatga ggtgcagccc aggggaggac agaggtgtta gtgcccccaa
     3121 ctcctgccag agccccagtc cagccacaga gtggctcaga aaggccattc ctagagggct
     3181 gcggccctcc cttctccctt gcccatgccc ccagagctgc ctgccgggca gggtggcacc
     3241 attgcaggag aggagcttgg cctccggggg tcaggcagga ggcgcctggc tagccagtgc
     3301 tggctccact gggcaggaag ccctggaccc ccaggtatga ggagggggtg gtcttagggt
     3361 tctgttccag gtctgccccg cccccctccc agccatgccc caggcagaac ttggaattca
     3421 ggtgtgcacc tgcaggctga ggggctctgt gagcaggtgc tgctcacaca gggagttcag
     3481 gcgccagcca agcccctgtg ctgctgggat aggcctgctt cacttaggga gcactgcctc
     3541 aagacaggta aagccccctc gtttgccccc acccccatgg ggccgctcag gagagaaact
     3601 cccattcacc cctttcccag ggtgctctct ctctaggtgg catgccagcc cccaaacaca
     3661 agtggctttt gggcccaggt gggtcagcct gctgcccctg ccccataccc cctcgggcca
     3721 ttgggacccc tgcccttcag atgtcctagg gtctaggagt ggggccagtc actgtgggaa
     3781 gaggccaggg gcttggccgg agaggcagcc cagggcagga cccagtcctg agtcctggag
     3841 cagggccagg gaggcgccca tcccgcccca gccagccgcc ctctctgctg tttcttctat
     3901 ttgttcttct tttcacccac agctctgtgt tcctgtcatc cctcctttca gcaaaagtcc
     3961 tgttcccgtt ccctctgtcc ccacccactc ctgttccccc aagaaaataa gctatcgttg
     4021 tatttgcaat ctatggatta gaggtttaag tatttattat tattggttaa ttattattaa
     4081 ttatgtaaat ttgcctccca tatgtctgtt gcgttgggtt tctgaggaga ccctgggtga
     4141 ggaggatgca ctggcttccc gcttctcgcc ccccacccct gtgctgtccg ggagacagtg
     4201 gtctggggcc actggttggg cccccttctc ccttccccct tccccttgtc ccttctgcag
     4261 gccgttgagg ggggctgtct gtctcagtct gtctctgctc ccactcttga ggcactggtt
     4321 accgcaaagt gagcagccag caggggggcg aaggtcctgt gttggccact gcctcctcca
     4381 gtgctgcagg aggcgggctg aggccccacc tggtggcttt cacctgaccc agccctgagt
     4441 cctctccaag cctctctccg gcccctccca cctggccact gcctcctcca gtgctgcggg
     4501 aggcgggcca gggccccacc tggtggcttt cacctgaccc agccctgagt cctctccaag
     4561 cctctctccg gcccctccca cctggccact gcctggcatt gggatcgccc caaaatggac
     4621 ccggcccctc ctgttatttg ctgggaagtc cagcggagga gagggtgcag gtcccccgct
     4681 gagcctccag tctctgtaga ctgggctgcc ggcccttcag ccccccttgg agcccctccc
     4741 gccacagccg caccttctgc tcccggcccc tccctttgta tttggagaca atgtgttgta
     4801 ataaagctta aagtggatgt tttc
//
