LOCUS       NM_004418               1685 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens dual specificity phosphatase 2 (DUSP2), mRNA.
ACCESSION   NM_004418
VERSION     NM_004418.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1685)
  AUTHORS   Ren,D., Li,W., Zeng,R., Liu,X., Liang,H., Xiong,W., Yang,C. and
            Jin,X.
  TITLE     Retinoblastoma-associated protein is important for TRIM24-mediated
            activation of the mTOR signaling pathway through DUSP2 action in
            prostate cancer
  JOURNAL   Cell Death Differ 31 (5), 592-604 (2024)
   PUBMED   38514847
  REMARK    GeneRIF: Retinoblastoma-associated protein is important for
            TRIM24-mediated activation of the mTOR signaling pathway through
            DUSP2 action in prostate cancer.
REFERENCE   2  (bases 1 to 1685)
  AUTHORS   Dan,Lu., Liu,L., Sun,Y., Song,J., Yin,Q., Zhang,G., Qi,F., Hu,Z.,
            Yang,Z., Zhou,Z., Hu,Y., Zhang,L., Ji,J., Zhao,X., Jin,Y.,
            McNutt,M.A. and Yin,Y.
  TITLE     The phosphatase PAC1 acts as a T cell suppressor and attenuates
            host antitumor immunity
  JOURNAL   Nat Immunol 21 (3), 287-297 (2020)
   PUBMED   31932812
  REMARK    GeneRIF: PAC1 is selectively upregulated in exhausted
            tumor-infiltrating lymphocytes and is associated with poor
            prognosis of patients with cancer. PAC1(hi) effector T cells lose
            their proliferative and effector capacities and convert into
            exhausted T cells.
REFERENCE   3  (bases 1 to 1685)
  AUTHORS   Liu,W., Tian,X., Ding,X. and Zhang,L.
  TITLE     Expression of Dual-Specificity Phosphatase 2 (DUSP2) in Patients
            with Serous Ovarian Carcinoma and in SKOV3 and OVCAR3 Cells In
            Vitro
  JOURNAL   Med Sci Monit 25, 10180-10189 (2019)
   PUBMED   31889045
  REMARK    GeneRIF: Down-regulation of DUSP2 expression in serous ovarian
            carcinoma was an independent risk factor for patient survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1685)
  AUTHORS   Yin,H., He,W., Li,Y., Xu,N., Zhu,X., Lin,Y. and Gou,X.
  TITLE     Loss of DUSP2 predicts a poor prognosis in patients with bladder
            cancer
  JOURNAL   Hum Pathol 85, 152-161 (2019)
   PUBMED   30458195
  REMARK    GeneRIF: Taken together, our findings for the first time suggested
            DUSP2 as a progression and prognosis biomarker for bladder cancer.
REFERENCE   5  (bases 1 to 1685)
  AUTHORS   Hou,P.C., Li,Y.H., Lin,S.C., Lin,S.C., Lee,J.C., Lin,B.W.,
            Liou,J.P., Chang,J.Y., Kuo,C.C., Liu,Y.M., Sun,H.S. and Tsai,S.J.
  TITLE     Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon
            Cancer Stemness
  JOURNAL   Cancer Res 77 (16), 4305-4316 (2017)
   PUBMED   28652251
  REMARK    GeneRIF: Authors report that hypoxia-mediated downregulation of the
            dual specificity phosphatase 2 (DUSP2) is critical for the
            accumulation of CSC in colorectal cancer.
REFERENCE   6  (bases 1 to 1685)
  AUTHORS   Yi,H., Morton,C.C., Weremowicz,S., McBride,O.W. and Kelly,K.
  TITLE     Genomic organization and chromosomal localization of the DUSP2
            gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11
  JOURNAL   Genomics 28 (1), 92-96 (1995)
   PUBMED   7590752
REFERENCE   7  (bases 1 to 1685)
  AUTHORS   Raingeaud,J., Gupta,S., Rogers,J.S., Dickens,M., Han,J.,
            Ulevitch,R.J. and Davis,R.J.
  TITLE     Pro-inflammatory cytokines and environmental stress cause p38
            mitogen-activated protein kinase activation by dual phosphorylation
            on tyrosine and threonine
  JOURNAL   J Biol Chem 270 (13), 7420-7426 (1995)
   PUBMED   7535770
REFERENCE   8  (bases 1 to 1685)
  AUTHORS   Martell,K.J., Kwak,S., Hakes,D.J., Dixon,J.E. and Trent,J.M.
  TITLE     Chromosomal localization of four human VH1-like protein-tyrosine
            phosphatases
  JOURNAL   Genomics 22 (2), 462-464 (1994)
   PUBMED   7806236
REFERENCE   9  (bases 1 to 1685)
  AUTHORS   Ward,Y., Gupta,S., Jensen,P., Wartmann,M., Davis,R.J. and Kelly,K.
  TITLE     Control of MAP kinase activation by the mitogen-induced
            threonine/tyrosine phosphatase PAC1
  JOURNAL   Nature 367 (6464), 651-654 (1994)
   PUBMED   8107850
REFERENCE   10 (bases 1 to 1685)
  AUTHORS   Rohan,P.J., Davis,P., Moskaluk,C.A., Kearns,M., Krutzsch,H.,
            Siebenlist,U. and Kelly,K.
  TITLE     PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase
  JOURNAL   Science 259 (5102), 1763-1766 (1993)
   PUBMED   7681221
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB475178.1 and BC007771.2.
            
            On Nov 22, 2018 this sequence version replaced NM_004418.3.
            
            Summary:  The protein encoded by this gene is a member of the dual
            specificity protein phosphatase subfamily.  These phosphatases
            inactivate their target kinases by dephosphorylating both the
            phosphoserine/threonine and phosphotyrosine residues.  They
            negatively regulate members of the mitogen-activated protein (MAP)
            kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated
            with cellular proliferation and differentiation.  Different members
            of the family of dual specificity phosphatases show distinct
            substrate specificities for various MAP kinases, different tissue
            distribution and subcellular localization, and different modes of
            inducibility of their expression by extracellular stimuli.  This
            gene product inactivates ERK1 and ERK2, is predominantly expressed
            in hematopoietic tissues, and is localized in the nucleus.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L11329.1, SRR1163655.87018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288943.5/ ENSP00000288943.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB475178.1         1-24
            25-1685             BC007771.2         1-1661
FEATURES             Location/Qualifiers
     source          1..1685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1685
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /note="dual specificity phosphatase 2"
                     /db_xref="GeneID:1844"
                     /db_xref="HGNC:HGNC:3068"
                     /db_xref="MIM:603068"
     exon            1..474
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1031
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="serine/threonine specific protein phosphatase; dual
                     specificity protein phosphatase PAC-1"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 2"
                     /protein_id="NP_004409.1"
                     /db_xref="CCDS:CCDS2016.1"
                     /db_xref="GeneID:1844"
                     /db_xref="HGNC:HGNC:3068"
                     /db_xref="MIM:603068"
                     /translation="MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVR
                     AARPVPWNALLRRRARGPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELR
                     PDSPAHVLLAALLHETRAGPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSR
                     SDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFR
                     YKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSR
                     RVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH"
     exon            475..596
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..816
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1685
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /note="hexamer: AATAAA"
     polyA_site      1685
                     /gene="DUSP2"
                     /gene_synonym="PAC-1; PAC1"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcgacc gctcgggcag cgccaccgcc acgagagccc gggacgcggg aaagaccgaa
       61 aggaagagga agaggcaccg gtggccatgg ggctggaggc ggcgcgcgag ctggagtgcg
      121 cggcgctggg cacgctgctg cgggatccgc gggaggcgga acgcacgctg ctgctggact
      181 gccgcccctt cctggccttc tgccggcgcc acgtgcgcgc cgcgcggcca gtgccttgga
      241 acgcgctgct gcggcgccgc gcgcgcggcc ctcctgccgc cgttctcgcc tgcctgctgc
      301 ccgaccgcgc gctgcggacg cgcctggtcc gcggggagct ggcgcgggcc gtggtgctgg
      361 acgagggcag tgcctcggtg gcggagctcc ggcccgacag cccggctcat gtgctgctgg
      421 ccgcgctgct gcacgagacc cgcgcggggc ccactgccgt gtacttcctg cgaggaggct
      481 tcgacggctt ccagggctgc tgtcccgatc tgtgctctga ggcccccgcc cctgcgctgc
      541 cgccaacagg ggacaaaacc agccgctccg actccagggc tcctgtctac gaccagggtg
      601 gccctgtgga gatcttgccc tacctgttcc tgggcagctg cagtcactcg tcagacctgc
      661 aggggctgca ggcctgtggc atcacagccg tcctcaacgt gtccgccagc tgccccaacc
      721 actttgaggg ccttttccgc tacaagagta tccctgtgga ggacaaccag atggtggaga
      781 tcagtgcctg gttccaggag gccataggct tcattgactg ggtgaagaac agcggaggcc
      841 gggtgctggt gcactgccag gcgggtatct cgcgctctgc caccatctgt ctggcatacc
      901 tcatgcagag tcgccgtgtg cggctggacg aggcctttga cttcgttaag cagcgccggg
      961 gggtcatctc ccccaacttc agtttcatgg ggcagctgct gcagtttgag acccaggtgc
     1021 tgtgtcactg aggtggtgcc cctctgcctg cctgccccac tgtgctggca ggagctgact
     1081 gtggactggt gggctcccct ctgggccagc acagtcccct cacctctggc agggctgcta
     1141 cctcctcaga gtttcagaag cccccacatg ggggctctag gaatgccggc atgctggtct
     1201 ttccgacctg gtgctcttct gctgggggac tgaggctggc cctcattcgg ggtcgggaac
     1261 caagggtgtg tctgctcttt ccctccccat cctctggcag aaatcagcta gacgctatac
     1321 cgtggactct ccctggtcca ccaccatgtt gaagcccttg gcagcctgag agctccaagg
     1381 aacaagctgt gacaaccagg agccctgtct gtgggttcgt ctgcccaggg cctggagccc
     1441 aagccctgtg ttcctgggga agctggggac ttgggaagtg atgggtgtgt catgttgcgt
     1501 gtgtctgtct gtgagccttt cacacctgtg ctggcgctgg aaaattattt gtgctcagct
     1561 gacatttaac actccctccc ccgcttcctc ctagccctgt gggcaggggt tggaaactta
     1621 gcactttata tttatacaga acattcagga tatgtcaata aaatattgtt atatttaaaa
     1681 aacaa
//
