LOCUS       NM_001286555            3075 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens dual specificity phosphatase 22 (DUSP22), transcript
            variant 1, mRNA.
ACCESSION   NM_001286555 XM_005249235
VERSION     NM_001286555.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3075)
  AUTHORS   Chen,X., Fang,M., Hong,J. and Guo,Y.
  TITLE     JNK Pathway-Associated Phosphatase Deficiency Facilitates
            Atherosclerotic Progression by Inducing T-Helper 1 and 17
            Polarization and Inflammation in an ERK- and NF-kappaB
            Pathway-Dependent Manner
  JOURNAL   J Atheroscler Thromb 31 (10), 1460-1478 (2024)
   PUBMED   38797677
  REMARK    GeneRIF: JNK Pathway-Associated Phosphatase Deficiency Facilitates
            Atherosclerotic Progression by Inducing T-Helper 1 and 17
            Polarization and Inflammation in an ERK- and NF-kappaB
            Pathway-Dependent Manner.
REFERENCE   2  (bases 1 to 3075)
  AUTHORS   Mu,X., Yu,C., Zhao,Y., Hu,X., Wang,H., He,Y. and Wu,H.
  TITLE     Exosomal miR-1228-5p down-regulates DUSP22 to promotes cell
            proliferation and migration in small cell lung cancer
  JOURNAL   Life Sci 351, 122787 (2024)
   PUBMED   38851418
  REMARK    GeneRIF: Exosomal miR-1228-5p down-regulates DUSP22 to promotes
            cell proliferation and migration in small cell lung cancer.
REFERENCE   3  (bases 1 to 3075)
  AUTHORS   Chen,B.J., Hsieh,S.M., Hsieh,T.H., Jhuang,J.Y. and Kao,Y.C.
  TITLE     DUSP22-rearranged primary cutaneous CD30-positive T-cell
            lymphoproliferative disorders and adult T-cell leukemia/lymphoma
            frequently share the LEF1+/TIA1- immunophenotype
  JOURNAL   Hum Pathol 150, 58-66 (2024)
   PUBMED   38971328
  REMARK    GeneRIF: DUSP22-rearranged primary cutaneous CD30-positive T-cell
            lymphoproliferative disorders and adult T-cell leukemia/lymphoma
            frequently share the LEF1+/TIA1- immunophenotype.
REFERENCE   4  (bases 1 to 3075)
  AUTHORS   Chen,L., Su,H., Tao,Z., Liang,C., Liu,Z., Dong,Y., Zheng,P. and
            Liu,Y.
  TITLE     DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs
            through Smad2/3 and MAPK Signaling Pathways
  JOURNAL   Cardiovasc Ther 2024, 5583961 (2024)
   PUBMED   38495810
  REMARK    GeneRIF: DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition
            in HUVECs through Smad2/3 and MAPK Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3075)
  AUTHORS   Shih,Y.C., Chen,H.F., Wu,C.Y., Ciou,Y.R., Wang,C.W., Chuang,H.C.
            and Tan,T.H.
  TITLE     The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination
            and activation of Lck downstream of TCR signalling
  JOURNAL   Nat Commun 15 (1), 532 (2024)
   PUBMED   38225265
  REMARK    GeneRIF: The phosphatase DUSP22 inhibits UBR2-mediated
            K63-ubiquitination and activation of Lck downstream of TCR
            signalling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3075)
  AUTHORS   Alonso,A., Narisawa,S., Bogetz,J., Tautz,L., Hadzic,R., Huynh,H.,
            Williams,S., Gjorloff-Wingren,A., Bremer,M.C., Holsinger,L.J.,
            Millan,J.L. and Mustelin,T.
  TITLE     VHY, a novel myristoylated testis-restricted dual specificity
            protein phosphatase related to VHX
  JOURNAL   J Biol Chem 279 (31), 32586-32591 (2004)
   PUBMED   15138252
REFERENCE   7  (bases 1 to 3075)
  AUTHORS   Chen,A.J., Zhou,G., Juan,T., Colicos,S.M., Cannon,J.P.,
            Cabriera-Hansen,M., Meyer,C.F., Jurecic,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Fletcher,F., Tan,T.H. and Belmont,J.W.
  TITLE     The dual specificity JKAP specifically activates the c-Jun
            N-terminal kinase pathway
  JOURNAL   J Biol Chem 277 (39), 36592-36601 (2002)
   PUBMED   12138158
REFERENCE   8  (bases 1 to 3075)
  AUTHORS   Alonso,A., Merlo,J.J., Na,S., Kholod,N., Jaroszewski,L.,
            Kharitonenkov,A., Williams,S., Godzik,A., Posada,J.D. and
            Mustelin,T.
  TITLE     Inhibition of T cell antigen receptor signaling by VHR-related MKPX
            (VHX), a new dual specificity phosphatase related to VH1 related
            (VHR)
  JOURNAL   J Biol Chem 277 (7), 5524-5528 (2002)
   PUBMED   11733513
REFERENCE   9  (bases 1 to 3075)
  AUTHORS   Shen,Y., Luche,R., Wei,B., Gordon,M.L., Diltz,C.D. and Tonks,N.K.
  TITLE     Activation of the Jnk signaling pathway by a dual-specificity
            phosphatase, JSP-1
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13613-13618 (2001)
   PUBMED   11717427
REFERENCE   10 (bases 1 to 3075)
  AUTHORS   Smith,A., Price,C., Cullen,M., Muda,M., King,A., Ozanne,B.,
            Arkinstall,S. and Ashworth,A.
  TITLE     Chromosomal localization of three human dual specificity
            phosphatase genes (DUSP4, DUSP6, and DUSP7)
  JOURNAL   Genomics 42 (3), 524-527 (1997)
   PUBMED   9205128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365272.20.
            
            On Sep 18, 2020 this sequence version replaced NM_001286555.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.775183.1, AK296402.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419235.7/ ENSP00000397459.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AL365272.20        23852-23925
            75-108              AL365272.20        35993-36026
            109-191             AL365272.20        43245-43327
            192-241             AL365272.20        66479-66528
            242-316             AL365272.20        77219-77293
            317-488             AL365272.20        79468-79639
            489-3075            AL365272.20        80134-82720
FEATURES             Location/Qualifiers
     source          1..3075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.3"
     gene            1..3075
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /note="dual specificity phosphatase 22"
                     /db_xref="GeneID:56940"
                     /db_xref="HGNC:HGNC:16077"
                     /db_xref="MIM:616778"
     exon            1..74
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..671
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1;
                     homolog of mouse dual specificity phosphatase LMW-DSP2;
                     mitogen-activated protein kinase phosphatase x; dual
                     specificity protein phosphatase 22; JNK-stimulating
                     phosphatase 1; MAP kinase phosphatase x; JNK-stimulatory
                     phosphatase-1; low molecular weight dual specificity
                     phosphatase 2; epididymis secretory sperm binding protein;
                     JNK pathway associated phosphatase"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 22 isoform
                     a"
                     /protein_id="NP_001273484.1"
                     /db_xref="CCDS:CCDS69035.1"
                     /db_xref="GeneID:56940"
                     /db_xref="HGNC:HGNC:16077"
                     /db_xref="MIM:616778"
                     /translation="MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPM
                     LEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAY
                     IMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQ
                     DAEEAKNILGKYKEQGRTEPQPGARRWSSFPALAPLTYDNYTTET"
     exon            75..108
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /inference="alignment:Splign:2.1.0"
     exon            109..191
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /inference="alignment:Splign:2.1.0"
     exon            192..241
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /inference="alignment:Splign:2.1.0"
     exon            242..316
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /inference="alignment:Splign:2.1.0"
     exon            317..488
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /inference="alignment:Splign:2.1.0"
     exon            489..3075
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3049..3054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /note="hexamer: AATAAA"
     polyA_site      3075
                     /gene="DUSP22"
                     /gene_synonym="JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2;
                     MKP-x; MKPX; VHX"
                     /note="major polyA site"
ORIGIN      
        1 atagtgcgcc tgcgaccaca cggccggggc gctagcgttc gccttcagcc accatgggga
       61 atgggatgaa caagatcctg cccggcctgt acatcggcaa cttcaaagat gccagagacg
      121 cggaacaatt gagcaagaac aaggtgacac atattctgtc tgtccacgat agtgccaggc
      181 ctatgttgga gggagttaaa tacctgtgca tcccagcagc ggattcacca tctcaaaacc
      241 tgacaagaca tttcaaagaa agtattaaat tcattcacga gtgccggctc cgcggtgaga
      301 gctgccttgt acactgcctg gccggggtct ccaggagcgt gacactggtg atcgcataca
      361 tcatgaccgt cactgacttt ggctgggagg atgccctgca caccgtgcgt gctgggagat
      421 cctgtgccaa ccccaacgtg ggcttccaga gacagctcca ggagtttgag aagcatgagg
      481 tccatcagta tcggcagtgg ctgaaggaag aatatggaga gagccctttg caggatgcag
      541 aagaagccaa aaacattctg ggtaaatata aggagcaagg gcgcacagag ccccagcccg
      601 gcgccaggcg gtggagcagt tttccggcac tggctccgct gacctacgat aattatacga
      661 cggagaccta acgcaagcga cctgctgcct tccttcccac tgcttgtctt cagtgtgccc
      721 ggctgggcag gggtgcggtg gtggtggccg atgaggacag gaaagggaga tagccagggc
      781 gaggtggggc gagggctcct tcccccaagc aacaccgccc agccctgctc caggcccctg
      841 cactccgccc acccctaccc tggctgcacc tgagcttgct gcccctgggg atgttgccca
      901 gtggctgtgc actgctctgt gcacgtgcgt gtgtgtgagt gcacttgtgt gtgggtgact
      961 aagtggatgc atgtgtgtgc ctgtgtgagt gagggtatgt gcacctaagt gtgtacatgt
     1021 gtgtatgttg tgaaagtgtc tgtgcacatg aatgtttgtg tgtgtgtgaa ctctttctta
     1081 ctgctggaag tcacagaatt catattgctg cccgggttgg tgtggccacc tttccctttg
     1141 tccaagactc cacatggaag gcatttgagc tcgacctccg aaaagctacc cagcaaagag
     1201 cagtctgtgc ctctgagcag accgtgagaa ctcaggggac gagtggctaa gagcatggcc
     1261 tctcccagaa cccacccagg gtggtgtggt gggggcaaca ggggccagac tcctctagag
     1321 ggagggtggc tctggggccc tggaaaacgt gagagactgc cctgagctgg tccagtgggc
     1381 cagcacttta taccaactca gcatttaagg gaagtatctt agattgcctc catctcaatg
     1441 tgaatgcacc aggctgaggg ttccctagcg ccttgagtca aggccacttt tcagcccatc
     1501 gagccctgag ttctacttgg tgtttgttct ctggagctga ttgcacttga gctctgtggt
     1561 gggcaggcgc actttagcct aagttgggtg ccccagggca ccccctcctc tctgctcctt
     1621 gccagcttca ttcactccca gcctctcgct gtcctcactt tgcaggggct cctcctcaac
     1681 atttgcatgc acctgcaaga attgggaaga aagagcattt attaggcact gtagcaattt
     1741 gcattttaaa atgcctgagc atttattaag cttcttggta ttcacttggg tttgataatt
     1801 gatctgagct acctcattga atgtttttgg aaaggtgttt tttggtatgc aagtcagctt
     1861 tgcctcacag ttgaaaatgt tcggtcatga ttgcttttga aaccaaaggg gaaggtaccg
     1921 atatcattga gctatttaaa gttgccagtt tgggctccag taatgctttc tggtgggtaa
     1981 aattccacat tcaggccacg agagcatcta cagtttgtac tctggggctg caggcatcct
     2041 gggacgctgt acgcaattca gtggtctagt cctttatacc gactcagatt ccttaagcat
     2101 gcagagtcac tcgaatgaaa aaacatactc gacctctccc taaaaagatg ttgcaaccca
     2161 gtttctctga attccaccac aaaaagagac cctgaataag aagagcagtt ttcctgtgca
     2221 tatagagggt gtgtcaaagg tgagcttttt ggggaccggg aaaaacaaag ttgcctgatt
     2281 ccgcgcaggt gcacaggccc cggatgtaca cccggaaagg ggagtgtggc tgtagaatca
     2341 tccatccgtc tacagctaaa acaatttgcc aataaagtac atgtttttcc taagccaaaa
     2401 ataaatacgt taacagaaaa atgatttagg atatagcttg aatgcttaaa tatgtgcacc
     2461 tttacaaacc tctcagtgta ttcttggagt tcttgaaatg ttgttttaat atttgttgcc
     2521 agtaatgttc tttcttcaca gccgctccgg gaattctgaa gttctgggcc tttctcagaa
     2581 gactgtaatg tacctgaagt ttctgaaata ttgcaaaccc acagagttta ggctggtgct
     2641 gccaaaaaga aaagcaacat agagtttaag tatccagtag tgatttgtaa acttgttttt
     2701 catttgaagc tgaatatata cgtagtcatg tttatgttga gaactaagga tattctttag
     2761 caagagaaaa tattttcccc ttatccccac tgctgtggag gtttctgtac ctcgcttgga
     2821 tgcctgtaag gatcccggga gccttgccgc actgccttgt gggtggcttg gcgctcgtga
     2881 ttgcttcctg tgaacgcctc ccaaggacga gcccagtgta gttgtgtggc gtgaactctg
     2941 cccgtgtgtt ctcaaattcc ccagcttggg aaatagccct tggtgtgggt tttatctctg
     3001 gtttgtgttc tccgtggtgg aattgaccga aagctctatg ttttcgttaa taaagggcaa
     3061 cttagccaag tttaa
//
