LOCUS       NM_004419               2477 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens dual specificity phosphatase 5 (DUSP5), mRNA.
ACCESSION   NM_004419
VERSION     NM_004419.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2477)
  AUTHORS   Chen,P., Wang,J., Yao,Y., Qu,Y., Ji,M. and Hou,P.
  TITLE     Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant
            thyroid cancer cells and improves their response to sorafenib
  JOURNAL   Endocrine 85 (3), 1268-1277 (2024)
   PUBMED   38564084
  REMARK    GeneRIF: Targeting DUSP5 suppresses malignant phenotypes of
            BRAF-mutant thyroid cancer cells and improves their response to
            sorafenib.
REFERENCE   2  (bases 1 to 2477)
  AUTHORS   Song,G., Zhao,F., Ni,R., Deng,B., Chen,S., Hu,R., Zheng,J.,
            Peng,Y., Liu,H., Luo,Y., Zhou,Z., Huang,G. and Shen,W.
  TITLE     Epithelial cells derived exosomal miR-203a-3p facilitates stromal
            inflammation of type IIIA chronic prostatitis/chronic pelvic pain
            syndrome by targeting DUSP5 and increasing MCP-1 generation
  JOURNAL   J Nanobiotechnology 22 (1), 236 (2024)
   PUBMED   38724995
  REMARK    GeneRIF: Epithelial cells derived exosomal miR-203a-3p facilitates
            stromal inflammation of type IIIA chronic prostatitis/chronic
            pelvic pain syndrome by targeting DUSP5 and increasing MCP-1
            generation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2477)
  AUTHORS   Yang,Z., Huang,D., Meng,M., Wang,W., Feng,J., Fang,L., Chen,H. and
            Zou,S.
  TITLE     BAF53A drives colorectal cancer development by regulating
            DUSP5-mediated ERK phosphorylation
  JOURNAL   Cell Death Dis 13 (12), 1049 (2022)
   PUBMED   36526622
  REMARK    GeneRIF: BAF53A drives colorectal cancer development by regulating
            DUSP5-mediated ERK phosphorylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2477)
  AUTHORS   Altan,Z. and Sahin,Y.
  TITLE     miR-203 suppresses pancreatic cancer cell proliferation and
            migration by modulating DUSP5 expression
  JOURNAL   Mol Cell Probes 66, 101866 (2022)
   PUBMED   36183924
  REMARK    GeneRIF: miR-203 suppresses pancreatic cancer cell proliferation
            and migration by modulating DUSP5 expression.
REFERENCE   5  (bases 1 to 2477)
  AUTHORS   Chen,H.D., Li,F., Chen,S., Zhong,Z.H., Gao,P.F. and Gao,W.Z.
  TITLE     METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA
            promotes gallbladder-cancer progression
  JOURNAL   Cancer Gene Ther 29 (7), 1012-1020 (2022)
   PUBMED   34799724
  REMARK    GeneRIF: METTL3-mediated N6-methyladenosine modification of DUSP5
            mRNA promotes gallbladder-cancer progression.
REFERENCE   6  (bases 1 to 2477)
  AUTHORS   Ueda,K., Arakawa,H. and Nakamura,Y.
  TITLE     Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional
            target of tumor suppressor p53
  JOURNAL   Oncogene 22 (36), 5586-5591 (2003)
   PUBMED   12944906
  REMARK    GeneRIF: DUSP5 is a direct target of p53.
REFERENCE   7  (bases 1 to 2477)
  AUTHORS   Kwak,S.P. and Dixon,J.E.
  TITLE     Multiple dual specificity protein tyrosine phosphatases are
            expressed and regulated differentially in liver cell lines
  JOURNAL   J Biol Chem 270 (3), 1156-1160 (1995)
   PUBMED   7836374
REFERENCE   8  (bases 1 to 2477)
  AUTHORS   Ishibashi,T., Bottaro,D.P., Michieli,P., Kelley,C.A. and
            Aaronson,S.A.
  TITLE     A novel dual specificity phosphatase induced by serum stimulation
            and heat shock
  JOURNAL   J Biol Chem 269 (47), 29897-29902 (1994)
   PUBMED   7961985
REFERENCE   9  (bases 1 to 2477)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 2477)
  AUTHORS   Martell,K.J., Kwak,S., Hakes,D.J., Dixon,J.E. and Trent,J.M.
  TITLE     Chromosomal localization of four human VH1-like protein-tyrosine
            phosphatases
  JOURNAL   Genomics 22 (2), 462-464 (1994)
   PUBMED   7806236
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF979291.1, CB991409.1,
            U15932.2, AL355512.22, BC062545.1 and BI495660.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004419.3.
            
            Summary:  The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily.  These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues.  They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
            with cellular proliferation and differentiation.  Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli.  This
            gene product inactivates ERK1, is expressed in a variety of tissues
            with the highest levels in pancreas and brain, and is localized in
            the nucleus. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.419819.1, AB209823.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369583.4/ ENSP00000358596.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BF979291.1         75-83
            10-424              CB991409.1         37-451
            425-425             U15932.2           420-420
            426-562             CB991409.1         453-589
            563-821             U15932.2           555-813
            822-963             AL355512.22        181442-181583
            964-2453            AL355512.22        184449-185938
            2454-2455           U15932.2           2444-2445
            2456-2473           BC062545.1         2413-2430
            2474-2477           BI495660.1         146-149
FEATURES             Location/Qualifiers
     source          1..2477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..2477
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /note="dual specificity phosphatase 5"
                     /db_xref="GeneID:1847"
                     /db_xref="HGNC:HGNC:3071"
                     /db_xref="MIM:603069"
     exon            1..594
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1370
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="serine/threonine specific protein phosphatase;
                     VH1-like phosphatase 3; dual specificity protein
                     phosphatase hVH3"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 5"
                     /protein_id="NP_004410.3"
                     /db_xref="CCDS:CCDS7566.1"
                     /db_xref="GeneID:1847"
                     /db_xref="HGNC:HGNC:3071"
                     /db_xref="MIM:603069"
                     /translation="MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLN
                     VNLNSVVLRRARGGAVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREE
                     SAARVVLTSLLACLPAGPRVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQ
                     CGKPVVNVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEA
                     CATHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMA
                     YLMKTKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAA
                     GSSLIGHLQTLSPDMQGAYCTFPASVLAPVPTHSTVSELSRSPVATATSC"
     exon            595..743
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..963
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..2477
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /note="hexamer: AATAAA"
     polyA_site      2477
                     /gene="DUSP5"
                     /gene_synonym="DUSP; HVH3"
                     /note="major polyA site"
ORIGIN      
        1 ggcttctagg gcggcgagcg gccgggctgg ctatcgagcg agcggggcgg gaacgcggag
       61 ttgcgccgcc gctcgggcgc cgggctccgt cgcggccgca gccccgcggg tcgccctccc
      121 gtgcctcgcc cgcggacacc ctggccgtgg acaccctggc cgtgggcacc cgcggggcgc
      181 gcggcgcggg gccgctggcc ggcggcggcg gcggcatgaa ggtcacgtcg ctcgacgggc
      241 gccagctgcg caagatgctc cgcaaggagg cggcggcgcg ctgcgtggtg ctcgactgcc
      301 ggccctatct ggccttcgct gcctcgaacg tgcgcggctc gctcaacgtc aacctcaact
      361 cggtggtgct gcggcgggcc cggggcggcg cggtgtcggc gcgctacgtg ctgcccgacg
      421 aggcggcgcg cgcgcggctc ctgcaggagg gcggcggcgg cgtcgcggcc gtggtggtgc
      481 tggaccaggg cagccgccac tggcagaagc tgcgagagga gagcgccgcg cgtgtcgtcc
      541 tcacctcgct actcgcttgc ctacccgccg gcccgcgggt ctacttcctc aaagggggat
      601 atgagacttt ctactcggaa tatcctgagt gttgcgtgga tgtaaaaccc atttcacaag
      661 agaagattga gagtgagaga gccctcatca gccagtgtgg aaaaccagtg gtaaatgtca
      721 gctacaggcc agcttatgac cagggtggcc cagttgaaat ccttcccttc ctctaccttg
      781 gaagtgccta ccatgcatcc aagtgcgagt tcctcgccaa cctgcacatc acagccctgc
      841 tgaatgtctc ccgacggacc tccgaggcct gcgcgaccca cctacactac aaatggatcc
      901 ctgtggaaga cagccacacg gctgacatta gctcccactt tcaagaagca atagacttca
      961 ttgactgtgt cagggaaaag ggaggcaagg tcctggtcca ctgtgaggct gggatctccc
     1021 gttcacccac catctgcatg gcttacctta tgaagaccaa gcagttccgc ctgaaggagg
     1081 ccttcgatta catcaagcag aggaggagca tggtctcgcc caactttggc ttcatgggcc
     1141 agctcctgca gtacgaatct gagatcctgc cctccacgcc caacccccag cctccctcct
     1201 gccaagggga ggcagcaggc tcttcactga taggccattt gcagacactg agccctgaca
     1261 tgcagggtgc ctactgcaca ttccctgcct cggtgctggc accggtgcct acccactcaa
     1321 cagtctcaga gctcagcaga agccctgtgg caacggccac atcctgctaa aactgggatg
     1381 gaggaatcgg cccagcccca agagcaactg tgatttttgt ttttaagact catggacatt
     1441 tcatacctgt gcaatactga agacctcatt ctgtcatgct gccccagtga gatagtgagt
     1501 ggtcaccagg cttgcaaatg aacttcagac ggacctcagg gtaggttctc gggactgaag
     1561 gaaggccaag ccattacggg agcacagcat gtgctgacta ctgtacttcc agacccctgc
     1621 cctcttggga ctgcccagtc cttgcacctc agagttcgcc ttttcatttc aagcataagg
     1681 caataaatac ctgcagcaac gtgggagaaa gaagttgctg gaccaggaga aaaggcagtt
     1741 atgaagccaa ttcattttga aggaagcaca atttccacct tattttttga actttggcag
     1801 tttcaatgtc tgtctctgtt gcttcggggc ataagctgat caccgtctag ttgggaaagt
     1861 aaccctacag ggtttgtagg gacatgatca gcatcctgat ttgaaccctg aaatgttgtg
     1921 tagacaccct cttgggtcca atgaggtagt tggttgaagt agcaagatgt tggcttttct
     1981 ggattttttt tgccatgggt tcttcactga ccttggactt tggcatgatt cttagtcata
     2041 cttgaacttg tctcattcca cctcttctca gagcaactct tcctttggga aaagagttct
     2101 tcagatcata gaccaaaaaa gtcatacctt cgaggtggta gcagtagatt ccaggaggag
     2161 aagggtactt gctaggtatc ctgggtcagt ggcggtgcaa actggtttcc tcagctgcct
     2221 gtccttctgt gtgcttatgt ctcttgtgac aattgttttc ctccctgccc ctggaggttg
     2281 tcttcaagct gtggacttct gggatttgca gattttgcaa cgtggtacta cttttttttt
     2341 ctttttgtct gttagttatt tctccagggg aaaaggcaat aattttctaa gacccgtgtg
     2401 aatgtgaaga aaagcagtat gttactggtt gttgttgttg ttcttgtttt ttatagtgta
     2461 aaataaaaat agtaaaa
//
