LOCUS       NM_004090               4095 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens dual specificity phosphatase 3 (DUSP3), mRNA.
ACCESSION   NM_004090
VERSION     NM_004090.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4095)
  AUTHORS   Ferruzo,P.Y.M., Boell,V.K., Russo,L.C., Oliveira,C.C. and
            Forti,F.L.
  TITLE     DUSP3 modulates IRES-dependent translation of mRNAs through
            dephosphorylation of the HNRNPC protein in cells under genotoxic
            stimulus
  JOURNAL   Biol Cell 116 (5), e2300128 (2024)
   PUBMED   38538536
  REMARK    GeneRIF: DUSP3 modulates IRES-dependent translation of mRNAs
            through dephosphorylation of the HNRNPC protein in cells under
            genotoxic stimulus.
REFERENCE   2  (bases 1 to 4095)
  AUTHORS   Chousakos,E., Katsoulas,N., Kavantzas,N., Stratigos,A. and
            Lazaris,A.C.
  TITLE     The role of dual-specificity phosphatase 3 in melanocytic
            oncogenesis
  JOURNAL   Exp Dermatol 31 (10), 1466-1476 (2022)
   PUBMED   35899430
  REMARK    GeneRIF: The role of dual-specificity phosphatase 3 in melanocytic
            oncogenesis.
            Review article
REFERENCE   3  (bases 1 to 4095)
  AUTHORS   Kim,B.R., Ha,J., Kang,E. and Cho,S.
  TITLE     Regulation of signal transducer and activator of transcription 3
            activation by dual-specificity phosphatase 3
  JOURNAL   BMB Rep 53 (6), 335-340 (2020)
   PUBMED   32475380
  REMARK    GeneRIF: Regulation of signal transducer and activator of
            transcription 3 activation by dual-specificity phosphatase 3.
REFERENCE   4  (bases 1 to 4095)
  AUTHORS   Russo,L.C., Farias,J.O. and Forti,F.L.
  TITLE     DUSP3 maintains genomic stability and cell proliferation by
            modulating NER pathway and cell cycle regulatory proteins
  JOURNAL   Cell Cycle 19 (12), 1545-1561 (2020)
   PUBMED   32380926
  REMARK    GeneRIF: DUSP3 maintains genomic stability and cell proliferation
            by modulating NER pathway and cell cycle regulatory proteins.
REFERENCE   5  (bases 1 to 4095)
  AUTHORS   Beaumont,V.A., Reiss,K., Qu,Z., Allen,B., Batista,V.S. and
            Loria,J.P.
  TITLE     Allosteric Impact of the Variable Insert Loop in Vaccinia
            H1-Related (VHR) Phosphatase
  JOURNAL   Biochemistry 59 (20), 1896-1908 (2020)
   PUBMED   32348128
  REMARK    GeneRIF: Allosteric Impact of the Variable Insert Loop in Vaccinia
            H1-Related (VHR) Phosphatase.
REFERENCE   6  (bases 1 to 4095)
  AUTHORS   Denu,J.M., Zhou,G., Wu,L., Zhao,R., Yuvaniyama,J., Saper,M.A. and
            Dixon,J.E.
  TITLE     The purification and characterization of a human dual-specific
            protein tyrosine phosphatase
  JOURNAL   J Biol Chem 270 (8), 3796-3803 (1995)
   PUBMED   7876121
  REMARK    Erratum:[J Biol Chem 1995 Apr 28;270(17):10358]
REFERENCE   7  (bases 1 to 4095)
  AUTHORS   Jones,K.A., Black,D.M., Brown,M.A., Griffiths,B.L., Nicolai,H.M.,
            Chambers,J.A., Bonjardim,M., Xu,C.F., Boyd,M., McFarlane,R. et al.
  TITLE     The detailed characterisation of a 400 kb cosmid walk in the BRCA1
            region: identification and localisation of 10 genes including a
            dual-specificity phosphatase
  JOURNAL   Hum Mol Genet 3 (11), 1927-1934 (1994)
   PUBMED   7874108
REFERENCE   8  (bases 1 to 4095)
  AUTHORS   Folander,K., Douglass,J. and Swanson,R.
  TITLE     Confirmation of the assignment of the gene encoding Kv1.3, a
            voltage-gated potassium channel (KCNA3) to the proximal short arm
            of human chromosome 1
  JOURNAL   Genomics 23 (1), 295-296 (1994)
   PUBMED   7829094
REFERENCE   9  (bases 1 to 4095)
  AUTHORS   Kamb,A., Futreal,P.A., Rosenthal,J., Cochran,C., Harshman,K.D.,
            Liu,Q., Phelps,R.S., Tavtigian,S.V., Tran,T., Hussey,C. et al.
  TITLE     Localization of the VHR phosphatase gene and its analysis as a
            candidate for BRCA1
  JOURNAL   Genomics 23 (1), 163-167 (1994)
   PUBMED   7829067
REFERENCE   10 (bases 1 to 4095)
  AUTHORS   Ishibashi,T., Bottaro,D.P., Chan,A., Miki,T. and Aaronson,S.A.
  TITLE     Expression cloning of a human dual-specificity phosphatase
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12170-12174 (1992)
   PUBMED   1281549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA104250.1, BC002682.1,
            AK129822.1, AC055813.9, DB171573.1, AK055834.1, DA167802.1,
            DA075379.1, BQ652984.1 and BQ575811.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004090.3.
            
            Summary: The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily. These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues. They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
            with cellular proliferation and differentiation. Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli. This
            gene maps in a region that contains the BRCA1 locus which confers
            susceptibility to breast and ovarian cancer. Although DUSP3 is
            expressed in both breast and ovarian tissues, mutation screening in
            breast cancer pedigrees and in sporadic tumors was negative,
            leading to the conclusion that this gene is not BRCA1. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.105724.1,
                                           SRR1803611.73793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226004.8/ ENSP00000226004.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA104250.1         24-29
            7-32                BC002682.1         9-34
            33-623              AK129822.1         1-591
            624-638             AC055813.9         77033-77047         c
            639-1079            AK129822.1         607-1047
            1080-1406           DB171573.1         251-577
            1407-1917           AK129822.1         1375-1885
            1918-2060           AK055834.1         968-1110
            2061-2489           DA167802.1         141-569
            2490-2798           DA075379.1         261-569
            2799-3526           BQ652984.1         40-767
            3527-3992           AC055813.9         73679-74144         c
            3993-4095           BQ575811.1         22-124              c
FEATURES             Location/Qualifiers
     source          1..4095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4095
                     /gene="DUSP3"
                     /gene_synonym="VHR"
                     /note="dual specificity phosphatase 3"
                     /db_xref="GeneID:1845"
                     /db_xref="HGNC:HGNC:3069"
                     /db_xref="MIM:600183"
     exon            1..178
                     /gene="DUSP3"
                     /gene_synonym="VHR"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..611
                     /gene="DUSP3"
                     /gene_synonym="VHR"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="serine/threonine specific protein phosphatase;
                     vaccinia virus phosphatase VH1-related; dual specificity
                     protein phosphatase VHR; vaccinia H1-related phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 3"
                     /protein_id="NP_004081.1"
                     /db_xref="CCDS:CCDS11469.1"
                     /db_xref="GeneID:1845"
                     /db_xref="HGNC:HGNC:3069"
                     /db_xref="MIM:600183"
                     /translation="MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASV
                     AQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYF
                     ERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREI
                     GPNDGFLAQLCQLNDRLAKEGKLKP"
     exon            179..405
                     /gene="DUSP3"
                     /gene_synonym="VHR"
                     /inference="alignment:Splign:2.1.0"
     exon            406..4095
                     /gene="DUSP3"
                     /gene_synonym="VHR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP3"
                     /gene_synonym="VHR"
                     /note="hexamer: AATAAA"
     polyA_site      4095
                     /gene="DUSP3"
                     /gene_synonym="VHR"
                     /note="major polyA site"
ORIGIN      
        1 gccgctctcc gcctcgcttg ctcctgccgg gcgtgcaggg ccccgccgcc gccatgtcgg
       61 gctcgttcga gctctcggtg caggatctca acgacctgct ctcggacggc agcggctgct
      121 acagcctccc gagccagccc tgcaacgagg tcaccccgcg gatctacgtg ggcaacgcgt
      181 ctgtggctca ggacatcccc aagctgcaga aactaggcat cacccatgtg ctgaacgcgg
      241 ctgagggcag gtccttcatg cacgtcaaca ccaatgccaa cttctacaag gactccggca
      301 tcacatacct gggcatcaag gccaacgaca cacaggagtt caacctcagc gcttactttg
      361 aaagggctgc cgacttcatt gaccaggctt tggctcaaaa gaatggccgg gtgctcgtcc
      421 actgccggga aggttatagc cgctccccaa cgctagttat cgcctacctc atgatgcggc
      481 agaagatgga cgtcaagtct gccctgagca tcgtgaggca gaaccgtgag atcggcccca
      541 acgatggctt cctggcccag ctctgccagc tcaatgacag actagccaag gaggggaagt
      601 tgaaacccta gggcaccccc accacctctg ctcgagaggt ccgtggggga ggccgtgggc
      661 aaaggtgtcc cgagctgcca tgtttaggaa acacactgta ccctgctccc agcatcacaa
      721 ggcacttgtc tacaagtgtg tcccaacaca gtcctgggcc actttcccca ccctggggag
      781 cacataaaga agcttgccaa ggggggcgtc cttgctcccc agttgtcctg tttctgtaac
      841 ttatgatgtc ttttccctga gatgggggct cagaggggga aggcctgtgg cctgcatgct
      901 tcccgatggc ccacggcagg aggtgtgtgg aagtgtaagg cctaagatgc tcacagaggt
      961 ccctcatgac ctcccttccc caactcccga atcctctctt gagtgtggac ctcaacacct
     1021 tgagccctag taaaggaact atgcaaatgc aggccactct ccccaccacg tctgtgccct
     1081 gcactgtccc cacagccttc cacaccctgt gcataggcag ccctctcacg tcttgaggtc
     1141 cgaagctggg gtgggggtgt ccgtcagtta ttagtggatg gagattccca cagcaaggct
     1201 gcatttgaat gatttcctta ggatgaatgg tccctacaca aagaggcctt gtgggcaaac
     1261 ctggagaacc ctcctaaatc catagagttt tcaaaatgtg aatctttgga agccttgagt
     1321 tcagaatctg ctgctctgga atatttccct tcgatcttat ctcagtcact tcgtttttga
     1381 gaagagtgat gccttgggca tgcttttttt tttttctttt ttagaaaaca gggagttgaa
     1441 gtccaaccta tttaaaaacc ccaccatttg gagaattaca agggttttgt cctgaattgt
     1501 agtgttggca agcccaagcc actcgtgcta actgcttttt gtctcggttg ctattccaag
     1561 aacagaagga ggaagttggc caattacagc gtgtgtgcat ggatgtgtgt ggggggcgtg
     1621 cctctcagaa acgcggccag aagacaagca gggaagtgaa aggtcccagg cacacaccct
     1681 gcccattgca ggtggctctt acagctctct ggtgccagca cgggatccct gaagtgactc
     1741 agccaggcag acatgagaca tggcggagtg tccaaatgga tcctttattg gtggtagagc
     1801 aaaaaaaccc aaacacgata aacctttcaa aagactttct aaggatgata ttggaatgca
     1861 ccagccctca catgtgtatg cacatttgcc agaatataag agttttgttt taaatacagt
     1921 cttgttagga ttttacgtta ttgttattat ggaaagtgat tgtgatgcta tttatcttca
     1981 gggtcactct gggcaaagag aaggtcctca gccatgcccc cagcaccttg cacataggtg
     2041 tctgataaaa gtttaagaaa gtaaacactt tttgagcacc aaatatatat agggcattgt
     2101 tctggtgggt gtgtcacgct cccagaagac tgaattcatg gtaggatcac tcgcaaggcc
     2161 ttgtgaagga gtcttaccta aaacgaaaga aatatcaggg acttttgttg actatttaca
     2221 actcagtttt acatttaaat tcaggcagtg ttaatatgcc aaggtaggga atgtgccttt
     2281 ttcagagttg gccaggagct cctggctggg acacggagag gcaggtgtgg cgtaaggcct
     2341 cactcccggc tgggaaggtc tctgatcaca cagaagcagc cctgcccagc ctggtcattt
     2401 gctgtccgct tttctctgtg accacagcag ccctgaacaa ccagtatgtg tcttcttctc
     2461 cagatagtga aaaaggtgtc cagataaacc cacctaagtg aaatggccat cctctaaact
     2521 gggtacctca ctgcacagct tctaggtagc cttccaactt aatctaactt gagcctcaca
     2581 gtaaccctgt aaagttagta gagcttgttc ttgtattgtg acctttttta aaaaaaagga
     2641 actgaggttc agaatgatta agggcctggc ccccagggtt gtccagctcc ataaggtgga
     2701 gctgggcaag attttgggtt tgctgctccc tgaagctgga ttctttcata cgatactctt
     2761 tctcaagaag ggggctccct gggatctcca ggtgtactgc acttaccctc aatccagccc
     2821 cggagaagca agtgaaaagg gtgggtccct cataggctag aatgtgcagc tctttctcca
     2881 ggtgggatgt agcaccccga agtagagctt tctgctctgc tcctggaaaa ggctagggag
     2941 ctggggctgg ggctcccctc ccatgaccag gcagtggtca ccccatggga caggcacagc
     3001 tacttacgcg aacacagcag gttggtgtgg ctggctaact aggacctctc gaaagtctct
     3061 gtgggggcat gagggagaaa aggccattgg gagaattact gcctttactt tgggactact
     3121 tttatgctga taacttggga tttcttgata gtccttcacc cctgaaaccc cgtatttact
     3181 taacaagatt tagctcttag ttcttcaagt aaaattaaag tctcttgtgt aagagccaac
     3241 acatgcccag ctgcggatgg gagctgttcc tggacagcct tctactgcct gggaagtgat
     3301 ggaacaggaa ctcagggtgc ccttaccccc tccccagacc tgttcccttt ctttgactga
     3361 cagagcacca tccaggcaaa attagagcgc caaatggttt tcttctcaat cttaaagcag
     3421 tatacctttc cacaggctcg tctgtgtccc tgccactctg agttatccag aaaccaccac
     3481 ctacaaatga ggggactcat ctagaagacc tctaaggtcc ccttttggct ctgaggggtc
     3541 tctaataatc cccacttgga attcagcacc gcaaggaaat tatgggtatg tgagccataa
     3601 tatgatgggc agcaggtggc gctgccttcc acccatggtg atggatggtt tggaaaggga
     3661 atgttggtgc cttttgtgcc acaagttaag atgctactgt tttaaaggaa aaaaaaaaaa
     3721 aaaagtactg atcttcaata tgaagacatg agcttttctc gcaggaaatt ttctttttca
     3781 cagaactggt gtcaggaatc actgaagggc taaccgtgat agtccttgca agtaagtcaa
     3841 ggttttatcc tgattggaaa tagaagacat ttccggttga gagaacagat tcgttggaag
     3901 cttaactttt gttgcctctt aacgccacca aattttaggg taatttgatt atgaaagagt
     3961 gaatttttct ggacagaaaa gggagagcta ccaaattgtt tttttctttt taaaaggaag
     4021 tttaatgtcc gttgtatcac aaatcagtgt taaaacacca gaactttagc caaaataaat
     4081 gtcttacatt acaaa
//
