LOCUS       NM_001947               3361 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens dual specificity phosphatase 7 (DUSP7), mRNA.
ACCESSION   NM_001947 XM_037430
VERSION     NM_001947.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3361)
  AUTHORS   Li,L., Wang,N., Xiong,Y., Guo,G., Zhu,M. and Gu,Y.
  TITLE     Transcription Factor FOSL1 Enhances Drug Resistance of Breast
            Cancer through DUSP7-Mediated Dephosphorylation of PEA15
  JOURNAL   Mol Cancer Res 20 (4), 515-526 (2022)
   PUBMED   34907034
  REMARK    GeneRIF: Transcription Factor FOSL1 Enhances Drug Resistance of
            Breast Cancer through DUSP7-Mediated Dephosphorylation of PEA15.
REFERENCE   2  (bases 1 to 3361)
  AUTHORS   Bai,H., Song,M., Jiao,R., Li,W., Zhao,J., Xiao,M., Jin,M., Zhang,Z.
            and Deng,H.
  TITLE     DUSP7 inhibits cervical cancer progression by inactivating the RAS
            pathway
  JOURNAL   J Cell Mol Med 25 (19), 9306-9318 (2021)
   PUBMED   34435746
  REMARK    GeneRIF: DUSP7 inhibits cervical cancer progression by inactivating
            the RAS pathway.
REFERENCE   3  (bases 1 to 3361)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3361)
  AUTHORS   Guo,X., Ramirez,I., Garcia,Y.A., Velasquez,E.F., Gholkar,A.A.,
            Cohn,W., Whitelegge,J.P., Tofig,B., Damoiseaux,R. and Torres,J.Z.
  TITLE     DUSP7 regulates the activity of ERK2 to promote proper chromosome
            alignment during cell division
  JOURNAL   J Biol Chem 296, 100676 (2021)
   PUBMED   33865857
  REMARK    GeneRIF: DUSP7 regulates the activity of ERK2 to promote proper
            chromosome alignment during cell division.
REFERENCE   5  (bases 1 to 3361)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3361)
  AUTHORS   Pasquali,C., Curchod,M.L., Walchli,S., Espanel,X., Guerrier,M.,
            Arigoni,F., Strous,G. and Hooft van Huijsduijnen,R.
  TITLE     Identification of protein tyrosine phosphatases with specificity
            for the ligand-activated growth hormone receptor
  JOURNAL   Mol Endocrinol 17 (11), 2228-2239 (2003)
   PUBMED   12907755
REFERENCE   7  (bases 1 to 3361)
  AUTHORS   Dowd,S., Sneddon,A.A. and Keyse,S.M.
  TITLE     Isolation of the human genes encoding the pyst1 and Pyst2
            phosphatases: characterisation of Pyst2 as a cytosolic
            dual-specificity MAP kinase phosphatase and its catalytic
            activation by both MAP and SAP kinases
  JOURNAL   J Cell Sci 111 (Pt 22), 3389-3399 (1998)
   PUBMED   9788880
REFERENCE   8  (bases 1 to 3361)
  AUTHORS   Smith,A., Price,C., Cullen,M., Muda,M., King,A., Ozanne,B.,
            Arkinstall,S. and Ashworth,A.
  TITLE     Chromosomal localization of three human dual specificity
            phosphatase genes (DUSP4, DUSP6, and DUSP7)
  JOURNAL   Genomics 42 (3), 524-527 (1997)
   PUBMED   9205128
REFERENCE   9  (bases 1 to 3361)
  AUTHORS   Groom,L.A., Sneddon,A.A., Alessi,D.R., Dowd,S. and Keyse,S.M.
  TITLE     Differential regulation of the MAP, SAP and RK/p38 kinases by
            Pyst1, a novel cytosolic dual-specificity phosphatase
  JOURNAL   EMBO J 15 (14), 3621-3632 (1996)
   PUBMED   8670865
REFERENCE   10 (bases 1 to 3361)
  AUTHORS   Muda,M., Boschert,U., Dickinson,R., Martinou,J.C., Martinou,I.,
            Camps,M., Schlegel,W. and Arkinstall,S.
  TITLE     MKP-3, a novel cytosolic protein-tyrosine phosphatase that
            exemplifies a new class of mitogen-activated protein kinase
            phosphatase
  JOURNAL   J Biol Chem 271 (8), 4319-4326 (1996)
   PUBMED   8626780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115284.4, DN999200.1, BC019107.2, X93921.1, CN429806.1 and
            AL110157.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001947.3.
            
            Summary: Dual-specificity phosphatases (DUSPs) constitute a large
            heterogeneous subgroup of the type I cysteine-based
            protein-tyrosine phosphatase superfamily. DUSPs are characterized
            by their ability to dephosphorylate both tyrosine and
            serine/threonine residues. DUSP7 belongs to a class of DUSPs,
            designated MKPs, that dephosphorylate MAPK (mitogen-activated
            protein kinase) proteins ERK (see MIM 601795), JNK (see MIM
            601158), and p38 (see MIM 600289) with specificity distinct from
            that of individual MKP proteins. MKPs contain a highly conserved
            C-terminal catalytic domain and an N-terminal Cdc25 (see MIM
            116947)-like (CH2) domain. MAPK activation cascades mediate various
            physiologic processes, including cellular proliferation, apoptosis,
            differentiation, and stress responses (summary by Patterson et al.,
            2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.9560.1,
                                           SRR1660805.169034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674, SAMN03568911
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000495880.2/ ENSP00000417183.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC115284.4         138333-138458       c
            127-494             DN999200.1         9-376
            495-1900            BC019107.2         1-1406
            1901-1966           X93921.1           1406-1471
            1967-2330           CN429806.1         48-411
            2331-3361           AL110157.1         372-1402
FEATURES             Location/Qualifiers
     source          1..3361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..3361
                     /gene="DUSP7"
                     /gene_synonym="MKPX; PYST2"
                     /note="dual specificity phosphatase 7"
                     /db_xref="GeneID:1849"
                     /db_xref="HGNC:HGNC:3073"
                     /db_xref="MIM:602749"
     exon            1..722
                     /gene="DUSP7"
                     /gene_synonym="MKPX; PYST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1465
                     /gene="DUSP7"
                     /gene_synonym="MKPX; PYST2"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="dual specificity protein phosphatase PYST2"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 7"
                     /protein_id="NP_001938.2"
                     /db_xref="CCDS:CCDS33766.2"
                     /db_xref="GeneID:1849"
                     /db_xref="HGNC:HGNC:3073"
                     /db_xref="MIM:602749"
                     /translation="MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAG
                     AATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLR
                     RLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQK
                     LRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSD
                     GESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILN
                     VTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAG
                     ISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCD
                     NHASSEQLYFSTPTNHNLFPLNTLEST"
     exon            723..1157
                     /gene="DUSP7"
                     /gene_synonym="MKPX; PYST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..3361
                     /gene="DUSP7"
                     /gene_synonym="MKPX; PYST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3337..3342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP7"
                     /gene_synonym="MKPX; PYST2"
                     /note="hexamer: AATAAA"
     polyA_site      3361
                     /gene="DUSP7"
                     /gene_synonym="MKPX; PYST2"
                     /note="major polyA site"
ORIGIN      
        1 gtttaattgg ggctgtcagg ccgcggtgcg cgcggagggc cgggcgggcg ggcgggacgg
       61 aggccgggag gccgggaggc cggggcggcg ggcgcgcagc tcggcgggag gcgggcgccc
      121 ggagacgcgg ctggggcccg cgcggccggg gcgccgtccc agggcagggc tgcccggccc
      181 cggccccggg ccgcccgcgc tccccatgaa aaaccagctc cgcggccccc cagcgcgggc
      241 gcacatgtcg acttcggggg cggcggcggc tgggggcacc cgggcggggt ccgagcccgg
      301 tgcggggtcg gggtccggcg caggcaccgg ggcgggcgcg gcgacggggg caggggccat
      361 gccctgcaag agcgccgagt ggctgcagga ggagctggag gcgcgcggcg gcgcgtcctt
      421 gctgctgctc gactgccggc cgcacgagct cttcgagtcg tcgcacatcg agacggccat
      481 caacctggcc atcccgggcc tcatgttgcg ccgcctgcgc aagggcaacc tgcccatccg
      541 ctccatcatc cccaaccacg ccgacaagga gcgcttcgcc acgcgctgca aggcggccac
      601 cgtgctgctc tacgacgagg ccacggccga gtggcagccc gagcccggcg ctcccgcctc
      661 cgtgctcggc ctgctcctac agaagctgcg cgacgacggc tgccaggcct actacctcca
      721 aggtggtttc aacaagtttc aaacagagta ctctgagcac tgcgagacca acgtggacag
      781 ctcttcctcg ccgagcagct cgccacccac ctcagtgctg ggcctggggg gcctgcgcat
      841 cagctctgac tgctccgacg gcgagtcgga ccgagagctg cccagcagtg ccaccgagtc
      901 agacggcagc cctgtgccat ccagccaacc agccttccct gtccagatcc tgccctacct
      961 ctacctcggc tgcgccaagg actccaccaa cctggacgtg ctcggcaagt atggcatcaa
     1021 gtatatcctc aatgtcacac ccaacctacc caacgccttc gagcacggcg gcgagttcac
     1081 ctacaagcag atccccatct ctgaccactg gagccagaac ctctcccagt tcttccctga
     1141 ggccatcagc ttcattgacg aagcccgctc caagaagtgt ggtgtcctgg tgcactgcct
     1201 ggcaggcatc agccgctcag tgacggtcac tgtggcctat ctgatgcaga agatgaacct
     1261 gtcactcaac gacgcctacg actttgtcaa gaggaaaaag tccaacatct cgcccaactt
     1321 caacttcatg gggcagctgc tggactttga gcggacgctg gggctaagca gcccgtgcga
     1381 caaccacgcg tcgagtgagc agctctactt ttccacgccc accaaccaca acctgttccc
     1441 actcaatacg ctggagtcca cgtgaggcct ggtgcacggg gggcatggca ccaggcccct
     1501 gctcggctct ccacagggct aggtgggaga gcccaagccc gccacctctg gcctgaggaa
     1561 cccccagatg tcacctgtgc ccagaggccc aggctgatcg gtgtcggagc gcccctcacc
     1621 atccttgggg gcagggcccg caggcaaggt ctcccactgc agggcttgct ggagaggcct
     1681 cggctcttgg acacgtggct ttgggcgtcc accagggcct catcctgtcc aggacgctcc
     1741 tttctgctga cagcccagcc agtttggctg ttttttaaag acacatccac ggacctgagt
     1801 ttacttttta cttttggcag gtaaatccaa gctccctgga gcacaaagag tgtttgagct
     1861 cttcttgatt tttctttttt tttttttttt ttaacaaaaa gtgttatttt caggctacat
     1921 gcaacagtgg attgtataac ccagtatttc atccctttcc tgatcctgca agagagagaa
     1981 atgttcagtt ttgtttttcg ttcaatttca aaaagcaagt atcgtgtttg tttttgtttt
     2041 tgttttttaa tggaaaagac agacgccatg ttgaccttga ccaaatgcgt tttgcacatg
     2101 tgtgaagcct ctgtttcctc agcgggccct tcttgaaggg gtggcttact gctcttcagg
     2161 tattgggacc cccagtcgtg ccgcctccca cccttggccc agtctgactt agctctgcat
     2221 tcgcctgtga tgactgctgc aagttgtgat tggtgggctg gatggtggtc tttgcatttt
     2281 ctgccgtctc atccatccct ctggtggtcc ctgcagacct ccctgaggca gaaggtgggg
     2341 accctggggc cctgccgctg tcccccagga ggtgggccgc agggggctgc caggcagtag
     2401 cattagccct ctggggtcag cccctaagaa ggcctgggct ctgagccctt ttatatactt
     2461 agccactact tctgtctgtc tgtctgtctc tctctcttcc tctccctctc tctctttctc
     2521 tctctccctc tctctctctt tctttctctc tccccccctc cctctctctt cctttcctct
     2581 ctcttgttgt aactgggagt ggaggcccag tggctgggga gacattaggt ggtggggccc
     2641 agcccgacct ccaggttctt ccttctccct agctgttgct ttggtctggc cactcccagc
     2701 ccccttgtcc ccttggaagc ttgccctgcc ctcatcttgc ccatgccttc tactgccagg
     2761 agacttgcac ccatttcaac cctagggcgg gggcaagtgg ggcaaggatg gaccagcaga
     2821 aggggggtaa ggctctgttc acttccccct gcctccacag aacgaagcca cggattccgt
     2881 tatcttcctc cagttttgtt ccttctccag cctcagttcc accaggtgtc aggactgcat
     2941 gggggcctgg ggcaggcaga ggagtcaggc cagggtccct gacggagcag cactcagcat
     3001 gtgagtgagg ccacagaaaa actctgcccc actgcttctt acctcacggg ggtggctttc
     3061 agggattctt tagcgcagca gattaaaatc ttgccacagt cgagaaattg acaacaagct
     3121 tccatgctgt acatggttct ctttttctct cttttatttt taaaaagaaa acccagaaag
     3181 atgtaccaga tttgtgtaaa tgagggtatg ccagaaggtg gccagttttg ctttatgatc
     3241 ttatgaagga agatttgtga ccctacgtat atatatacac acacatacat atatatatat
     3301 atcccgaacc aacaacggga ctttgtttat attgcaaata aatattattt tttctttaaa
     3361 a
//
