LOCUS       NM_001319658             797 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dual specificity phosphatase 23 (DUSP23), transcript
            variant 1, mRNA.
ACCESSION   NM_001319658
VERSION     NM_001319658.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 797)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 797)
  AUTHORS   Balada,E., Felip,L., Ordi-Ros,J. and Vilardell-Tarres,M.
  TITLE     DUSP23 is over-expressed and linked to the expression of DNMTs in
            CD4+ T cells from systemic lupus erythematosus patients
  JOURNAL   Clin Exp Immunol 187 (2), 242-250 (2017)
   PUBMED   27737517
  REMARK    GeneRIF: this study shows that DUSP23 mRNA levels in CD4+ T cells
            are higher in the systemic lupus erythematosus patients
REFERENCE   3  (bases 1 to 797)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   4  (bases 1 to 797)
  AUTHORS   Jeong,D.G., Wei,C.H., Ku,B., Jeon,T.J., Chien,P.N., Kim,J.K.,
            Park,S.Y., Hwang,H.S., Ryu,S.Y., Park,H., Kim,D.S., Kim,S.J. and
            Ryu,S.E.
  TITLE     The family-wide structure and function of human dual-specificity
            protein phosphatases
  JOURNAL   Acta Crystallogr D Biol Crystallogr 70 (Pt 2), 421-435 (2014)
   PUBMED   24531476
REFERENCE   5  (bases 1 to 797)
  AUTHORS   Reiner,A.P., Beleza,S., Franceschini,N., Auer,P.L., Robinson,J.G.,
            Kooperberg,C., Peters,U. and Tang,H.
  TITLE     Genome-wide association and population genetic analysis of
            C-reactive protein in African American and Hispanic American women
  JOURNAL   Am J Hum Genet 91 (3), 502-512 (2012)
   PUBMED   22939635
REFERENCE   6  (bases 1 to 797)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 797)
  AUTHORS   Friedberg,I., Nika,K., Tautz,L., Saito,K., Cerignoli,F.,
            Friedberg,I., Godzik,A. and Mustelin,T.
  TITLE     Identification and characterization of DUSP27, a novel
            dual-specific protein phosphatase
  JOURNAL   FEBS Lett 581 (13), 2527-2533 (2007)
   PUBMED   17498703
REFERENCE   8  (bases 1 to 797)
  AUTHORS   Takagaki,K., Satoh,T., Tanuma,N., Masuda,K., Takekawa,M., Shima,H.
            and Kikuchi,K.
  TITLE     Characterization of a novel low-molecular-mass dual-specificity
            phosphatase-3 (LDP-3) that enhances activation of JNK and p38
  JOURNAL   Biochem J 383 (Pt. 3), 447-455 (2004)
   PUBMED   15281913
REFERENCE   9  (bases 1 to 797)
  AUTHORS   Alonso,A., Burkhalter,S., Sasin,J., Tautz,L., Bogetz,J., Huynh,H.,
            Bremer,M.C., Holsinger,L.J., Godzik,A. and Mustelin,T.
  TITLE     The minimal essential core of a cysteine-based protein-tyrosine
            phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ
  JOURNAL   J Biol Chem 279 (34), 35768-35774 (2004)
   PUBMED   15201283
  REMARK    GeneRIF: the smallest active protein-tyrosine phosphatase yet (only
            16 kDa) belongs to the group of small Vaccinia virus VH1-related
            dual specific phosphatases; gene is located on human chromosome
            1q23.1 and consists of only two coding exons
REFERENCE   10 (bases 1 to 797)
  AUTHORS   Wu,Q., Li,Y., Gu,S., Li,N., Zheng,D., Li,D., Zheng,Z., Ji,C.,
            Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel dual-specificity
            phosphatase 23 gene from human fetal brain
  JOURNAL   Int J Biochem Cell Biol 36 (8), 1542-1553 (2004)
   PUBMED   15147733
  REMARK    GeneRIF: DUSP23 showed distinctive phosphatase activity toward
            p-nitrophenyl phosphate, as well as oligopeptides containing
            phospho-tyrosine and phospho-threonine residues. Furthermore,
            DUSP23 could dephosphorylate p44ERK1 but not p38 and p54SAPKbeta in
            vitro
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590560.9, DA428735.1, AB164404.1 and BG823348.1.
            
            On May 17, 2019 this sequence version replaced NM_001319658.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI761974.1, BM676758.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368107.2/ ENSP00000357087.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AL590560.9         5934-5974
            42-56               DA428735.1         1-15
            57-795              AB164404.1         1-739
            796-797             BG823348.1         737-738
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..797
                     /gene="DUSP23"
                     /gene_synonym="DUSP25; LDP-3; LDP3; MOSP; VHZ"
                     /note="dual specificity phosphatase 23"
                     /db_xref="GeneID:54935"
                     /db_xref="HGNC:HGNC:21480"
                     /db_xref="MIM:618361"
     exon            1..406
                     /gene="DUSP23"
                     /gene_synonym="DUSP25; LDP-3; LDP3; MOSP; VHZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..592
                     /gene="DUSP23"
                     /gene_synonym="DUSP25; LDP-3; LDP3; MOSP; VHZ"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="low-molecular-mass dual-specificity phosphatase 3;
                     VH1-like member Z; VH1-like phosphatase Z; testicular
                     tissue protein Li 59"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 23"
                     /protein_id="NP_001306587.1"
                     /db_xref="CCDS:CCDS1187.1"
                     /db_xref="GeneID:54935"
                     /db_xref="HGNC:HGNC:21480"
                     /db_xref="MIM:618361"
                     /translation="MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTE
                     RGPPHSDSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFGRT
                     GTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK"
     exon            407..797
                     /gene="DUSP23"
                     /gene_synonym="DUSP25; LDP-3; LDP3; MOSP; VHZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      774..779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP23"
                     /gene_synonym="DUSP25; LDP-3; LDP3; MOSP; VHZ"
                     /note="hexamer: AATAAA"
     polyA_site      797
                     /gene="DUSP23"
                     /gene_synonym="DUSP25; LDP-3; LDP3; MOSP; VHZ"
                     /note="major polyA site"
ORIGIN      
        1 agaccacgtg gcccgggagg cgccgaggcc aggtaggtgg tgagttactt ggctcggagc
       61 gggcgagggg acgcgtgggc ggagcggggc tggccagcct cggcccccat gacccgctgt
      121 cctgtgccct ttcccagcga tgggcgtgca gccccccaac ttctcctggg tgcttccggg
      181 ccggctggcg ggactggcgc tgccgcggct ccccgcccac taccagttcc tgttggacct
      241 gggcgtgcgg cacctggtgt ccctgacgga gcgcgggccc cctcacagcg acagctgccc
      301 cggcctcacc ctgcaccgcc tgcgcatccc cgacttctgc ccgccggccc ccgaccagat
      361 cgaccgcttc gtgcagatcg tggacgaggc caacgcacgg ggagaggctg tgggagtgca
      421 ctgtgctctg ggctttggcc gcactggcac catgctggcc tgttacctgg tgaaggagcg
      481 gggcttggct gcaggagatg ccattgctga aatccgacga ctacgacccg gctccatcga
      541 gacctatgag caggagaaag cagtcttcca gttctaccag cgaacgaaat aaggggcctt
      601 agtacccttc taccaggccc tcactcccct tccccatgtt gtcgatgggg ccagagatga
      661 agggaagtgg actaaagtat taaaccctct agctcccatt ggctgaagac actgaagtag
      721 cccacccctg caggcaggtc ctgattgaag gggaggcttg tactgctttg ttgaataaat
      781 gagttttacg aaccagg
//
