LOCUS       NM_001394               5553 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript
            variant 1, mRNA.
ACCESSION   NM_001394
VERSION     NM_001394.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5553)
  AUTHORS   Pei,W., Yin,W., Yu,T., Zhang,X., Zhang,Q., Yang,X., Shi,C., Shen,W.
            and Liu,G.
  TITLE     Dual-Specificity Phosphatase 4 Promotes Malignant Features in
            Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation
  JOURNAL   Dig Dis Sci 69 (8), 2856-2874 (2024)
   PUBMED   38824257
  REMARK    GeneRIF: Dual-Specificity Phosphatase 4 Promotes Malignant Features
            in Colorectal Cancer Through Cyclic-AMP Response Element Binding
            Protein/Protein Kinase CAMP-Activated Catalytic Subunit Beta
            Activation.
REFERENCE   2  (bases 1 to 5553)
  AUTHORS   Liu,X., Ye,Z., Rao,D., Chen,Q. and Zhang,Z.
  TITLE     DUSP4 maintains the survival and LSD1 protein stability in
            esophageal squamous cell carcinoma cells by inhibiting JNK
            signaling-dependent autophagy
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (2), 115-122 (2024)
   PUBMED   38286920
  REMARK    GeneRIF: DUSP4 maintains the survival and LSD1 protein stability in
            esophageal squamous cell carcinoma cells by inhibiting JNK
            signaling-dependent autophagy.
REFERENCE   3  (bases 1 to 5553)
  AUTHORS   Hao,S.H., Ma,X.D., Xu,L., Xie,J.D., Feng,Z.H., Chen,J.W.,
            Chen,R.X., Wang,F.W., Tang,Y.H., Xie,D. and Cai,M.Y.
  TITLE     Dual specific phosphatase 4 suppresses ferroptosis and enhances
            sorafenib resistance in hepatocellular carcinoma
  JOURNAL   Drug Resist Updat 73, 101052 (2024)
   PUBMED   38262246
  REMARK    GeneRIF: Dual specific phosphatase 4 suppresses ferroptosis and
            enhances sorafenib resistance in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 5553)
  AUTHORS   Wang,E., Pan,A.L., Bagchi,P., Rangaraju,S., Seyfried,N.T.,
            Ehrlich,M.E., Salton,S.R. and Zhang,B.
  TITLE     Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in
            Alzheimer's Disease
  JOURNAL   Biomolecules 14 (1), 66 (2024)
   PUBMED   38254666
  REMARK    GeneRIF: Proteomic Signaling of Dual-Specificity Phosphatase 4
            (DUSP4) in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5553)
  AUTHORS   Mandal,J., Yu,Z.C., Shih,I.M. and Wang,T.L.
  TITLE     ARID1A loss activates MAPK signaling via DUSP4 downregulation
  JOURNAL   J Biomed Sci 30 (1), 94 (2023)
   PUBMED   38071325
  REMARK    GeneRIF: ARID1A loss activates MAPK signaling via DUSP4
            downregulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5553)
  AUTHORS   Husi,H., Ward,M.A., Choudhary,J.S., Blackstock,W.P. and Grant,S.G.
  TITLE     Proteomic analysis of NMDA receptor-adhesion protein signaling
            complexes
  JOURNAL   Nat Neurosci 3 (7), 661-669 (2000)
   PUBMED   10862698
REFERENCE   7  (bases 1 to 5553)
  AUTHORS   Smith,A., Price,C., Cullen,M., Muda,M., King,A., Ozanne,B.,
            Arkinstall,S. and Ashworth,A.
  TITLE     Chromosomal localization of three human dual specificity
            phosphatase genes (DUSP4, DUSP6, and DUSP7)
  JOURNAL   Genomics 42 (3), 524-527 (1997)
   PUBMED   9205128
REFERENCE   8  (bases 1 to 5553)
  AUTHORS   Chu,Y., Solski,P.A., Khosravi-Far,R., Der,C.J. and Kelly,K.
  TITLE     The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and
            MKP-2 have unique substrate specificities and reduced activity in
            vivo toward the ERK2 sevenmaker mutation
  JOURNAL   J Biol Chem 271 (11), 6497-6501 (1996)
   PUBMED   8626452
REFERENCE   9  (bases 1 to 5553)
  AUTHORS   King,A.G., Ozanne,B.W., Smythe,C. and Ashworth,A.
  TITLE     Isolation and characterisation of a uniquely regulated threonine,
            tyrosine phosphatase (TYP 1) which inactivates ERK2 and p54jnk
  JOURNAL   Oncogene 11 (12), 2553-2563 (1995)
   PUBMED   8545112
REFERENCE   10 (bases 1 to 5553)
  AUTHORS   Guan,K.L. and Butch,E.
  TITLE     Isolation and characterization of a novel dual specific
            phosphatase, HVH2, which selectively dephosphorylates the
            mitogen-activated protein kinase
  JOURNAL   J Biol Chem 270 (13), 7197-7203 (1995)
   PUBMED   7535768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA645190.1, AK314820.1,
            AL137704.1, AC084262.6 and BC012900.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001394.6.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily. These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues. They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
            with cellular proliferation and differentiation. Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli. This
            gene product inactivates ERK1, ERK2 and JNK, is expressed in a
            variety of tissues, and is localized in the nucleus. Two
            alternatively spliced transcript variants, encoding distinct
            isoforms, have been observed for this gene. In addition, multiple
            polyadenylation sites have been reported. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.76161.1, U48807.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240100.7/ ENSP00000240100.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               DA645190.1         67-414
            349-927             AK314820.1         340-918
            928-2078            AL137704.1         1809-2959
            2079-3451           AC084262.6         102422-103794       c
            3452-5553           BC012900.1         1-2102
FEATURES             Location/Qualifiers
     source          1..5553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..5553
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /note="dual specificity phosphatase 4"
                     /db_xref="GeneID:1846"
                     /db_xref="HGNC:HGNC:3070"
                     /db_xref="MIM:602747"
     exon            1..839
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..1591
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine specific protein phosphatase; VH1
                     homologous phosphatase 2; MAP kinase phosphatase 2; dual
                     specificity protein phosphatase 4; dual specificity
                     protein phosphatase hVH2; mitogen-activated protein kinase
                     phosphatase 2"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 4 isoform
                     1"
                     /protein_id="NP_001385.1"
                     /db_xref="CCDS:CCDS6072.1"
                     /db_xref="GeneID:1846"
                     /db_xref="HGNC:HGNC:3070"
                     /db_xref="MIM:602747"
                     /translation="MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGK
                     CLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLY
                     SAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSK
                     TKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLD
                     ALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRV
                     LVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQV
                     LATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSP
                     SC"
     exon            840..985
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1205
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..5553
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /note="hexamer: AAGAAA"
     polyA_site      2078
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /note="major polyA site"
     regulatory      5534..5539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /note="hexamer: AATAAA"
     polyA_site      5553
                     /gene="DUSP4"
                     /gene_synonym="HVH2; MKP-2; MKP2; TYP"
                     /note="major polyA site"
ORIGIN      
        1 ctggctgggg cagtgcgctg agcgccggag gagcgtaggc agggcagcgc tggcgccagt
       61 ggcgacagga gccgcgcgac cggcaaaaat acacgggagg ccgtcgccga aaagagtccg
      121 cggtcctctc tcgtaaacac actctcctcc accggcgcct ccccctccgc tctgcgcgcc
      181 gcccggctgg gcgcccgagg ccgctccgac tgctatgtga ccgcgaggct gcgggaggaa
      241 ggggacaggg aagaagaggc tctcccgcgg gagcccttga ggaccaagtt tgcggccact
      301 tctgcaggcg tcccttctta gctctcgccc gcccctttct gcagcctagg cggcccgggt
      361 tctcttctct tcctcgcgcg cccagccgcc tcggttcccg gcgaccatgg tgacgatgga
      421 ggagctgcgg gagatggact gcagtgtgct caaaaggctg atgaaccggg acgagaatgg
      481 cggcggcgcg ggcggcagcg gcagccacgg caccctgggg ctgccgagcg gcggcaagtg
      541 cctgctgctg gactgcagac cgttcctggc gcacagcgcg ggctacatcc taggttcggt
      601 caacgtgcgc tgtaacacca tcgtgcggcg gcgggctaag ggctccgtga gcctggagca
      661 gatcctgccc gccgaggagg aggtacgcgc ccgcttgcgc tccggcctct actcggcggt
      721 catcgtctac gacgagcgca gcccgcgcgc cgagagcctc cgcgaggaca gcaccgtgtc
      781 gctggtggtg caggcgctgc gccgcaacgc cgagcgcacc gacatctgcc tgctcaaagg
      841 cggctatgag aggttttcct ccgagtaccc agaattctgt tctaaaacca aggccctggc
      901 agccatccca cccccggttc cccccagtgc cacagagccc ttggacctgg gctgcagctc
      961 ctgtgggacc ccactacacg accagggggg tcctgtggag atccttccct tcctctacct
     1021 cggcagtgcc taccatgctg cccggagaga catgctggac gccctgggca tcacggctct
     1081 gttgaatgtc tcctcggact gcccaaacca ctttgaagga cactatcagt acaagtgcat
     1141 cccagtggaa gataaccaca aggccgacat cagctcctgg ttcatggaag ccatagagta
     1201 catcgatgcc gtgaaggact gccgtgggcg cgtgctggtg cactgccagg cgggcatctc
     1261 gcggtcggcc accatctgcc tggcctacct gatgatgaag aaacgggtga ggctggagga
     1321 ggccttcgag ttcgttaagc agcgccgcag catcatctcg cccaacttca gcttcatggg
     1381 gcagctgctg cagttcgagt cccaggtgct ggccacgtcc tgtgctgcgg aggctgctag
     1441 cccctcggga cccctgcggg agcggggcaa gacccccgcc acccccacct cgcagttcgt
     1501 cttcagcttt ccggtctccg tgggcgtgca ctcggccccc agcagcctgc cctacctgca
     1561 cagccccatc accacctctc ccagctgtta gagccgccct gggggcccca gaaccagagc
     1621 tggctcccag caagggtagg acgggccgca tgcgggcaga aagttgggac tgagcagctg
     1681 ggagcaggcg accgagctcc ttccccatca tttctccttg gccaacgacg aggccagcca
     1741 gaatggcaat aaggactccg aatacataat aaaagcaaac agaacactcc aacttagagc
     1801 aataacggct gccgcagcag ccagggaaga ccttggtttg gtttatgtgt cagtttcact
     1861 tttccgatag aaatttctta cctcattttt ttaagcagta aggcttgaag tgatgaaacc
     1921 cacagatcct agcaaatgtg cccaaccagc tttactaaag ggggaggaag ggagggcaaa
     1981 gggatgagaa gacaagtttc ccagaagtgc ctggttctgt gtacttgtcc ctttgttgtc
     2041 gttgttgtag ttaaaggaat ttcatttttt aaaagaaatc ttcgaaggtg tggttttcat
     2101 ttctcagtca ccaacagatg aataattatg cttaataata aagtatttat taagactttc
     2161 ttcagagtat gaaagtacaa aaagtctagt tacagtggat ttagaatata tttatgttga
     2221 tgtcaaacag ctgagcaccg tagcatgcag atgtcaaggc agttaggaag taaatggtgt
     2281 cttgtagata tgtgcaaggt agcatgatga gcaacttgag tttgttgcca ctgagaagca
     2341 ggcgggttgg gtgggaggag gaagaaaggg aagaattagg tttgaattgc tttttaaaaa
     2401 aaaaagaaaa gaaaaagaca gcatctcact atgttgccaa ggctcatctt gagaagcagg
     2461 cgggttgggt gggaggagga agaaagggaa gaattaggtt tgaattgctt ttttaaaaaa
     2521 aaagaaaaga aaaaaaaaga cagcatctca ctatgttgcc aaggctcatc tcaagctctt
     2581 gggctcaaga gatcctccca cctcggcctc ctgagtagct gggactgcag gtgtgtgtca
     2641 tcatgaccaa tgtgaattgc ttttgaagct ggttcatggg catgtaggcc accgaagcaa
     2701 ttttagacca cagtaagtca agcttttttc cctccgatga tcactgggtg gttgcagcat
     2761 tttttgcata aacctgccta agacttgtct atcgtctgtg atcaatatgc catattacac
     2821 taaggtgctc ctggaaaatt gggtgcagtt caaattttcc tacagcaaat catttggcaa
     2881 ggccagccat tggggaaacc agacaactag agataaccct gaaatgaatc cttttgtaaa
     2941 ttgaagcacc atcttttctt tttttgcata aattggaggt tttaatttta gggcagttac
     3001 ctgaagtgaa atataccaac aatttcttgt gttctttaaa ttcctagtta ggtgaatatt
     3061 tttgaaggtc ctcttttgaa taaagagggg aatggacacc acatttcagg tcttctcgaa
     3121 gtgtggaagg gcaagagagc atcagtgagc tgatggtgga ttgcttacat cggattccat
     3181 tggtatgaat ttcccaaact ggaaatcaaa gcgccagggt ggggttgggg ctgactgctg
     3241 gtgagggggc tggccgctgg ctcccgtgac gtgcgtcatg ggcacgcagg cgccattttg
     3301 aatctatcgt cggcacgtgg gtgccatttt gaatccttag ttgggccttt ctaaatggag
     3361 aatggctttg gagggagaca cgttttctgt ggggagggtt tgggggggag ggaggaggga
     3421 acaagctaca tgctattttg tttgtagtat tgtggaacag tcttgttatg gagtgccagc
     3481 ttagaggttg ttgcaaactt gtctagaagt gagagcatgg ttttttttag ccctttgaga
     3541 gtctacatct aatgaacatt cttgctcacc cataaataac gtcaagcctc aatgtcaccg
     3601 tcacgttggg atactctttc tcatctggca tcctagacag gacaaggttg gttacctttc
     3661 cttccatgaa ccatgaacct gtgacggcat cattcatcct gacttcacca agctccgcct
     3721 gtgggtgagg ccagagctcc cactggcaat ttttagaaga gccagaggct ccctgcttcc
     3781 tctagaaata acagttcagg gtgaagcatg gagggtttca gttcccagac aatggaacca
     3841 tttagagaca acacagttgg acatttccac tttttccttg attcctggaa gtccagtggg
     3901 ttctgcagct gaaaaagccc tgggtcccag cagcagagag acaggacaga ggggatgctt
     3961 gggcggggag ggacggtaac ctgcagaaca gattccattt ttatagaacg agtacacgtt
     4021 tgctaaaaca gtcctgcttt cccagactgg attcccacca cagggacagt cggaactcag
     4081 gactagctcc agcgacatct ttcctccgaa ttcaagcctt ctatcacaat gtcaaaacag
     4141 ctatttataa agccattttc attgtacttg ataacagcac gagtcccaaa acttttagaa
     4201 ataaaatagg acattggctt gattgaaaag agggactttt taaaaattgt tctttcgtca
     4261 gaagcctttt ggatgactta caatagctct gatgaagata ccaccccagc gtcagtccaa
     4321 taggtcagtg agtttcaaca ggcatccatc cctcccatga agggattctg gtgatgggaa
     4381 gtttctgtaa tgacaggaaa gcattgaccc tcattgattg tcaactttgg tattagccat
     4441 gaaagacagg atgctcattg ggtgttctgt agagtgagga atgctgccta ttccctccca
     4501 gaacgtctga cccaggggtg tgtgttgagg agccctgggg gaaatggacc aagttttccc
     4561 acagagcagt attaggctga agagcaggtg actggtaggc cccagctccc atcattccct
     4621 cccaaagcca ttttgttcag ttgctcatcc acgctggatt ccagagagtt ttccaatttg
     4681 ggaagccatg agaaaggttt ttaaatcttg ggaagatgga gagagggaca taggatagtt
     4741 gactccaaca tgacaggaag aggctggaga ttgggaattg gccatcaacc aagcctgtag
     4801 tagtaaagcc atggtcccgc attggaatta cttggggaac ttatacagtt ctgataccca
     4861 ggctctccta gaccagttca accaattcta ggtgggggac tcaggcatca gtgtgtttcg
     4921 tagctccccg ggtgttttcc ctgtgcagcc gagcttggga aactgccatg ctttttggat
     4981 gtcaaggcgc tgttggaggc tgggtgtgac agcacagagc caggttgtct tgtggaaacc
     5041 acagccacgg gtttgccact ggctcagcat ggcctcactg ccagtcccag cctggctgag
     5101 ggacaagatg gtttctcttg ggagttcctg agtggagcac ccttccaggc tttttgaaag
     5161 ccagctgatc tgtggagcct tgttaaggga ctcaatacgg tgtttggata ttgatgtttt
     5221 tccttgagac tgtcttgtcc atcaataaag atggaggatg tctcctcttt gaaccccgct
     5281 tccccaccag tactctctct cccttagagt ttatgagtta ttcaaggagg agacttctta
     5341 aagacagcaa cgcaattctt gtaacttgtg taaatagccc catctttcag agtgatacca
     5401 tttctacatt tgataatgcc tgtattcctg taggatgtat atagtttagg ggattttttt
     5461 tttgtttggt tttgtttttt agaagtcaat atgtctggtt ttatttattg cttgaaaaag
     5521 atcatttgaa aaaaataaat acattttcaa cca
//
