LOCUS       NM_080876               5191 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens dual specificity phosphatase 19 (DUSP19), transcript
            variant 1, mRNA.
ACCESSION   NM_080876
VERSION     NM_080876.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5191)
  AUTHORS   Chang,T.M., Chu,P.Y., Lin,H.Y., Huang,K.W., Hung,W.C., Shan,Y.S.,
            Chen,L.T. and Tsai,H.J.
  TITLE     PTEN regulates invasiveness in pancreatic neuroendocrine tumors
            through DUSP19-mediated VEGFR3 dephosphorylation
  JOURNAL   J Biomed Sci 29 (1), 92 (2022)
   PUBMED   36336681
  REMARK    GeneRIF: PTEN regulates invasiveness in pancreatic neuroendocrine
            tumors through DUSP19-mediated VEGFR3 dephosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5191)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5191)
  AUTHORS   Liu,Y., Ao,S., Zhang,H., Zhang,Y., Wang,Y., Yang,X. and Leng,H.
  TITLE     Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in neuronal
            cells by depending on the regulation of the miR-222-3p/DUSP19 axis
  JOURNAL   Biochem Biophys Res Commun 553, 126-133 (2021)
   PUBMED   33770577
  REMARK    GeneRIF: Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in
            neuronal cells by depending on the regulation of the
            miR-222-3p/DUSP19 axis.
REFERENCE   4  (bases 1 to 5191)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5191)
  AUTHORS   Xie,X.K., Xu,Z.K., Xu,K. and Xiao,Y.X.
  TITLE     DUSP19 mediates spinal cord injury-induced apoptosis and
            inflammation in mouse primary microglia cells via the NF-kB
            signaling pathway
  JOURNAL   Neurol Res 42 (1), 31-38 (2020)
   PUBMED   31813339
  REMARK    GeneRIF: DUSP19 mediates spinal cord injury-induced apoptosis and
            inflammation in mouse primary microglia cells via the NF-kB
            signaling pathway.
REFERENCE   6  (bases 1 to 5191)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 5191)
  AUTHORS   Patterson,K.I., Brummer,T., O'Brien,P.M. and Daly,R.J.
  TITLE     Dual-specificity phosphatases: critical regulators with diverse
            cellular targets
  JOURNAL   Biochem J 418 (3), 475-489 (2009)
   PUBMED   19228121
  REMARK    Review article
REFERENCE   8  (bases 1 to 5191)
  AUTHORS   Cheng,H., Gao,Q., Jiang,M., Ma,Y., Ni,X., Guo,L., Jin,W., Cao,G.,
            Ji,C., Ying,K., Xu,W., Gu,S., Ma,Y., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human protein
            phosphatase, LMW-DSP3
  JOURNAL   Int J Biochem Cell Biol 35 (2), 226-234 (2003)
   PUBMED   12479873
  REMARK    GeneRIF: LMW-DSP3 was expressed in the heart, lung, liver, and
            pancreas, and the expression level in the pancreas was highest. The
            LMW-DSP3 gene was located in human chromosome 2q32, and consisted
            of five exons spanning 21kb of human genomic DNA[LMW-DSP3]
REFERENCE   9  (bases 1 to 5191)
  AUTHORS   Zama,T., Aoki,R., Kamimoto,T., Inoue,K., Ikeda,Y. and Hagiwara,M.
  TITLE     Scaffold role of a mitogen-activated protein kinase phosphatase,
            SKRP1, for the JNK signaling pathway
  JOURNAL   J Biol Chem 277 (26), 23919-23926 (2002)
   PUBMED   11959862
REFERENCE   10 (bases 1 to 5191)
  AUTHORS   Zama,T., Aoki,R., Kamimoto,T., Inoue,K., Ikeda,Y. and Hagiwara,M.
  TITLE     A novel dual specificity phosphatase SKRP1 interacts with the MAPK
            kinase MKK7 and inactivates the JNK MAPK pathway. Implication for
            the precise regulation of the particular MAPK pathway
  JOURNAL   J Biol Chem 277 (26), 23909-23918 (2002)
   PUBMED   11959861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB063186.1, AC064871.6 and BC035000.1.
            
            On May 17, 2019 this sequence version replaced NM_080876.3.
            
            Summary: Dual-specificity phosphatases (DUSPs) constitute a large
            heterogeneous subgroup of the type I cysteine-based
            protein-tyrosine phosphatase superfamily. DUSPs are characterized
            by their ability to dephosphorylate both tyrosine and
            serine/threonine residues. They have been implicated as major
            modulators of critical signaling pathways. DUSP19 contains a
            variation of the consensus DUSP C-terminal catalytic domain, with
            the last serine residue replaced by alanine, and lacks the
            N-terminal CH2 domain found in the MKP (mitogen-activated protein
            kinase phosphatase) class of DUSPs (see MIM 600714) (summary by
            Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035000.1, SRR1660809.52393.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354221.5/ ENSP00000346160.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-876               AB063186.1         194-1069
            877-4981            AC064871.6         140129-144233
            4982-5191           BC035000.1         4974-5183
FEATURES             Location/Qualifiers
     source          1..5191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.1"
     gene            1..5191
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /note="dual specificity phosphatase 19"
                     /db_xref="GeneID:142679"
                     /db_xref="HGNC:HGNC:18894"
                     /db_xref="MIM:611437"
     exon            1..413
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..841
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stress-activated protein kinase pathway-regulating
                     phosphatase 1; dual specificity protein phosphatase 19;
                     protein phosphatase SKRP1; dual specificity phosphatase
                     TS-DSP1; SAPK pathway-regulating phosphatase 1; low
                     molecular weight dual specificity phosphatase 3"
                     /codon_start=1
                     /product="dual specificity protein phosphatase 19 isoform
                     1"
                     /protein_id="NP_543152.1"
                     /db_xref="CCDS:CCDS2289.1"
                     /db_xref="GeneID:142679"
                     /db_xref="HGNC:HGNC:18894"
                     /db_xref="MIM:611437"
                     /translation="MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVE
                     EVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGV
                     ENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAI
                     VIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS"
     exon            414..460
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..613
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..5191
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1048..1053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1082
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /note="major polyA site"
     regulatory      3786..3791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /note="hexamer: AATAGA"
     polyA_site      3823
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
     regulatory      4789..4794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /note="hexamer: AATAAA"
     polyA_site      4822
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /note="major polyA site"
     regulatory      4884..4889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
                     /note="hexamer: ATTAAA"
     polyA_site      4908
                     /gene="DUSP19"
                     /gene_synonym="DUSP17; LMWDSP3; SKRP1; TS-DSP1"
ORIGIN      
        1 acattgcatc gctgggataa acggagctgg acgactcagt ctcttggtct gtggctgctg
       61 cggttacctg gatgggcgag cacctctgag gctggctttg ttacctgggc aataagggac
      121 tagcagttca gccgttttct atgcctgctg gatttgtttg tatttgttcc cagccactgc
      181 tcatgtaatg tactccctta accaggaaat taaagcattc tcccggaata atctcaggaa
      241 gcaatgcacc agggtgacaa cgctaactgg aaagaaaatt atagaaacat ggaaagatgc
      301 cagaattcat gttgtggaag aagtagagcc gagcagtggg ggtggttgtg gttatgtgca
      361 ggaccttagc tcggacctgc aagttggcgt tattaagcca tggttgctcc tagggtcaca
      421 agatgctgct catgatttgg atacactgaa aaagaataag gtgactcata ttcttaatgt
      481 tgcatatgga gttgaaaatg ctttcctcag tgactttaca tataagagca tttctatatt
      541 ggatctgcct gaaaccaaca tcctgtctta ttttccagaa tgttttgaat ttattgaaga
      601 agcaaaaaga aaagatggag tggttcttgt tcattgtaat gcaggcgttt ccagggctgc
      661 tgcaattgta ataggtttcc tgatgaattc tgaacaaacc tcatttacca gtgctttttc
      721 tttggtgaaa aatgcaagac cttccatatg tccaaattct ggcttcatgg agcagcttcg
      781 tacatatcaa gagggcaaag aaagcaataa gtgtgacaga atacaggaga acagttcatg
      841 agttgcattg tagcagacaa tggacaactg tagtttctga attgacttct atagccatct
      901 tttccctttt ttggagagta gactagcaaa actccctttt ttctcttgcc ttttttatgc
      961 ataaatggag gtcaatttga ttgtcctgac ctactgtata agtaaatttc aaatgtcatt
     1021 actttctctt tgttattata atgtgtgatt aaatgctttt ttaaattgct aagggaaaat
     1081 aacaaagtgt tagtaatcat tgctttctgt agaagaaaaa ggtttaaatt taaaatgtgt
     1141 atttagagca tggagagaat catttaatga agcctatttt tctgttccag caactgtttt
     1201 tatgaaagaa aaacttgaaa tgctacttaa cttactattt caaagggaag tatatttctt
     1261 tttaaagaat ctttttaaga ttaaaaatga ataccttaaa tctcccaaaa gagataacca
     1321 gtatctgaag gtttatacaa tatttacaca gtggctacaa tattcacaaa attcttatgt
     1381 tctcttatga aaaatataca cttttcattt tgtcttcttc tttttttttc tttttttaga
     1441 tggagtttgg ctcttgtcac ccaggctgga gtgcaatggc gcaatctcag ctcactgcaa
     1501 cctctgcctc ccgggttcaa gcgattctcc tgccccagcc tcccatatag ctgggattat
     1561 aggtgcctgc caccatgccc agctaatttt tgtgttttta gtagagatgg agtctcacca
     1621 cataggccag gcagtctcga actcctgacc tcaggtgatc cacccacctt ggcctctcta
     1681 aatactggga ttacaggcgt gagccactgc atccgacctc attttgtttt tttcaattct
     1741 gttatcggca tttctttctt ttttttttta atgtataggt gttctgtcat acgttattgt
     1801 gagctttggt tctttgaaca ggtgatctat tctcttacat tttgtgcttt ttatcttggg
     1861 tgcctagcat tctgtttttt tgatcctatg tcataatttt ttgagaaaat gtttgatact
     1921 gcaagatcat tgtttagtgg tctgttttct acttcagtat tctaccagag aacatatttt
     1981 ttaggggaga agggttatgg ttttgtaaga aactttaaat atacttttag gagacccaca
     2041 atcatttaca gttttatctt tggcctttga ataggttctt ttttctttaa tgtctccgta
     2101 tttgaagaac tgagctctgt acattataaa tttgcttaaa gattttgatt ttttcttcag
     2161 aatatggtat acttaaaatt aattaattaa gacagtttct tttttctttt cttttttttt
     2221 tttttcgaga cagggtcttg ctctgtcacc taggctagag tggagtggca tgaacacaac
     2281 gcactgcagc ctctacctcc tgggctcaag cagtcctccc acctcagtct cctgagtagc
     2341 tgagactaca gctgtgcgcc accacatctg gctaatttta tttttatttt tgtagagaca
     2401 ggagtcttgc catgttgccc aggctgatct caaactccta ggcttaagtg atcctcccgc
     2461 cttagcctcc caagtgctag gattacaggc atcagccacc acgcctggcc tgatagtttc
     2521 cacatagttt ttcatgactt agaagatatc attgccatgt aggttttatt tttaaaagtc
     2581 ttgagctctt cttaaatata cattataaag agcaagcata gatggaaagt gcatattgaa
     2641 cacatctgtg catttgagaa ggcaggcttt catatgctgt catgagcaaa aagtagaagt
     2701 gataaatgca agttatgttt tgagattgct tacaccgtga caagatgcca tcacttgtga
     2761 tgttatgaac tgttataaac tctttgcttc tgctaagaag cagtctaaat ataatcaacg
     2821 tacagtgagc tctttgaagc caaccaaggc aggcagaacc ctcttaaata tgagactgat
     2881 gtataggttc tctctatggt cagtatcact ggataagcct tctcctttca taagaaagga
     2941 tgtatttaaa tacattttat tttgctaaat cctgtttagt tttcagccat taaatgtcac
     3001 atgaagcctt gatagaattt gttcataatg gctcatgtat tattattatt tttgagatgg
     3061 agttttgctc ttaatgatat tattattatt tgagacagag ttttgctctt attgcccagg
     3121 ctggagtgca gtggcgtgat cttggctcac tgcaacctct gcctcccagc ttcaagcgat
     3181 tctcctgtat cagcctccca agtagctggg attataggca tgtgccacca tgcccagcaa
     3241 attttgtatt tttttttggt agagacaggg ttcaaccatg ttggtcaggc tggtctcgaa
     3301 ctcctgaccg caagtgatcc acacgccttg gtctcccaaa gtgctgggat tacggtgtta
     3361 gccactacac ctggcctgga ttgtgtatta tttatgtctg tagtttatat gcttagttgt
     3421 tgcctatagt gatctgggta agattcaaac atttatcttt tgtatcttct acagaagtgc
     3481 tttgagcatc aaatttgttt taacgttaaa ttgtagtttg ctgtattaaa atagatcaat
     3541 gaatataatt cagtctttta ggggcaccaa gtaaagcata aggtcatata tactatacaa
     3601 tatgtttatt gcacttccca tggggataaa tcactctgtc attcctagtt attttaaaaa
     3661 aagaacttta tgattacggt cctctttctc acatactgca aacttaaaag atacatacac
     3721 caaatatagg tctgttttaa aggagaggaa aaatagttca aggagttttt gcctctttgt
     3781 ttttcaatag attattctgc cattttttaa aggaaaggga aaatgaaaac agcatgtctt
     3841 tttaaacatt gaaaagaaat atggaggctt taaaccgcaa actgaaaaag ctgagtagaa
     3901 caaaggcagt ggagcataca atacaattct atttatttga ggttaattga agttaataat
     3961 ttttaaattt ttttctaatt ttatgcctta aaataggttt ctgattacat aaaatttgaa
     4021 tagaacactc aagaagtatg tagatttttg aaaaacccaa acaatattct tcttagattt
     4081 ttggaggcaa aatttagacc agtatactaa ttcaaaagac aaatatttca gaggaagtgg
     4141 agtacagtat ttaacatttt gtttgcaatt ttactttttc ttcccttctt ccctattgaa
     4201 ccttgattaa aatgtatgaa tacaatactt ggattttttt ttttcagctt agactctgat
     4261 aatttcagtg gtagtgggga aacctgaatt tgtcagcatg attatttgta actcagattg
     4321 ttcaaatgta tatagaaggt ccccttcaag tgttgtttct ccaagtagtc ataaatgtag
     4381 caagtataaa tcagaatatc atcttataat cttacagagt taacctaatg agtcaatacc
     4441 tttataagca aaaccatgat aaatttaaaa acaacagaaa tgtggcatga ttacttattt
     4501 atttgttcca ggtgactcta aatagttgat ttttctgcct gaaggatcct gaacatattt
     4561 agttaccctg tagttattta ggaatttaaa ccagaagact ttgaagttgt atattcttgc
     4621 aatgcataaa atgacattat aatcaacaaa cttatggttt gtttcaattg atgcacacaa
     4681 aaaataactt atagttagac ttttctattt caagtaaagc tttgagttac ttgtttttat
     4741 acatattcat catgtaccct ttattgtttc taggtgttga tatactttaa taaaaatgat
     4801 atgtttaata ttttcccatt aatatatttc tttgaagcta tttgttttaa aagatgtaac
     4861 acttatttgc tgtcaaattc tgaattaaaa aatctgttgg tggccaggcg cagtggctca
     4921 tgcctgtaat cccaacattt tgggaggcca aggagatgga tcacttgagg ccaggagttc
     4981 aagaccagcc tggccaacat ggcaaaaccc catcactaaa aatacaaaaa ttacccgggc
     5041 atggtggtgg gtgcctgtaa tcccagcttc ttaggaggct gaggtaggag aattgcttga
     5101 ccctgggagg tggaggtggc agtgagccga gatagcacca ctgcacttct agttgacaga
     5161 gtgagactct gactcaaaaa aaaaaaaaaa a
//
