LOCUS       NM_001003892            1135 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens dual specificity phosphatase 29 (DUSP29), transcript
            variant 1, mRNA.
ACCESSION   NM_001003892
VERSION     NM_001003892.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1135)
  AUTHORS   Hayashi,T., Sadaki,S., Tsuji,R., Okada,R., Fuseya,S., Kanai,M.,
            Nakamura,A., Okamura,Y., Muratani,M., Wenchao,G., Sugasawa,T.,
            Mizuno,S., Warabi,E., Kudo,T., Takahashi,S. and Fujita,R.
  TITLE     Dual-specificity phosphatases 13 and 27 as key switches in muscle
            stem cell transition from proliferation to differentiation
  JOURNAL   Stem Cells 42 (9), 830-847 (2024)
   PUBMED   38975693
  REMARK    GeneRIF: Dual-specificity phosphatases 13 and 27 as key switches in
            muscle stem cell transition from proliferation to differentiation.
REFERENCE   2  (bases 1 to 1135)
  AUTHORS   Cooper,L.M., West,R.C., Hayes,C.S. and Waddell,D.S.
  TITLE     Dual-specificity phosphatase 29 is induced during neurogenic
            skeletal muscle atrophy and attenuates glucocorticoid receptor
            activity in muscle cell culture
  JOURNAL   Am J Physiol Cell Physiol 319 (2), C441-C454 (2020)
   PUBMED   32639872
  REMARK    GeneRIF: Dual-specificity phosphatase 29 is induced during
            neurogenic skeletal muscle atrophy and attenuates glucocorticoid
            receptor activity in muscle cell culture.
REFERENCE   3  (bases 1 to 1135)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1135)
  AUTHORS   Lei,T.Y., Wang,H.T., Li,F., Cui,Y.Q., Fu,F., Li,R. and Liao,C.
  TITLE     De Novo 1.77-Mb Microdeletion of 10q22.2q22.3 in a Girl With
            Developmental Delay, Speech Delay, Congenital Cleft Palate, and
            Bilateral Hearing Impairment
  JOURNAL   Cleft Palate Craniofac J 54 (3), 343-350 (2017)
   PUBMED   27031267
REFERENCE   5  (bases 1 to 1135)
  AUTHORS   Zhao,B.M., Keasey,S.L., Tropea,J.E., Lountos,G.T., Dyas,B.K.,
            Cherry,S., Raran-Kurussi,S., Waugh,D.S. and Ulrich,R.G.
  TITLE     Phosphotyrosine Substrate Sequence Motifs for Dual Specificity
            Phosphatases
  JOURNAL   PLoS One 10 (8), e0134984 (2015)
   PUBMED   26302245
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1135)
  AUTHORS   Lountos,G.T., Tropea,J.E. and Waugh,D.S.
  TITLE     Structure of human dual-specificity phosphatase 27 at 2.38 A
            resolution
  JOURNAL   Acta Crystallogr D Biol Crystallogr 67 (Pt 5), 471-479 (2011)
   PUBMED   21543850
  REMARK    GeneRIF: Here, the overexpression, purification and structure
            determination of DUPD1 (also known as DUSP27) at 2.38 A resolution
            are presented.
REFERENCE   7  (bases 1 to 1135)
  AUTHORS   Friedberg,I., Nika,K., Tautz,L., Saito,K., Cerignoli,F.,
            Friedberg,I., Godzik,A. and Mustelin,T.
  TITLE     Identification and characterization of DUSP27, a novel
            dual-specific protein phosphatase
  JOURNAL   FEBS Lett 581 (13), 2527-2533 (2007)
   PUBMED   17498703
  REMARK    GeneRIF: a cytosolic enzyme, expressed in skeletal muscle, liver
            and adipose tissue, suggesting its possible role in energy
            metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL392111.12 and AC018511.5.
            
            On Jul 1, 2020 this sequence version replaced NM_001003892.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138525.473341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2158800
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338487.6/ ENSP00000340609.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AL392111.12        4454-4527           c
            75-308              AC018511.5         144713-144946       c
            309-529             AC018511.5         130195-130415       c
            530-1135            AC018511.5         123870-124475       c
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..1135
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /note="dual specificity phosphatase 29"
                     /db_xref="GeneID:338599"
                     /db_xref="HGNC:HGNC:23481"
                     /db_xref="MIM:618574"
     exon            1..74
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            75..308
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..771
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="dual specificity phosphatase DUPD1; atypical
                     dual-specific protein phosphatase; dual specificity
                     phosphatase 27; dual specificity phosphatase and pro
                     isomerase domain containing 1"
                     /codon_start=1
                     /product="dual specificity phosphatase 29"
                     /protein_id="NP_001003892.1"
                     /db_xref="CCDS:CCDS31223.1"
                     /db_xref="GeneID:338599"
                     /db_xref="HGNC:HGNC:23481"
                     /db_xref="MIM:618574"
                     /translation="MTSGEVKTSLKNAYSSAKRLSPKMEEEGEEEDYCTPGAFELERL
                     FWKGSPQYTHVNEVWPKLYIGDEATALDRYRLQKAGFTHVLNAAHGRWNVDTGPDYYR
                     DMDIQYHGVEADDLPTFDLSVFFYPAAAFIDRALSDDHSKILVHCVMGRSRSATLVLA
                     YLMIHKDMTLVDAIQQVAKNRCVLPNRGFLKQLRELDKQLVQQRRRSQRQDGEEEDGR
                     EL"
     exon            309..529
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /inference="alignment:Splign:2.1.0"
     exon            530..1135
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1111..1116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /note="hexamer: ATTAAA"
     polyA_site      1135
                     /gene="DUSP29"
                     /gene_synonym="DUPD1; DUSP27; FMDSP"
                     /note="major polyA site"
ORIGIN      
        1 gtggctgggc gtgcggctgc tacatgcccc acggaccaga acctcccgac gcggccaggc
       61 cccggcacac ccagctgcag aaaggagaga aaatcccttg gctctaaaat gacatctgga
      121 gaagtgaaga caagcctcaa gaatgcctac tcatctgcca agaggctgtc gccgaagatg
      181 gaggaggaag gggaggagga ggactactgc acccctggag cctttgagct ggagcggctc
      241 ttctggaagg gcagtcccca gtacacccac gtcaacgagg tctggcccaa gctctacatt
      301 ggcgatgagg cgacggcgct ggaccgctat aggctgcaga aggcggggtt cacgcacgtg
      361 ctgaacgcgg cccacggccg ctggaacgtg gacactgggc ccgactacta ccgcgacatg
      421 gacatccagt accacggcgt ggaggccgac gacctgccca ccttcgacct cagtgtcttc
      481 ttctacccgg cggcagcctt catcgacaga gcgctaagcg acgaccacag taagatcctg
      541 gttcactgcg tcatgggccg cagccggtca gccaccctgg tcctggccta cctgatgatc
      601 cacaaggaca tgaccctggt ggacgccatc cagcaagtgg ccaagaaccg ctgcgtcctc
      661 ccgaaccggg gctttttgaa gcagctccgg gagctggaca agcagctggt gcagcagagg
      721 cgacggtccc agcgccagga cggtgaggag gaggatggca gggagctgta ggcccgactc
      781 acagggccag cagaggcact tggggacaga ggggagaggc agaacatagc cctggcctag
      841 gactccagag aagggatggt gaaaccgaag ctcgactctt ccaaaccatc ttgttcaact
      901 tccccatgtg tgctggggac agggaggacc cagagctgcc cccgggcaga gctgagcgct
      961 cagcctctca gcaaaatggg agggacgggc tccccggctc tgggtcacag aggagcatgc
     1021 cacgctgcac caagtctcct gctttggttt tgtttttttg gtgagaagga agagggaaaa
     1081 gattttaaaa tgtgtaggca gtatgttgtg attaaacgtt tggctttgtc tgaaa
//
