LOCUS       NM_024025               1754 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens dual specificity phosphatase 26 (DUSP26), transcript
            variant 1, mRNA.
ACCESSION   NM_024025
VERSION     NM_024025.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Guler,S., Zik,B. and Yalcin,A.
  TITLE     Upregulation of dual-specificity phosphatase-26 is required for
            transforming growth factor beta1(TGFbeta1)-induced
            Epithelial-mesenchymal transition in A549 and PANC1 cells
  JOURNAL   Mol Biol Rep 49 (11), 10195-10204 (2022)
   PUBMED   36053282
  REMARK    GeneRIF: Upregulation of dual-specificity phosphatase-26 is
            required for transforming growth factor beta1(TGFbeta1)-induced
            Epithelial-mesenchymal transition in A549 and PANC1 cells.
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Cui,Z., Li,D., Zhao,J. and Chen,K.
  TITLE     Falnidamol and cisplatin combinational treatment inhibits non-small
            cell lung cancer (NSCLC) by targeting DUSP26-mediated signal
            pathways
  JOURNAL   Free Radic Biol Med 183, 106-124 (2022)
   PUBMED   35278641
  REMARK    GeneRIF: Falnidamol and cisplatin combinational treatment inhibits
            non-small cell lung cancer (NSCLC) by targeting DUSP26-mediated
            signal pathways.
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Eroglu,B., Jin,X., Deane,S., Ozturk,B., Ross,O.A., Moskophidis,D.
            and Mivechi,N.F.
  TITLE     Dusp26 phosphatase regulates mitochondrial respiration and
            oxidative stress and protects neuronal cell death
  JOURNAL   Cell Mol Life Sci 79 (4), 198 (2022)
   PUBMED   35313355
  REMARK    GeneRIF: Dusp26 phosphatase regulates mitochondrial respiration and
            oxidative stress and protects neuronal cell death.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Wang,Y., Han,D., Zhou,T., Chen,C., Cao,H., Zhang,J.Z., Ma,N.,
            Liu,C., Song,M., Shi,J., Jin,X., Cao,F. and Dong,N.
  TITLE     DUSP26 induces aortic valve calcification by antagonizing
            MDM2-mediated ubiquitination of DPP4 in human valvular interstitial
            cells
  JOURNAL   Eur Heart J 42 (30), 2935-2951 (2021)
   PUBMED   34179958
  REMARK    GeneRIF: DUSP26 induces aortic valve calcification by antagonizing
            MDM2-mediated ubiquitination of DPP4 in human valvular interstitial
            cells.
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Thompson,E.M. and Stoker,A.W.
  TITLE     A Review of DUSP26: Structure, Regulation and Relevance in Human
            Disease
  JOURNAL   Int J Mol Sci 22 (2), 776 (2021)
   PUBMED   33466673
  REMARK    GeneRIF: A Review of DUSP26: Structure, Regulation and Relevance in
            Human Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Prabhakar,S., Asuthkar,S., Lee,W., Chigurupati,S., Zakharian,E.,
            Tsung,A.J. and Velpula,K.K.
  TITLE     Targeting DUSPs in glioblastomas - wielding a double-edged sword?
  JOURNAL   Cell Biol Int 38 (2), 145-153 (2014)
   PUBMED   24155099
  REMARK    Review article
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Yu,W., Imoto,I., Inoue,J., Onda,M., Emi,M. and Inazawa,J.
  TITLE     A novel amplification target, DUSP26, promotes anaplastic thyroid
            cancer cell growth by inhibiting p38 MAPK activity
  JOURNAL   Oncogene 26 (8), 1178-1187 (2007)
   PUBMED   16924234
  REMARK    GeneRIF: DUSP26 effectively dephosphorylates p38 and has a little
            effect on extracellular signal-regulated kinase in anaplastic
            thyroid cancer.
REFERENCE   8  (bases 1 to 1754)
  AUTHORS   Wang,J.Y., Lin,C.H., Yang,C.H., Tan,T.H. and Chen,Y.R.
  TITLE     Biochemical and biological characterization of a
            neuroendocrine-associated phosphatase
  JOURNAL   J Neurochem 98 (1), 89-101 (2006)
   PUBMED   16805799
REFERENCE   9  (bases 1 to 1754)
  AUTHORS   Hu,Y. and Mivechi,N.F.
  TITLE     Association and regulation of heat shock transcription factor 4b
            with both extracellular signal-regulated kinase mitogen-activated
            protein kinase and dual-specificity tyrosine phosphatase DUSP26
  JOURNAL   Mol Cell Biol 26 (8), 3282-3294 (2006)
   PUBMED   16581800
REFERENCE   10 (bases 1 to 1754)
  AUTHORS   Vasudevan,S.A., Skoko,J., Wang,K., Burlingame,S.M., Patel,P.N.,
            Lazo,J.S., Nuchtern,J.G. and Yang,J.
  TITLE     MKP-8, a novel MAPK phosphatase that inhibits p38 kinase
  JOURNAL   Biochem Biophys Res Commun 330 (2), 511-518 (2005)
   PUBMED   15796912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA132743.1, BC001613.1 and
            AB237597.1.
            
            On Nov 24, 2018 this sequence version replaced NM_024025.2.
            
            Summary: This gene encodes a member of the tyrosine phosphatase
            family of proteins and exhibits dual specificity by
            dephosphorylating tyrosine as well as serine and threonine
            residues. This gene has been described as both a tumor suppressor
            and an oncogene depending on the cellular context. This protein may
            regulate neuronal proliferation and has been implicated in the
            progression of glioblastoma through its ability to dephosphorylate
            the p53 tumor suppressor. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.941397.1,
                                           SRR3476690.320093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256261.9/ ENSP00000256261.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               DA132743.1         84-185
            103-1751            BC001613.1         1-1649
            1752-1754           AB237597.1         1648-1650
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..1754
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /note="dual specificity phosphatase 26"
                     /db_xref="GeneID:78986"
                     /db_xref="HGNC:HGNC:28161"
                     /db_xref="MIM:618368"
     exon            1..359
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            360..656
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..1071
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="low-molecular-mass dual-specificity phosphatase 4;
                     dual specificity phosphatase 26 (putative);
                     mitogen-activated protein kinase phosphatase 8; Novel
                     amplified gene in thyroid anaplastic cancer; MAP kinase
                     phosphatase 8; dual specificity phosphatase SKRP3;
                     neuroendocrine-associated phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 26"
                     /protein_id="NP_076930.1"
                     /db_xref="CCDS:CCDS6092.1"
                     /db_xref="GeneID:78986"
                     /db_xref="HGNC:HGNC:28161"
                     /db_xref="MIM:618368"
                     /translation="MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLN
                     VFELERLLYTGKTACNHADEVWPGLYLGDQDMANNRRELRRLGITHVLNASHSRWRGT
                     PEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVSRSA
                     TLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA"
     exon            657..871
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1754
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1734..1739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /note="hexamer: AATAAA"
     polyA_site      1754
                     /gene="DUSP26"
                     /gene_synonym="DSP-4; DUSP24; LDP-4; LDP4; MKP-8; MKP8;
                     NATA1; NEAP; SKRP3"
                     /note="major polyA site"
ORIGIN      
        1 gtaattggtg cagctctgag aacacacgca tgcattccag gcggtgctgc tggggctcgg
       61 cggggccgtg tctggtctgc aaggcgcgcg ggctcgtggg gggttggctg gggagcccac
      121 gctgcctggc gactcgggcc accgaatgtg agaccgagtc cctttatgtc accagcgcac
      181 acgctgattt gaaccctgct tcgacgtgtg tgtcatggct taaaaatagc tgctaatctg
      241 tcaacctgtc ttgggcagaa acagcggcgg cgacagcagc aggagcgtca tggccgtggc
      301 gctgtctgcg ccggcgatcc gcctttcgga ctgaggccca gcgcagcgct tgcaaagagc
      361 agcagctacc tggcaactga acccatcatc accacagcca ctcctgcagc tgccacggtt
      421 tctgccacct ctaagatgtg ccctggtaac tggctttggg cttctatgac ttttatggcc
      481 cgcttctccc ggagtagctc aaggtctcct gttcgaactc gagggaccct ggaggagatg
      541 ccaaccgttc aacatccttt cctcaatgtc ttcgagttgg agcggctcct ctacacaggc
      601 aagacagcct gtaaccatgc cgacgaggtc tggccaggcc tctatctcgg agaccaggac
      661 atggctaaca accgccggga gcttcgccgc ctgggcatca cgcacgtcct caatgcctca
      721 cacagccggt ggcgaggcac gcccgaggcc tatgaggggc tgggcatccg ctacctgggt
      781 gttgaggccc acgactcgcc agcctttgac atgagcatcc acttccagac ggctgccgac
      841 ttcatccacc gggcgctgag ccagccagga gggaagatcc tggtgcattg tgctgtgggc
      901 gtgagccgat ccgccaccct ggtactggcc tacctcatgc tgtaccacca ccttaccctc
      961 gtggaggcca tcaagaaagt caaagaccac cgaggcatca tccccaaccg gggcttcctg
     1021 aggcagctcc tggccctgga ccgcaggctg cggcagggtc tggaagcatg aggggagggg
     1081 gagagaggtc aggccaggcc cgtgggtagg tccctggctc ccagctggag ataggaggcc
     1141 caggtggcag gtagcaggag gcccagatca cccatcctcc cctggggtca ggagaggccg
     1201 agccccaggc cactgtcact ctttgtggga ggggacgggg agtgaggttg ggcagtgtgg
     1261 tggatgggca cccaggaagg gttgaccagg gaaggaggca gctaggctgt agatggaaga
     1321 tggtcctggg attcgaacac cgctgggatc tggccagggt gctccctggg attcacagtc
     1381 ccttcccctc tttgtgccca agtgtttccc tctctccctc accaaaacaa aagggccatc
     1441 tctgccctgc acttgtgcag aaagtcaggg atacggcaag catgaatgca atggtgtaga
     1501 gttgtgtgaa acccctagca tagagacaga cagcgaagag atggtgtgaa aagcttgcag
     1561 aaccagacag agaaccccac agactttcca ctccaagcac aggaggaggt agctagcgtg
     1621 tgagggttgg cactaggccc acggctgctg cttgggccaa aaacatacag aggtgcatgg
     1681 ctggcagtct tgaaattgtc actcgcttac tggatccaag cgtctcgagg ataaataaag
     1741 atcatgaaaa agaa
//
