LOCUS       NM_001946               3627 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens dual specificity phosphatase 6 (DUSP6), transcript
            variant 1, mRNA.
ACCESSION   NM_001946
VERSION     NM_001946.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3627)
  AUTHORS   Wang,Y., Lv,Y., Jiang,X., Yu,X., Wang,D., Liu,D., Liu,X. and Sun,Y.
  TITLE     Long non-coding RNA NORAD regulates megakaryocyte differentiation
            and proplatelet formation via the DUSP6/ERK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 715, 150004 (2024)
   PUBMED   38678784
  REMARK    GeneRIF: Long non-coding RNA NORAD regulates megakaryocyte
            differentiation and proplatelet formation via the DUSP6/ERK
            signaling pathway.
REFERENCE   2  (bases 1 to 3627)
  AUTHORS   Tai,C.H., Wang,C.C., Shih,Y.C., Chen,Y.J., Chen,B.K. and Chen,L.C.
  TITLE     Functional Role of DUSP6 in the EGFR-mediated Progression of Head
            and Neck Squamous Cell Carcinoma
  JOURNAL   Anticancer Res 44 (6), 2545-2554 (2024)
   PUBMED   38821599
  REMARK    GeneRIF: Functional Role of DUSP6 in the EGFR-mediated Progression
            of Head and Neck Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 3627)
  AUTHORS   Yoo,D.H., Im,Y.S., Oh,J.Y., Gil,D. and Kim,Y.O.
  TITLE     DUSP6 is a memory retention feedback regulator of ERK signaling for
            cellular resilience of human pluripotent stem cells in response to
            dissociation
  JOURNAL   Sci Rep 13 (1), 5683 (2023)
   PUBMED   37029196
  REMARK    GeneRIF: DUSP6 is a memory retention feedback regulator of ERK
            signaling for cellular resilience of human pluripotent stem cells
            in response to dissociation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3627)
  AUTHORS   Yang,J., Xu,P., Chen,Z., Zhang,X., Xia,Y., Fang,L., Xie,L., Li,B.
            and Xu,Z.
  TITLE     N6-methyadenosine modified SUV39H2 regulates homologous
            recombination through epigenetic repression of DUSP6 in gastric
            cancer
  JOURNAL   Cancer Lett 558, 216092 (2023)
   PUBMED   36806557
  REMARK    GeneRIF: N6-methyadenosine modified SUV39H2 regulates homologous
            recombination through epigenetic repression of DUSP6 in gastric
            cancer.
REFERENCE   5  (bases 1 to 3627)
  AUTHORS   Pu,Y., Han,J., Zhang,M., Liu,M., Abdusamat,G. and Liu,H.
  TITLE     SKA1 promotes tumor metastasis via SAFB-mediated transcription
            repression of DUSP6 in clear cell renal cell carcinoma
  JOURNAL   Aging (Albany NY) 14 (23), 9679-9698 (2022)
   PUBMED   36462498
  REMARK    GeneRIF: SKA1 promotes tumor metastasis via SAFB-mediated
            transcription repression of DUSP6 in clear cell renal cell
            carcinoma.
REFERENCE   6  (bases 1 to 3627)
  AUTHORS   Muda,M., Theodosiou,A., Gillieron,C., Smith,A., Chabert,C.,
            Camps,M., Boschert,U., Rodrigues,N., Davies,K., Ashworth,A. and
            Arkinstall,S.
  TITLE     The mitogen-activated protein kinase phosphatase-3 N-terminal
            noncatalytic region is responsible for tight substrate binding and
            enzymatic specificity
  JOURNAL   J Biol Chem 273 (15), 9323-9329 (1998)
   PUBMED   9535927
REFERENCE   7  (bases 1 to 3627)
  AUTHORS   Smith,A., Price,C., Cullen,M., Muda,M., King,A., Ozanne,B.,
            Arkinstall,S. and Ashworth,A.
  TITLE     Chromosomal localization of three human dual specificity
            phosphatase genes (DUSP4, DUSP6, and DUSP7)
  JOURNAL   Genomics 42 (3), 524-527 (1997)
   PUBMED   9205128
REFERENCE   8  (bases 1 to 3627)
  AUTHORS   Groom,L.A., Sneddon,A.A., Alessi,D.R., Dowd,S. and Keyse,S.M.
  TITLE     Differential regulation of the MAP, SAP and RK/p38 kinases by
            Pyst1, a novel cytosolic dual-specificity phosphatase
  JOURNAL   EMBO J 15 (14), 3621-3632 (1996)
   PUBMED   8670865
REFERENCE   9  (bases 1 to 3627)
  AUTHORS   Muda,M., Boschert,U., Dickinson,R., Martinou,J.C., Martinou,I.,
            Camps,M., Schlegel,W. and Arkinstall,S.
  TITLE     MKP-3, a novel cytosolic protein-tyrosine phosphatase that
            exemplifies a new class of mitogen-activated protein kinase
            phosphatase
  JOURNAL   J Biol Chem 271 (8), 4319-4326 (1996)
   PUBMED   8626780
REFERENCE   10 (bases 1 to 3627)
  AUTHORS   Balasubramanian,R. and Crowley,W.F. Jr.
  TITLE     Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA105027.1, BC037236.1,
            BC003143.1, BF087219.1 and AC024909.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001946.3.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily. These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues. They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
            with cellular proliferation and differentiation. Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli. This
            gene product inactivates ERK2, is expressed in a variety of tissues
            with the highest levels in heart and pancreas, and unlike most
            other members of this family, is localized in the cytoplasm.
            Mutations in this gene have been associated with congenital
            hypogonadotropic hypogonadism. Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.69088.1,
                                           SRR1660809.29006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279488.8/ ENSP00000279488.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA105027.1         359-373
            16-2452             BC037236.1         1-2437
            2453-2802           BC003143.1         2339-2688
            2803-3037           BF087219.1         248-482
            3038-3627           AC024909.28        5850-6439
FEATURES             Location/Qualifiers
     source          1..3627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..3627
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /note="dual specificity phosphatase 6"
                     /db_xref="GeneID:1848"
                     /db_xref="HGNC:HGNC:3072"
                     /db_xref="MIM:602748"
     exon            1..862
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..1608
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1;
                     serine/threonine specific protein phosphatase; MAP kinase
                     phosphatase 3; dual specificity protein phosphatase PYST1;
                     mitogen-activated protein kinase phosphatase 3"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 6 isoform
                     a"
                     /protein_id="NP_001937.2"
                     /db_xref="CCDS:CCDS9033.1"
                     /db_xref="GeneID:1848"
                     /db_xref="HGNC:HGNC:3072"
                     /db_xref="MIM:602748"
                     /translation="MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQEL
                     YESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESS
                     SDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSP
                     PLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGC
                     AKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAI
                     SFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNF
                     NFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST"
     exon            863..1300
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..3627
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2777..2782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /note="hexamer: AATAAA"
     polyA_site      2802
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /note="major polyA site"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /note="hexamer: AATAAA"
     polyA_site      2993
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
     regulatory      3600..3605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
                     /note="hexamer: AATAAA"
     polyA_site      3627
                     /gene="DUSP6"
                     /gene_synonym="HH19; MKP3; PYST1"
ORIGIN      
        1 atccattgag gagctgcctc gcgcaggggg tgtgcgaggc tgagtccaag agatagcaaa
       61 tcgagtctta aataatccgg ggagaaagac gcccgggtag atttgaggtg cagccttgga
      121 gggagggatt agaagccgct agactttttt tcctcccctc tcagtagcac ggagtccgaa
      181 ttaattggat ttcattcact ggggaggaac aaaaactatc tgggcagctt cattgagaga
      241 gattcattga cactaagagc cagcggctgc agctgggtgc agagagaacc tccggcttta
      301 cttctgtctc gtctgcccca accgctagcc tcggcttggg taaggcgagg cggaattaaa
      361 ccccgctccg agagcggcag cttcgcgcgc ggtgcgctcg gcctatgcct gccccgaggg
      421 gcgtctggta ggcaccccgc cctctcccgc agctcgaccc ccatgataga tacgctcaga
      481 cccgtgccct tcgcgtcgga aatggcgatc agcaagacgg tggcgtggct caacgagcag
      541 ctggagctgg gcaacgagcg gctgctgctg atggactgcc ggccgcagga gctatacgag
      601 tcgtcgcaca tcgagtcggc catcaacgtg gccatcccgg gcatcatgct gcggcgcctg
      661 cagaagggta acctgccggt gcgcgcgctc ttcacgcgcg gcgaggaccg ggaccgcttc
      721 acccggcgct gtggcaccga cacagtggtg ctctacgacg agagcagcag cgactggaac
      781 gagaatacgg gcggcgagtc ggtgctcggg ctgctgctca agaagctcaa ggacgagggc
      841 tgccgggcgt tctacctgga aggtggcttc agtaagttcc aagccgagtt ctccctgcat
      901 tgcgagacca atctagacgg ctcgtgtagc agcagctcgc cgccgttgcc agtgctgggg
      961 ctcgggggcc tgcggatcag ctctgactct tcctcggaca tcgagtctga ccttgaccga
     1021 gaccccaata gtgcaacaga ctcggatggt agtccgctgt ccaacagcca gccttccttc
     1081 ccagtggaga tcttgccctt cctctacttg ggctgtgcca aagactccac caacttggac
     1141 gtgttggagg aattcggcat caagtacatc ttgaacgtca cccccaattt gccgaatctc
     1201 tttgagaacg caggagagtt taaatacaag caaatcccca tctcggatca ctggagccaa
     1261 aacctgtccc agtttttccc tgaggccatt tctttcatag atgaagcccg gggcaagaac
     1321 tgtggtgtct tggtacattg cttggctggc attagccgct cagtcactgt gactgtggct
     1381 taccttatgc agaagctcaa tctgtcgatg aacgatgcct atgacattgt caaaatgaaa
     1441 aaatccaaca tatcccctaa cttcaacttc atgggtcagc tgctggactt cgagaggacg
     1501 ctgggactca gcagcccatg tgacaacagg gttccagcac agcagctgta ttttaccacc
     1561 ccttccaacc agaatgtata ccaggtggac tctctgcaat ctacgtgaaa gaccccacac
     1621 ccctccttgc tggaatgtgt ctggcccttc agcagtttct cttggcagca tcagctgggc
     1681 tgctttcttt gtgtgtggcc ccaggtgtca aaatgacacc agctgtctgt actagacaag
     1741 gttaccaagt gcggaattgg ttaatactaa cagagagatt tgctccattc tctttggaat
     1801 aacaggacat gctgtataga tacaggcagt aggtttgctc tgtacccatg tgtacagcct
     1861 acccatgcag ggactgggat tcgaggactt ccaggcgcat agggtagaac caaatgatag
     1921 ggtaggagca tgtgttcttt agggccttgt aaggctgttt ccttttgcat ctggaactga
     1981 ctatataatt gtcttcaatg aagactaatt caattttgca tatagaggag ccaaagagag
     2041 atttcagctc tgtatttgtg gtatcagttt ggaaaaaaaa atctgatact ccatttgatt
     2101 attgtaaata tttgatcttg aatcacttga cagtgtttgt ttgaattgtg tttgtttttt
     2161 cctttgatgg gcttaaaaga aattatccaa agggagaaag agcagtatgc cacttcttaa
     2221 aacagaacaa aacaaaaaaa gaaaattgtg ctcttttcta atccaaaggg tatatttgca
     2281 gcatgcttga ctttaccaat tctgatgaca tctttacgga cactattatc actaagacct
     2341 tgttatggcg aagtctttag tctttttcat gtattttcct catgattttt tctctttatg
     2401 tagtttgact atgccttacc tttgtaaata tttttgcttg tgttgtcgca aaggggataa
     2461 tctgggaaag acaccaaatc atgggctcac tttaaaaaaa gaaagaataa aaaaaccttc
     2521 agctgtgcta aacagtatat tacctctgta taaaattctt cagggagtgt cacctcaaat
     2581 gcaatacttt gggttggttt ctttccttta aaaaaatttg tataaaactg gaagtgtgtg
     2641 tgtgtgagca tgggtaccca tttgataaga gaaatgcatt tgattgtgaa gaagggagag
     2701 ttaaattctc cattatgttc gtggtgtaaa gtttagagct ggaatttatt ataagaatgt
     2761 aaaaccttaa attattaata aataactatt ttggctattg aatgtgtgtt tttaaaaact
     2821 cagttatacc tatgtgtgaa gtgacacatt ttagaacttt ttcattcagg gattgatttt
     2881 gacttgtagg catagtaggg caaggttctt ttaagctttt cctagaacgt ttttcagcag
     2941 cagtttatga aattcatcgt ttgccacgaa taaagatgac atcctagaat ggaccgactg
     3001 taccgtgtat atgaacaata cctcttatga gtatagttcc ggcttaagat tttaaagccc
     3061 ctgaagaaaa atgaacctat agagcatagc ttgctgagga atacaatttg gatattaacc
     3121 acagagaggt gtagcagaat accaagatga cagccacatg ttaacctcct ccctatcctt
     3181 cactgtcagg atcttctgct ttataatgct gagataatgc caaagaggaa gtagggataa
     3241 ttctttttcc agtctgttgt catgggcaat tctacctgca gatatcctag tgtgagaatg
     3301 ctgaatccag aatgatgtct ccactttttc ccctagcatg cgcatggcaa ggcatatcta
     3361 agcttcctca ccgtgtcagg atatggcttt agaattttac attggcactt aggaggcaac
     3421 tttgtcatcc ctgttgtaat gtgctttttt gtttaactgg cttgggatgt gggtcagaaa
     3481 cccttattga aacttgtggg gattatttta gtttcttttc aagctaaaga ctttatatct
     3541 tgccattttt cttgggacct accctctcct tacctcaaat gtaaaaatac acaaaccaaa
     3601 ataaaaggca ggtgtatgga atcaaaa
//
