LOCUS       NM_001370465            4648 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens dual specificity phosphatase 28 (DUSP28), transcript
            variant 1, mRNA.
ACCESSION   NM_001370465 XM_024452814
VERSION     NM_001370465.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4648)
  AUTHORS   Zhang,J. and Guo,Y.
  TITLE     DUSP28 promotes cell proliferation, migration, and invasion by
            Akt/beta-catenin/Slug axis in breast cancer
  JOURNAL   Acta Biochim Pol 69 (4), 711-717 (2022)
   PUBMED   36520087
  REMARK    GeneRIF: DUSP28 promotes cell proliferation, migration, and
            invasion by Akt/beta-catenin/Slug axis in breast cancer.
REFERENCE   2  (bases 1 to 4648)
  AUTHORS   Lee,J., Lee,J. and Kim,J.H.
  TITLE     Scattered DUSP28 is a novel biomarker responsible for aggravating
            malignancy via the autocrine and paracrine signaling in metastatic
            pancreatic cancer
  JOURNAL   Cancer Lett 456, 1-12 (2019)
   PUBMED   30902562
  REMARK    GeneRIF: DUSP28 significantly increased the migration, invasion,
            and viability of metastatic pancreatic cancer cells through the
            activation of CREB, AKT, and ERK1/2 signaling pathways.
            Erratum:[Cancer Lett. 2024 Feb 28;583:216454. doi:
            10.1016/j.canlet.2023.216454.. PMID: 38044256]
REFERENCE   3  (bases 1 to 4648)
  AUTHORS   Ku,B., Hong,W., Keum,C.W., Kim,M., Ryu,H., Jeon,D., Shin,H.C.,
            Kim,J.H., Kim,S.J. and Ryu,S.E.
  TITLE     Structural and biochemical analysis of atypically low
            dephosphorylating activity of human dual-specificity phosphatase 28
  JOURNAL   PLoS One 12 (11), e0187701 (2017)
   PUBMED   29121083
  REMARK    GeneRIF: Structural and biochemical analysis of atypically low
            dephosphorylating activity of human dual-specificity phosphatase 28
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4648)
  AUTHORS   Lee,J., Lee,J., Yun,J.H., Choi,C., Cho,S., Kim,S.J. and Kim,J.H.
  TITLE     Autocrine DUSP28 signaling mediates pancreatic cancer malignancy
            via regulation of PDGF-A
  JOURNAL   Sci Rep 7 (1), 12760 (2017)
   PUBMED   28986588
  REMARK    GeneRIF: These results establish novel insight into DUSP28 and
            PDGF-A related autonomous signaling pathway in pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4648)
  AUTHORS   Lee,J., Lee,J., Yun,J.H., Jeong,D.G. and Kim,J.H.
  TITLE     DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and
            survival of AsPC-1 human pancreatic cancer cells
  JOURNAL   Tumour Biol 37 (9), 12193-12202 (2016)
   PUBMED   27230679
  REMARK    GeneRIF: Results collectively indicate unique links between
            dual-specificity phosphatase 28 (DUSP28) and mucins MUC5B/MUC16 and
            their roles in pancreatic cancer.
REFERENCE   6  (bases 1 to 4648)
  AUTHORS   Lee,J., Hun Yun,J., Lee,J., Choi,C. and Hoon Kim,J.
  TITLE     Blockade of dual-specificity phosphatase 28 decreases
            chemo-resistance and migration in human pancreatic cancer cells
  JOURNAL   Sci Rep 5, 12296 (2015)
   PUBMED   26212664
  REMARK    GeneRIF: Collectively, these results indicate that DUSP28 plays a
            key role in drug resistance and migratory activity in human
            pancreatic cells, and suggest that targeting DUSP28 might have
            clinical relevance in eradicating malignant pancreatic cancers.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4648)
  AUTHORS   Wang,D., Han,S., Peng,R., Jiao,C., Wang,X., Han,Z. and Li,X.
  TITLE     DUSP28 contributes to human hepatocellular carcinoma via regulation
            of the p38 MAPK signaling
  JOURNAL   Int J Oncol 45 (6), 2596-2604 (2014)
   PUBMED   25230705
  REMARK    GeneRIF: Taken together, these data demonstrate that DUSP28 plays a
            significant role in HCC progression and may be a feasible molecular
            target for anti-cancer therapy.
REFERENCE   8  (bases 1 to 4648)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124862.4.
            
            On Aug 29, 2019 this sequence version replaced NM_001370465.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.746862.1, BC036198.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000405954.2/ ENSP00000385885.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-721               AC124862.4         74330-75050         c
            722-4648            AC124862.4         70151-74077         c
FEATURES             Location/Qualifiers
     source          1..4648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..4648
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
                     /note="dual specificity phosphatase 28"
                     /db_xref="GeneID:285193"
                     /db_xref="HGNC:HGNC:33237"
     exon            1..721
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..859
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="dual specificity phosphatase 28"
                     /protein_id="NP_001357394.1"
                     /db_xref="CCDS:CCDS33418.1"
                     /db_xref="GeneID:285193"
                     /db_xref="HGNC:HGNC:33237"
                     /translation="MGPAEAGRRGAASPVPPPLVRVAPSLFLGSARAAGAEEQLARAG
                     VTLCVNVSRQQPGPRAPGVAELRVPVFDDPAEDLLAHLEPTCAAMEAAVRAGGACLVY
                     CKNGRSRSAAVCTAYLMRHRGLSLAKAFQMVKSARPVAEPNPGFWSQLQKYEEALQAQ
                     SCLQGEPPALGLGPEA"
     exon            722..4648
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
                     /note="hexamer: AATAAA"
     polyA_site      3406
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
                     /note="major polyA site"
     regulatory      4624..4629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
                     /note="hexamer: AGTAAA"
     polyA_site      4648
                     /gene="DUSP28"
                     /gene_synonym="DUSP26; VHP"
ORIGIN      
        1 acagacgcaa gcccagtgcc acaggccgcg ggggcgggga ggacggcgcc cggggacaga
       61 gaacatggga cgcagagcgg tccaaggccc cggcgccctg gtgaggccca aacctcccgc
      121 catgccccgg ccccaacgag acccaagccc cctgtcccgg cccagcgccc gcgggggacc
      181 caagccccag cctggtccac ctcggaggcc tctaggaccc gggggcgccc ggcggcccgc
      241 ccggctccca caaatagact cctgggcggg cgcctgagcc cccaaaatag atcctcaggg
      301 cccaaaagca gactcttcgg cgggcgccat gggaccggca gaagctgggc gccgcggggc
      361 cgcctcgccc gtacctccac cgttggtgcg cgtcgcgccc tcactcttcc tcgggagcgc
      421 gcgagccgcg ggcgcggagg agcagctggc gcgcgcggga gtcacgctgt gcgtcaacgt
      481 ctcccgccag cagcccggcc cgcgcgcgcc cggcgtggca gagctgcgcg tgcccgtgtt
      541 cgacgacccg gctgaggacc tgctggcgca cctggagccc acgtgcgccg ccatggaggc
      601 cgcggtgcgc gccggcggcg cctgcctagt ctactgcaag aacggccgca gccgctcggc
      661 cgccgtctgc accgcgtacc tcatgcggca ccgcggcctc agcctggcga aggccttcca
      721 gatggtgaag agcgctcgcc cggtagcaga accgaacccg ggcttctggt ctcagctcca
      781 gaagtatgag gaggccctcc aggcccagtc ctgcctgcag ggagagcccc cagccttagg
      841 gttgggccct gaggcttgaa gcttgaaggc ctgctgcctg gaggaaggat gtccctgcac
      901 tgatacagaa ggctggtctt tacccttctt cctcactgtc atatcgagtt ttcctttgtg
      961 tgtgtgtgtg tgaaacatag tgcttttaat tttatatttc cggctgaggt gatgcacaaa
     1021 ttatcttaca gacacaaaaa gaaatacatt tggtaaaaca tcgaagacaa attaagaaaa
     1081 agcaaatagg gatcctccat tatttacact ccagaatctt gagtgtttgg gggtgccggc
     1141 gcattctacc agtctcaggg aaggacatga gtacagacta cagtaatcag aatctgagtc
     1201 ataggtgaaa tcaggaaaag caactcttct tgtgtttatt tttagtagtg tcataagaac
     1261 ggactagttc ttcctgcgtg accacggatg cttctgtttg agaaaatgca tacccacgtg
     1321 ggacatttag atcaagaaag ctgttgatga agacattgtt gaagggcaac ttgggtgatt
     1381 ggggaattat tctcttcatc agcccctctg caatacagct ggagctgtcc cataggagtt
     1441 cggacaatta cggacatcct ttttctttct ctctttcttt ttttttgttt gtttgtttga
     1501 gacagagtct ctgttgccca ggctggagtg cagtggcgca atcccggctc actgcaacct
     1561 ccgcctccct ggttcaagtg attctcctgc ctcagcctcc tgagtagctg ggactacagg
     1621 tgtgtgacac cagacccggc taattttttg tatttttagt agagatgggg ggtttcacca
     1681 tgttagccag gatggtctca aactcctgac ctcgtgatcc acccacctca gcctcccaaa
     1741 gtgctgggat tacaggcgtg agccaccgtg cccagcctcc tttttctatt actagagaac
     1801 tccaggacat taagaatttc aaaagtgatt ttttcaccca tggcttctac ggtgacagag
     1861 tatggtgttc ctgtagggaa acaaagccaa gtttttttgc tcctttcact aaagctgctt
     1921 catccgggga ggaagcctgg tagattataa tatttccagg gataacagtg tggcacacag
     1981 ataacagggt aagaaattgg tctatatagt tttctgtggg atggccattc tcaatgttct
     2041 ccaataaact ggggtaatta aaatatcagg gctcggatgg aaggtgttgc accataaatg
     2101 acacctgcag tggtacttgt taaatgtctt aacattgcaa gtgagggttc ccattttatc
     2161 agaaaataga aattttacct gcccaagttc ttcactgaga ttgaatgtgc tggccatggt
     2221 gtggacacta tttactttat aatgcacatc ttgatcccag tttataaact gggcctgaat
     2281 atatttcaca atttccatag tgaccagcag actaatgggg atgaggtact gttataagat
     2341 gatgaacacc agtatgtcaa acacaatgct gtgagctgga atcctctttc aggtaccaaa
     2401 tgtcaccata ctttttattc catagcacgg ctcccacgca gctcactaca gacatgacca
     2461 gagcagcagg aaccaaaggg agacccgccc attgtcactt tcttaatctc tgatctcttg
     2521 aggtgatttg acagaattct gcaggaattt ggtttcaaag ccagtgtaaa caactatgcc
     2581 agtgatccac tgagcatttc tttttttttt ttcttgagac ggagtctcac tctggtgccc
     2641 aggctggagt gggcgccatc ttggctcact gcaagctccg cctcccggct tcatgccatt
     2701 ctcgtccttc agcctcctga gtggctggga ttacaggcgc ccgccaccac gcctagctaa
     2761 tttctttgta tttttggtag agacggggtt tcactgtgtt agccaggatg gtctcaatct
     2821 cctgacctca tgatcctccc gcctcggcct cccaaagcgc tgggattaca ggcgtgagcc
     2881 acctcgcccg gccaatccac tgagcatttc taagctgtgt atctcttaac aagacccagt
     2941 caggccctat tggaacaggg cttttaccac ctaggcggaa gctcagccat tgaaatgacg
     3001 atcaggtgct tcacggtcta tttttccaga taggcctaac agctggtttt ctgtttgcat
     3061 ttcagctgtt tctggcaaag cctgccgtgt cttacatttg tctctctatc cggattagat
     3121 gttgctatat gaacacatcg ggactgtgtc tgcaggaagg agctccccat tcgaggcctt
     3181 cacagtgtca cccacattca cctctttcca cttaaacgtg tcccatgaat cttgtcataa
     3241 cagttttgtg ttccttaact attttgtctg ccatgtcatt tatgatgtat ataacctctt
     3301 taatgcctga aatcataaga ataatcatca aaggcaagag ggttgtatat tttcccgttg
     3361 gagacacatc tggaatttgc tgcaataaaa taataataag aaagcattgg cagctttggt
     3421 aaactgcaga ttcaaaaatc gagggagaaa tgagcacacg ctgtacttgg ctgtacatat
     3481 aattgctgac tgtgggttgc agaaatttct ctcaagcatc atcaccactt ttgctcagtt
     3541 atcagtagta ataacagcaa tcaaaactga aactgctcca gatgcctgtc taggaagtat
     3601 ggttttccat ccttcctact gctttcttca caagagaatc ctccacctca gtggccctga
     3661 agtggcctga agggcccgct ctgcggtcct gccaccagtg ccctctgagg tccatggtcc
     3721 cacggcacca cggccgccca gtgcactcgc ctccacactg agttttcatt tttcccagtt
     3781 aagccccatc ttccggaaat gcagctccag agggtctctg tcccctcttg ctggtggggc
     3841 aagggtctgc gcatcagacc acatggaccc ctgcaccacc atctgctccg tcctctccct
     3901 ctggtcagct cagcttatta aacaagcctt ggtcaggaaa atctaaacca cttaaggaac
     3961 tgggcagaaa gaaactgaat gcagggagaa gaaggctggg gagccaagga caggagagga
     4021 gacatagggg agtcacaggg acctgccacc cagatcccca ctgcctgatg tcctggctgt
     4081 ggagggcacc tggagctgcc agcagagcct cctgcccacc agctgctgaa gccacagtac
     4141 atctccttcc tcccacctcc cagacctctc actggtctca tctgggcacc gaacatggga
     4201 agcccctcct gtgacaggca ggggagaagg aggctgtgct gacagacggc ctggtgaggg
     4261 aacccgggag gcctccagca tctgcacccc tctcctactt tgatctctgt ttcaccaaca
     4321 ttgcacccca acttaaggtc acatagctac tgtcaagcca acaaggtgct gcctctcccg
     4381 ccgtgtgagg gtggaacccc ataagccacc actggaggca tccaagcatg ttgattcctt
     4441 ctctagttca gacaccacct ctcctggaca tcctgtggcc taaagactat cctagaatca
     4501 acactcctta aataggagtg gggaaagaaa aggaaaatgt gtgtaataca tgtgaatcac
     4561 agataacgta gtcattggtt aatatataca actacgcgta tttacattct gtatgcgtca
     4621 atgagtaaaa tactgtggtt ggtgctta
//
