LOCUS       NM_022076                868 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dual specificity phosphatase 21 (DUSP21), mRNA.
ACCESSION   NM_022076
VERSION     NM_022076.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 868)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 868)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 868)
  AUTHORS   Deng,Q., Li,K.Y., Chen,H., Dai,J.H., Zhai,Y.Y., Wang,Q., Li,N.,
            Wang,Y.P. and Han,Z.G.
  TITLE     RNA interference against cancer/testis genes identifies dual
            specificity phosphatase 21 as a potential therapeutic target in
            human hepatocellular carcinoma
  JOURNAL   Hepatology 59 (2), 518-530 (2014)
   PUBMED   23929653
  REMARK    GeneRIF: DUSP21 plays an important role in sustaining
            hepatocellular carcinoma (HCC) cell proliferation and may thus act
            as a potential therapeutic target in HCC treatment.
REFERENCE   4  (bases 1 to 868)
  AUTHORS   Hood,K.L., Tobin,J.F. and Yoon,C.
  TITLE     Identification and characterization of two novel
            low-molecular-weight dual specificity phosphatases
  JOURNAL   Biochem Biophys Res Commun 298 (4), 545-551 (2002)
   PUBMED   12408986
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF533018.1 and AA813372.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_022076.3.
            
            Summary: This gene encodes a member of the dual specificity
            phosphatase family, specifically the low molecular weight dual
            specificity phosphatase family. The encoded protein localizes to
            both the cytoplasm and the nucleus and functions to remove
            phosphate groups from phosphotyrosine and phosphothreonine
            residues.[provided by RefSeq, Mar 2009].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY156515.1, AY121807.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339042.6/ ENSP00000343244.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-866               AF533018.1         21-886
            867-868             AA813372.1         4-5                 c
FEATURES             Location/Qualifiers
     source          1..868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..868
                     /gene="DUSP21"
                     /gene_synonym="LMWDSP21"
                     /note="dual specificity phosphatase 21"
                     /db_xref="GeneID:63904"
                     /db_xref="HGNC:HGNC:20476"
                     /db_xref="MIM:300678"
     exon            1..868
                     /gene="DUSP21"
                     /gene_synonym="LMWDSP21"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..685
                     /gene="DUSP21"
                     /gene_synonym="LMWDSP21"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="low molecular weight dual specificity phosphatase
                     21; BJ-HCC-26 tumor antigen; LMW-DSP21"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 21"
                     /protein_id="NP_071359.3"
                     /db_xref="CCDS:CCDS14264.1"
                     /db_xref="GeneID:63904"
                     /db_xref="HGNC:HGNC:20476"
                     /db_xref="MIM:300678"
                     /translation="MTASASSFSSSQGVQQPSIYSFSQITRSLFLSNGVAANDKLLLS
                     SNRITAIVNASVEVVNVFFEGIQYIKVPVTDARDSRLYDFFDPIADLIHTIDMRQGRT
                     LLHCMAGVSRSASLCLAYLMKYHSMSLLDAHTWTKSRRPIIRPNNGFWEQLINYEFKL
                     FNNNTVRMINSPVGNIPDIYEKDLRMMISM"
     regulatory      849..854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP21"
                     /gene_synonym="LMWDSP21"
                     /note="hexamer: ATTAAA"
     polyA_site      868
                     /gene="DUSP21"
                     /gene_synonym="LMWDSP21"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctcc aacacctagc ctgagacttg gcggcgcggc tgctatcctg aactagcttg
       61 gtaagtgttg tgtcccgaac cagcgtagag agacctcgga ccagccgcct tgatgacagc
      121 atccgcgtcc tccttttcat catctcaggg tgtccagcag ccctccatct acagcttctc
      181 ccaaataacc agaagcttgt ttctcagcaa tggtgtggcc gccaacgaca aactccttct
      241 gtccagcaat cgcatcaccg ccattgtcaa tgcctcggtg gaagtggtca acgtattctt
      301 cgagggcatt cagtacataa aggtgcctgt taccgatgct cgtgactcgc gtctctacga
      361 cttttttgac cccattgctg atcttatcca caccatcgat atgaggcagg gccgtacgct
      421 gctgcactgc atggctggag tgagccgttc cgcctcactg tgccttgcgt acctcatgaa
      481 ataccactcc atgtcgctgc tggacgccca tacatggacc aagtcgcgcc gccccatcat
      541 ccggcccaac aacggctttt gggaacagct catcaattac gaattcaagc tgtttaataa
      601 caacaccgtg cgcatgatca actcgccggt aggtaacatc cctgacatct atgagaagga
      661 cctacgtatg atgatatcaa tgtaagccat cccggccagc ccctgacatc tgccatcgat
      721 cttgcaccaa gactgaactt gaacactgac attttgttag taaagaaaac cggatggtgc
      781 cttgttaaag ggcaagaaaa aagggagggg gttggagttt tgaacgtagt aagccttacc
      841 ttaatagaat taaattcatg aaacataa
//
